scholarly journals Catalytic asymmetric hydrometallation of cyclobutenes with salicylaldehydes

2022 ◽  
Author(s):  
F. Wieland Goetzke ◽  
Mireia Sidera ◽  
Stephen P. Fletcher
Keyword(s):  
Organic Synthesis ◽  
Bioactive Compounds ◽  
Catalytic Asymmetric

Chiral, substituted cyclobutanes are common motifs in bioactive compounds and intermediates in organic synthesis but few asymmetric routes for their synthesis are known.

Recent Advances in C–Br Bond Formation

Synlett ◽  
2021 ◽  
Author(s):  
Ying-Yeung Yeung ◽  
Jonathan Wong
Keyword(s):  
Organic Synthesis ◽  
Aromatic Compounds ◽  
Bond Formation ◽  
Cross Coupling ◽  
Catalytic Site ◽  
Atom Transfer ◽  
Bond Forming ◽  
Recent Advances ◽  
Catalytic Asymmetric ◽  
Site Selective

AbstractOrganobromine compounds are extremely useful in organic synthesis. In this perspective, a focused discussion on some recent advancements in C–Br bond-forming reactions is presented.1 Introduction2 Selected Recent Advances2.1 Catalytic Asymmetric Bromopolycyclization of Olefinic Substrates2.2 Catalytic Asymmetric Intermolecular Bromination2.3 Some New Catalysts and Reagents for Bromination2.4 Catalytic Site-Selective Bromination of Aromatic Compounds2.5 sp3 C–H Bromination via Atom Transfer/Cross-Coupling3 Outlook

Metalloporphyrin catalysts for organic synthesis

2004 ◽  
Vol 08 (09) ◽  
pp. 1166-1171 ◽  
Author(s):  
Gérard Simonneaux ◽  
Pietro Tagliatesta
Keyword(s):  
Organic Synthesis ◽  
Enantiomeric Excess ◽  
Catalytic Reactions ◽  
Terminal Alkynes ◽  
Asymmetric Oxidation ◽  
Carbene Transfer ◽  
Catalytic Asymmetric ◽  
Chiral Systems ◽  
Metalloporphyrin Catalysts

Novel chiral systems for the catalytic asymmetric oxidation and cyclopropanation of olefins based on metalloporphyrins containing iron, ruthenium and manganese, have been recently introduced. High catalyst turnover numbers and sometimes high enantiomeric excess were observed. New catalytic reactions with metalloporphyrins have recently been reported; these are the olefination of aldehydes and cyclotrimerization of terminal alkynes. Dendrimers and polymers containing metalloporphyrins, have also been found to be efficient catalysts for oxidation and carbene transfer.

Study on the synthesis of thioamides from aldehyde N-tert-butylsulfinyl amide and sulfur in aqueous media

2021 ◽  
pp. 54-60
Author(s):  
Pham Xuan Thao
Keyword(s):  
Organic Chemistry ◽  
Metal Complex ◽  
Organic Synthesis ◽  
Noble Metal ◽  
High Temperatures ◽  
Bioactive Compounds ◽  
Plant Protection ◽  
Aqueous Media ◽  
Environmentally Friendly ◽  
Straightforward Method

Thioamides have been widely used in the fields of medicine and organic chemistry, some of which are essential bioactive compounds, plant protection agents, and drugs. It could also be used as a vulcanizing agent, an additive to lubricants and greases, and a ligand in organic synthesis. Usually, thioamide is synthesized at high temperatures or in the microwave using an expensive noble metal complex as catalysts. This paper presented a straightforward method for synthesizing thioamides by using N-tert-butylsulfinyl amide, aldehyde, and sulfur. The reaction was carried out in water, which is an environmentally friendly solvent. The reaction selectivity and yield were up to 89%.

scholarly journals Polyfluoroalkylated 2-ethoxymethylene- 3-oxo esters: synthesis and chemical properties overview

2017 ◽  
Vol 89 (8) ◽  
pp. 1209-1222 ◽  
Author(s):  
Victor I. Saloutin ◽  
Yulia S. Kudyakova ◽  
Marina V. Goryaeva ◽  
Yanina V. Burgart ◽  
Oleg N. Chupakhin
Keyword(s):  
Metal Complexes ◽  
Organic Synthesis ◽  
Bioactive Compounds ◽  
Chemical Properties ◽  
Building Blocks ◽  
High Reactivity ◽  
Organic Reagents ◽  
Fine Organic Synthesis ◽  
Fine Organic ◽  
And Chemical Properties

AbstractThe review focuses on the synthesis and chemical properties of polyfluoroalkylated 2-ethoxymethylene-3-oxo esters. The scope and peculiarities of their use as organic reagents in reactions with various N-, C-, O-, mono- and dinucleophiles are discussed in detail. The high reactivity of such derivatives is employed in the construction of enaminoketone, arene and heterocycle frameworks. Particular attention is paid to applications of these building blocks as chemicals for fine organic synthesis, bioactive compounds and metal complexes synthesis.

Laccase Catalysis

Biotechnology ◽  
2019 ◽  
pp. 2054-2089
Author(s):  
Helina Patel ◽  
Akshaya Gupte
Keyword(s):  
Green Chemistry ◽  
Molecular Oxygen ◽  
Organic Synthesis ◽  
Bioactive Compounds ◽  
Cost Effective ◽  
Biochemical Properties ◽  
Physico Chemical ◽  
Grafting Reactions ◽  
Increasing Demand ◽  
Made In

The search for cost-effective and environmental benign practices for the production of bioactive compounds has gained considerable attention since last decade, due to increasing demand of eco-friendly processes. Many industries have started adopting routes for the development of green chemistry by employing enzymatic approaches to overcome the limitations of physico-chemical methods and environmental concerns. Laccase is one such enzyme which has gained considerable attention in recent years as a biocatalyst in organic synthesis. Laccases possess versatile biochemical properties and the reactions catalyzed by laccase require only molecular oxygen with concomitant release of water as a byproduct. They have been widely used for reactions such as dimerization, polymerization, coupling, and grafting reactions and for antibiotic modifications. This chapter summarizes the advances that have been made in developing technologies based on laccase mediated reactions in the field of medicine, agriculture, food, and pharmaceuticals.

scholarly journals Highly enantioselective isomerization of primary allylic alcohols catalyzed by (P,N)-iridium complexes

2010 ◽  
Vol 82 (7) ◽  
pp. 1461-1469 ◽  
Author(s):  
Luca Mantilli ◽  
David Gérard ◽  
Sonya Torche ◽  
Céline Besnard ◽  
Clément Mazet
Keyword(s):  
Asymmetric Catalysis ◽  
Organic Synthesis ◽  
Industrial Application ◽  
Allylic Alcohols ◽  
Iridium Complexes ◽  
Allylic Amines ◽  
Reaction Conditions ◽  
Significant Challenge ◽  
Catalytic Asymmetric

The catalytic asymmetric isomerization of allylic amines to enamines stands out as one of the most accomplished and well-studied reactions in asymmetric catalysis as illustrated by its industrial application. In contrast, the related asymmetric isomerization of primary allylic alcohols to the corresponding aldehydes still constitutes a significant challenge in organic synthesis. Herein, we show that under appropriate reaction conditions, iridium-hydride catalysts promote the isomerization of primary allylic alcohols under very mild reaction conditions. The best catalysts deliver the desired chiral aldehydes with unprecedented levels of enantioselectivity and good yields. Mechanistic hypotheses have been drawn based on preliminary investigations.

Copper-catalyzed aminoboration and hydroamination of alkenes with electrophilic amination reagents

2014 ◽  
Vol 86 (3) ◽  
pp. 291-297 ◽  
Author(s):  
Koji Hirano ◽  
Masahiro Miura
Keyword(s):  
Organic Synthesis ◽  
Building Blocks ◽  
Electrophilic Amination ◽  
Catalytic Asymmetric

Abstract A copper-catalyzed regioselective, stereospecific, and enantioselective aminoboration reaction of alkenes with bis(pinacolato)diboron and O-acylated hydroxylamines has been developed to deliver the corresponding β-aminoalkylboranes, which can be important building blocks in organic synthesis. In addition, this methodology has been applied to a formal regioselective hydroamination of styrenes by replacement of the diboron reagent with polymethylhydrosiloxane (PMHS). The catalytic asymmetric hydroamination is also possible by using an appropriate chiral biphosphine ligand.

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