Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling
Keyword(s):
The study identified a novel secreted protein PRX-like 2 activated in M-CSF-stimulated monocytes (PAMM) from human and mouse adipocytes. The adipocyte-derived PAMM suppresses macrophage activation by inhibiting mitogen-activated protein kinase (MAPK) signalling pathway, which may represent a novel mechanism to resolve the chronic inflammation in the obese adipose tissues.
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pp. 5839-5845
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