Reproducibility of three different methods of measuring baroreflex sensitivity in normal subjects

1998 ◽  
Vol 95 (5) ◽  
pp. 575-581 ◽  
Author(s):  
S. W. LORD ◽  
R. H. CLAYTON ◽  
M. C. S. HALL ◽  
J. C. GRAY ◽  
A. MURRAY ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Spectral Method ◽  
Coefficient Of Variation ◽  
Baroreflex Sensitivity ◽  
Low Frequency ◽  
Frequency Component ◽  
Non Invasive ◽  
Invasive Method ◽  
Head Up Tilt ◽  
Invasive Measurement

1.Baroreflex sensitivity is a useful tool for investigating cardiovascular reflexes in a number of clinical settings. Several different methods of measuring baroreflex sensitivity are available. In order to determine a clinically useful non-invasive method of measuring baroreflex sensitivity we compared two methods (spectral analysis and the Valsalva manoeuvre) with regard to reproducibility, agreement with a standard invasive method (phenylephrine infusion) and failure rate. 2.Twenty-six healthy subjects aged 22 to 63 years attended on three separate occasions for measurement of baroreflex sensitivity using the different methods. The effect of a recent head-up tilt on baroreflex sensitivity was measured. 3.Reproducibility was best for the low-frequency component of the spectral method [coefficient of variation 25.0% (range 3.5–42.4%)] and worst for the Valsalva method [coefficient of variation 29.3% (range 13.8–93.1%)]. Both non-invasive methods overestimated values compared with the phenylephrine method [bias of low-frequency component of the spectral method, 1.17 (0.38–3.6); bias of the Valsalva method, 1.13 (0.19–6.7)]. The high-frequency component of the spectral method did not agree with the phenylephrine method. 4.The spectral analysis method had the fewest failures (seven subjects with a failure on at least one occasion), and the phenylephrine method the most (16 subjects with a failure on at least one occasion). A short head-up tilt did not affect the subsequent non-invasive measurement of baroreflex sensitivity. 5.It was concluded that the low-frequency component of the spectral method was the most clinically useful non-invasive measurement of baroreflex sensitivity.

ASSESSMENT OF PARASYMPATHETIC CONTROL OF BLOOD VESSEL BY PULSATION SPECTRUM AND COMPARISON WITH SPECTRAL METHOD OF RR INTERVALS

2003 ◽  
Vol 15 (01) ◽  
pp. 8-16
Author(s):  
CHANG-WEI HSIEH ◽  
CHI-WU MAO ◽  
MING-SHING YOUNG ◽  
TZUNG-LIEH YEH
Keyword(s):  
Spectral Method ◽  
High Frequency ◽  
Autonomic Function ◽  
Low Frequency ◽  
Frequency Component ◽  
Short Term ◽  
Non Invasive ◽  
Spectrum Method ◽  
Pulsation Spectrum ◽  
Parasympathetic Control

A new pulse spectrum method of assessing autonomic function was examined in a pharmacological experiment on eight healthy volunteers. The pulse pressure data is obtained under control condition and in parasympathetic blocked by atropine. Compared with the spectral method of heart rate variability (HRV), which is wide-spreading in laboratory studies and clinical diagnosis nowadays, the method of pulsation spectrum provides a new and direct view to assess parasympathetic control. As can be seen from the results, the high frequency of pulsation harmonics are reduced by the parasympathetic blocked, and on the contrary, low frequency component increased. By the analysis of linear regression, the pulsation spectrum method indicates more correlations with atropine doses. We anticipate that the non-invasive assessment of short-term autonomic function will come to be performed more reliably and conveniently by using this method.

scholarly journals The Tangential Force Affecting the Radial Baffles in a Stirred Vessel: Analysis of the Macro-instability Related Component

10.14311/450 ◽  
2003 ◽  
Vol 43 (4) ◽  
Author(s):  
P. Hasal ◽  
I. Fořt ◽  
J. Kratěna
Keyword(s):  
Experimental Data ◽  
Spectral Analysis ◽  
Tangential Force ◽  
Low Frequency ◽  
Frequency Component ◽  
Relative Magnitude ◽  
Tangential Component ◽  
Vertical Position ◽  
Total Force ◽  
Rushton Turbine

Experimental data obtained by measuring the tangential component of the force affecting radial baffles in a flat-bottomed cylindrical mixing vessel stirred with a Rushton turbine impeller is analysed. Spectral analysis of the experimental data demonstrated the presence of its macro-instability (MI) related low-frequency component embedded in the total force. Two distinct dimensionless frequencies (both directly proportional to the impeller speed of rotation N) of the occurence of the MI component were detected: a lower frequency of approximately 0.025N and a higher frequency of about 0.085N. The relative magnitude QMI of the MI-related component of the total tangential force was evaluated by a combination of proper orthogonal decomposition (POD) and spectral analysis. The values of magnitude QMI varied in the interval [rom approximately 0.05 to 0.30. The magnitude QMI takes maximum values at low Reynolds number values (in laminar and transitional regions). In the turbulent region (ReM >20000) the QMI value is low and practically constant. The dependence oj the QMI values on vertical position in the vessel is only marginal. The results suggest that the magnitude of the MI component of the force is significantly influenced by the liquid viscosity and density.

scholarly journals Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying

2017 ◽  
Vol 46 (2) ◽  
pp. 792-801 ◽  
Author(s):  
W-J Guo ◽  
S-K Yao ◽  
Y-L Zhang ◽  
S-Y Du ◽  
H-F Wang ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Delayed Gastric Emptying ◽  
Low Frequency ◽  
Treatment Method ◽  
Frequency Component ◽  
High Frequency Component ◽  
Vagal Activity ◽  
Nervous Function

Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio. Results Overall and proximal GE were delayed in 47.2% and 50.9% of the patients, respectively. Spectral analysis of HRV showed that the HF in patients with delayed proximal GE was significantly lower and that the LF/HF ratio was significantly higher than those in patients with normal proximal GE after a meal. Conclusion Delayed proximal GE might be caused by disrupted sympathovagal balance as a result of decreased vagal activity after a meal. Improvement in vagal activity may constitute an effective treatment method for patients with FD.

Exploring directionality in spontaneous heart period and systolic pressure variability interactions in humans: implications in the evaluation of baroreflex gain

2005 ◽  
Vol 288 (4) ◽  
pp. H1777-H1785 ◽  
Author(s):  
Giandomenico Nollo ◽  
Luca Faes ◽  
Alberto Porta ◽  
Renzo Antolini ◽  
Flavia Ravelli
Keyword(s):  
Spectral Analysis ◽  
Spectral Component ◽  
Systolic Pressure ◽  
Low Frequency ◽  
Systolic Arterial Pressure ◽  
Phase Lag ◽  
Healthy Humans ◽  
Head Up Tilt ◽  
Causal Approach ◽  
Young Subjects

Although in physiological conditions RR interval and systolic arterial pressure (SAP) are likely to interact in a closed loop, the traditional cross-spectral analysis cannot distinguish feedback (FB) from feedforward (FF) influences. In this study, a causal approach was applied for calculating the coherence from SAP to RR ( Ks-r) and from RR to SAP ( Kr-s) and the gain and phase of the baroreflex transfer function. The method was applied, compared with the noncausal one, to RR and SAP series taken from 15 healthy young subjects in the supine position and after passive head-up tilt. For the low frequency (0.04–0.15 Hz) spectral component, the enhanced FF coupling ( Kr-s = 0.59 ± 0.21, significant in 14 subjects) and the blunted FB coupling ( Ks-r = 0.17 ± 0.17, significant in 4 subjects) found at rest indicated the prevalence of nonbaroreflex mechanisms. The tilt maneuver recovered FB influences ( Ks-r = 0.47 ± 0.16, significant in 14 subjects), which were stronger than FF interactions ( Ks-r = 0.34 ± 0.19, significant in 9 subjects). At the respiratory frequency, the RR-SAP regulation was balanced at rest ( Ks-r = 0.30 ± 0.18 and Kr-s = 0.29 ± 0.20, significant in 11 and 8 subjects) and shifted toward FB mechanisms after tilt ( Ks-r = 0.35 ± 0.19 and Kr-s = 0.19 ± 0.11, significant in 14 and 8 subjects). The causal baroreflex gain estimates were always lower than the corresponding noncausal values and decreased significantly from rest to tilt in both frequency bands. The tilt-induced increase of the phase lag from SAP to RR suggested a shift from vagal to sympathetic modulation. Thus the importance of nonbaroreflex interactions pointed out the necessity of accounting for causality in the cross-spectral analysis of the interactions between cardiovascular variables in healthy humans.

Age dependency of cardiovascular autonomic responses to head-up tilt in healthy subjects

2004 ◽  
Vol 96 (6) ◽  
pp. 2333-2340 ◽  
Author(s):  
Tomi Laitinen ◽  
Leo Niskanen ◽  
Ghislaine Geelen ◽  
Esko Länsimies ◽  
Juha Hartikainen
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
High Frequency ◽  
Healthy Subjects ◽  
Baroreflex Sensitivity ◽  
Low Frequency ◽  
Upright Position ◽  
Vascular Responses ◽  
Autonomic Responses ◽  
Head Up Tilt

In elderly subjects, heart rate responses to postural change are attenuated, whereas their vascular responses are augmented. Altered strategy in maintaining blood pressure homeostasis during upright position may result from various cardiovascular changes, including age-related cardiovascular autonomic dysfunction. This exploratory study was conducted to evaluate impact of age on cardiovascular autonomic responses to head-up tilt (HUT) in healthy subjects covering a wide age range. The study population consisted of 63 healthy, normal-weight, nonsmoking subjects aged 23–77 yr. Five-minute electrocardiogram and finger blood pressure recordings were performed in the supine position and in the upright position 5 min after 70° HUT. Stroke volume was assessed from noninvasive blood pressure signals by the arterial pulse contour method. Heart rate variability (HRV) and systolic blood pressure variability (SBPV) were analyzed by using spectral analysis, and baroreflex sensitivity (BRS) was assessed by using sequence and cross-spectral methods. Cardiovascular autonomic activation during HUT consisted of decreases in HRV and BRS and an increase in SBPV. These changes became attenuated with aging. Age correlated significantly with amplitude of HUT-stimulated response of the high-frequency component ( r = -0.61, P < 0.001) and the ratio of low-frequency to high-frequency power of HRV ( r = -0.31, P < 0.05) and indexes of BRS (local BRS: r = -0.62, P < 0.001; cross-spectral baroreflex sensitivity in the low-frequency range: r = -0.38, P < 0.01). Blood pressure in the upright position was maintained well irrespective of age. However, the HUT-induced increase in heart rate was more pronounced in the younger subjects, whereas the increase in peripheral resistance was predominantly observed in the older subjects. Thus it is likely that whereas the dynamic capacity of cardiac autonomic regulation decreases, vascular responses related to vasoactive mechanisms and vascular sympathetic regulation become augmented with increasing age.

Sympathetic-Parasympathetic Activation During Spontaneous Attacks of Cluster Headache: Evaluation by Spectral Analysis of Heart-Rate Fluctuations

Cephalalgia ◽  
1995 ◽  
Vol 15 (6) ◽  
pp. 504-510 ◽  
Author(s):  
M De Marinis ◽  
S Strano ◽  
M Granata ◽  
C Urani ◽  
S Lino ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
Cluster Headache ◽  
Low Frequency ◽  
Sympathetic Activation ◽  
Autonomic Balance ◽  
Spectral Parameters ◽  
Rate Fluctuation ◽  
Head Up Tilt

Twenty-four hour ECG Holter and blood-pressure monitorings were performed in eight patients suffering from cluster headache. Spectral analysis of heart-rate fluctuation was used to assess the autonomic balance under basal conditions, after head-up tilt, and during a spontaneous attack. Normal autonomic balance was found at rest and during sympathetic activation obtained with head-up tilt in the interparoxysmal period. Before the onset of headache, an increase in the low-frequency (LF) component of the power spectrum was apparent in all patients. This sign of sympathetic activation was followed by an increase in the high-frequency (HF) component that developed about 2000 beats after the onset of headache and rapidly overcame the LF component until the end of pain. Significant differences were found when comparing the spectral parameters [total spectral values (TP), power of the LF and HF components and LF/HF ratio] obtained before, during and after headache. During the attack, blood pressure increased and heart rate decreased in all subjects. There appears to be a primary activation of both sympathetic and parasympathetic functions in cluster headache attacks. The sympathetic component seems to be involved mostly in the development of the attack, whereas the parasympathetic activation seems to occur, following the onset of the attack, independently of the pain.

Continuous, on-line, real-time spectral analysis of SAP signals during cardiopulmonary bypass

1995 ◽  
Vol 268 (6) ◽  
pp. H2329-H2335
Author(s):  
M. W. Yang ◽  
T. B. Kuo ◽  
S. M. Lin ◽  
K. H. Chan ◽  
S. H. Chan
Keyword(s):  
Spectral Analysis ◽  
Cardiopulmonary Bypass ◽  
Blood Vessels ◽  
Real Time ◽  
Low Frequency ◽  
Frequency Component ◽  
Very Low Frequency ◽  
Frequency Components ◽  
On Line ◽  
Very High

We communicated the application of continuous, on-line, real-time power spectral analysis of systemic arterial pressure (SAP) signals during cardiopulmonary bypass when the heart was functionally but reversibly disconnected from the blood vessels. Based on observations from 15 cases of successfully completed coronary artery bypass grafting procedures, we found that the very low (0.00-0.08 Hz), low (0.08-0.15 Hz)-, high (0.15-0.25 Hz)-, and very high (0.80-1.60 Hz) frequency components of SAP signals exhibited differential changes before, during, and after cardiopulmonary bypass. In particular, the very low-frequency component, which purportedly represents the contribution of vasomotor activity to SAP, presented only a mild decrease in power during hypothermic cardioplegia. Interestingly, the total peripheral resistance also manifested only a slight reduction during the same period. On the other hand, the low-, high-, and very high frequency components were essentially eliminated. These results unveiled an active role for the blood vessels in the maintenance of SAP during cardiopulmonary bypass, possibly as a result of a maintained vasomotor tone as reflected by the sustained very low frequency component of the SAP signals.

scholarly journals Predictive value of very low frequency at spectral analysis among patients with unexplained syncope assessed by head-up tilt testing

2018 ◽  
Vol 111 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Michela Anna Pia Ciliberti ◽  
Francesco Santoro ◽  
Luigi Flavio Massimiliano Di Martino ◽  
Antonio Cosimo Rinaldi ◽  
Giuseppe Salvemini ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Predictive Value ◽  
Low Frequency ◽  
Tilt Testing ◽  
Very Low Frequency ◽  
Head Up Tilt ◽  
Unexplained Syncope

Altered Dynamics of the Circadian Relationship between Systemic Arterial Pressure and Cardiac Sympathetic Drive Early on in Mild Hypertension

1994 ◽  
Vol 86 (2) ◽  
pp. 209-215 ◽  
Author(s):  
S. Guzzetti ◽  
S. Dassi ◽  
M. Balsamà ◽  
G. B. Ponti ◽  
M. Pagani ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Neural Control ◽  
Mild Hypertension ◽  
Clinical Laboratory ◽  
Spectral Component ◽  
Low Frequency ◽  
Frequency Component ◽  
Regulatory Mechanisms ◽  
Non Invasive ◽  
Normotensive Subjects

1. This study was designed to test the hypothesis that simultaneous non-invasive assessment of the circadian variations in both intermittent arterial pressure and the continuous 24 h changes of spectral markers of cardiac neural control could provide new information on cardiovascular regulatory mechanisms, in hypertensive patients and normotensive subjects. To test this hypothesis we studied 18 subjects with mild hypertension and 11 normotensive subjects in whom we recorded simultaneously non-invasive intermittent arterial pressure and Holter electrocardiogram for 24 h. We also studied the same subjects during resting and standing conditions in the clinical laboratory. 2. The normalized power of the low-frequency (∼0.1 Hz) spectral component of R-R interval variability, considered mainly a marker of sympathetic drive to the sino-atrial node, was, at rest, significantly higher in the hypertensive than in the normotensive subjects, as already reported. Moreover, the values of the low-frequency component at rest recorded in the clinical laboratory were significantly correlated with those obtained from ambulatory recording during night rest. The decrease in the values of arterial pressure during the night-time was accompanied by a reduction in the power of the low-frequency component only in the case of normotensive subjects. Accordingly, the slope of the regression of the low-frequency component as a function of systolic arterial pressure during ambulatory recordings was steep in normotensive subjects and flat in hypertensive subjects. 3. The computer analysis of Holter recordings combined with ambulatory arterial pressure monitoring seems to provide a new method with which to quantify the early changes in cardiovascular regulatory mechanisms that could help to identify individuals at higher risk.

scholarly journals Medicine detection with Low Frequency Electromagnetic Signals

2020 ◽  
Vol 17 ◽  
Keyword(s):  
Low Frequency ◽  
Molecular Structures ◽  
New Method ◽  
Pain Reliever ◽  
Non Invasive ◽  
Reliever Medication ◽  
Invasive Method ◽  
Electromagnetic Signals ◽  
Magnet Resonance

This paper presents a new, non-invasive method to detect molecular structures inside materials . There have been different methods to detect molecular structures such as Chromatography, Spectroscopy and Nuclear Magnet Resonance. A brief description of these methods is presented and how they are used. Then the new method is presented using an apparatus emitting low frequency electromagnetic signals. This paper presents how the frequencies are found, that are used to detect molecular structures. The method was applied for finding the frequencies of four pain-reliever medication. Discussion follows on the results. Conclusions are drawn and further work is proposed

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