Oxygen-producing proenzyme hydrogels for photodynamic mediated metastasis-inhibited combinational therapy

2021 ◽  
Author(s):  
Jiansheng Liu ◽  
Xueqin Qing ◽  
Qin Zhang ◽  
Ningyue Yu ◽  
Mengbin Ding ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Solid Tumors ◽  
Therapeutic Efficacy ◽  
Tumor Metastasis ◽  
Combinational Therapy ◽  
Hypoxic Tumor

Photodynamic therapy (PDT) has provided a promising approach for treatment of solid tumors, while the therapeutic efficacy is often limited due to hypoxic tumor microenvironment, resulting in tumor metastasis. We...

scholarly journals Advances in nanomaterials for treatment of hypoxic tumor

2020 ◽  
Author(s):  
Mei-Zhen Zou ◽  
Wen-Long Liu ◽  
Han-Shi Chen ◽  
Xue-Feng Bai ◽  
Fan Gao ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
High Mortality ◽  
Therapeutic Efficacy ◽  
Tumor Invasion ◽  
Tumor Recurrence ◽  
Tumor Therapy ◽  
Functional Nanomaterials ◽  
Oxygen Levels ◽  
Hypoxic Conditions ◽  
Hypoxic Tumor

Abstract The hypoxic tumor microenvironment is characterized by disordered vasculature and rapid proliferation of tumors, resulting from tumor invasion, progression and metastasis. The hypoxic conditions restrict efficiency of tumor therapies, such as chemotherapy, radiotherapy, phototherapy and immunotherapy, leading to serious results of tumor recurrence and high mortality. Recently, research has concentrated on developing functional nanomaterials to treat hypoxic tumors. In this review, we categorize such nanomaterials into (i) nanomaterials that elevate oxygen levels in tumors for enhanced oxygen-dependent tumor therapy and (ii) nanomaterials with diminished oxygen dependence for hypoxic tumor therapy. To elevate oxygen levels in tumors, oxygen-carrying nanomaterials, oxygen-generating nanomaterials and oxygen-economizing nanomaterials can be used. To diminish oxygen dependence of nanomaterials for hypoxic tumor therapy, therapeutic gas-generating nanomaterials and radical-generating nanomaterials can be used. The biocompatibility and therapeutic efficacy of these nanomaterials are discussed.

A biomimetic nanozyme/camptothecin hybrid system for synergistically enhanced radiotherapy

2020 ◽  
Vol 8 (24) ◽  
pp. 5312-5319 ◽  
Author(s):  
Daoming Zhu ◽  
Meng Lyu ◽  
Wei Jiang ◽  
Meng Suo ◽  
Qinqin Huang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Solid Tumors ◽  
Tumor Cells ◽  
Hybrid System ◽  
Therapeutic Regimen ◽  
Hypoxic Tumor

Although radiotherapy (RT) has been an effective therapeutic regimen for regulating most solid tumors, its effect is limited by the hypoxic tumor microenvironment and radio-tolerance of tumor cells to a large extent.

Nanoengineering of newly designed chlorin e6 derivative for amplified photodynamic therapy via regulating lactate metabolism

Nanoscale ◽  
2021 ◽  
Author(s):  
Xiaohan Qin ◽  
Mengzhu Zhang ◽  
Xu Hu ◽  
Qian Du ◽  
Zhipeng Zhao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Therapeutic Efficacy ◽  
Chlorin E6 ◽  
Lactate Metabolism

Chlorin e6 (Ce6) is a widely utilized photosensitizer in photodynamic therapy (PDT) against tumor growth, but its hydrophobic feature and the hypoxia in tumor microenvironment greatly compromise its therapeutic efficacy....

scholarly journals A Tumor Microenvironment-Responsive Poly(amidoamine) Dendrimer Nanoplatform for Hypoxia-Responsive Chemo/Chemodynamic Therapy

2021 ◽  
Author(s):  
Yingchao Hao ◽  
Yue Gao ◽  
Yu Fan ◽  
Changchang Zhang ◽  
Mengsi Zhan ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Cells ◽  
Breast Cancer Cells ◽  
Tumor Metastasis ◽  
Phenylboronic Acid ◽  
Pamam Dendrimers ◽  
Synergistic Inhibition ◽  
Catalytic Metal ◽  
Hypoxic Tumor ◽  
Tumor Types

Abstract Background: Chemodynamic therapy is a promising cancer treatment with specific therapeutic effect at tumor sites, since toxic hydroxyl radical (·OH) could only be generated by Fenton or Fenton-like reaction at the tumor microenvironment (TME) with low pH and high endogenous hydrogen peroxide (H2O2). However, the low concentration of catalytic metal ions, excessive glutathione (GSH) and aggressive hypoxia at tumor site seriously restrict its curative outcomes.Results: In this study, polyethylene glycol-phenylboronic acid (PEG-PBA)-modified generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers were synthesized as a targeted nanocarrier to chelate Cu(II) and then encapsulate hypoxia-sensitive drug tirapazamine (TPZ) by the formation of hydrophobic Cu(II)/TPZ complex for hypoxia-enhanced chemo/chemodynamic therapy. The formed G5.NHAc-PEG-PBA@Cu(II)/TPZ (GPPCT) with good stability could be specifically accumulated at tumors, efficiently taken up by tumor cells overexpressing sialic acid residues, and release Cu(II) ions and TPZ quickly in weakly acidic tumor sites via pH-sensitive dissociation of Cu(II)/TPZ. In vitro and in vivo experiments using murine breast cancer cells (4T1) demonstrated that the GPPCT nanoplatform could efficiently generate toxic ·OH in tumor cells while simultaneously deplete GSH, effectively kill hypoxic tumor cells by activated TPZ radicals, reduce tumor metastasis, and show no significant systemic toxicity.Conclusions: The targeted GPPCT nanoplatform may be developed for the synergistic inhibition of different tumor types by hypoxia-enhanced chemo/chemodynamic therapy.

An oxygen-enriched thermosensitive hydrogel for the relief of a hypoxic tumor microenvironment and enhancement of radiotherapy

2021 ◽  
Author(s):  
Xiaowei Yang ◽  
Yaoben Wang ◽  
Tianjiao Mao ◽  
Yang Wang ◽  
Ruili Liu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Solid Tumors ◽  
Composite Hydrogel ◽  
Thermosensitive Hydrogel ◽  
Hypoxic Tumor

An injectable and thermosensitive composite hydrogel was prepared to deliver exogenous oxygen to solid tumors for the relief of a hypoxic tumor microenvironment and improvement of radiotherapeutic efficacy as a potent radiosensitizer.

scholarly journals The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression

2021 ◽  
Vol 22 (12) ◽  
pp. 6560
Author(s):  
Huogang Wang ◽  
Mingo M. H. Yung ◽  
Hextan Y. S. Ngan ◽  
Karen K. L. Chan ◽  
David W. Chan
Keyword(s):  
Tumor Microenvironment ◽  
Solid Tumors ◽  
Tumor Metastasis ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Macrophage Polarization ◽  
Interleukin 10 ◽  
The Body ◽  
Metastatic Progression ◽  
The Impact

Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths. Metastasis is a multistage event in which cancer cells escape from the primary tumor survive in the circulation and disseminate to distant sites. According to Stephen Paget's “Seed and Soil” hypothesis, metastatic capacity is determined not only by the internal oncogenic driving force but also by the external environment of tumor cells. Throughout the body, macrophages are required for maintaining tissue homeostasis, even in the tumor milieu. To fulfill these multiple functions, macrophages are polarized from the inflammation status (M1-like) to anti-inflammation status (M2-like) to maintain the balance between inflammation and regeneration. However, tumor cell-enforced tumor-associated macrophages (TAMs) (a high M2/M1 ratio status) are associated with poor prognosis for most solid tumors, such as ovarian cancer. In fact, clinical evidence has verified that TAMs, representing up to 50% of the tumor mass, exert both protumor and immunosuppressive effects in promoting tumor metastasis through secretion of interleukin 10 (IL10), transforming growth factor β (TGFβ), and VEGF, expression of PD-1 and consumption of arginine to inhibit T cell anti-tumor function. However, the underlying molecular mechanisms by which the tumor microenvironment favors reprogramming of macrophages to TAMs to establish a premetastatic niche remain controversial. In this review, we examine the latest investigations of TAMs during tumor development, the microenvironmental factors involved in macrophage polarization, and the mechanisms of TAM-mediated tumor metastasis. We hope to dissect the critical roles of TAMs in tumor metastasis, and the potential applications of TAM-targeted therapeutic strategies in cancer treatment are discussed.

Palladium Cube with Pt Shell Deposition for Localized Surface Plasmon Resonance Enhanced Photodynamic and Photothermal Therapy of Hypoxic Tumor

2021 ◽  
Author(s):  
Wenxiang Gu ◽  
Zhiyuan Hua ◽  
Zheng Li ◽  
Zhiheng Cai ◽  
Wandong Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Surface Plasmon Resonance ◽  
Tumor Microenvironment ◽  
Localized Surface Plasmon Resonance ◽  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Localized Surface Plasmon ◽  
Shell Deposition ◽  
Hypoxic Tumor ◽  
Solid Tumor Therapy

Multifunctional phototherapy nanoagents for imaging-guided synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) are highly desirable in the field of solid tumor therapy. Nevertheless, the tumor microenvironment (TME) inherently charactered...

scholarly journals Emerging Nanoparticle Strategies for Modulating Tumor-Associated Macrophage Polarization

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1912
Author(s):  
Lu Shi ◽  
Hongchen Gu
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Immunotherapy ◽  
Solid Tumors ◽  
Therapeutic Efficacy ◽  
Macrophage Polarization ◽  
Immune Systems ◽  
Plastic Characteristic ◽  
Tumor Associated Macrophage ◽  
Great Progress ◽  
Tumor Phenotype

Immunotherapy has made great progress in recent years, yet the efficacy of solid tumors remains far less than expected. One of the main hurdles is to overcome the immune-suppressive tumor microenvironment (TME). Among all cells in TME, tumor-associated macrophages (TAMs) play pivotal roles because of their abundance, multifaceted interactions to adaptive and host immune systems, as well as their context-dependent plasticity. Underlying the highly plastic characteristic, lots of research interests are focused on repolarizing TAMs from M2-like pro-tumor phenotype towards M1-like antitumoral ones. Nanotechnology offers great opportunities for targeting and modulating TAM polarization to mount the therapeutic efficacy in cancer immunotherapy. Here, this mini-review highlights those emerging nano-approaches for TAM repolarization in the last three years.

scholarly journals Platelet-Mediated Protection of Cancer Cells From Immune Surveillance – Possible Implications for Cancer Immunotherapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Laurent Schmied ◽  
Petter Höglund ◽  
Stephan Meinke
Keyword(s):  
Tumor Microenvironment ◽  
Nk Cells ◽  
Cancer Cells ◽  
Solid Tumors ◽  
Solid Tumor ◽  
Tumor Metastasis ◽  
Nk Cell ◽  
High Exposure ◽  
Hematological Cancers ◽  
The Impact

The growing insights in the complex interactions between metastatic cancer-cells and platelets have revealed that platelet tumor cell interactions in the blood stream are an important factor supporting tumor metastasis. An increased coagulability of platelets facilitates the vascular evasion and establishment of solid tumor metastasis. Furthermore, platelets can support an immunosuppressive tumor microenvironment or shield tumor cells directly from engagement of cytotoxic lymphocytes as e.g., natural killer (NK) cells. Platelets are both in the tumor microenvironment and systemically the quantitatively most important source of TGF-β, which is a key cytokine for immunosuppression in the tumor microenvironment. If similar platelet-tumor interactions are of physiological relevance in hematological malignancies remains less well-studied. This might be important, as T- and NK cell mediated graft vs. leukemia effects (GvL) are well-documented and malignant hematological cells have a high exposure to platelets compared to solid tumors. As NK cell-based immunotherapies gain increasing attention as a therapeutic option for patients suffering from hematological and other malignancies, we review the known interactions between platelets and NK cells in the solid tumor setting and discuss how these could also apply to hematological cancers. We furthermore explore the possible implications for NK cell therapy in patients with solid tumors and patients who depend on frequent platelet transfusions. As platelets have a protective and supportive effect on cancer cells, the impact of platelet transfusion on immunotherapy and the combination of immunotherapy with platelet inhibitors needs to be evaluated.

A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

2021 ◽  
Vol 57 (34) ◽  
pp. 4134-4137
Author(s):  
Rongrong Zheng‡ ◽  
Xiayun Chen‡ ◽  
Linping Zhao ◽  
Ni Yang ◽  
Runtian Guan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mitochondrial Respiration ◽  
Tumor Treatment ◽  
Hypoxic Tumor

A porphysome-based photodynamic O2 economizer is developed to inhibit mitochondrial respiration for enhanced photodynamic therapy against hypoxic tumors.

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