Language-Impaired 4-Year-Olds

1987 ◽  
Vol 52 (2) ◽  
pp. 156-173 ◽  
Author(s):  
D. V. M. Bishop ◽  
A. Edmundson
Keyword(s):  
Language Disorder ◽  
Control Group ◽  
Prospective Longitudinal Study ◽  
Language Impaired ◽  
Normal Limits ◽  
Outcome Group ◽  
Nonverbal Ability ◽  
Language Measures ◽  
The One ◽  
Prospective Longitudinal

In a prospective, longitudinal study, 87 language-impaired children were assessed at the ages of 4, 4½, and 5½ years on a battery of language measures. In 37% of children, who were termed the "good outcome group," the language disorder had resolved by the age of 5½ years so that children were indistinguishable from a control group. If one restricted consideration only to those 68 children whose nonverbal ability was within normal limits, the figure rose to 44%. Outcome for individual children (good or poor) could be predicted with 90% accuracy on the basis of test measures obtained at 4 years. The best predictor was ability to tell back a simple story to pictures. The one language measure that did not relate to outcome was phonological competence.

scholarly journals Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

2017 ◽  
Vol 27 (1) ◽  
pp. 91 ◽  
Author(s):  
Ingrid Cristiane Pereira Gomes ◽  
Hugo Nivaldo Melo ◽  
Suyaluane Italla Amana Melo ◽  
Nelmo Vasconcelos de Menezes ◽  
Tulio Vinicius Paes Dantas ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Pubertal Development ◽  
Hereditary Diseases ◽  
Control Group ◽  
Age At Menarche ◽  
Prospective Longitudinal Study ◽  
Cellular Expression ◽  
Z Scores ◽  
Prospective Longitudinal

Introduction: Hereditary haemoglobinopathies are the most common group of monogenic hereditary diseases in the world. Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands. Objective: The evaluation of the growth pattern and pubertal development of a group of patients with sickle-cell anaemia (SCA) from childhood to adulthood. Method: Thirty patients with SCA between the ages of 10 and 23 years were evaluated in a prospective longitudinal study at three points in time (Te1: 2005; Te2: 2010 and Te3: 2015) and compared with controls. Anthropometric, pubertal and hormonal evaluations were carried out. Age- and gender-specific Z-scores for weight, height and BMI (body mass index) were calculated according to the reference growth standards. Results: Thirty patients with SCA (mean age = 13.93 years) were evaluated at Te1 and 26 patients (mean age = 25.08 years) at Te3. The SCA group lower showed Z-scores for weight (p = 0.0002), height (p = 0.0184) and BMI (p = 0.0011) than the control group at Te1. At Te3, there was no difference in height, but weight (p = <0.0001) and BMI (p = <0.0001) were lower in the SCA group. Men showed greater weight commitment than women at the three study times (Te1: p = 0.0340, Te2: p = 0.0426 and Te3: p = 0.0387) and lower BMI in Te3 (p = 0.0155) in the SCA group. There was a significant increase in weight when comparing Te1 with Te3 (p = 0.0009) and in height when comparing Te1 with Te2 (p = 0.0292) and with Te3 (p = 0.0003) in the SCA group. There was a significant increase in weight when comparing Te1 and Te3 (p = 0.0009) and in height when comparing Te1 and Te2 (p = 0.0292) and Te3 (p = 0.0003) in the SCA group. At Te1, 14 cases and 2 controls were prepubertal. Bone age was delayed in 12 patients. Age at menarche was delayed and lower in the SCA group (mean = 15 years). Five patients had gestated, but no patient had experienced fatherhood. At Te1, TSH levels were higher (p = 0.0080) and T3 levels were lower (p = 0.0020) in the SCA group. At Te3, LH and FSH levels were higher in men with SCA (p = 0.0014; p; 0.0002). IGF-I levels were lower in cases both at Te1 (p = 0.0002) and at Te3 (p = 0.0032). Conclusions: Patients with SCA showed growth impairment and pubertal delay compared with healthy controls. However, albeit belatedly, they reached normal sexual maturation and height in adulthood. Women with SCA showed no fertility problems. The findings highlight the need to investigate the intention of paternity and fertility among men with SCA.

scholarly journals Impact of early extraction of the deciduous canine on relief of severe crowding:

2021 ◽  
Author(s):  
Mhanna A. Aljabab ◽  
Muteb Algharbi ◽  
Jan Huggare ◽  
Farhan Bazargani
Keyword(s):  
Orthodontic Treatment ◽  
Treatment Time ◽  
Permanent Teeth ◽  
Control Group ◽  
Fisher Exact Test ◽  
Prospective Longitudinal Study ◽  
Treatment Need ◽  
Exact Test ◽  
Number Of Visits ◽  
Prospective Longitudinal

ABSTRACT Objectives To explore whether there were any differences in orthodontic treatment need, treatment complexity, treatment time, or the number of visits between a group of children receiving early intervention (extraction of upper and lower deciduous canines) and an age- and condition-matched control group without intervention. Materials and Methods Patient records and study casts in the late mixed or early permanent dentitions of 46 subjects (20 from the extraction group and 26 from the control group) of an earlier prospective longitudinal study were retrieved. Orthodontic treatment need and complexity were assessed by the index of complexity, outcome, and need (ICON). Statistical calculations were performed by t-test for parametric outcome variables (treatment time, number of visits, and orthodontic treatment need) and Fisher exact test for the categorical variable (tooth extractions). Results There were no statistically significant differences between the groups in ICON scores of orthodontic treatment need (extraction group, mean score 59.8; control group, mean score 52.8), number of visits (mean of about 15 visits for both groups), or treatment time (extraction group, mean 21.5 months; control group, mean 20.3 months). The extraction of permanent teeth was more prevalent in the deciduous canine extraction group (59%) as compared with the control group (28%); however, this was not statistically significant (P = .07) but showed a tendency toward worsening the crowding and the future need of orthodontic extractions. Conclusions Early removal of deciduous primary canines will reduce neither the need for later orthodontic treatment nor its complexity, nor will it shorten the treatment time.

scholarly journals Evaluation of a relationship between malocclusion and idiopathic scoliosis in children and adolescents

2019 ◽  
Vol 13 (6) ◽  
pp. 600-606
Author(s):  
M. Laskowska ◽  
D. Olczak-Kowalczyk ◽  
M. Zadurska ◽  
J. Czubak ◽  
M. Czubak-Wrzosek ◽  
...  
Keyword(s):  
Idiopathic Scoliosis ◽  
Cobb Angle ◽  
Clinical Symptoms ◽  
Open Bite ◽  
Control Group ◽  
Level Of Evidence ◽  
Prospective Longitudinal Study ◽  
Stomatognathic System ◽  
Main Thoracic ◽  
Prospective Longitudinal

Purpose Idiopathic scoliosis is a developmental deformation of the vertebral column of an unknown aetiology. Its clinical symptoms and hypothetical causative factors may affect the stomatognathic system. The aim of this study was to analyse the relationships between the prevalence and type of malocclusions, and the presence of idiopathic scoliosis, its location and severity. Methods This was a prospective longitudinal study. The study group consisted of 80 patients with idiopathic scoliosis and the control group of 61 healthy individuals. Standard standing long-cassette radiographs were taken of all of the patients in the idiopathic scoliosis group in order to confirm diagnosis, to determine localization and the Cobb angle of the curve. Both groups underwent standard clinical dental examination. Results The most commonly observed types included right main thoracic (R-MT) and thoracolumbar or left lumbar scoliosis (Cobb angle 11° to 125°). In the idiopathic scoliosis group, prevalence of malocclusions was greater than in the control group (95% versus 82%). In the idiopathic scoliosis group more than one type of malocclusion was observed with a higher incidence than that in the control group (63.8% versus 37.7%; p = 0.002). A correlation between the left proximal thoracic (L-PT) curve with anterior partial open bite was demonstrated (p = 0.323), between thoracic dextroscoliosis main thoracic with lateral partial cross bite (p = 0.230) and a correlation between scoliosis severity and malocclusion in the event of L-PT and anterior partial open bite (p = 0.330) and R-MT and scissors bite (p = 0.248). Conclusion The incidence of malocclusions is greater in children with idiopathic scoliosis than in their healthy peers Level of Evidence III

scholarly journals The clinical value of the delta finger to palm distance in systemic sclerosis

Reumatismo ◽  
2020 ◽  
Vol 72 (1) ◽  
pp. 44-51
Author(s):  
A. Javinani ◽  
S. Mostafaei ◽  
F. Gharibdoost ◽  
A.R. Jamshidi ◽  
R. Atef Yekta ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Clinical Manifestations ◽  
Digital Ulcers ◽  
Clinical Value ◽  
Prospective Longitudinal Study ◽  
Linear Effect ◽  
One Year ◽  
The One ◽  
Prospective Longitudinal

Systemic sclerosis (SSc) is a collagen-vascular disorder characterized by fibrosis and vasculopathy. Delta finger to palm distance (delta FTP) is an index measuring the distance between the tip of the third finger to the distal palmar crease in the flexed and extended position. The present study aimed to evaluate the clinical value of delta FTP and to assess the correlation of delta FTP with modified Rodnan skin score (mRSS) and forced vital capacity (FVC) over the 12-month follow-up. This prospective longitudinal study began with 50 participants who were followed for twelve months. Lowess smoothing and linear regression were applied to detect and assess the relationship between delta FTP and mRSS. p-values were adjusted by the Benjamini-Hochberg method (BHM) as a control for false discovery rate. Delta FTP was lower among patients with higher disease duration (p-valueadj: 0.008), diffuse cutaneous SSc (p-valueadj: 0.006), digital ulcers (p-valueadj: 0.003), telangiectasia (p-valueadj: 0.006) and dysphagia (p-valueadj: 0.036). The mRSS has a significant negative linear effect on the delta FTP at the baseline and the end of the follow-up (r: -0.31 and -0.40, respectively). Moreover, changes of mRSS and delta FTP showed a negative linear association over time (r: -0.22). These linear effects remained significant after regrouping the patients based on their SSc subtype. Delta FTP and FVC were not correlated either at the baseline or at the end. It seems that the delta FTP can be a valuable clinical index, supported by its correlated changes with mRSS and other SSc clinical manifestations over the one-year follow-up.

Estimation of Antiphospholipid Antibodies in a Prospective Longitudinal Study of Children with Migraine

Cephalalgia ◽  
2004 ◽  
Vol 24 (10) ◽  
pp. 831-837 ◽  
Author(s):  
T Avcin ◽  
G Markelj ◽  
V Niksic ◽  
Z Rener-Primec ◽  
S Cucnik ◽  
...  
Keyword(s):  
Antiphospholipid Antibodies ◽  
Tension Type Headache ◽  
Control Group ◽  
Healthy Children ◽  
Prospective Longitudinal Study ◽  
Glycoprotein I ◽  
Patient Groups ◽  
Unselected Group ◽  
Type Headache ◽  
Prospective Longitudinal

The aim of this study was to determine the prevalence and clinical significance of antiphospholipid antibodies (aPL) in children with migraine. The values of anti-cardiolipin (aCL) and antiβ2 glycoprotein I (antiβ2GPI) antibodies were assayed by an ELISA method in 52 children with migraine and 22 children with tension-type headache. The control group consisted of 61 apparently healthy children at regular preventive visits. Two monoclonal β2GPI dependent aCL (HCAL and EY2C9) were used as calibrators. Lupus anticoagulant (LA) was determined by a modified dilute Russell viper venom time test. Persistently positive aPL were observed during the follow-up in 16.3% of children with migraine (9.3% for aCL, 7.0% for antiβ2GPI and 0% for LA) and in 16.7% of children with tension-type headache (11.1% for aCL, 5.6% for antiβ2GPI and 0% for LA). The prevalence of aPL did not differ significantly between patient groups and healthy children. The prevalence of aPL does not appear to be increased in an unselected group of children with migraine, however, the possible role of aPL in individual cases of paediatric migraine can not be excluded.

scholarly journals Blood group and Human Leucocyte Antigen sub-type as determinants to keloid formation and Recurrence in Keloid Patients; A prospective longitudinal cohort study

2021 ◽  
Author(s):  
Ferdinand Nangole ◽  
Kelsey Ouyang ◽  
George Agak ◽  
Julius Ogeng'o ◽  
Anzala Omu
Keyword(s):  
Blood Group ◽  
Genetic Factors ◽  
Control Group ◽  
Prospective Longitudinal Study ◽  
Female Ratio ◽  
Blood Group A ◽  
Significant Difference ◽  
Group A ◽  
Surgical Conditions ◽  
Prospective Longitudinal

Abstract The role of genetic factors in keloid is a firmed by the fact that keloids have been shown to occur among members of the same family.. We undertook this study to determine whether there is any association between patients’ bloodgroup and HLA sub-types to keloids and keloid recurrence. This was a prospective longitudinal study of patients with keloids and a control of patients managed for other surgical conditions with no keloids. Blood was taken from each patient and analysed for blood group and HLA sub-types using the sequence specific primer geno-typing. Data captured were summarized and analysed using students T-test to compare means. Probability values significance was at 0.05. A total of 90 patients with keloids and 59 in a control group were followed up in the study. The male to female ratio of the patients was 2:1. The most common blood group for both groups was blood group O at 51.3% and 49.2%, followed by blood group A and B respectively. Patients with keloids had a significantly higher positive alleles with DQA*01, DQB1*05, DQB1*06 and DRB1*15. There was an association between blood group A and DQB1*06 and recurrence. In conclusion, this study demonstrates that there is significant difference in HLA sub-types among patients who form keloids and the non-keloid forming patients among our study cohorts. Salient differences were also noted in patients with keloid recurrence based on their blood group, a pointer to the significance of genetic factors in keloid pathogenesis and severity.

Developmental Intervention for Low Birth Weight Infants: Improved Early Developmental Outcome

PEDIATRICS ◽  
1987 ◽  
Vol 80 (1) ◽  
pp. 68-74
Author(s):  
Michael B. Resnick ◽  
Fonda Davis Eyler ◽  
Robert M. Nelson ◽  
Donald V. Eitzman ◽  
Richard L. Bucciarelli
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Infant Development ◽  
Development Program ◽  
Control Group ◽  
Low Birth Weight Infants ◽  
Prospective Longitudinal Study ◽  
Traditional Care ◽  
Prospective Longitudinal

This prospective longitudinal study was designed to evaluate the effects of a multidisciplinary infant development program (IDP) on the mental and physical development of low birth weight infants (&lt;1,800 g). Infants in the neonatal intensive care were randomly assigned to the IDP or to traditional care (control group). IDP infants received developmental interventions in the hospital and at home through the first 2 years of life. Counseling and parenting education were provided to their parents during this same period. The control group received all the postnatal care and referrals customarily given in traditional care. Both IDP and control infants were enrolled in an independent follow-up program, which used the Bayley Scales of Infant Development in a blind evaluation design. The IDP group had a significantly lower incidence of developmental delay (P &lt; .05) and scored significantly higher than the control group (P &lt; .05) on mean mental and physical indices at 12 and 24 months of adjusted age.

scholarly journals Twin-twin transfusion syndrome: neurodevelopment of infants treated with laser surgery

2016 ◽  
Vol 74 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Denise Campos ◽  
Amabile V. Arias ◽  
Thatiane M. Campos-Zanelli ◽  
Daniela S. Souza ◽  
Orlando G. dos Santos Neto ◽  
...  
Keyword(s):  
High Risk Group ◽  
Fine Motor ◽  
Laser Coagulation ◽  
Control Group ◽  
First Year ◽  
Term Infants ◽  
Prospective Longitudinal Study ◽  
Fetoscopic Laser Coagulation ◽  
First Year Of Life ◽  
Prospective Longitudinal

ABSTRACT Objective To assess the neurodevelopmental functions of survivors of twin-twin transfusion syndrome (TTTS) treated by fetoscopic laser coagulation (FLC), during the first year of life, comparing them to a control group; and to verify the influence of specific variables on neurodevelopment. Method This was a prospective, longitudinal study. The sample comprised 33 monochorionic diamniotic twins who underwent FLC for treatment of TTTS and 22 full-term infants of single-fetus pregnancies. Bayley Scales of Infant and Toddler Development Screening Test were used for evaluation. Prenatal, perinatal and postnatal information were obtained. Results There was an increased frequency of infants in the TTTS group with inadequate performance compared to the control group. The identified variables (fetal donor, low economic income and cardiorespiratory disease) negatively impacted expressive communication and fine motor skills. Conclusion Although through follow-up is recommended in all TTTS survivors, particular attention is required for the high-risk group as defined in this study.

Story Grammar Ability in Children with and without Language Disorder

1987 ◽  
Vol 30 (4) ◽  
pp. 539-552 ◽  
Author(s):  
Donna Disegna Merritt ◽  
Betty Z. Liles
Keyword(s):  
Language Disorder ◽  
Control Group ◽  
Story Grammar ◽  
Original Stories ◽  
Language Impaired ◽  
Story Retelling ◽  
Story Generation ◽  
Subordinate Clauses ◽  
Frequency Of Use ◽  
Grammar Rules

Twenty language-impaired and unimpaired children ages 9:0 to 11:4 participated in three story tasks. The children generated three original stories, retold two adventure stories, and then answered two sets of comprehension questions after each retelling. Stein and Glenn's (1979) story grammar rules were adapted and used to analyze the narratives. The generated and retold stories produced by the language-disordered children contained fewer complete story episodes, a lower mean number of main and subordinate clauses per complete episode, and a lower frequency of use of story grammar components than those of the control group. The story hierarchies produced by both groups were highly similar, though, in both story generation and story retelling. The groups also did not differ in their understanding of the factual details of the retold stories, but did differ significantly in their comprehension of the relationships linking the critical parts of the stories together. The results are discussed relative to cognitive organizational deficits of language-impaired children.

Proportional and Functional Analogical Reasoning in Normal and Language-Impaired Children

1988 ◽  
Vol 53 (4) ◽  
pp. 440-448 ◽  
Author(s):  
Marilyn A. Nippold ◽  
Barbara J. Erskine ◽  
Donald B. Freed
Keyword(s):  
Language Impairment ◽  
Specific Language Impairment ◽  
Analogical Reasoning ◽  
Control Group ◽  
Nonverbal Intelligence ◽  
Normal Children ◽  
Language Impaired ◽  
New Concepts ◽  
The One ◽  
Impaired Children

Teachers often use analogies in classroom settings to clarify new concepts for their students. However, analogies may inadvertently confuse the youngster who has difficulty identifying the one-to-one comparisons underlying them. Although analogical reasoning has been studied extensively in normal children, no information was available concerning this construct in children having a specific language impairment. Thus, it was unknown to what extent they might be deficient in analogical reasoning. Therefore, in the present study, 20 children ages 6--8 years (mean age = 7:6) having normal nonverbal intelligence but deficits in language comprehension were administered tasks of verbal and perceptual proportional analogical reasoning and a problem-solving task of functional analogical reasoning. Compared to a normal-language control group matched on the basis of chronological age and sex, the language-impaired group was deficient in all three tasks of analogical reasoning. However, when the factor of nonverbal intelligence was controlled statistically, the differences between the groups on each of the tasks were removed. Additional findings were that verbal proportional analogical reasoning was significantly correlated to perceptual proportional analogical reasoning and to functional analogical reasoning. Implications for assessment and intervention with young school-age language-impaired children are discussed.

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