scholarly journals Electrochemical analysis of the carboxy-14C-labelled aliphatic carboxylic acid metabolites resulting from tracer studies

1977 ◽  
Vol 167 (2) ◽  
pp. 505-507 ◽  
Author(s):  
G H Walker ◽  
D E Hathway
Keyword(s):  
Carboxylic Acid ◽  
Electrochemical Analysis ◽  
Acid Biosynthesis ◽  
Tracer Studies ◽  
Aliphatic Carboxylic Acid ◽  
Carboxylic Acid Groups ◽  
Acid Metabolites ◽  
Kolbe Reaction ◽  
Aliphatic Carboxylic Acids ◽  
Important Evidence

14C02 output from carboxy-14C-labelled aliphatic carboxylic acids is measured in the micro-scale Kolbe reaction. Irrespective of whether rats were dosed with 1,1-dichloro[1-14C]ethylene or with chloro[1-14C]acetic acid, 1 mol.equiv. of the resulting thio[14C]diglycollic acid yields by electrolysis approx. 0.7 equiv. of 14CO2, which is interpreted in terms of the labelling of one of the carboxylic acid groups of thiodiglycollic acid. This observation provides important evidence concerning thiodiglycollic acid biosynthesis from 1.1-dichloroethylene.

ALIPHATIC CARBOXYLIC ACIDS IN CHERNOZEMIC SOILS

1982 ◽  
Vol 62 (3) ◽  
pp. 487-494 ◽  
Author(s):  
J. F. Dormaar
Keyword(s):  
Organic Matter ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Dioctyl Phthalate ◽  
Gas Chromatography Mass Spectrometry ◽  
Grass Species ◽  
Aliphatic Carboxylic Acid ◽  
High Resolution Gas Chromatography ◽  
Aliphatic Carboxylic Acids ◽  
Extractable Organic Matter

For Chernozemic soils, published information on the aliphatic carboxylic acid fraction of the organic matter is scarce. Yet, geologically they are chemically stable and persist for long periods of time. The distribution of chloroform/methanol-extractable aliphatic carboxylic acids in five uncultivated and three cultivated Chernozemic soils and the roots of four grass species was, therefore, determined. Twenty-three organic acids (up to C30) were tentatively identified by high resolution gas chromatography-mass spectrometry. Hexanedioic acid and dioctyl phthalate were suspected of being contaminants. The relative proportions of aliphatic carboxylic acids varied for different soils. Tree invasions, overgrazing, and cultivation decreased the total aliphatic carboxylic acid content at the expense of the lower weight aliphatic carboxylic acids. Since the aliphatic carboxylic acids formed only a small portion of the total solvent-extractable organic matter and decreased after cultivation, the results do not explain the observation reported earlier that solvent-extractable organic matter of Chernozemic soils increased as a result of cultivation.

scholarly journals Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 502
Author(s):  
Hanene Belkahla ◽  
Andrei Alexandru Constantinescu ◽  
Tijani Gharbi ◽  
Florent Barbault ◽  
Alexandre Chevillot-Biraud ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cancer Therapy ◽  
Computational Study ◽  
Carcinoma Cells ◽  
Maghemite Nanoparticles ◽  
Carboxylic Acid Groups ◽  
Lung Carcinoma Cells ◽  
Biological Studies ◽  
Apoptotic Effect ◽  
Carboxylic Groups

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This makes it a promising agent for cancer therapy. Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups. The two resulting nanovectors, NH-TRAIL@NPs-CO and CO-TRAIL@NPs-NH, were thoroughly characterized. Biological studies performed on human breast and lung carcinoma cells (MDA-MB-231 and H1703 cell lines) established these nanovectors are potential agents for cancer therapy. The pro-apoptotic effect is somewhat greater for CO-TRAIL@NPs-NH than NH-TRAIL@NPs-CO, as evidenced by viability studies and apoptosis analysis. A computational study indicated that regardless of whether TRAIL is attached to NPs through an acid or an amino group, DR4 recognition is not affected in either case.

Aliphatic Carboxylic Acid as Hydrogen-Bond Donor for Converting CO2 and Epoxide into Cyclic Carbonate under Mild Conditions

2021 ◽  
Author(s):  
Zheng Wang ◽  
Yajun Wang ◽  
Qianjie Xie ◽  
Zhiying Fan ◽  
Yehua Shen
Keyword(s):  
Hydrogen Bond ◽  
Carboxylic Acid ◽  
Value Added ◽  
Cyclic Carbonate ◽  
Hydrogen Bond Donor ◽  
Title Reaction ◽  
Aliphatic Carboxylic Acid ◽  
Mild Conditions ◽  
Atmospheric Carbon

The coupling of CO2 and epoxide is promising way to reduce atmospheric carbon by converting it into value-added cyclic carbonate. Pursuing efficient catalysts is highly attractive for the title reaction....

Dual-temperature and pH responsive (ethylene glycol)-based nanogels via structural design

2014 ◽  
Vol 5 (8) ◽  
pp. 3061-3070 ◽  
Author(s):  
Yohei Kotsuchibashi ◽  
Ravin Narain
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Salt Concentration ◽  
Structural Design ◽  
Solution Temperature ◽  
Ph Responsive ◽  
Solution Ph ◽  
Critical Solution Temperature ◽  
Carboxylic Acid Groups ◽  
The Core

Dual-temperature and pH responsive (ethylene glycol)-based nanogels were synthesized. Both the core and the shell of the nanogels showed a lower critical solution temperature (LCST) and the LCST of the shell was strongly affected by the solution pH and salt concentration due to the presence of carboxylic acid groups at the nanogel surface.

Metal ion retention properties of water-insoluble polymers containing carboxylic acid groups

2005 ◽  
Vol 99 (3) ◽  
pp. 697-705 ◽  
Author(s):  
Bernabé L. Rivas ◽  
Benita Quilodrán ◽  
Eduardo Quiroz
Keyword(s):  
Carboxylic Acid ◽  
Metal Ion ◽  
Carboxylic Acid Groups ◽  
Insoluble Polymers

scholarly journals Comparison of Three Solid Phase Materials for the Extraction of Carboxylic Acids from River Water Followed by 2D GC × GC-TOFMS Determination

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
G. O. Bosire ◽  
J. C. Ngila ◽  
H. Parshotam
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Natural Organic Matter ◽  
Solid Phase ◽  
Cooling Water ◽  
Raw Water ◽  
Aliphatic Carboxylic Acid ◽  
Hydrophobic Nature ◽  
Relationship Of

The extraction and determination of aliphatic and aromatic carboxylic acids as well as their influence on the aromaticity and molecularity relationship of natural organic matter (NOM) in water are reported in this study. Three solid phase extraction (SPE) sorbents were used and their extraction efficiencies evaluated after chromatographic determinations (using gas chromatography with a time of flight mass spectrometer (GC × GC-TOFMS) and liquid chromatography with organic carbon detector (LC-OCD)). More than 42 carboxylic acids were identified in raw water from the Vaal River, which feeds the Lethabo Power Generation Station, South Africa, with cooling water. The aromatic carboxylic acid efficiency (28%) was achieved by using Strata™X SPE while the highest aliphatic carboxylic acid efficiency (92.08%) was achieved by silica SPE. The hydrophobic nature of NOM in water depends on the nature of organic compounds in water, whether aromatic or aliphatic. The LC-OCD was used to assess the hydrophobicity levels of NOM as a function of these carboxylic acids in cooling water. The LC-OCD results showed that the aromatic nature of NOM in SPE filtered water followed the order Silica>Strata X>C-18. From the results, the hydrophobicity degree of the samples depended on the type and number of carboxylic acids that were removed by the SPE cartridges.

Oxidation of poly[bis(4-methylphenoxy)phosphazene] surfaces and chemistry of the surface carboxylic acid groups

1992 ◽  
Vol 4 (4) ◽  
pp. 769-775 ◽  
Author(s):  
Harry R. Allcock ◽  
Richard J. Fitzpatrick ◽  
Lawrence Salvati
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acid Groups
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