Deep and Compact Dentinal Tubule Occlusion via Biomimic Mineralization and Mineral Overgrowth

Nanoscale ◽  
2021 ◽  
Author(s):  
Zhuo Chen ◽  
Yuyan Duan ◽  
Songzhe Shan ◽  
Kaida Sun ◽  
Gang Wang ◽  
...  
Keyword(s):  
Dentin Hypersensitivity ◽  
Dentinal Tubule ◽  
Desensitizing Agents ◽  
External Stimuli ◽  
Tubule Occlusion

Dentinal tubule (DT) occlusion by desensitizing agents has been widely applied to inhibit the transmission of external stimuli that cause dentin hypersensitivity (DH). However, most desensitizing agents merely accomplish porous...

Hydroxyapatite, a potent agent to reduce dentin hypersensitivity; systematic review

2021 ◽  
Vol 71 (11) ◽  
pp. 2604-2610
Author(s):  
Hashmat Gul ◽  
Muhammad Asad Ghaffar ◽  
Muhammad Kaleem ◽  
Abdul Samad Khan
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Web Of Science ◽  
In Vitro Studies ◽  
Dentin Hypersensitivity ◽  
Dentinal Tubule ◽  
Dentin Permeability ◽  
Tubule Occlusion

Objective: This study reviews different modes of application of hydroxyapatite for treatment of dentin hypersensitivity via dentinal tubule occlusion. Methods: Literature search was performed using keywords, “hydroxyapatite and dentin hypersensitivity, hydroxyapatite and dentinal tubule occlusion, hydroxyapatite and dentin permeability, dentinal tubule occlusion” on Pubmed, Science Direct and Web of Science, which involved the results of previous 10 years (2009-2018). After screening, 16 studies were included in systematic review. Results: The results of in-vitro studies showed that application of hydroxyapatite caused dentinal tubule occlusion leading to reduction in dentin permeability and reduction in dentin hypersensitivity. Conclusion: Hydroxyapatite has the potential to reduce dentin hypersensitivity via dentinal tubule occlusion within 2-8 weeks. Keywords: Dentin hypersensitivity, Hydroxyapatite, Dentinal tubule occlusion. Continuous...

scholarly journals Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3150
Author(s):  
Manuel Toledano-Osorio ◽  
Raquel Osorio ◽  
Estrella Osorio ◽  
Antonio L. Medina-Castillo ◽  
Manuel Toledano
Keyword(s):  
Mechanical Properties ◽  
Citric Acid ◽  
Complex Modulus ◽  
Polymeric Nanoparticles ◽  
In Vitro Study ◽  
Dentin Hypersensitivity ◽  
Dentinal Tubule ◽  
Tubule Occlusion ◽  
Acid Challenge

Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs, (3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne®. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA and Student–Newman–Keuls tests were used (p < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne® have around 30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped NPs, but in the case of specimens treated with Sensodyne®, complex modulus values were reduced below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced acid-resistant tubular occlusion and increased the mechanical properties of dentin.

Evaluation of Dentinal Changes Following Application of Three Different Desensitizing Agents

2017 ◽  
Vol 68 (7) ◽  
pp. 1573-1577 ◽  
Author(s):  
Simona Stoleriu ◽  
Galina Pancu ◽  
Angela Ghiorghe ◽  
Dorina Cerasella Sincar ◽  
Sorina Solomon ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Dentinal Tubule ◽  
Nacl Solution ◽  
Human Teeth ◽  
Desensitizing Agents ◽  
Strontium Acetate ◽  
Dentin Tubules ◽  
Tubule Occlusion ◽  
Scanning Electron

The aim of this in vitro study was to evaluate the effect of three desensitizing tooth pastes on the dentinal tubule occlusion. Thirty dentin discs having a thickness of 3 mm were obtained by cutting human teeth. The discs were submersed in citric acid for 30 seconds to open the dentin tubules. Then the discs were cut in two halves. In each group 10 halves were kept in 0.9% NaCl solution) and the other 10 halves were exposed to the action of one of the tested desensitizing toothpastes. The dentin samples were placed in the machine designed to simulate tooth brushing. Three commercial desensitizing toothpastes were chosen to be applied on dentin surface. The morphology of dentin samples and the level of tubule occlusion was scored using scanning electron microscope. All the three desensitizing toothpastes demonstrated significant effects on dentinal tubule occlusion. The tooth paste containing arginine and calcium carbonate as active ingredients showed the highest degree of tubule occlusion, followed by the dentifrice containing strontium acetate and sodium fluoride.

scholarly journals Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 591 ◽  
Author(s):  
Jungin Bae ◽  
Woo-Sung Son ◽  
Kyung-Hyeon Yoo ◽  
Seog-Young Yoon ◽  
Moon-Kyoung Bae ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Calcium Ion ◽  
Pamam Dendrimer ◽  
Dentin Hypersensitivity ◽  
Dentinal Tubule ◽  
Dentinal Tubules ◽  
Releasing Effect ◽  
Clinical Conditions ◽  
Tubule Occlusion ◽  
Mesoporous Bioactive Glass

Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and PAMAM@MBN. After soaking each sample in simulated body fluid (SBF), we observed ion-releasing effects and dentin remineralization effects for 30 days. Also, we prepared 30 premolars to find the ratio of occluded dentinal tubules after applying MBN and PAMAM@MBN, respectively. The results showed that PAMAM did not disrupt the calcium ion-releasing ability or the dentin remineralization of MBN. The PAMAM@MBN showed a better occluding effect for dentinal tubules than that of MBN (p < 0.05). In terms of dentinal tubule occlusion, the gap between MBN was well occluded due to PAMAM. This implies that PAMAM@MBN could be effectively used in dentinal tubule sealing and remineralization.

scholarly journals Effects of desensitizing agents on dentinal tubule occlusion

2004 ◽  
Vol 12 (2) ◽  
pp. 144-148 ◽  
Author(s):  
César Augusto Galvão Arrais ◽  
Daniel Chi Ngai Chan ◽  
Marcelo Giannini
Keyword(s):  
Thin Layer ◽  
Sem Analysis ◽  
Clinical Aspect ◽  
Dentinal Tubule ◽  
Third Molars ◽  
Potassium Oxalate ◽  
Dentinal Tubules ◽  
Dentin Surface ◽  
Desensitizing Agents ◽  
Tubule Occlusion

The aim of this study was to evaluate the features of dentinal tubules occlusion following application of three commercially available desensitizing agents: potassium oxalate-based / Oxa-Gel (OX), HEMA and glutaraldehyde-based / Gluma Desensitizer (GD) and acidulated phosphate fluoride-based / Nupro Gel (AF). Buccal cervical areas of twenty-four extracted human third molars were smoothed and wet-polished with SiC papers and diamond pastes, in order to simulate the clinical aspect of hypersensitive dentin cervical surfaces. The teeth were randomly divided into four groups (n=6), according to the dentin surface treatments: G1: untreated; G2: OX; G3: GD; G4: AF. Specimens were fractured in the lingual-buccal direction and prepared for SEM analysis. OX promoted tubule occlusion by crystal-like deposits in the lumen of the tubules. While GL created a thin layer over the dentin surface, AF application produced precipitates that occluded the tubules. According to the SEM analysis, all desensitizing agents were able to occlude the dentinal tubules.

The Evaluation of Dentinal Tubule Occlusion by Desensitizing Agents: A Real-time Measurement of Dentinal Fluid Flow Rate and Scanning Electron Microscopy

2013 ◽  
Vol 38 (4) ◽  
pp. 419-428 ◽  
Author(s):  
SY Kim ◽  
EJ Kim ◽  
DS Kim ◽  
IB Lee
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Fluid Flow ◽  
Dentinal Tubule ◽  
Different Types ◽  
Dentinal Fluid Flow ◽  
Desensitizing Agents ◽  
Light Curing ◽  
Tubule Occlusion ◽  
Scanning Electron

SUMMARY The aims of this study were to examine changes in dentinal fluid flow (DFF) during the application of a desensitizing agent and to compare the permeability reduction levels among different types of desensitizing agents. A cervical cavity was prepared for the exposure of cervical dentin on an extracted human premolar connected to a subnanoliter fluid flow measuring device under 20 cm of water pressure. The cavity was acid-etched with 32% phosphoric acid to make dentin highly permeable. The different types of desensitizing agents that were applied on the cavity were Seal&Protect as the light-curing adhesive type, SuperSeal and BisBlock as oxalate types, Gluma Desensitizer as the protein-precipitation type, and Bi-Fluoride 12 as the fluoride type. DFF was measured from the time before the application of the desensitizing agent throughout the application procedure to five minutes after the application. The characteristics of dentinal tubule occlusion of each desensitizing agent were examined by scanning electron microscopy. The DFF rate after each desensitizing agent application was significantly reduced when compared to the initial DFF rate before application for all of the desensitizing agents (p&lt;0.05). Seal&Protect showed a greater reduction in the DFF rate when compared to Gluma Desensitizer and Bi-Fluoride 12 (p&lt;0.05). SuperSeal and BisBlock exhibited a greater reduction in DFF rate when compared to Bi-Fluoride 12 (p&lt;0.05). The dentin hypersensitivity treatment effects of the employed desensitizing agents in this study were confirmed through real-time measurements of DFF changes. The light-curing adhesive and oxalate types showed greater reduction in the DFF rate than did the protein-precipitation and fluoride types.

scholarly journals Effect of Erosion/Abrasion Challenge on the Dentin Tubule Occlusion Using Different Desensitizing Agents

2017 ◽  
Vol 28 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Gabriela D. Canali ◽  
Rodrigo N. Rached ◽  
Rui F. Mazur ◽  
Evelise M. Souza
Keyword(s):  
Repeated Measurements ◽  
Dentinal Tubule ◽  
Third Molars ◽  
Citric Acid Solution ◽  
Healthy Human ◽  
Dentin Permeability ◽  
Dentin Tubule ◽  
Before And After ◽  
Desensitizing Agents ◽  
Tubule Occlusion

The aim of the study was to evaluate dentinal tubule occlusion, measuring the dentin permeability (Lp) and using different desensitizing agents before and after abrasive/erosive challenge. Dentin discs from 42 healthy human third molars were obtained. Minimum Lp was measured after a smear layer simulation using #600 SiC paper and maximum Lp after an immersion in 0.5 M EDTA. The specimens were treated with different desensitizers: two varnishes (Clinpro XT Varnish-CV, Fluor Protector-FP), a paste (Desensibilize Nano P-NP) and a gel (Oxa Gel-OG). The Lp of each specimen was measured immediately after the desensitizers’ application. The discs were subjected to erosion/abrasion cycles for 7 days, with 0.5% citric acid solution (6x/day) and tooth brushing (3x/day). Lp was measured after the first, fourth and seventh day of the challenge. The data were analyzed by 3-way ANOVA with repeated measurements and by a Games-Howell test (α=5%). FP and CV did not show significant differences in Lp immediately after application until the 7th day (p<0.05). OG showed a significant increase in Lp after the 4th and 7th days. NP resulted in a significantly higher permeability compared to the other materials immediately after the application and after the 1st day of challenge. All the desensitizers reduced the dentin permeability immediately after application. However, only the varnishes were able to maintain the occlusive effect after the erosion/abrasion challenge.

In Vitro Effect of Innovative Desensitizing Agents on Dentin Tubule Occlusion and Erosive Wear

2019 ◽  
Vol 44 (2) ◽  
pp. 168-177 ◽  
Author(s):  
SA Garofalo ◽  
LO Sakae ◽  
AC Machado ◽  
SR Cunha ◽  
DM Zezell ◽  
...  
Keyword(s):  
Erosive Wear ◽  
Repeated Measure ◽  
Control Group ◽  
Dentin Hypersensitivity ◽  
Surface Loss ◽  
Dentin Tubule ◽  
Desensitizing Agents ◽  
Dentin Tubules ◽  
Vitro Effect ◽  
Tubule Occlusion

SUMMARY Purpose: The purpose of this study was to evaluate the effects of four in-office desensitizing products on dentin tubule occlusion and erosive wear. Methods: Dentin hypersensitivity was simulated by EDTA application for five minutes. The specimens were randomly allocated into five groups (n=11), according to treatment: No treatment - Control (C), Duraphat (DUR), Desensibilize Nano P (NP), ClinPro XT Varnish (XTV), and ClinPro White Varnish (CWV). They were then submitted to erosive/abrasive cycling for five days. After EDTA, treatment, and cycling, the specimens were analyzed with an environmental scanning electron microscope (ESEM) to verify the number of opened dentin tubules (ODT) which were counted by using ImageJ software, and with a profilometer to determine the surface curvature/loss. ESEM data were analyzed with two-way repeated measure analysis of variance and Tukey tests. For the profilometer, data were analyzed with Kruskal-Wallis, Tukey, and Mann-Whitney tests. Results: After treatment, all groups showed lower ODT than the control, without significant differences between them. After cycling, the only group that showed lower ODT than the control was group XTV; however, it did not significantly differ from the other groups. For the profilometric analysis, there were significant differences in SL between the experimental times after treatment and after cycling for all groups (p&lt;0.05). After cycling, no surface loss was detected in groups DUR and XTV, which presented a significantly different curvature than group NP and the control group, but not from group CWV. Surface loss was detected for the control and groups NP and CWV, without difference among them. Conclusion: All desensitizing agents tested presented promising results concerning the obliteration of dentin tubules immediately after treatment. XTV was the only desensitizer capable of preventing the reopening of the tubules after the erosive/abrasive challenges. XTV and DUR presented a protective effect against dentin erosive wear.

scholarly journals Comparitive Evaluation of Novel Desensitising Agents on Dentinal Tubule Occlusion-A Scanning Electron Microscopic Study

2020 ◽  
pp. 11-18
Author(s):  
Dr. Madhavi Ajit Shetty ◽  
Dr. Sharad Kokate ◽  
Dr. Vibha Hegde
Keyword(s):  
Control Group ◽  
Dentinal Tubule ◽  
Tetraacetic Acid ◽  
Electron Microscopic ◽  
Dentinal Tubules ◽  
Scanning Electron Microscopic Study ◽  
Scanning Electron Microscopic ◽  
Desensitizing Agents ◽  
Dentinal Hypersensitivity ◽  
Tubule Occlusion

Aim: To comparatively evaluate the occlusion of dentinal tubules by four novel desensitizing agents for treatment of Dentinal Hypersensitivity. Materials and Methods: The Diode Laser and three commercially available Desensitizers the NovaminR group- (SHY-NMTM), Colgate Sensitive Pro-relief, Gluma were investigated in this study. 30 extracted mandibular molars were used (n=30). They were divided into 5 groups including the control group in which no treatment was done. Teeth were ground under water-cooled trimming wheel, to prepare flat dentin surfaces. The dentin surfaces were etched to remove any smear plugs and to mimic the open dentinal tubules of sensitive dentin using 0.5 M Ethylene Diamine Tetraacetic Acid (pH 7.4) for two minutes (applied with a micro brush) and then rinsed with an air-water syringe for 30 seconds.

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