scholarly journals Attention, Speech-Language Dissociations, and Stuttering Chronicity

2020 ◽  
Vol 29 (1) ◽  
pp. 157-167 ◽  
Author(s):  
Cara M. Singer ◽  
Tedra A. Walden ◽  
Robin M. Jones
Keyword(s):  
Statistical Approach ◽  
Parent Report ◽  
Group Differences ◽  
Complex Nature ◽  
Expressive Vocabulary ◽  
Final Time ◽  
Attention Span ◽  
Final Time Point ◽  
Language Evaluations ◽  
Developmental Stuttering

Summary The purpose of this study was to investigate the singular and joint contributions of speech-language dissociations and attention (i.e., distractibility and attention span) to stuttering chronicity. Method Participants, aged 3;0–4;11 (years;months) at an initial visit, were classified as persisting ( n = 10; 9 boys), recovered ( n = 32; 23 boys), and nonstuttering ( n = 28; 19 boys) based on multiple speech and language evaluations spread across 2 years. The evaluations included assessments of articulation, receptive and expressive vocabulary, and omnibus receptive and expressive language. These measures were used to identify speech-language dissociations using a correlation-based statistical approach. Attentional characteristics, which included measures of distractibility and attention span, were based on parent report. Analyses investigated between-group differences related to dissociations and attentional characteristics as well as the relation between these indices. Results There were no significant between-group differences for the persisting and recovered groups on measures of speech-language dissociations; however, the recovered group was found to exhibit less optimal attention span than the persisting group. In addition, children with dissociations exhibited less optimal distractibility and attention spans at the final time point than children without dissociations. Conclusions Present results indicate that attention is related to both stuttering chronicity and the presence of speech-language dissociations; however, they do not support the notion that dissociations are associated with stuttering persistence. These results provide novel insights into the complex nature of the association between developmental stuttering, speech-language dissociations, and attention.

scholarly journals A Multi-Method Investigation of Pragmatic Development in Individuals With Down Syndrome

2017 ◽  
Vol 122 (4) ◽  
pp. 289-309 ◽  
Author(s):  
Michelle Lee ◽  
Lauren Bush ◽  
Gary E. Martin ◽  
Jamie Barstein ◽  
Nell Maltman ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Executive Function ◽  
Theory Of Mind ◽  
Parent Report ◽  
Standardized Assessments ◽  
Pragmatic Competence ◽  
Pragmatic Language ◽  
Expressive Vocabulary ◽  
Pragmatic Development ◽  
Mental Age

Abstract This longitudinal study examined pragmatic language in boys and girls with Down syndrome (DS) at up to three time points, using parent report, standardized and direct assessments. We also explored relationships among theory of mind, executive function, nonverbal mental age, receptive and expressive vocabulary, grammatical complexity, and pragmatic competence. Controlling for cognitive and language abilities, children with DS demonstrated greater difficulty than younger typically developing controls on parent report and standardized assessments, but only girls with DS differed on direct assessments. Further, pragmatic skills of individuals with DS developed at a delayed rate relative to controls. Some sex-specific patterns of pragmatic impairments emerged. Theory of mind and executive function both correlated with pragmatic competence. Clinical and theoretical implications are discussed.

scholarly journals Vocabulary used by ethno-linguistically diverse South African toddlers: A parent report using the Language Development Survey

2013 ◽  
Vol 60 (1) ◽  
Author(s):  
Aurellia Shamaleni Gonasillan ◽  
Juan Bornman ◽  
Michal Harty
Keyword(s):  
Early Childhood ◽  
Language Development ◽  
South African ◽  
Early Childhood Development ◽  
Linguistically Diverse ◽  
Parent Report ◽  
Childhood Development ◽  
Expressive Vocabulary ◽  
Learning And Teaching ◽  
African Context

Objective: The primary aim of this study was to ascertain the relevance of the vocabulary of the Language Development Survey (LDS) for typically developing South African toddlers who attend ethno-linguistically diverse early childhood development centres.Rationale: The need for exploration of the expressive vocabulary of this population stems from the diverse linguistic contexts to which toddlers are exposed on a day-to-day basis in South Africa. Many parents prefer English as the language of learning and teaching for their child. As a result, toddlers interact with ethno-linguistically diverse peers from a young age, usually within their early childhood development centres.Method: An adapted version of the LDS was presented to 40 middle-class parents in Mpumalanga. Vocabulary commonly used by toddlers was determined and a comparison of parent responses made between the present study and the original American-based survey.Results: Results revealed that nouns were used most often by toddlers, in keeping with research on vocabulary acquisition. Significant correlations between the two groups were evident in 12 of the 14 categories. Parents reported that nouns, verbs, adjectives and words from other word classes were used similarly by toddlers, despite differences in their linguistic exposure.Conclusions: These findings suggest that the LDS is a valuable clinical screening tool for speech-language therapists who deliver services to toddlers within the South African context.

scholarly journals Comparison between fractal analysis and radiopacity evaluation as a tool for studying repair of an osseous defect in an animal model using biomaterials

2019 ◽  
Vol 48 (7) ◽  
pp. 20180466
Author(s):  
Nathália R. Gomes ◽  
Juliano D.S. Albergaria ◽  
Jonathas A. de S. Henriques ◽  
Tânia M.P. Amaral ◽  
Evandro N. Abdo ◽  
...  
Keyword(s):  
Animal Model ◽  
Fractal Analysis ◽  
Bone Repair ◽  
Blood Clot ◽  
Bovine Bone ◽  
Final Time ◽  
Significant Difference ◽  
Final Time Point ◽  
Osseous Defect ◽  
Time Point

Objectives: To evaluate bone repair of an osseous defect in a rat animal model through fractal analysis and radiopacity analysis in radiographic images. Methods: 120 rats were subjected to extraction of their first molar and divided into four groups (n = 6/group) according to the material used for bone grafting: mineralized bovine bone, demineralized bovine bone (DBB), blood clot (BC - control) or Bio-Oss® (BO). The animals were sacrificed after 1, 7, 14, 21 and 49 days and subjected to radiographic evaluation. For fractal analysis (FA), a square regionof interest of 30 × 30 pixels was used, and radiopacity was measured as the mean gray scale (MGS) value for three points of 5 × 5 pixels in the apical, medial and coronal regions of the defect. Histomorphometric evaluation was realized as the gold standard for bone neo-formation and maturation of the new osseous matrix. Results: Histomorphometric evaluation suggested that DBB showed faster mineralized deposition and resulted in more mature bone at the final time point of evaluation. Mineralized bovine bone and Bio-Oss presented similar results. The mineralized groups did not show significant differences in bone maturation. The radiopacity analysis revealed a significant difference (p < 0.05) between the DBB and blood clot groups at the final time point. FA did not show any significant differences at the final time point. Conclusions: Mean gray scale seemed to be more effective for the quantification of bone repair than FA in the demineralized group in this animal model. Results for the mineralized groups did not reveal a significant difference, leading to the conclusion that both methods are effective.

Propensity score analysis: an alternative statistical approach for HRD researchers

2016 ◽  
Vol 40 (8/9) ◽  
pp. 660-675
Author(s):  
Greggory L. Keiffer ◽  
Forrest C. Lane
Keyword(s):  
Propensity Score ◽  
Human Resource Development ◽  
Statistical Approach ◽  
Propensity Score Analysis ◽  
Analysis Of Covariance ◽  
Group Differences ◽  
Causal Inferences ◽  
Data Set ◽  
Content Type ◽  
Score Analysis

Purpose This paper aims to introduce matching in propensity score analysis (PSA) as an alternative statistical approach for researchers looking to make causal inferences using intact groups. Design/methodology/approach An illustrative example demonstrated the varying results of analysis of variance, analysis of covariance and PSA on a heuristic data set. The three approaches were compared by results and violations of statistical assumptions. Findings Through the illustrative example, it is demonstrated how different statistical approaches can produce varied results. Only PSA mitigated pre-existing group differences without violating the assumption of independence. Originality/value This paper attempts to answer calls in the literature for more robust statistical methodologies to better inform human resource development practice and theory.

A long-term predictive validity study: Can the CDI Short Form be used to predict language and early literacy skills four years later?

2012 ◽  
Vol 40 (4) ◽  
pp. 821-835 ◽  
Author(s):  
DILARA DENIZ CAN ◽  
MARIKA GINSBURG-BLOCK ◽  
ROBERTA MICHNICK GOLINKOFF ◽  
KATHRYN HIRSH-PASEK
Keyword(s):  
Language Development ◽  
Early Literacy ◽  
Predictive Validity ◽  
Phonemic Awareness ◽  
Short Form ◽  
Parent Report ◽  
Literacy Skills ◽  
Hierarchical Regression ◽  
Expressive Vocabulary ◽  
Decoding Skills

ABSTRACTThis longitudinal study examined the predictive validity of the MacArthur Communicative Developmental Inventories-Short Form (CDI-SF), a parent report questionnaire about children's language development (Fenson, Pethick, Renda, Cox, Dale & Reznick, 2000). Data were first gathered from parents on the CDI-SF vocabulary scores for seventy-six children (mean age=1 ; 10). Four years later (mean age=6 ; 1), children were assessed on language outcomes (expressive vocabulary, syntax, semantics and pragmatics) and code-related skills, including phonemic awareness, word recognition and decoding skills. Hierarchical regression analyses revealed that early expressive vocabulary accounted for 17% of the variance in picture vocabulary, 11% of the variance in syntax, and 7% of the variance in semantics, while not accounting for any variance in pragmatics in kindergarten. CDI-SF scores did not predict code-related skills in kindergarten. The importance of early vocabulary skills for later language development and CDI-SF as a valuable research tool are discussed.

Prevention and Reversal of Lupus in NZB/NZW Mice by Transplantation of Purified Allogeneic Hematopoietic Stem Cells (HSC) with Non-Myeloablative Conditioning (NMT).

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3198-3198
Author(s):  
Stephanie Smith-Berdan ◽  
Daphne Gille ◽  
Julie L. Christensen
Keyword(s):  
Lupus Erythematosus ◽  
Matched Control ◽  
Mixed Chimerism ◽  
Final Time ◽  
Myeloablative Conditioning ◽  
Hematopoietic Stem ◽  
Living Well ◽  
Nuclear Antigens ◽  
Final Time Point ◽  
Antibodies To Dsdna

Abstract Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. Patients’ refractory to therapy may be considered for hematopoietic stem cell transplantation. Using lupus prone female NZB x NZW (NZBW) mice, we tested the ability of highly enriched, allogeneic HSC to prevent and reverse autoimmune symptoms with FACS purified haplo-identical allogeneic HSC. Ablative conditioning: 92 animals were given lethal TBI (14.5 Gy) and divided among 4 groups (Table 1). Urine and serology tested monthly, final time point before death tabulated. Transplantation with either syngeneic HSC or WBM accelerated disease in these mice, resulting in a rate of death exceeding age matched controls. Allogeneic transplanted mice had significantly greater survival above all groups (p= 0.0243). Proteinuria, elevated levels of circulating immune complexes (CIC), and auto-antibodies to dsDNA, nuclear antigens (ANA) and histones were lower in allo-HSC animals compared to the other ablative conditioning groups (p≤ 0.0001). Overall survival (OS) in allo-HSC animals was still unexceptional, possibly due to regimen related toxicity (TRM). Table 1: Ablative age@TX=75 days Age Matched Control Syngeneic WBM Syngeneic HSC Allogeneic HSC N 15 21 28 28 OS@420 days of age 20% 0% 0% 53% Proteinuria 100% 74% 75% 15% CIC 93% 81% 100% 25% Anti-dsDNA 100% 91% 100% 39% Anti-ANA 100% 86% 93% 39% Anti-Histone 93% 91% 100% 46% NMT conditioning: To determine if we could attenuate disease in NZBW mice already progressing into lupus-like disease with transplantation of allogeneic, purified HSC and reduce TRM, we developed a non-myeloablative conditioning protocol (2x5 Gy TBI + ATG + a-ASIALO-GM1) achieving an average mixed chimerism of 50%. Animals were treated at ~241 days with established symptoms of lupus (Table 2). While the group receiving conditioning alone, had a slight survival advantage over age matched control mice, the transplanted mice had greatly increased OS with 70% living well beyond 500 days of age (>250 days from transplant). Allo-HSC mice showed reversal or stabilization of their lupus symptoms including proteinuria, CIC, dsDNA and histone. Table 2: NMT age@Tx=241 days Age Matched Control Allogeneic HSC Conditioned Only N 10 33 30 OS@500 days of age 0% 70% 0% Proteinuria@Tx 20% 49% 47% Final Proteinuria 100% 39% 67% CIC 67% 50% 74% Anti-dsDNA 85% 15% 44% Anti-Histone 100% 37% 66% Conclusions: Ablative and NMT transplant can treat lupus; OS after NMT exceeds ablative conditioning; Induction of mixed chimerism with purified allogeneic HSC using NMT conditioning treats established lupus. The ability of pure HSC transplant and establishment of durable mixed chimerism to reverse established lupus makes it a reasonable strategy to test in man.

Interactive Focused Stimulation for Toddlers With Expressive Vocabulary Delays

1996 ◽  
Vol 39 (6) ◽  
pp. 1274-1283 ◽  
Author(s):  
Luigi Girolametto ◽  
Patsy Steig Pearce ◽  
Elaine Weitzman
Keyword(s):  
Parent Report ◽  
Free Play ◽  
Control Group ◽  
Expressive Vocabulary ◽  
Delayed Treatment ◽  
Focused Stimulation ◽  
Play Interaction ◽  
Experimental Group ◽  
Target Words

This study explores the effects of training parents to administer focused stimulation intervention to teach specific target words to their toddlers with expressive vocabulary delays. Twenty-five mothers and their late-talking toddlers were randomly assigned to treatment and delayed-treatment (control) groups. Vocabulary targets were individually selected for each toddler based on the child's phonetic repertoire and parent report of vocabulary development. Following treatment, mothers' language input was slower, less complex, and more focused than mothers in the control group. Concomitantly, their children used more target words in naturalistic probes, used more words in free-play interaction, and were reported to have larger vocabularies overall as measured by parent report. In addition, the treatment had an effect on language development—children in the experimental group used more multiword combinations and early morphemes than children in the control group. The implications of these results are discussed with regard to the role of focused stimulation intervention for children with expressive vocabulary delays.

scholarly journals Identifying Developmental Language Disorder in Vietnamese Children

2019 ◽  
Vol 62 (5) ◽  
pp. 1452-1467 ◽  
Author(s):  
Giang T. Pham ◽  
Sonja Pruitt-Lord ◽  
Catherine E. Snow ◽  
Yen Hoang Thi Nguyen ◽  
Ben Phạm ◽  
...  
Keyword(s):  
Language Disorder ◽  
Risk Groups ◽  
Parent Report ◽  
Developmental Language Disorder ◽  
Clinical Markers ◽  
Expressive Vocabulary ◽  
Language Performance ◽  
Language Sampling ◽  
Language Measures ◽  
Mean Length Of Utterance

Purpose Developmental language disorder (DLD), defined by low language performance despite otherwise normal development, can negatively impact children's social and academic outcomes. This study is the 1st to examine DLD in Vietnamese. To lay the foundation, we identified cases of DLD in Vietnam and explored language-specific characteristics of the disorder. Method Teacher ratings of 1,250 kindergarteners living in Hanoi, Vietnam, were used to recruit children with and without risk for DLD. One hundred four children completed direct measures of vocabulary and language sampling, and their parents completed in-depth surveys. We examined convergence and divergence across tasks to identify measures that could serve as reliable indicators of risk. Then, we compared performance on direct language measures across ability levels. Results There were positive associations between teacher and parent report and between report and direct language measures. Three groups were identified based on convergence across measures: DLD, some risk for DLD, and no risk. The DLD group performed lowest on measures of receptive and expressive vocabulary, mean length of utterance, and grammaticality. Although children with DLD exhibited a greater number of errors, the types of errors found were similar across DLD and No Risk groups. Conclusions Similar to rates found globally, 7% of the kindergarten population in Vietnam exhibited risk for DLD. Results highlight the importance of parent and teacher report and the value of multiple measures to identify DLD. We discuss potential clinical markers for DLD in the Vietnamese language and outline future directions.

scholarly journals Immunogenicity of Different Routine Poliovirus Vaccination Schedules: A Randomized, Controlled Trial in Karachi, Pakistan

2017 ◽  
Vol 217 (3) ◽  
pp. 443-450 ◽  
Author(s):  
Ali F Saleem ◽  
Ondrej Mach ◽  
Mohammad T Yousafzai ◽  
Asia Khan ◽  
William C Weldon ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Large Scale ◽  
Controlled Trial ◽  
Oral Poliovirus Vaccine ◽  
Immunization Schedule ◽  
Final Time ◽  
Time Points ◽  
Final Time Point ◽  
Increasing Risk

Abstract Background We assessed immunity against polioviruses induced with a new Pakistani poliovirus immunization schedule and compared it to alternative poliovirus immunization schedules. Methods Newborns were randomized to undergo vaccination based on 1 of 5 vaccination schedules, with doses administered at birth and at 6, 10, and 14 weeks of age. Arm A received inactivated poliovirus vaccine (IPV) at all time points. Arm B received bivalent oral poliovirus vaccine (bOPV) at all time points. Arms C and D received bOPV at the first 3 time points and bOPV plus IPV at the final time point (the current schedule). Arm E received trivalent OPV (tOPV) at all time points. At 22 weeks of age, all children received 1 challenge dose of tOPV, and children in arm D received 1 additional IPV dose. Sera were analyzed for the presence of poliovirus neutralizing antibodies at birth and 14 and 22 weeks of age. Results Seroconversion for poliovirus type 1 (PV1) at 22 weeks of age was observed in 80% of individuals in arm A, 97% in arm B, 94% in arm C, 96% in arm D, and 94% in arm E; for PV2, seroconversion frequencies were 84%, 19%, 53%, 49%, and 93%, respectively; and for PV3, seroconversion frequencies were 93%, 94%, 98%, 94%, and 85%, respectively. Conclusions The current immunization schedule in Pakistan induced high seroconversion rates for PV1 and PV3; however, it induced PV2 seroconversion in only half of study subjects. There is a growing cohort of young children in Pakistan who are unprotected against PV2; and this creates an increasing risk of a large-scale outbreak of poliomyelitis caused by circulating vaccine-derived PV2.

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