scholarly journals Nanoscale hybrid systems based on carbon nanotubes for biological sensing and control

2017 ◽  
Vol 37 (2) ◽  
Author(s):  
Youngtak Cho ◽  
Narae Shin ◽  
Daesan Kim ◽  
Jae Yeol Park ◽  
Seunghun Hong
Keyword(s):  
Carbon Nanotubes ◽  
Cell Growth ◽  
Hybrid Systems ◽  
Tissue Regeneration ◽  
Biological Sensing ◽  
Concise Review ◽  
Highly Sensitive ◽  
Cell Growth And Differentiation ◽  
Biological Interfaces ◽  
And Control

This paper provides a concise review on the recent development of nanoscale hybrid systems based on carbon nanotubes (CNTs) for biological sensing and control. CNT-based hybrid systems have been intensively studied for versatile applications of biological interfaces such as sensing, cell therapy and tissue regeneration. Recent advances in nanobiotechnology not only enable the fabrication of highly sensitive biosensors at nanoscale but also allow the applications in the controls of cell growth and differentiation. This review describes the fabrication methods of such CNT-based hybrid systems and their applications in biosensing and cell controls.

scholarly journals Growth, Properties, and Applications of Branched Carbon Nanostructures

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2728
Author(s):  
Sharali Malik ◽  
Silvia Marchesan
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Regeneration ◽  
Carbon Nanostructures ◽  
Structural Features ◽  
Theoretical Studies ◽  
Concise Review ◽  
Wide Range ◽  
Growth Properties ◽  
Experimental And Theoretical Studies ◽  
Advanced Applications

Nanomaterials featuring branched carbon nanotubes (b-CNTs), nanofibers (b-CNFs), or other types of carbon nanostructures (CNSs) are of great interest due to their outstanding mechanical and electronic properties. They are promising components of nanodevices for a wide variety of advanced applications spanning from batteries and fuel cells to conductive-tissue regeneration in medicine. In this concise review, we describe the methods to produce branched CNSs, with particular emphasis on the most widely used b-CNTs, the experimental and theoretical studies on their properties, and the wide range of demonstrated and proposed applications, highlighting the branching structural features that ultimately allow for enhanced performance relative to traditional, unbranched CNSs.

Electrically conductive nanocomposite hydrogels embedded with functionalized carbon nanotubes for spinal cord injury

2018 ◽  
Vol 42 (21) ◽  
pp. 17671-17681 ◽  
Author(s):  
Xifeng Liu ◽  
Joseph C. Kim ◽  
A. Lee Miller ◽  
Brian E. Waletzki ◽  
Lichun Lu
Keyword(s):  
Carbon Nanotubes ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Growth ◽  
Electrically Conductive ◽  
Functionalized Carbon Nanotubes ◽  
Nanocomposite Hydrogels ◽  
Cord Injury ◽  
Cell Growth And Differentiation ◽  
Conductive Hydrogels

Electrically conductive hydrogels incorporated with CNTs support PC12 cell growth and differentiation and hold promise for nerve regeneration.

scholarly journals Real-Time In Vivo Bioluminescent Imaging for Evaluating the Efficacy of Antibiotics in a Rat Staphylococcus aureus Endocarditis Model

2005 ◽  
Vol 49 (1) ◽  
pp. 380-387 ◽  
Author(s):  
Yan Q. Xiong ◽  
Julie Willard ◽  
Jagath L. Kadurugamuwa ◽  
Jun Yu ◽  
Kevin P. Francis ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Real Time ◽  
Imaging System ◽  
Bioluminescent Imaging ◽  
Vancomycin Therapy ◽  
Treatment Groups ◽  
Highly Sensitive ◽  
Relevant Animal Model ◽  
And Control

ABSTRACT Therapeutic options for invasive Staphylococcus aureus infections have become limited due to rising antimicrobial resistance, making relevant animal model testing of new candidate agents more crucial than ever. In the present studies, a rat model of aortic infective endocarditis (IE) caused by a bioluminescently engineered, biofilm-positive S. aureus strain was used to evaluate real-time antibiotic efficacy directly. This strain was vancomycin and cefazolin susceptible but gentamicin resistant. Bioluminescence was detected and quantified daily in antibiotic-treated and control animals with IE, using a highly sensitive in vivo imaging system (IVIS). Persistent and increasing cardiac bioluminescent signals (BLS) were observed in untreated animals. Three days of vancomycin therapy caused significant reductions in both cardiac BLS (>10-fold versus control) and S. aureus densities in cardiac vegetations (P < 0.005 versus control). However, 3 days after discontinuation of vancomycin therapy, a greater than threefold increase in cardiac BLS was observed, indicating relapsing IE (which was confirmed by quantitative culture). Cefazolin resulted in modest decreases in cardiac BLS and bacterial densities. These microbiologic and cardiac BLS differences during therapy correlated with a longer time-above-MIC for vancomycin (>12 h) than for cefazolin (∼4 h). Gentamicin caused neither a reduction in cardiac S. aureus densities nor a reduction in BLS. There were significant correlations between cardiac BLS and S. aureus densities in vegetations in all treatment groups. These data suggest that bioluminescent imaging provides a substantial advance in the real-time monitoring of the efficacy of therapy of invasive S. aureus infections in live animals.

scholarly journals IL-4 and anti-CD40 protect against Fasmediated B cell apoptosis and induce B cell growth and differentiation

1996 ◽  
Vol 8 (5) ◽  
pp. 791-798 ◽  
Author(s):  
Kenji Nakanishi ◽  
Kiyoshi Matsui ◽  
Shin-ichiro Kashiwamura ◽  
Yasuhiro Nishioka ◽  
Jun Nomura ◽  
...  
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Cell Apoptosis ◽  
Cell Growth And Differentiation
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