Maternal zinc and intrauterine growth retardation

1985 ◽  
Vol 68 (4) ◽  
pp. 395-399 ◽  
Author(s):  
Karen Simmer ◽  
R. P. H. Thompson
Keyword(s):  
Racial Differences ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Intrauterine Growth Retardation ◽  
Maternal Plasma ◽  
Intrauterine Growth ◽  
Group I ◽  
Appropriate For Gestational Age ◽  
Group Ii ◽  
Zinc Levels

1. The levels of zinc in plasma, erythrocytes, polymorphonuclear (PMN) and mononuclear (MN) white cells were measured after delivery in women giving birth to appropriate-for-gestational-age (AGA) babies (group I mothers), or small-for-gestational-age (SGA) babies (group II mothers) and in non-pregnant controls. 2. Mean maternal plasma zinc and albumin levels 24-48 h after delivery were lower than in controls, but PMN and MN zinc levels were unchanged. PMN zinc levels were lower than those of MN cells. 3. PMN and MN zinc levels were significantly lower in group II mothers than in group I, irrespective of smoking habits. There were no racial differences in peripheral white cell zinc levels. 4. PMN, and to a lesser degree MN, zinc levels were lower in smoking than in non-smoking mothers. 5. Erythrocyte zinc did not correlate with other zinc measurements nor with the size of the babies. Fetal erythrocyte zinc levels were one-third of maternal levels. 6. A combination of smoking and/or low PMN zinc levels selects 85% of mothers having small-for-gestational-age babies.

Predicting infant temperament from neonatal reactivity for AGA/SGA twin pairs

Twin Research ◽  
1998 ◽  
Vol 1 (2) ◽  
pp. 65-70 ◽  
Author(s):  
Marilyn L Riese
Keyword(s):  
Gestational Age ◽  
Growth Retardation ◽  
Small For Gestational Age ◽  
Intrauterine Growth Retardation ◽  
Infant Temperament ◽  
Social Orientation ◽  
Group Differences ◽  
Intrauterine Growth ◽  
Appropriate For Gestational Age ◽  
Bull's Eye

AbstractThe predictive relation between neonatal reactivity and 12-, 18-, and 24-month temperament was assessed for 22 appropriate-for-gestational-age (AGA)/small-for-gestational-age (SGA) twin pairs. Neonatal reactivity included ratings of visual and auditory orienting responses to a bull's-eye, rattle, bell, voice, and face plus voice combined, as well as alertness. Infant temperament ratings were made of emotional tone, activity, attentiveness, and social orientation to staff during ageappropriate activities in the laboratory. There were no group differences in the neonatal or infant ratings. For AGA twins, a pattern of predictive correlations was obtained between neonatal reactivity and temperament at each age. A similar predictive pattern was not observed for the SGA twins. Group differences in rates of maturation related to stresses associated with intrauterine growth retardation influenced the significance of the neonatal variables for later temperament development.

ALTERATIONS IN HUMAN BRAIN BIOCHEMISTRY FOLLOWING INTRAUTERINE GROWTH RETARDATION

PEDIATRICS ◽  
1972 ◽  
Vol 50 (3) ◽  
pp. 403-411
Author(s):  
H. Peter Chase ◽  
N. Noreen Welch ◽  
Carol S. Dabiere ◽  
N. S. Vasan ◽  
L. Joseph Butterfield
Keyword(s):  
Human Brain ◽  
Gestational Age ◽  
Growth Retardation ◽  
Small For Gestational Age ◽  
Intrauterine Growth Retardation ◽  
Similar Reduction ◽  
Myelin Lipids ◽  
Intrauterine Growth ◽  
Appropriate For Gestational Age ◽  
The Brain

Analyses of brains from six infants whose birth weights were "small for gestational age" (SGA) and ten infants whose birth weights were ‘appropriate for gestational age" (AGA) show the cerebellum to be the area of the brain most greatly affected by intrauterine underdevelopment. The SGA cerebellar weight was reduced 37% and cellularity 35%, compared to reductions of only 21% and 19% for weight and cellularity in the remainder of the brain. The myelin lipids, cerebroside and sulfatide, were significantly reduced (p < .01) in concentration or total quantity in the brains of SGA infants, in contrast to phospholipids, cholesterol, and gangliosides which did not show a similar reduction. Galactolipid sulfotransferase activity, important in sulfatide formation, was also significantly reduced (p < .01) in the brains from SGA infants.

Comparison of Phototherapy Results in Small-for-Gestational-Age and Appropriate-for-Gestational-Age Infants Weighing Less Than 2,000 Grams

PEDIATRICS ◽  
1985 ◽  
Vol 75 (2) ◽  
pp. 413-441
Author(s):  
Joan E. Hodgman ◽  
Paul Y. K. Wu ◽  
Nathaniel B. White ◽  
Dolores A. Bryla
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Congenital Defects ◽  
Intrauterine Growth ◽  
Appropriate For Gestational Age ◽  
Study Population ◽  
Similar Weight ◽  
Gestational Age At Birth ◽  
Evaluation Techniques

The infant who is small for gestational age (SGA) is more mature at birth than similar weight infants who are appropriate for gestational age (AGA). Whether the SGA infant behaves as does the larger gestationally equivalent infant, or whether there are specific changes related to intrauterine growth retardation is a matter of some interest in the understanding of the special needs of these infants. The National Institute of Child Health and Human Development (NICHD) phototherapy study provided a large newborn population for whom birth weight, gestational age at birth, and, thereby, intrauterine growth were carefully assessed. Infants who weighed 2,000 g or more at birth were included in the study only when they became jaundiced, whereas infants who weighed less than 2,000 g at birth were routinely entered into the study. Consequently, this report will be limited to the lowbirth-weight population selected by birth weight. Too few SGA babies were present in the groups with greater birth weight to allow meaningful comparisons. PATIENT SELECTIQN All infants whose birth weight was less than 2,000 g were entered into the study at 24 ± 12 hours. Those excluded from the study were: (1) infants who died before 24 hours, (2) infants with serious congenital defects, and (3) infants whose mothers refused consent for study. The study population consisted of 922 infants surviving at 24 hours. Gestational age was calculated from the first day of the last menstrual period obtained from maternal history and also by the evaluation techniques of Dubowitz.25 Intrauterine growth was determined by plotting birth weight and gestational age on the Denver Intrauterine Growth Curves8; infants below the 10th percentile were considered SGA.

Study of Cord Blood Erythropoietin, Leptin and Adiponectin Levels in Neonates with Hypoxic Ischemic Encephalopathy

2020 ◽  
Vol 20 (2) ◽  
pp. 213-220
Author(s):  
Adel A. Hagag ◽  
Mohamed S. El Frargy ◽  
Amal E. Abd El-Latif
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Apgar Score ◽  
Moderate Degree ◽  
Early Predictors ◽  
Group I ◽  
Appropriate For Gestational Age ◽  
Group Ii ◽  
Normal Neonates ◽  
Ischemic Encephalopathy

Background: Hypoxic ischemic encephalopathy (HIE) is a serious condition which results in neonatal morbidity and mortality. Early prediction of HIE especially in the first six hours of birth leads to early treatment with better prognosis. Aim: The aim of this study was to compare the concentrations of leptin, adiponectin, and erythropoietin between normal neonates and those with HIE for the possible use of these markers for assessment of the degree of HIE and as markers for early prediction of HIE. Patients and Methods: This study was carried out on 50 appropriate for gestational age (AGA) neonates with HIE born in Tanta University Hospital during the period from June 2016 to March 2018 (Group I). This study also included 50 appropriate for gestational age (AGA) normal neonates not suffering from any complications and matched with group I in age and sex as a control group (Group II). For all neonates in both groups, the following were done: Complete prenatal, natal, and postnatal history, assessment of APGAR score at 5 and 10 minutes, complete clinical examination with special account on clinical evidence of encephalopathy including hypotonia, abnormal oculomotor or pupillary movements, weak or absent suckling, apnea, hyperpnea, or seizures, measurement of cord blood gases and measurement of serum erythropoietin, leptin and adiponectin levels by ELISA immediately after birth. Results: There were no significant differences between Group I and Group II regarding gestational age, male to female ratio, mode of delivery, and weight while there were significant differences regarding Apgar score at 1 and 5 minutes with significantly lower Apgar score at 1 and 5 minutes in group I compared with Group II. There were significantly lower cord blood PH and adiponectin level and significantly higher cord blood Leptin and erythropoietin in group I compared with group II. There were significant differences between cord blood adiponectin, leptin, erythropoietin, and PH in different degrees of HIE with significantly lower cord blood adiponectin and PH and significantly higher cord blood leptin and erythropoietin in severe degree of hypoxia compared with moderate degree and in moderate degree compared with mild degree of hypoxia. There was a significant positive correlation between cord blood erythropoietin and leptin and a significant negative correlation between cord blood erythropoietin and both adiponectin and PH in studied neonates with hypoxia. ROC curve showed that EPO had the best sensitivity and specificity followed by leptin then adiponectin while the PH had the least sensitivity and specificity as early predictors of hypoxic neonates. Conclusion and Recommendations: Neonates with HIE had lower cord blood PH and adiponectin levels and higher leptin and erythropoietin levels than normal healthy neonates at birth and during the early postnatal period. The significant differences between cord blood erythropoietin, leptin, and adiponectin between neonates with hypoxia compared with normal neonates may arouse our attention about the use of these markers in the cord blood as early predictors of neonatal HIE which can lead early treatment and subsequently better prognosis.

Babies Who Are Small for Gestational Age

1995 ◽  
Vol 16 (9) ◽  
pp. 354-354
Author(s):  
Barbara K. Russell
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Intrauterine Growth Retardation ◽  
Growth Parameters ◽  
Mortality Rates ◽  
Heterogeneous Population ◽  
Growth Chart ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Definition Of

Small for gestational age (SGA) is a term applied to a heterogeneous population of babies who do not meet the expected growth parameters for their gestational age. The definition of SGA is variable, but the clinical definition used most often is any baby who weighs less than 2500 g and falls below the 10th percentile on the growth chart for its gestational age. These infants are at increased risk for hypoglycemia, polycythemia, and temperature instability and suffer higher neonatal mortality rates. Although they often are used interchangeably, the terms SGA and intrauterine growth retardation (IUGR) are not always synonymous. Approximately 60% of infants classified as SGA are constitutionally small babies who are small for gestational age but not growth retarded.

Small for gestational age foetus

2014 ◽  
Vol 155 (33) ◽  
pp. 1301-1305
Author(s):  
Norbert Pásztor ◽  
Zoltán Kozinszky ◽  
Attila Pál
Keyword(s):  
Gestational Age ◽  
Growth Retardation ◽  
Small For Gestational Age ◽  
Intrauterine Growth Retardation ◽  
Pathological Condition ◽  
Labour Induction ◽  
Clinical Aspects ◽  
Optimal Timing ◽  
Screening Methods ◽  
Intrauterine Growth

A small for gestational age foetus is defined by the foetal weight below the 10th centile for the corresponding gestational age. However, the vast majority of these cases has no apparent underlying abnormality, while in other cases a serious causative pathological condition can be identified. The detection, follow-up and treatment of an intrauterine growth retarded, compromised foetus has great obstetric and neonatologic relevance. In this review, the causes, clinical aspects and screening methods of intrauterine growth retardation are summarized based on the most recent international guidelines. Furthermore, recommendations regarding the monitoring and the optimal timing of the labour induction of pregnancies complicated with intrauterine growth retardation are discussed. Orv. Hetil., 2014, 155(33), 1301–1305.

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