Structure of human glutathione S-transferase class Mu genes

Nucleotide sequencing of a human cosmid clone shows that the exon-intron structures of a glutathione S-transferase multigene family are conserved between man and rat, that the human gene family is clustered and that gene conversion events have occurred within the cluster. In addition, between man and rat, there is a high degree of nucleotide sequence identity not only in exons but also in some introns. These conserved sequences are coincident with homologous sequences subject to gene conversion in both species, and hence the utilization of gene conversion by this gene family has itself been conserved. By using transient-expression assay the conserved/converted regions are shown to be capable of modulating transcriptional activity. The data suggest that DNA repair by gene conversion may be a chemical immunity mechanism. which could result in acquired resistance to toxins and, in particular, drug resistance due to glutathione S-transferase in tumours.

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The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila melanogaster

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)98410-3 ◽

1993 ◽

Vol 268 (13) ◽

pp. 9737-9746

Author(s):

Y.P. Toung ◽

T.S. Hsieh ◽

C.P. Tu

Keyword(s):

Drosophila Melanogaster ◽

Gene Family ◽

Glutathione S Transferase ◽

Intronless Gene

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Structure of the murine serum amyloid A gene family. Gene conversion.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)83932-7 ◽

1986 ◽

Vol 261 (18) ◽

pp. 8442-8452 ◽

Cited By ~ 2

Author(s):

C A Lowell ◽

D A Potter ◽

R S Stearman ◽

J F Morrow

Keyword(s):

Gene Family ◽

Gene Conversion ◽

Serum Amyloid A ◽

Serum Amyloid ◽

Amyloid A ◽

Family Gene

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Multiple forms of the human gene-specific transcription factor USF. II. DNA binding properties and transcriptional activity of the purified HeLa USF.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)37884-0 ◽

1988 ◽

Vol 263 (24) ◽

pp. 11994-12001 ◽

Cited By ~ 9

Author(s):

M Sawadogo

Keyword(s):

Transcription Factor ◽

Dna Binding ◽

Transcriptional Activity ◽

Human Gene ◽

Multiple Forms ◽

Binding Properties ◽

Specific Transcription Factor ◽

Dna Binding Properties

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A novel human gene ZNF415 with five isoforms inhibits AP-1- and p53-mediated transcriptional activity

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2006.09.161 ◽

2006 ◽

Vol 351 (1) ◽

pp. 33-39 ◽

Cited By ~ 12

Author(s):

Yingduan Cheng ◽

Yuequn Wang ◽

Yanmei Li ◽

Yun Deng ◽

Junjian Hu ◽

...

Keyword(s):

Transcriptional Activity ◽

Human Gene

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Adaptive Evolution and Frequent Gene Conversion in the Brain Expressed X-Linked Gene Family in Mammals

Biochemical Genetics ◽

10.1007/s10528-008-9148-8 ◽

2008 ◽

Vol 46 (5-6) ◽

pp. 293-311 ◽

Cited By ~ 14

Author(s):

Liqing Zhang

Keyword(s):

Gene Family ◽

Gene Conversion ◽

Adaptive Evolution ◽

Linked Gene ◽

The Brain

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Genome-wide identification, evolution, and expression analysis of the NPR1-like gene family in pears

PeerJ ◽

10.7717/peerj.12617 ◽

2021 ◽

Vol 9 ◽

pp. e12617

Author(s):

Yarui Wei ◽

Shuliang Zhao ◽

Na Liu ◽

Yuxing Zhang

Keyword(s):

Gene Family ◽

Stress Responses ◽

Systemic Acquired Resistance ◽

Acquired Resistance ◽

Signal Transduction Pathway ◽

Promoter Regions ◽

Systematic Analysis ◽

Genome Wide ◽

Pathogenesis Related ◽

Genome Level

The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) plays a master regulatory role in the salicylic acid (SA) signal transduction pathway and plant systemic acquired resistance (SAR). Members of the NPR1-like gene family have been reported to the associated with biotic/abiotic stress in many plants, however the genome-wide characterization of NPR1-like genes has not been carried out in Chinese pear (Pyrus bretschneideri Reld). In this study, a systematic analysis was conducted on the characteristics of the NPR1-like genes in P. bretschneideri Reld at the whole-genome level. A total nine NPR1-like genes were detected which eight genes were located on six chromosomes and one gene was mapped to scaffold. Based on the phylogenetic analysis, the nine PbrNPR1-like proteins were divided into three clades (Clades I–III) had similar gene structure, domain and conserved motifs. We sorted the cis-acting elements into three clades, including plant growth and development, stress responses, and hormone responses in the promoter regions of PbrNPR1-like genes. The result of qPCR analysis showed that expression diversity of PbrNPR1-like genes in various tissues. All the genes were up-regulated after SA treatment in leaves except for Pbrgene8896. PbrNPR1-like genes showed circadian rhythm and significantly different expression levels after inoculation with Alternaria alternata. These findings provide a solid insight for understanding the functions and evolution of PbrNPR1-like genes in Chinese pear.

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