A zwitterionic red-emitting water-soluble conjugated polymer with high resistance to nonspecific binding for two-photon cell imaging and good singlet oxygen production capability

2021 ◽  
Author(s):  
Yan-Qin Huang ◽  
Shan-Shan Jiang ◽  
Li-Xiang Pan ◽  
Rui Zhang ◽  
Kun-Lin Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
High Resistance ◽  
Conjugated Polymer ◽  
Cell Imaging ◽  
Water Soluble ◽  
Oxygen Production ◽  
Nonspecific Binding ◽  
Two Photon

Water-soluble conjugated polymers (WSCPs) with dual capability of two-photon imaging and singlet oxygen (1O2) production have become one type of the most promising agents in noninvasive imaging guided photodynamic therapy...

Water-Soluble Conjugated Polymers for Simultaneous Two-Photon Cell Imaging and Two-Photon Photodynamic Therapy

2013 ◽  
Vol 1 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Xiaoqin Shen ◽  
Lin Li ◽  
Agnes Chow Min Chan ◽  
Nengyue Gao ◽  
Shao Q. Yao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Cell Imaging ◽  
Water Soluble ◽  
Two Photon

scholarly journals Two-Photon Photodynamic Therapy by Water-Soluble Self-Assembled Conjugated Porphyrins

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Time Resolved ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Luminescence Measurement ◽  
Water Soluble Porphyrin

Studies on two-photon absorption (2PA) photodynamic therapy (PDT) by using three water-soluble porphyrin self-assemblies consisting of ethynylene-linked conjugatedbis(imidazolylporphyrin) are reviewed. 2PA cross-section values in water were obtained by an open aperture Z-scan measurement, and values were extremely large compared with those of monomeric porphyrins such as hematoporphyrin. These compounds were found to generate singlet oxygen efficiently upon one- as well as two-photon absorption as demonstrated by the time-resolved luminescence measurement at the characteristic band of singlet oxygen at 1270 nm and by using its scavenger. Photocytotoxicities for HeLa cancer cells were examined and found to be as high as those of hematoporphyrin, demonstrating that these compounds are potential candidates for 2PA-photodynamic therapy agents.

Gold nanorod enhanced conjugated polymer/photosensitizer composite nanoparticles for simultaneous two-photon excitation fluorescence imaging and photodynamic therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (41) ◽  
pp. 19551-19560 ◽  
Author(s):  
Shuang Li ◽  
Xiaoqin Shen ◽  
Qing-Hua Xu ◽  
Yong Cao
Keyword(s):  
Photodynamic Therapy ◽  
Energy Transfer ◽  
Singlet Oxygen ◽  
Plasmon Resonance ◽  
Conjugated Polymer ◽  
Oxygen Generation ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Photon Excitation ◽  
Two Photon Excitation

Plasmon resonance and energy transfer are integrated to prepare nano-photosensitizers with enhanced two-photon excitation fluorescence and singlet oxygen generation ability.

Syntheses and properties of acetylene-linked bis- and trisporphyrins toward two-photon photodynamic therapy

2007 ◽  
Vol 11 (06) ◽  
pp. 406-417 ◽  
Author(s):  
Yusuke Inaba ◽  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Cross Section ◽  
Sodium Salt ◽  
Absorption Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Photon Irradiation ◽  
Two Photon

Acetylene-bridged bisporphyrins and trisporphyrins having branched bulky bis(carboxylethyl)methyl meso-substituents were synthesized. These compounds showed large effective two-photon absorption cross-section values at 890 nm measured by using a nanosecond Z-scan method. Sodium salt of hydrolyzed trisporphyrins showed broad and red-shifted Q-bands over 900 nm. Two-photon absorption cross-section values of water-soluble dimers in water were similar to, or slightly larger than, those of ester forms evaluated in toluene. Furthermore, the generation of singlet oxygen upon one-photon irradiation for dimers in water was confirmed.

scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

The Measurement of Singlet Oxygen Production in an Experimental Tongue Cancer Model as an Indicator for Photodynamic Therapy

2013 ◽  
Vol 136 (0) ◽  
pp. 62-69
Author(s):  
Ying-Ying Wu ◽  
Toru Hirano ◽  
Junko Yamamoto ◽  
Guang-Wu Huang ◽  
Seiji Yamamoto ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Tongue Cancer ◽  
Oxygen Production ◽  
Cancer Model
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