Chestnut-like macro-acanthosphere triggered hemostasis: a featured mechanism based on puncturing red blood cells

Nanoscale ◽  
2021 ◽  
Author(s):  
Yang Liu ◽  
kun yu ◽  
Songming Shang ◽  
Ruiqi Xie ◽  
Fei Lu ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Massive Bleeding ◽  
Acute Hemorrhage ◽  
Threatening Condition ◽  
Life Threatening

Acute hemorrhage that occurs after trauma is a life-threatening condition. Hence, to halt massive bleeding, there is a critical need to develop a suitable therapy. In this study, we developed...

Massive Transfusion

2018 ◽  
pp. 169-180
Author(s):  
Jay Berger
Keyword(s):  
Red Blood Cells ◽  
Blood Volume ◽  
Blood Cells ◽  
Massive Transfusion ◽  
Fresh Frozen Plasma ◽  
Metabolic Complications ◽  
Packed Red Blood Cells ◽  
Fresh Frozen ◽  
Life Threatening ◽  
Frozen Plasma

Massive transfusion is defined as transfusion of 3 units of packed red blood cells in less than 1 hour in an adult, replacement of more than 1 blood volume in 24 hours, or replacement of more than 50% of blood volume in 3 hours. Massive transfusion protocols are implemented in cases of life-threatening hemorrhage after trauma, during a surgical procedure, or during childbirth. These protocols are intended to minimize the adverse effects of hypovolemia, dilutional anemia, metabolic complications, and coagulopathy with early empiric replacement of blood products and transfusion of fresh frozen plasma, platelets, and packed red blood cells in a composition that approximates that of whole blood.

scholarly journals An Efficient Image Classification of Malaria Parasite Using Convolutional Neural Network and ADAM Optimizer

2021 ◽  
Vol 12 (2) ◽  
pp. 3376-3384
Author(s):  
K. Kranthi Kumar, Et. al.
Keyword(s):  
Machine Learning ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Information Science ◽  
Data Intensive ◽  
Learning Techniques ◽  
Protozoan Infection ◽  
Life Threatening ◽  
On Line ◽  
Infected Cells

Machine learning can be a technique of nursing lysis that automatically develops an analytical model. It is a branch of synthetic intelligence that believes that systems are going to learn information, determine patterns of information and decide with degraded human intervention. Machine learning addresses the question of how computers can be constructed that improve mechanically through knowledge. It lies at the intersection of technology and statistics and at the center of artificial data and information science, one in all the quickest increasing technical fields of nowadays. Recent advances in machine learning were driven by the event of latest learning and theories also as by the constant explosion. The event of latest learning algorithms and also theory and the in-progress growth within the accessibility of on-line information also as low-priced computation crystal rectifier to recent progress within the field of machine learning. Additional evidence-based decision-making could be carried out in science, technology and trade, including healthcare, production, education and monetary modelling, enforcement and promotion, with adoption of mechanical learning techniques based on data-intensive methods. The results are also available. The infection can be a life-threatening disease. The bite of a nursing partner is often transmitted in dipterous Anopheles. In infected mosquitoes, plasmodium parasite is a gift. The parasite is discharged into your blood after you bite this dipterous insect once it bites you. Once your body is composed of the parasites, they mature into the liver. The mature parasites enter the blood for several days when red blood cells start to infect. In red blood cells, parasites increase over 48-72 hours, causing infected cells to divide. The parasites still infect red blood cells, which last 2 to 3 days in cycles. This paper is used for observation of protozoan infection with a deep learning idea.

scholarly journals Effect of Intra- and Post-Operative Fluid and Blood Volume on Postoperative Pulmonary Edema in Patients with Intraoperative Massive Bleeding

2021 ◽  
Vol 10 (18) ◽  
pp. 4224
Author(s):  
Young-Suk Kwon ◽  
Haewon Kim ◽  
Hanna Lee ◽  
Jong-Ho Kim ◽  
Ji-Su Jang ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Risk Factor ◽  
Confidence Interval ◽  
Pulmonary Edema ◽  
Red Blood Cells ◽  
Blood Volume ◽  
Blood Cells ◽  
Massive Bleeding ◽  
Hazard Ratio ◽  
Blood Volumes

In patients with intraoperative massive bleeding, the effects of fluid and blood volume on postoperative pulmonary edema are uncertain. Patients with intraoperative massive bleeding who had undergone a non-cardiac surgery in five hospitals were enrolled in this study. We evaluated the association of postoperative pulmonary edema risk and intra- and post-operatively administered fluid and blood volumes in patients with intraoperative massive bleeding. In total, 2090 patients were included in the postoperative pulmonary edema analysis, and 300 patients developed pulmonary edema within 72 h of the surgery. The postoperative pulmonary edema with hypoxemia analysis included 1660 patients, and the condition occurred in 161 patients. An increase in the amount of red blood cells transfused per hour after surgery increased the risk of pulmonary edema (hazard ratio: 1.03; 95% confidence interval: 1.01–1.05) p = 0.013) and the risk of pulmonary edema with hypoxemia (hazard ratio: 1.04; 95% confidence interval: 1.01–1.07; p = 0.024). An increase in the red blood cells transfused per hour after surgery increased the risk of developing pulmonary edema. This increase can be considered as a risk factor for pulmonary edema.

Retrospektywna analiza przypadku wzmożonej hemolizy u pacjentki z opóźnioną hemolityczną reakcją poprzetoczeniową spowodowaną przeciwciałami anty-K

2018 ◽  
Vol 21 (2) ◽  
Author(s):  
Bożena Andrys ◽  
Katarzyna Korybalska
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Genetic Disorders ◽  
Hematological Parameters ◽  
Transfusion Reaction ◽  
Ferritin Concentration ◽  
Packed Red Blood Cells ◽  
Human Red Blood Cells ◽  
Hemolytic Transfusion Reaction ◽  
Life Threatening

Hyperhemolysis is a life-threatening undesirable post-transfusion reaction characterized by a decrease in hemoglobin (Hb), hematocrit (Hct), reticulocytopenia and increase in ferritin concentration. It usually occurs in patients with hemoglobinopathies, rarely in people without genetic disorders of human red blood cells. The case concerns a 79-year-old woman who, due to a trophic ulcer and erysipelas, received one unit of kell positive packed red blood cells (pRBC). The patient did not exhibit symptoms of hypoxia despite the reduced value of hematological parameters (Hb: 10.4 g/dl, Hct: 31%). Delayed hemolytic transfusion reaction (DHTR) occurred after 11 days, with the presence of anti-K antibodies (Hb: 6.1 g/dl, Hct: 17%). Despite transfusion of three pRBC properly selected against patient’s antigens, only a transient increase in Hb and Hct was observed (Hb: 8.1 g/dl, Hct: 22%). These parameters rapidly decreased within 18 hours (Hb: 6.7 g/dl, Hct: 18%). The patient died due to circulatory and respiratory failure.

scholarly journals Effect of Intra- and Postoperative Fluid and Blood Volume on Postoperative Pulmonary Edema in Patients With Intraoperative Massive Bleeding: Multi-Center Cohort Study Using Time Varying Analysis

2020 ◽  
Author(s):  
Young Suk Kwon ◽  
Jun Woo Choi ◽  
Hanna Lee ◽  
Jong Ho Kim ◽  
Ji Su Jang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Pulmonary Edema ◽  
Red Blood Cells ◽  
Blood Volume ◽  
Blood Cells ◽  
Medical Center ◽  
Massive Bleeding ◽  
Hazard Ratio ◽  
Time Varying

Abstract BackgroundIn patients with massive bleeding during surgery, the effect of intra- and postoperative fluid and blood volume on postoperative pulmonary edema is uncertain. The aim of this study is evaluating the occurrence risk relationship through time-varying analysis between postoperative pulmonary edema and intra- and postoperatively administered volume of fluid and blood in patients with intraoperative massive bleeding.MethodsThis study is a retrospective cohort study and data was obtained from the clinical data warehouse at Hallym University Medical Center, a multi-institutional data registry of 5 hospitals of Hallym University. Patients with intraoperative massive bleeding (≥40% of average blood volume) and who underwent a non-cardiac surgery at 5 hospitals between January 1, 2010, and December 31, 2019 were enrolled the study. The primary outcome was postoperative pulmonary edema occurrence within 72 hours after surgery. Secondary outcomes were postoperative pulmonary edema with hypoxemia. ResultsIn total, 2090 patients were included in the postoperative pulmonary edema analysis, and 300 patients developed pulmonary edema within 72 hours after surgery. The postoperative pulmonary edema hypoxemia analysis with hypoxia included 1660 patients; pulmonary edema with hypoxemia occurred in 161 patients. The increase in the amount of red blood cells/average blood volume/hour after surgery increased the risk of developing pulmonary edema after surgery (hazard ratio: 1.03, 95% confidence interval [1.01–1.05], P = 0.013) and the risk of developing pulmonary edema with hypoxemia (hazard ratio: 1.04, 95% confidence interval [1.01–1.07], P = 0.024).ConclusionIn this study, an increase in the transfusion of red blood cells per hour after surgery increased the risk of developing pulmonary edema after surgery. This increase can be considered a risk factor for the incidence of pulmonary edema.

scholarly journals Masivno krvavljenje i mehanizmi koagulopatije u traumi

2006 ◽  
Vol 53 (4) ◽  
pp. 89-92
Author(s):  
N. Popovic ◽  
Z. Blagojevic ◽  
V. Nikolic ◽  
Lj. Arsenijevic ◽  
A. Karamarkovic ◽  
...  
Keyword(s):  
Massive Bleeding ◽  
Vascular Integrity ◽  
Small Vessels ◽  
Civilian Trauma ◽  
Risk Of Mortality ◽  
Lethal Triad ◽  
Increased Risk ◽  
Threatening Condition ◽  
Life Threatening ◽  
Dilutional Coagulopathy

Trauma is disease of the young, mainly affecting people between 15-40 years of age. Uncontrolled massive bleeding is the leading cause of early in-hospital mortality, within 48h of admission, and the second leading cause of prehospital death in victims of both military and civilian trauma, accounting for 40-45% of the total fatalities. Coagulopathy develops early after injury and is present in 25- 36% of trauma victims upon admission to the emergency department. Coagulopathy correlates to the severity of trauma and is associated with an increased risk of mortality. The aim of this paper is to explain pathophysiology of developing coagulopathy in trauma. The coagulopathy in the trauma patient is complex and multifactorial. It includes: dilutional coagulopathy, hypothermia, acidosis, hyperfibrinolysis, anemia and consumption coagulopathy. When the patient develops the so called ?lethal triad? of hypothermia, acidosis and coagulopathy, surgical restoration of vascular integrity may be insufficient to achieve a definitive control of blood loss and non-mechanical bleeding from small vessels, usually terminated by spontaneous coagulation, becomes a life-threatening condition.

scholarly journals Sickle Cell Disease: Metabolomic Profiles of Vaso-Occlusive Crisis in Plasma and Erythrocytes

2020 ◽  
Vol 9 (4) ◽  
pp. 1092 ◽  
Author(s):  
Klétigui Casimir Dembélé ◽  
Charlotte Veyrat-Durebex ◽  
Aldiouma Guindo ◽  
Stéphanie Chupin ◽  
Lydie Tessier ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Predictive Biomarkers ◽  
Predictive Performance ◽  
Cell Disease ◽  
Nitric Oxide Metabolism ◽  
Life Threatening ◽  
Median Area

The metabolomic profile of vaso-occlusive crisis, compared to the basal state of sickle cell disease, has never been reported to our knowledge. Using a standardized targeted metabolomic approach, performed on plasma and erythrocyte fractions, we compared these two states of the disease in the same group of 40 patients. Among the 188 metabolites analyzed, 153 were accurately measured in plasma and 143 in red blood cells. Supervised paired partial least squares discriminant analysis (pPLS-DA) showed good predictive performance for test sets with median area under the receiver operating characteristic (AUROC) curves of 99% and mean p-values of 0.0005 and 0.0002 in plasma and erythrocytes, respectively. A total of 63 metabolites allowed discrimination between the two groups in the plasma, whereas 61 allowed discrimination in the erythrocytes. Overall, this signature points to altered arginine and nitric oxide metabolism, pain pathophysiology, hypoxia and energetic crisis, and membrane remodeling of red blood cells. It also revealed the alteration of metabolite concentrations that had not been previously associated with sickle cell disease. Our results demonstrate that the vaso-occlusive crisis has a specific metabolomic signature, distinct from that observed at steady state, which may be potentially helpful for finding predictive biomarkers for this acute life-threatening episode.

Postinjury Life Threatening Coagulopathy: Is 1:1 Fresh Frozen Plasma: Packed Red Blood Cells the Answer?

2008 ◽  
Vol 65 (2) ◽  
pp. 261-271 ◽  
Author(s):  
Jeffry L. Kashuk ◽  
Ernest E. Moore ◽  
Jeffrey L. Johnson ◽  
James Haenel ◽  
Michael Wilson ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Fresh Frozen Plasma ◽  
Packed Red Blood Cells ◽  
Fresh Frozen ◽  
Life Threatening ◽  
Frozen Plasma

Hemoglobin crystals of the red blood cells in the human renal cortex: electron microscopic observations of the renal lithiasis

1978 ◽  
Vol 36 (2) ◽  
pp. 480-481
Author(s):  
Kosuke Ueda ◽  
Hiroto Washida ◽  
Nakazo Watari
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Renal Cortex ◽  
Uranyl Acetate ◽  
Osmic Acid ◽  
Renal Lithiasis ◽  
Electron Microscopic ◽  
Hemoglobin C ◽  
First Case ◽  
Ultrathin Sections

IntroductionHemoglobin crystals in the red blood cells were electronmicroscopically reported by Fawcett in the cat myocardium. In the human, Lessin revealed crystal-containing cells in the periphral blood of hemoglobin C disease patients. We found the hemoglobin crystals and its agglutination in the erythrocytes in the renal cortex of the human renal lithiasis, and these patients had no hematological abnormalities or other diseases out of the renal lithiasis. Hemoglobin crystals in the human erythrocytes were confirmed to be the first case in the kidney.Material and MethodsTen cases of the human renal biopsies were performed on the operations of the seven pyelolithotomies and three ureterolithotomies. The each specimens were primarily fixed in cacodylate buffered 3. 0% glutaraldehyde and post fixed in osmic acid, dehydrated in graded concentrations of ethanol, and then embedded in Epon 812. Ultrathin sections, cut on LKB microtome, were doubly stained with uranyl acetate and lead citrate.

Densitometric Identification of Primitive Erythroblasts After Reaction With Diaminobenzidine

1973 ◽  
Vol 31 ◽  
pp. 328-329
Author(s):  
John A. Trotter
Keyword(s):  
Red Blood Cells ◽  
Analytical Method ◽  
Blood Cells ◽  
Guinea Pigs ◽  
Specific Protein ◽  
Visual Examination ◽  
Hemoglobin Synthesis ◽  
Peroxidatic Activity ◽  
Small Density

Hemoglobin is the specific protein of red blood cells. Those cells in which hemoglobin synthesis is initiated are the earliest cells that can presently be considered to be committed to erythropoiesis. In order to identify such early cells electron microscopically, we have made use of the peroxidatic activity of hemoglobin by reacting the marrow of erythropoietically stimulated guinea pigs with diaminobenzidine (DAB). The reaction product appeared as a diffuse and amorphous electron opacity throughout the cytoplasm of reactive cells. The detection of small density increases of such a diffuse nature required an analytical method more sensitive and reliable than the visual examination of micrographs. A procedure was therefore devised for the evaluation of micrographs (negatives) with a densitometer (Weston Photographic Analyzer).

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