scholarly journals Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency

RSC Advances ◽  
2021 ◽  
Vol 11 (55) ◽  
pp. 34788-34794
Author(s):  
Mário S. P. Correia ◽  
Bhawana Thapa ◽  
Miroslav Vujasinovic ◽  
J.-Matthias Löhr ◽  
Daniel Globisch
Keyword(s):  
Urine Samples ◽  
Plasma Samples ◽  
Age Dependency ◽  
Plasma And Urine Samples ◽  
The Individual ◽  
Individual Human

Profile of the human core sulfatome in urine and plasma samples.

scholarly journals Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Xin-Jie Xu ◽  
Xiao-E Cai ◽  
Fan-Chao Meng ◽  
Tian-Jia Song ◽  
Xiao-Xi Wang ◽  
...  
Keyword(s):  
Autism Spectrum ◽  
Urine Samples ◽  
Metabolic Profiles ◽  
Plasma Samples ◽  
Typically Developing ◽  
Children With Asd ◽  
Full Picture ◽  
Plasma And Urine Samples ◽  
Healthy Control ◽  
Age Range

Background: Autism spectrum disorder (ASD) is defined as a pervasive developmental disorder which is caused by genetic and environmental risk factors. Besides the core behavioral symptoms, accumulated results indicate children with ASD also share some metabolic abnormalities.Objectives: To analyze the comprehensive metabolic profiles in both of the first-morning urine and plasma samples collected from the same cohort of autistic boys.Methods: In this study, 30 autistic boys and 30 tightly matched healthy control (HC) boys (age range: 2.4~6.7 years) were recruited. First-morning urine and plasma samples were collected and the liquid chromatography–mass spectrometry (LC-MS) was applied to obtain the untargeted metabolic profiles. The acquired data were processed by multivariate analysis and the screened metabolites were grouped by metabolic pathway.Results: Different discriminating metabolites were found in plasma and urine samples. Notably, taurine and catechol levels were decreased in urine but increased in plasma in the same cohort of ASD children. Enriched pathway analysis revealed that perturbations in taurine and hypotaurine metabolism, phenylalanine metabolism, and arginine and proline metabolism could be found in both of the plasma and urine samples.Conclusion: These preliminary results suggest that a series of common metabolic perturbations exist in children with ASD, and confirmed the importance to have a comprehensive analysis of the metabolites in different biological samples to reveal the full picture of the complex metabolic patterns associated with ASD. Further targeted analyses are needed to validate these results in a larger cohort.

scholarly journals Virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients

2020 ◽  
Author(s):  
Ning Zhang ◽  
Yuhuan Gong ◽  
Fanping Meng ◽  
Yuhai Bi ◽  
Penghui Yang ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Patient Discharge ◽  
Urine Samples ◽  
Virus Dynamics ◽  
Plasma Samples ◽  
Virus Shedding ◽  
Detection Point ◽  
Plasma And Urine Samples ◽  
Discharged Patients ◽  
Upper Respiratory

Diagnosis is the key point for confirmation and treatment of COVID-19. we focused on comparative analysis of virus dynamics between the upper respiratory and feces specimens in the COVID-19 patients. A total of 66 upper respiratory swabs, 51 feces, 56 urine and 56 plasma samples were sequentially collected from 23 patients in a designated hospital. The plasma and urine samples were all negative, except for urine samples from two severe cases at the latest available detection point. Conversely, virus was shed in respiratory swabs and feces samples during the diseased period. Ten of 12 (83.3%) cases were positive for feces samples, while 14 of 21 (66.7%) were positive for respiratory samples. In addition, the median duration of virus shedding was 10.0 days (IQR 8.0 to 17.0) in the upper respiratory swabs, but was 22.0 days (IQR 15.5 to 23.5) for the feces. Notably, at 26 days after discharge, case 3 (a 45-year-old) was detected positive again in the feces samples, but appears to be healthy and negative for respiratory swabs. These results indicated that beside respiratory samples, intestinal samples (e.g. feces) should be recommended for diagnosis of COVID-19, especially before a patient discharge and for monitoring the relapse of discharged patients.

Spatial and Temporal Organization of the Individual Human Cerebellum

2018 ◽  
Author(s):  
Scott Marek ◽  
Joshua S. Siegel ◽  
Evan M. Gordon ◽  
Ryan V. Raut ◽  
Caterina Gratton ◽  
...  
Keyword(s):  
Temporal Organization ◽  
Human Cerebellum ◽  
The Individual ◽  
Individual Human

Organizing Things in Dickens

2018 ◽  
Author(s):  
Elaine Auyoung
Keyword(s):  
Human Body ◽  
Individual Experience ◽  
Bleak House ◽  
Narrative Structures ◽  
Concrete Objects ◽  
Comprehension Process ◽  
The Individual ◽  
Individual Human

This chapter demonstrates how the organization of narrative information can shape a reader’s impression of what is represented. It focuses on two ways in which concrete objects are arranged in Charles Dickens’s Bleak House: as specific members of general categories and as part of causally connected narrative structures. Dickens relies on these representational strategies to capture a scale of reality no longer suited to the individual human body. In doing so, he also reveals that the realist novel’s conventional commitment to individual experience at the scale of concrete particulars reflects constraints on the comprehension process.

Annual changes in 6-sulphatoxymelatonin excretion in man

1988 ◽  
Vol 117 (4) ◽  
pp. 470-476 ◽  
Author(s):  
Christopher J. Bojkowski ◽  
Josephine Arendt
Keyword(s):  
Intermediate Phase ◽  
Urine Samples ◽  
Plasma Samples ◽  
Annual Change ◽  
Melatonin Secretion ◽  
Normal Volunteers ◽  
Plasma Melatonin ◽  
Annual Rhythm ◽  
Major Urinary Metabolite ◽  
Annual Changes

Abstract: A recently developed RIA for 6-sulphatoxymelatonin, the major urinary metabolite of melatonin, has been used to investigate the annual change in melatonin secretion in humans. Twenty plasma samples were taken from 18 volunteers throughout a 24-h period and simultaneous 6-hourly urine samples were also collected. Plasma melatonin and urinary 6-sulphatoxymelatonin were measured by RIA. 6-Sulphatoxymelatonin assayed in the urine samples was shown to be a good index of the rhythmic characteristics of the plasma melatonin secretion. To study annual changes in excretion four sequential 6-hourly urine samples were collected at monthly intervals from 16 normal volunteers for 13 months. Cosinor curves were fitted to the 6-sulphatoxymelatonin excretion data and the 24-h rhythm was described by the cosinor parameters: amplitude, mesor and acrophase. Significant differences in the acrophase were found during the year. The summer acrophase was phase advanced relative to the winter acrophase by about 1.5 h while intermediate phase positions were observed in spring/autumn. The 24-h excretion of urinary 6-sulphatoxymelatonin was remarkably consistent and there was no annual rhythm. In contrast, the daytime 6-sulphatoxymelatonin excretion between 12.00–18.00 h showed a statistically significant seasonal rhythm, with peaks in December/January and in July.

History: changing the forms or forming the changes?

2005 ◽  
Vol 13 (1) ◽  
pp. 47-66 ◽  
Author(s):  
SVEND ERIK LARSEN
Keyword(s):  
Cultural History ◽  
18Th Century ◽  
Point Of View ◽  
Future Planning ◽  
Long Period ◽  
Close Analysis ◽  
Vitruvian Man ◽  
Human Responsibility ◽  
The Individual ◽  
Individual Human

Change in European cultural history has, for a long period, been discussed through two interrelated notions, that of science and that of history. This paper traces the various stages of this discussion from Antiquity to the present day from the point of view of history. Two reoccurring and paradigmatic characters of mythological descent, Odysseus and Prometheus, illustrate how history as a realm for human responsibility and future planning has established itself as a specific European construct, with the 18th century as its final breakthrough in practical and ideological terms. A close analysis of Leonardo da Vinci's drawing the Vitruvian Man, in statu nascendi, shows how the individual human being carrying the obligations and the promises of this history, is envisioned. The final remarks underline the importance of scientific knowledge in the concrete shaping of this responsibility and a plea for an increased cooperation across the disciplines.

scholarly journals In the Absence of the Rule of Law: Everyday Lawyering, Dignity and Resistance in Myanmar’s ‘Disciplined Democracy’

2018 ◽  
Vol 28 (5) ◽  
pp. 573-599
Author(s):  
Alex Batesmith ◽  
Jake Stevens
Keyword(s):  
Rule Of Law ◽  
Legal System ◽  
State Power ◽  
Human Experience ◽  
Legal Systems ◽  
Material Support ◽  
The Rule Of Law ◽  
Alternative Perspective ◽  
The Individual ◽  
Individual Human

This article explores how ‘everyday’ lawyers undertaking routine criminal defence cases navigate an authoritarian legal system. Based on original fieldwork in the ‘disciplined democracy’ of Myanmar, the article examines how hegemonic state power and a functional absence of the rule of law have created a culture of passivity among ordinary practitioners. ‘Everyday’ lawyers are nevertheless able to uphold their clients’ dignity by practical and material support for the individual human experience – and in so doing, subtly resist, evade or disrupt state power. The article draws upon the literature on the sociology of lawyering and resistance, arguing for a multilayered understanding of dignity going beyond lawyers’ contributions to their clients’ legal autonomy. Focusing on dignity provides an alternative perspective to the otherwise often all-consuming rule of law discourse. In authoritarian legal systems, enhancing their clients’ dignity beyond legal autonomy may be the only meaningful contribution that ‘everyday’ lawyers can make.

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