scholarly journals A Novel Anti-Tumor/Anti-Tumor-Associated Fibroblast/Anti-mPEG Tri-Specific Antibody to Maximize the Efficacy of mPEGylated Nanomedicines against Fibroblast-Rich Solid Tumor

2021 ◽  
Author(s):  
Michael Chen ◽  
Ming Sheu ◽  
Tian-Lu Cheng ◽  
Steve R Roffler ◽  
Shyr-Yi Lin ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Solid Tumor ◽  
Specific Antibody ◽  
Therapeutic Efficacy ◽  
Tumor Treatment ◽  
Methoxypolyethylene Glycol ◽  
Physical Barriers

The therapeutic efficacy of methoxypolyethylene glycol (mPEG)-coated nanomedicines in solid tumor treatment is hindered by tumor-associated fibroblasts (TAFs), which promote tumor progression and form physical barriers. We developed an anti-HER2/anti-FAP/anti-mPEG...

An Agent-Based Model of Solid Tumor Progression

2009 ◽  
pp. 187-198 ◽  
Author(s):  
Didier Dréau ◽  
Dimitre Stanimirov ◽  
Ted Carmichael ◽  
Mirsad Hadzikadic
Keyword(s):  
Tumor Progression ◽  
Solid Tumor ◽  
Agent Based Model ◽  
Agent Based

Biomineralization-inspired dasatinib nanodrug with sequential infiltration for effective solid tumor treatment

Biomaterials ◽  
2021 ◽  
Vol 267 ◽  
pp. 120481
Author(s):  
Yanhong Liu ◽  
Lingchao Li ◽  
Jiyong Liu ◽  
Mengnan Yang ◽  
Honglan Wang ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Tumor Treatment

scholarly journals Oligosaccharyltransferase: A Gatekeeper of Health and Tumor Progression

2019 ◽  
Vol 20 (23) ◽  
pp. 6074 ◽  
Author(s):  
Yoichiro Harada ◽  
Yuki Ohkawa ◽  
Yasuhiko Kizuka ◽  
Naoyuki Taniguchi
Keyword(s):  
Tumor Progression ◽  
Protein Modification ◽  
Current Knowledge ◽  
Genetic Disorders ◽  
Cell Communication ◽  
Drug Resistant ◽  
Malignant Cells ◽  
Tumor Treatment ◽  
Membrane Protein Complex ◽  
Growing Body

Oligosaccharyltransferase (OST) is a multi-span membrane protein complex that catalyzes the addition of glycans to selected Asn residues within nascent polypeptides in the lumen of the endoplasmic reticulum. This process, termed N-glycosylation, is a fundamental post-translational protein modification that is involved in the quality control, trafficking of proteins, signal transduction, and cell-to-cell communication. Given these crucial roles, N-glycosylation is essential for homeostasis at the systemic and cellular levels, and a deficiency in genes that encode for OST subunits often results in the development of complex genetic disorders. A growing body of evidence has also demonstrated that the expression of OST subunits is cell context-dependent and is frequently altered in malignant cells, thus contributing to tumor cell survival and proliferation. Importantly, a recently developed inhibitor of OST has revealed this enzyme as a potential target for the treatment of incurable drug-resistant tumors. This review summarizes our current knowledge regarding the functions of OST in the light of health and tumor progression, and discusses perspectives on the clinical relevance of inhibiting OST as a tumor treatment.

scholarly journals Engineering a HER2-specific antibody–drug conjugate to increase lysosomal delivery and therapeutic efficacy

2019 ◽  
Vol 37 (5) ◽  
pp. 523-526 ◽  
Author(s):  
Jeffrey C. Kang ◽  
Wei Sun ◽  
Priyanka Khare ◽  
Mostafa Karimi ◽  
Xiaoli Wang ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Therapeutic Efficacy ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug
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