pH-sensitive silica-based core-shell nanogel prepared via RAFT polymerization: Investigation of core size effect on the doxorubicin release profile

2021 ◽  
Author(s):  
Hassan Farmanbordar ◽  
Mohammad Sadegh Amini-Fazl ◽  
Reza Mohammadi
Keyword(s):  
Cancer Therapy ◽  
Size Effect ◽  
Raft Polymerization ◽  
Therapeutic Index ◽  
Ph Sensitive ◽  
Release Profile ◽  
Core Shell ◽  
Core Size ◽  
Doxorubicin Release

In cancer therapy, one of the famous treatments is chemotherapy (CT); however, the efficiency of chemotherapy is restricted by numerous factors. To improve the therapeutic index of CT, nanoparticles were...

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

2020 ◽  
Vol 21 (11) ◽  
pp. 1084-1098
Author(s):  
Fengqian Chen ◽  
Yunzhen Shi ◽  
Jinming Zhang ◽  
Qi Liu
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Epigenetic Therapy ◽  
Cancer Therapies ◽  
Therapeutic Benefits ◽  
High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

scholarly journals Gold/Polyoxometalate Core/Shell Nanoparticles for Combined Chemotherapy–Photothermal Cancer Therapy

2021 ◽  
Author(s):  
Somia Tomane ◽  
Claire Wilhelm ◽  
Souhir Boujday ◽  
Alexandre Fromain ◽  
Antoine Miche ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Core Shell ◽  
Combined Chemotherapy ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

MnO2-Coated Porous Pt@CeO2 Core-Shell Nanostructures for Photoacoustic Imaging-Guided Tri-modal Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Qing Xu ◽  
Danyang Li ◽  
Haijun Zhou ◽  
Biaoqi Chen ◽  
Junlei Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Conversion Efficiency ◽  
Photoacoustic Imaging ◽  
Core Shell ◽  
Photothermal Conversion ◽  
The Core ◽  
Shell Nanostructures

We describe the synthesis of MnO2-coated porous Pt@CeO2 core–shell nanostructures (Pt@CeO2@MnO2) as a new theranostic nano-platform. The porous Pt cores endow the core–shell nanostructures with high photothermal conversion efficiency (80%)...

scholarly journals ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 29986-29996
Author(s):  
Xiuxiu Qi ◽  
Hongmei Yan ◽  
Yingxue Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Core Shell ◽  
Assembly Process ◽  
Block Polymer ◽  
Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

Sign in / Sign up

Export Citation Format

Share Document