Reproducible assessment of vaginal and rectal mucosal and skin blood flow: laser doppler fluximetry of the pelvic microcirculation

2000 ◽  
Vol 98 (2) ◽  
pp. 201-207 ◽  
Author(s):  
A. V. EMMANUEL ◽  
M. A. KAMM ◽  
R. W. BEARD
Keyword(s):  
Blood Flow ◽  
Menstrual Cycle ◽  
Postmenopausal Women ◽  
Luteal Phase ◽  
Vascular Reactivity ◽  
Rectal Mucosa ◽  
Premenopausal Women ◽  
Follicular Phase ◽  
Laser Doppler ◽  
Head Up Tilt

Pelvic venous congestion is a common cause of chronic pelvic pain in women of reproductive age. Although this condition represents a functional disturbance of the pelvic circulation which is related to the menstrual cycle, its aetiology remains unknown. Indirect techniques demonstrate that the vasoconstrictive reflex response of the microcirculation of the foot to a rise in venous pressure is attenuated throughout the menstrual cycle. We wished to develop a simple and non-invasive direct measure of pelvic blood flow to aid diagnosis of this condition. Laser doppler blood flux measurements of the skin of the big toe and of the vaginal and rectal mucosa in the follicular and luteal phases of the menstrual cycle in 12 healthy asymptomatic premenopausal women (mean age 30 years) with regular cycles and in four healthy asymptomatic postmenopausal women (mean age 59 years) were carried out both in the supine position and in response to 40° head-up tilt. The coefficient of variation of resting vaginal flux was lower for measurements in postmenopausal women (0.04) and in premenopausal women in the follicular phase (0.07) compared with those in the luteal phase (0.16). At rest, vaginal blood flow was higher than rectal and skin flux in both premenopausal and postmenopausal women. In the follicular phase a decrease in flow was observed in response to head-up tilt in the skin (-32.0%), vagina (-34.3%) and rectum (-9.4%). In the luteal phase this reflex was attenuated at these three sites (-8.6%, +6.7% and +7.4% respectively). There were no significant reflex changes in postmenopausal women. Thus laser doppler fluximetry is a reproducible method for comparing the flux of blood in the microcirculation of the skin and of the vaginal and rectal mucosa. The skin is the least sensitive site for testing vascular reactivity in response to cyclical changes. The vaginal and rectal microcirculations are the most sensitive sites for testing visceral cyclical reactivity, and have the advantage of direct anatomical relevance. The follicular phase of the menstrual cycle is associated with greatest vascular reactivity and is the most appropriate phase during which to test for abnormal vascular responses.

Effects of the menstrual cycle on mood, neurocognitive and neuroendocrine function in healthy premenopausal women

2004 ◽  
Vol 34 (1) ◽  
pp. 93-102 ◽  
Author(s):  
C. S. SYMONDS ◽  
P. GALLAGHER ◽  
J. M. THOMPSON ◽  
A. H. YOUNG
Keyword(s):  
Menstrual Cycle ◽  
Hpa Axis ◽  
Luteal Phase ◽  
Reaction Times ◽  
Premenopausal Women ◽  
Follicular Phase ◽  
Continuous Performance Task ◽  
Biological Difference ◽  
Basal Cortisol ◽  
The Relationship

Background. Neurocognitive functioning may be impaired in the luteal phase of the menstrual cycle due to associated changes in hypothalamic–pituitary–adrenal (HPA) axis function. This study examines the relationship between changes in neurocognition and HPA axis function in different phases of the menstrual cycle.Method. Fifteen female volunteers, free from psychiatric history and hormonal medication were tested twice, during mid-follicular and late-luteal phases in a randomized, crossover design. Mood, neurocognitive function, and basal cortisol and dehydroepiandrosterone (DHEA) were profiled.Results. Relative to the follicular phase, verbal fluency was impaired in the luteal phase and reaction times speeded on a continuous performance task, without affecting overall accuracy. ‘Hedonic’ scores on the UWIST-MACL scale were decreased in the luteal phase. There was also evidence of changes in the function of the HPA axis, with 24 h urinary cortisol concentrations and salivary DHEA levels being significantly lower during the luteal phase.Conclusions. These data suggest that luteal phase HPA axis function is lower than in the follicular phase in premenopausal healthy women. This putative biological difference may be important for our understanding of the aetiopathogenesis of menstrually related mood change and neurocognitive disturbance.

scholarly journals Variation in the Renin Angiotensin System throughout the Normal Menstrual Cycle

2002 ◽  
Vol 13 (2) ◽  
pp. 446-452
Author(s):  
Mala Chidambaram ◽  
John A. Duncan ◽  
Vesta S. Lai ◽  
Daniel C. Cattran ◽  
John S. Floras ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Lower Body Negative Pressure ◽  
Premenopausal Women ◽  
Renin Angiotensin System ◽  
Follicular Phase ◽  
Systemic Hemodynamic ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Normal Menstrual Cycle

ABSTRACT. It has been demonstrated elsewhere that circulating renin angiotensin system (RAS) components peak when plasma estrogen levels are highest, during the luteal phase of the normal menstrual cycle. This phenomenon has been attributed to “activation” of the RAS. The end-organ vasoconstrictive response to this phenomenon has not been well established. In two related experiments, the RAS was studied in healthy, premenopausal women during predefined phases of the normal menstrual cycle. In the first experiment, the circulating components of the RAS and the systemic hemodynamic response to incremental lower body negative pressure (LBNP) during the follicular and luteal phases of the menstrual cycle were examined. Response variables included mean arterial pressure (MAP), renin, plasma renin activity (PRA), angiotensin II (AngII), and aldosterone. Baseline levels of renin, PRA, and aldosterone were significantly higher in the luteal phase. In response to LBNP, there were significant increases in all variables in both phases; however, the humoral response to this stimulus was significantly augmented in the luteal phase compared with the follicular phase. Despite these elevations in circulating components of the RAS during the luteal phase, subjects were unable to maintain MAP in response to LBNP, exhibiting a dramatic depressor response that did not occur during the follicular phase. In the second experiment, renal and peripheral hemodynamic function at baseline, and in response to AngII blockade with losartan, were examined in women during these high and low estrogen phases of the menstrual cycle. The renal and peripheral hemodynamic responses were similar in the luteal phase and the follicular phase. These results demonstrate that, despite an increase in circulating RAS components during the luteal phase of the menstrual cycle, the system is blunted rather than “activated,” at least at a tissue level. Further studies are needed to clarify this mechanism.

scholarly journals Relationship Of FEF25-75, Pefr And SVC With Estrogen And Progesterone Level In Postmenopausal Women

1970 ◽  
Vol 6 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Zinat Ara Polly ◽  
Shelina Begum ◽  
Sultana Ferdousi ◽  
Noorzahan Begum ◽  
Taskina Ali ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Negative Correlation ◽  
Luteal Phase ◽  
Premenopausal Women ◽  
Follicular Phase ◽  
Progesterone Level ◽  
Serum Progesterone ◽  
Estrogen Level ◽  
Menopausal Women ◽  
Post Menopausal

Background: Deterioration of lung function is common in women after menopause, which may be related to very low estrogen and progesterone level. Objective: To observe FEF25-75, PEFR and SVC (slow vital capacity) values in apparently healthy postmenopausal women to find out their relationships with serum estrogen and progesterone. Methods: This study was carried out in the Department of Physiology in BSMMU, Dhaka in the year 2007. 30 healthy postmenopausal women aged 45 to 60 years and 30 healthy premenopausal women aged 20 to 30 years during their different phases of menstrual cycle were studied. Postmenopausal women were residents of Dhaka city and premenopausal subjects were medical students. FEF25-75, PEFR and SVC of all subjects were measured by a digital micro spirometer. Their estrogen and progesterone levels were estimated by Micro particle Enzyme Immunoassay (MEIA) method. Data were analyzed by Pearson’s correlation coefficient test, one way ANOVA and unpaired‘t’ test Results: The mean percentage of predicted values of FEF25-75 and PEFR were lower in postmenopausal women compared to those of follicular and luteal phases of premenopausal women but it was not significant. Measured values of SVC was Significantly (p<.001) lower in postmenopausal women compared to those of follicular and luteal phases of premenopausal women. Again Mean serum estrogen and progesterone levels were significantly (p<.001) lower in post menopausal women compared to those of follicular and luteal phases of premenopausal women. In post menopausal women, FEF25-75 was positively, PEFR and SVC were negatively correlated with progesterone level. PEFR and SVC showed positive correlattion and FEF25-75 showed negative correlation with serum estrogen level. All these correlations were statistically non significant. In premenopausal women FEF25-75 and PEFR showed positive correlation and SVC showed negative correlation with serum progesterone level. The relationships were statistically significant in luteal phase but nonsignificant in follicular phase. FEF25-75 ,PEFR and SVC were positively correlated with serum estrogen level in luteal phase but FEF25-75 and PEFR negatively correlated and SVC positively correlated with estrogen level in follicular phase. Conclusion: The outcome of this study shows FEF25-75 , PEFR and SVC may be reduced in postmenopausal women which in turn may be associated with their low progesterone and estrogen levels. DOI: http://dx.doi.org/10.3329/jbsp.v6i2.9761 JBSP 2011 6(2): 116-121

scholarly journals Computed tomography contrast enhancement pattern of the uterus in premenopausal women in relation to menstrual cycle and hormonal contraception

2020 ◽  
pp. 028418512095840
Author(s):  
Konstantinos Angelopoulos ◽  
Magnus Palmér ◽  
Berit Gull ◽  
Niklas Lundqvist ◽  
Linda Kopelia ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Menstrual Cycle ◽  
Contrast Enhancement ◽  
Luteal Phase ◽  
Hormonal Contraception ◽  
Premenopausal Women ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Homogeneous Type ◽  
Menstrual Cycle Phase

Background There are different types of computed tomography (CT) contrast enhancement patterns of the uterus. It is not known whether these are hormonally dependent. Purpose To assess the relationship between these patterns and the menstrual cycle in non-users of hormonal contraception, and the possible impact of hormonal contraception. Material and Methods Prospective observational study of abdominal CT scans of 53 premenopausal women of whom 28 were non-users and 25 users of hormonal contraception. The non-users were divided according to menstrual cycle phase: follicular (n = 12); ovulatory (n = 1); and luteal (n = 12). The pattern and intensity of contrast enhancement of the uterine myometrium were assessed. Results The dominant pattern of contrast enhancement of the myometrium was the diffuse homogeneous type in both non-users and users. The intensity of the enhancement measured in Hounsfield units (HU) was higher in the follicular phase (median 102, range 73–130) compared to the luteal phase in non-users (median 92, range 57–130); however this was not statistically significant ( P = 0.2). The HU values observed in users (median 95, range 45–160) were at the same levels compared to those of the luteal phase in non-users. Conclusion The dominant pattern of contrast enhancement in the portal venous phase of the myometrium in fertile ages is the diffuse homogeneous type and is independent of menstrual cycle phase or the use of hormonal contraception. However, these factors seem to play a role in the intensity of contrast enhancement, with a tendency of higher HU values in the follicular phase of non-users.

scholarly journals Effect of Menopause on Pulmonary Functions: An Analysis!

2017 ◽  
Vol 5 (2) ◽  
pp. 99-101
Author(s):  
Kshama V Kedar ◽  
Radha P Munje ◽  
Amar K Karia
Keyword(s):  
Menstrual Cycle ◽  
Lung Function ◽  
Pulmonary Function ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Pulmonary Function Tests ◽  
Premenopausal Women ◽  
Pulmonary Functions ◽  
Function Tests

ABSTRACT Introduction Sex hormones play an important role in women's health. There is a close relationship between female sex hormones and lung function in postmenopausal women. Deterioration of lung function is observed more after menopause. Estrogen deficiency after menopause accelerates the adverse effects of biological aging on lung mechanics in postmenopausal women. Our study uses a spirometer to analyze and evaluate these effects of menopausal aging. Objective To study the effects of menopause on pulmonary function tests in women of perimenopausal age group. Materials and methods This study was carried out in the Department of Obstetrics and Gynecology in Indira Gandhi Government Medical College & Hospital (IGGMC) Nagpur, India. Totally 50 women each in premenopausal and menopausal age groups were included in our study. Venous blood was collected under aseptic precautions on 10 to 14 and 18 to 23 days corresponding to follicular and luteal phase of menstrual cycle in premenopausal and postmenopausal women. Serum estrogen and progesterone levels were estimated by microparticle enzyme immunoassay. The pulmonary function of all subjects was measured with digital microspirometer and data collected. The peak expiratory flow rate (PEFR), forced expiratory flow (FEF)25-75, forced expiratory volume (FEV1), and forced vital capacity (FVC) were studied and correlated with symptoms. Data analysis was done using Student's unpaired t-test and chi-squared test. Results The mean percentages of predicted values of FEF25-75 and PEFR were lower in postmenopausal women compared with premenopausal women. Mean serum estrogen levels were significantly lower in postmenopausal women as compared with premenopausal women. Progesterone levels were lower in postmenopausal women and in proliferative phase of premenopausal women as compared with luteal phase of menstrual cycle. Conclusion As menopause sets in, decrease in hormonal levels leads to decreased lung capacity as evident by pulmonary function tests. Decreased pulmonary function test can be attributed to lower levels of sex hormones estrogen and progesterone in postmenopausal women. How to cite this article Karia AK, Kedar KV, Munje RP. Effect of Menopause on Pulmonary Functions: An Analysis! J South Asian Feder Menopause Soc 2017;5(2):99-101.

scholarly journals Soy Isoflavones Exert Modest Hormonal Effects in Premenopausal Women1

1999 ◽  
Vol 84 (1) ◽  
pp. 192-197 ◽  
Author(s):  
Alison M. Duncan ◽  
Barbara E. Merz ◽  
Xia Xu ◽  
Theodore C. Nagel ◽  
William R. Phipps ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Weight Control ◽  
Control Diet ◽  
Premenopausal Women ◽  
Dehydroepiandrosterone Sulfate ◽  
Follicular Phase ◽  
Soy Isoflavones ◽  
Sex Hormone Binding Globulin ◽  
Early Follicular Phase

Soy isoflavones are hypothesized to be responsible for changes in hormone action associated with reduced breast cancer risk. To test this hypothesis, we studied the effects of isoflavone consumption in 14 premenopausal women. Isoflavones were consumed in soy protein powders and provided relative to body weight (control diet, 10 ± 1.1; low isoflavone diet, 64 ± 9.2; high isoflavone diet, 128 ± 16 mg/day) for three menstrual cycles plus 9 days in a randomized cross-over design. During the last 6 weeks of each diet period, plasma was collected every other day for analysis of estrogens, progesterone, LH, and FSH. Diet effects were assessed during each of four distinctly defined menstrual cycle phases. Plasma from the early follicular phase was analyzed for androgens, cortisol, thyroid hormones, insulin, PRL, and sex hormone-binding globulin. The low isoflavone diet decreased LH (P = 0.009) and FSH (P = 0.04) levels during the periovulatory phase. The high isoflavone diet decreased free T3 (P = 0.02) and dehydroepiandrosterone sulfate (P = 0.02) levels during the early follicular phase and estrone levels during the midfollicular phase (P = 0.02). No other significant changes were observed in hormone concentrations or in the length of the menstrual cycle, follicular phase, or luteal phase. Endometrial biopsies performed in the luteal phase of cycle 3 of each diet period revealed no effect of isoflavone consumption on histological dating. These data suggest that effects on plasma hormones and the menstrual cycle are not likely to be the primary mechanisms by which isoflavones may prevent cancer in premenopausal women.

scholarly journals Hemodynamic responses to strength exercise with blood flow restriction during different phases of the menstrual cycle

Motricidade ◽  
2017 ◽  
Vol 13 (3) ◽  
pp. 31 ◽  
Author(s):  
Gabriel Rodrigues Neto ◽  
Jefferson Silva Novaes ◽  
Adenilson Targino de Araújo Júnior ◽  
Júlio César Gomes Silva ◽  
Rodrigo Poderoso Souza ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Blood Flow Restriction ◽  
Strength Exercise ◽  
Double Product ◽  
Flow Restriction ◽  
Low Load

The present study aimed to determine the influence of low-load (LL) resistance exercise (RE) with blood flow restriction (BFR) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), double product (DP) and oxygen saturation (SpO2) during the phases of the menstrual cycle (MC). Thirty untrained women were randomly and proportionally divided into three groups: HI = high-intensity exercises (80% of one-repetition maximum (1RM)); LL = low-load exercises (20% of 1RM); and LL+BFR = LL exercises combined with BFR. The exercise sessions were performed during the 3rd-4th days (follicular phase), 16th day (ovulatory phase) and the 24th-26th days (luteal phase) of the MC. Before and immediately after the exercises, SBP, DBP, HR and SpO2 were evaluated. We observed an increase in SBP, HR and DP in the three phases of the MC for all groups (p < 0.05). Groups LL and/or LL+BFR exhibited a greater increase in SBP, DBP, MBP, HR and DP when compared with the HI group (p < 0.05), and in the three groups, SpO2 was not reduced (p > 0.05). There was a significant effect of the MC phases on HR and DP (p < 0.05). We conclude that the three groups exhibited increased SBP, HR and DP; however, SpO2 was not different. Furthermore, groups LL and LL+BFR exhibited greater increases in hemodynamics, and the MC phases seem to influence only HR and DP.

Effect of luteal phase elevation in core temperature on forearm blood flow during exercise

1997 ◽  
Vol 82 (4) ◽  
pp. 1079-1083 ◽  
Author(s):  
Margaret A. Kolka ◽  
Lou A. Stephenson
Keyword(s):  
Blood Flow ◽  
Menstrual Cycle ◽  
Core Temperature ◽  
Luteal Phase ◽  
Forearm Blood Flow ◽  
Venous Occlusion ◽  
Follicular Phase ◽  
Dew Point ◽  
Early Follicular Phase ◽  
Midluteal Phase

Kolka, Margaret A., and Lou A. Stephenson. Effect of luteal phase elevation in core temperature on forearm blood flow during exercise. J. Appl. Physiol. 82(4): 1079–1083, 1997.—Forearm blood flow (FBF) as an index of skin blood flow in the forearm was measured in five healthy women by venous occlusion plethysmography during leg exercise at 80% peak aerobic power and ambient temperature of 35°C (relative humidity 22%; dew-point temperature 10°C). Resting esophageal temperature (Tes) was 0.3 ± 0.1°C higher in the midluteal than in the early follicular phase of the menstrual cycle ( P < 0.05). Resting FBF was not different between menstrual cycle phases. The Tes threshold for onset of skin vasodilation was higher (37.4 ± 0.2°C) in midluteal than in early follicular phase (37.0 ± 0.1°C; P < 0.05). The slope of the FBF to Tes relationship was not different between menstrual cycle phases (14.0 ± 4.2 ml ⋅ 100 ml−1 ⋅ min−1 ⋅ °C−1for early follicular and 16.3 ± 3.2 ml ⋅ 100 ml−1 ⋅ min−1 ⋅ °C−1for midluteal phase). Plateau FBF was higher during exercise in midluteal (14.6 ± 2.2 ml ⋅ 100 ml−1 ⋅ min−1 ⋅ °C−1) compared with early follicular phase (10.9 ± 2.4 ml ⋅ 100 ml−1 ⋅ min−1 ⋅ °C−1; P < 0.05). The attenuation of the increase in FBF to Tes occurred when Tes was 0.6°C higher and at higher FBF in midluteal than in early follicular experiments ( P < 0.05). In summary, the FBF response is different during exercise in the two menstrual cycle phases studied. After the attenuation of the increase in FBF and while Tes was still increasing, the greater FBF in the midluteal phase may have been due to the effects of increased endogenous reproductive endocrines on the cutaneous vasculature.

Effect of Menopause on Pulmonary Functions: An Analysis

2017 ◽  
Vol 5 (1) ◽  
pp. 16-18 ◽  
Author(s):  
Amar K Karia ◽  
Kshama V Kedar ◽  
Radha P Munje
Keyword(s):  
Menstrual Cycle ◽  
Lung Function ◽  
Pulmonary Function ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Premenopausal Women ◽  
Age Group ◽  
Pulmonary Functions ◽  
Function Test

ABSTRACT Background Sex hormones play an important role in women’s health. There is a close relationship between female sex hormones and lung function in postmenopausal women. Deterioration of lung function is observed more after menopause. Estrogen deficiency after menopause accelerates adverse effects of biological aging on lung mechanics in postmenopausal women. Our study uses spirometer to analyze and evaluate these effects of menopausal aging. Objective To study the effects of menopause on pulmonary function tests in women of perimenopausal age group. Materials and methods This study was carried out in the Department of Obstetrics and Gynecology in Indira Gandhi Government Medical College & Hospital, Nagpur, India. A total of 50 women each in premenopausal and menopausal age group were included in our study. Venous blood was collected under aseptic precaution on 10 to 14 days and 18 to 23 days corresponding to follicular and luteal phase of menstrual cycle in premenopausal women and in postmenopausal women, and serum estrogen and progesterone levels were estimated by microparticle enzyme immunoassay. Pulmonary function of all subjects was measured with digital micro spirometer and data collected. Peak expiratory flow rate (PEFR), forced expiratory flow (FEF)25-75, forced expiratory volume in 1 second, and forced vital capacity were studied and correlated with symptoms. Data analysis was done using Student’s unpaired t-test and chi-square test. Results The mean percentage of predicted values of FEF25-75 and PEFR were lower in postmenopausal women compared with premenopausal women. Mean serum estrogen levels were significantly lower in postmenopausal women as compared with premenopausal women. Progesterone levels were lower in postmenopausal women and in proliferative phase of premenopausal women as compared with luteal phase of menstrual cycle. Conclusion As menopause sets in decreased hormonal levels leads to decreased lung capacity as evident by pulmonary function test. Decreased pulmonary function test can be attributed to lower levels of sex hormones estrogen and progesterone in postmenopausal women. How to cite this article Karia AK, Kedar KV, Munje RP. Effect of Menopause on Pulmonary Functions: An Analysis. J South Asian Feder Menopause Soc 2017;5(1):16-18.

EVALUATION OF CHANGES IN CARDIORESPIRATORY FUNCTIONS DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE IN YOUNG WOMEN

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shehnaz Shaikh
Keyword(s):  
Menstrual Cycle ◽  
Sample Size ◽  
Young Women ◽  
Luteal Phase ◽  
Uterine Wall ◽  
Normal Weight ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Granulose Cells ◽  
Efficiency Test

Introduction: Menstrual cycle or menstruation involved discharge of sanguinous fluid and a sloughing of uterine wall. In women menstruation occurs at regular intervals on an average of 28 days, although most women gave a history of regular intervals of 28 to 30 days. About 10% -15% of women showed cycle at the precise 28 ± 2 days intervals when menstrual calendar was utilized. Normally in young women in different phases of ovarian cycles the plasma levels of estrogen vary. Ovulation occurs in the first 12-13th day of menstrual cycle, which is termed estrogen surge and second occurs in mid-luteal phase. During mid cycle or follicular phase of menstrual cycle the plasma concentration of progesterone is very low about 0.9 ng/mL. its level starts rising owing to secretion from the granulose cells. During luteal phase progesterone level reaches its peak value of 18 ng/mL and its level fall to a minimum value toward the end of the cycle. Estrogen affects local and systemic vasodilation. The menstrual cycle envelops two fundamental stages, the follicular stage (FP) and the luteal stage (LP). The follicular stage can part advance into two substages; the early FP, which is characterised with moo concentrations of both the key hormones estrogen and progesterone; and the mid FP where estrogen is tall autonomously from progesterone. The LP is epitomized by tall concentration of both estrogen and progesterone. These two fundamental stages are isolated by a soak surge in luteinizing hormone activating ovulation. These recurrent changes are said to be frequency unsurprising while long time. Aim: The main aim of this study is to evaluate the Cardiorespiratory functions changes during different Phases of Menstrual Cycle.   Material and methods: In this study, 20 with normal weight, 20 with obese and 20 with overage were included and taken them as a sample size. In this study all the young women those were recruited as a sample size are unmarried, undergraduate female student with the between the age group of 18-22years, having regular 28+6 days menstrual cycle for at least last 6months prior to this study. For the collection of data all the participants were instructed to attend the physiology lab department during each of three different phases. Day-2 during menstrual phase, Day-7, during follicular phase and Day-22 during luteal phase and the following parameters were recorded as Anthropometric measurements, measuring of pulse rate and blood pressure and cardiac efficiency test. Result: In general, work out proficiency changed essentially amid the distinctive stages of the menstrual cycle with the most elevated amid luteal stage and least amid menstrualo stage. There was no critical contrast in impact test amid menstrual stage, follicular stage and luteal stage of menstrual cycle among three bunches of people. Conclusion: We have watched noteworthy increment in cardiac and respiratory proficiency within the luteal stage of the menstrual cycle in ordinary weight people. Lower wellness levels were watched in overweight and stout females. In this manner hone of customary work out and admissions of solid slim down which offer assistance in lessening the weight and in turn the BMI will offer assistance in improving the physical wellness of the people. Keywords: Cardiorespiratory, Menstrual cycle, expiratory blast test

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