Blood group and Human Leucocyte Antigen sub-type as determinants to keloid formation and Recurrence in Keloid Patients; A prospective longitudinal cohort study

Abstract The role of genetic factors in keloid is a firmed by the fact that keloids have been shown to occur among members of the same family.. We undertook this study to determine whether there is any association between patients’ bloodgroup and HLA sub-types to keloids and keloid recurrence. This was a prospective longitudinal study of patients with keloids and a control of patients managed for other surgical conditions with no keloids. Blood was taken from each patient and analysed for blood group and HLA sub-types using the sequence specific primer geno-typing. Data captured were summarized and analysed using students T-test to compare means. Probability values significance was at 0.05. A total of 90 patients with keloids and 59 in a control group were followed up in the study. The male to female ratio of the patients was 2:1. The most common blood group for both groups was blood group O at 51.3% and 49.2%, followed by blood group A and B respectively. Patients with keloids had a significantly higher positive alleles with DQA*01, DQB1*05, DQB1*06 and DRB1*15. There was an association between blood group A and DQB1*06 and recurrence. In conclusion, this study demonstrates that there is significant difference in HLA sub-types among patients who form keloids and the non-keloid forming patients among our study cohorts. Salient differences were also noted in patients with keloid recurrence based on their blood group, a pointer to the significance of genetic factors in keloid pathogenesis and severity.

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Relationship of Blood Group Type and SARS-CoV-2 Infection: Experience in A Peripheral Military Hospital

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v39i2.52389 ◽

2021 ◽

Vol 39 (2) ◽

pp. 94-99

Author(s):

Md Soleman Badsha ◽

Md Mizanur Rahman Khan ◽

SM Belal Uddin ◽

Kamrun Nesa

Keyword(s):

Blood Group ◽

Statistical Significance ◽

Blood Groups ◽

Military Hospital ◽

Control Group ◽

P Value ◽

Percentage Distribution ◽

Blood Group A ◽

Significant Difference ◽

Group A

Introduction: Clinical studies have shown that advanced age and chronic diseases increase the risk of infection. Different studies have found blood groups are also a determining factor of severity. However, in Bangladesh it is yet to have any clinical pattern in this respect. The aim of this study is to find out whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection. Methods: The study is a retrospective cohort study. It included all hospitalized RT-PCR confirmed COVID-19 patients in Combined Military Hospital (CMH) Barishal. We included both genders and people who are older than 14 years of age. The study was conducted during the period between 4th June and 3rd August, 2020. In this period total 556 individuals reported and tested for SARS-CoV-2 where COVID +ve patients are served as patient group and COVID –ve patients are served as the controls. Results: Our sample consists of 185 patients; we found a percentage distribution of 34.6%, 39.5%, 5.4%, and 20.54% for blood groups A, B, AB and O, respectively. Blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (34.6% vs. 21.83%, p-value 0.045 (<0.05); OR: 1.894).On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group (20.54% vs 32.88%, p-value0.049 (<0.05); OR: 0.528). Although there was a higher percentage distribution of the B blood group among COVID-19 patients as compared to the control groups, this difference did not reach statistical significance. Also, there was no significant difference in the risk of COVID-19 in blood group AB with a distribution of 6.2% in control group, and5.4% in COVID-19 patients. Conclusion: The results of the present study suggest that the blood group A might have a role in increased susceptibility to the COVID-19 infection and the blood group O might be somewhat protective. J Bangladesh Coll Phys Surg 2021; 39(2): 94-99

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Association of ABO blood groups with presentation and outcomes of confirmed SARS CoV-2 infection: A prospective study in the largest COVID-19 dedicated hospital in Bangladesh

PLoS ONE ◽

10.1371/journal.pone.0249252 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0249252

Author(s):

Reaz Mahmud ◽

Mohammad Aftab Rassel ◽

Farhana Binte Monayem ◽

S. K. Jakaria Been Sayeed ◽

Md Shahidul Islam ◽

...

Keyword(s):

Blood Group ◽

Blood Groups ◽

Abo Blood Groups ◽

Duration Of Symptoms ◽

Presenting Symptoms ◽

Blood Group A ◽

Group I ◽

Significant Difference ◽

Group A ◽

Group Ii

Background Globally, studies have shown conflicting results regarding the association of blood groups with SARS CoV-2 infection. Objective To observe the association between ABO blood groups and the presentation and outcomes of confirmed COVID-19 cases. Design, setting, and participants This was a prospective cohort study of patients with mild-to-moderately severe COVID-19 infections who presented in the COVID-19 unit of Dhaka Medical College Hospital and were enrolled between 01 June and 25 August, 2020. Patients were followed up for at least 30 days after disease onset. We grouped participants with A-positive and A-negative blood groups into group I and participants with other blood groups into group II. Results The cohort included 438 patients; 52 patients were lost to follow-up, five died, and 381 completed the study. The prevalence of blood group A [144 (32.9%)] was significantly higher among COVID-19 patients than in the general population (p < 0.001). The presenting age [mean (SD)] of group I [42.1 (14.5)] was higher than that of group II [38.8 (12.4), p = 0.014]. Sex (p = 0.23) and co-morbidity (hypertension, p = 0.34; diabetes, p = 0.13) did not differ between the patients in groups I and II. No differences were observed regarding important presenting symptoms, including fever (p = 0.72), cough (p = 0.69), and respiratory distress (p = 0.09). There was no significant difference in the median duration of symptoms in the two group (12 days), and conversion to the next level of severity was observed in 26 (20.6%) and 36 patients (13.8%) in group I and II, respectively. However, persistent positivity of RT-PCR at 14 days of initial positivity was more frequent among the patients in group I [24 (19%)] than among those in group II [29 (11.1%)]. Conclusions The prevalence of blood group A was higher among COVID-19 patients. Although ABO blood groups were not associated with the presentation or recovery period of COVID-19, patients with blood group A had delayed seroconversion.

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The Factors Influencing the Risk of Perforation in Patients with Peptic Ulcers: A Cross-Sectional Study from Central Iraq

Acta Facultatis Medicae Naissensis ◽

10.2478/afmnai-2018-0030 ◽

2018 ◽

Vol 35 (4) ◽

pp. 282-288

Author(s):

Ibtesam Khalid Salih ◽

Ali Malik Sheya’a ◽

Qays Ahmed Hassan ◽

Ayad Khani Mykhan

Keyword(s):

Risk Factors ◽

Peptic Ulcer ◽

Blood Group ◽

Significant Risk ◽

Minor Role ◽

Peptic Ulcer Perforation ◽

Peptic Ulcers ◽

Female Ratio ◽

Blood Group A ◽

Group A

Abstract The aim of this study was to evaluate the risk factors that influence the perforation, regardless of the presence of H. pylori infection, in a sample of Iraqi patients with peptic ulcers, admitted to Al-Kindy Teaching Hospital. A total of 90 patients who had perforated peptic ulcer participated in this study. The diagnosis was based on history, clinical examination, laboratory and radiological investigations and was confirmed intraoperatively. A number of probable risk factors for perforation were investigated. Eighty participants were males and 10 were females (male to female ratio 8:1). About 42.2% of patients were in their fifth decade of life. Forty-nine (54.4%) patients were asymptomatic before perforation occurred. Among the risk factors, smoking (66.7%), stress (60%) and blood group A (53.3%) play a significant risk for the occurrence of perforation. We concluded that smoking, stress, non-steroidal anti-inflammatory drugs, and to a lesser extent fasting and blood group A, play a major role as risk factors for the occurrence of peptic ulcer perforation. Other factors seem to play a minor role in this respect.

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STUDIES ON HUMAN ANTIBODIES

Journal of Experimental Medicine ◽

10.1084/jem.119.3.453 ◽

1964 ◽

Vol 119 (3) ◽

pp. 453-465 ◽

Cited By ~ 29

Author(s):

James C. Allen ◽

Henry G. Kunkel ◽

Elvin A. Kabat

Keyword(s):

Blood Group ◽

Tetanus Toxoid ◽

Genetic Factors ◽

Teichoic Acid ◽

Human Antibodies ◽

Blood Group A ◽

Myeloma Proteins ◽

Group A ◽

Specific Factors

Human antibodies against dextran, teichoic acid, blood group A substance, levan, tetanus toxoid, and nuclei were isolated and analyzed for their content of Gm(a), Gm(b), and Inv(a) γ-globulin genetic factors. The majority of these antibodies contained all the genetic factors determined in the donor's whole γ-globulin, but in many antibodies at very different concentrations. In a few instances specific factors could not be detected despite their presence in the individual's whole γ-globulin. Different antibodies isolated from the serum of the same individual showed different relative concentrations of genetic factors. The distribution of genetic factors seen in certain isolated human antibodies appeared to approach the selective occurrence of these factors in myeloma proteins.

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Association of Pre-hypertension with blood groups in young population.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.11.469 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1820-1824

Author(s):

Benash Altaf ◽

Shireen Jawed ◽

Fakiha Behram ◽

Zeeshan Ali Khan ◽

Shakeela Naz

Keyword(s):

Blood Group ◽

Demographic Data ◽

Cross Sectional Study ◽

Blood Groups ◽

P Value ◽

Continuous Variables ◽

Cross Sectional ◽

Blood Group A ◽

Significant Difference ◽

Group A

Objectives: Pakistan has highest mortality rate due to hypertension and its complications. Hypertension is a squealed of Pre- hypertension which is believed to start at adolescent and continue to adulthood. Association of blood group with hypertension is evident but still hypothesized. This study aims to find the frequency of prehypertension and its association with blood group. Study Design: Cross sectional study. Setting: Aziz Fatimah Medical and Dental College, Faisalabad. Period: 15 March’18 to 15 Sep’18. Material and Methods: It was comprised of in comprised of 100 MBBS students. Demographic data including age, weight, height, waist and hip circumference, and BMI was determined. Blood group was determined with help of conventional slide method. Blood pressure was measured by auscultatory method. Data was analyzed by using SPSS 21. Continuous variables are given in mean and standard deviation. Categorical data was given in frequency and percentages. P value≤ 0.05 is taken as significant. Results: Out of 100 participants most common blood group was group ‘O’ (43%) followed by B (35 %) and AB (13%) and A (9%).36% of total population was pre-hypertensive and 64% were normotensive. Prehypertension is most commonly found in blood group ‘A’ (77%) followed by blood group ‘O’ (46.5%). Significant difference was found in means of SBP (p value= 0.001*) and DBP (p value= 0.000*) among the various blood groups. Conclusion: Most common blood group in studied population was ‘O’ although hypertension was most commonly observed in blood group A followed by ‘O’.

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Distribution of ABO, Rhesus D and Subgroups of ABO among Blood Donors in Sokoto, North Western Nigeria

International Blood Research & Reviews ◽

10.9734/ibrr/2020/v11i130120 ◽

2020 ◽

pp. 6-13

Author(s):

A. B. Ibrahim ◽

H. Attahiru ◽

O. Erhabor ◽

P. F. Udomah ◽

A. Yakubu ◽

...

Keyword(s):

Blood Group ◽

Blood Donors ◽

Blood Groups ◽

Blood Group A ◽

Significant Difference ◽

Tile Method ◽

Group A ◽

The Common ◽

Group B ◽

North Western

ABO, Rhesus D and subgroups of ABO are highly immunogenic and are the common cause of antibody production in mismatched blood transfusions, haemolytic transfusion reaction and maternal alloimmunization. The aim of this study was to determine the occurrence of ABO, Rh D and subgroups of ABO among blood donors attending Specialist Hospital Sokoto, Nigeria. ABO, Rhesus D and subgroups of ABO antigen status of 176 blood donors with mean age of 30.44 ± 8.210 years attending Specialist Hospital Sokoto were determined using tile method for ABO and Rh D and conventional tube method for anti- A1, anti- H reagents for ABO subgroups respectively. Among the 176 subjects tested, blood group O+ was the most frequent group with 93 (52.8%), 39 (22.2%) were blood group B+, 37(21.0%) were blood group A+, 5 (2.8%) were blood group AB+, 2 (1.1%) were blood group O-. No data was obtained for A-, B- and AB- blood groups. Out of 37 A blood groups obtained, 31 (83.8%) had A1 antigens and 6 (16.2%) had A2 antigens. Out of the 5 AB blood groups, all had A1B antigens. The study also shows that there was statistically significant difference between blood group A and ethnic groups (Hausa, Fulani and Yoruba) (p<0.05). Blood group O was found to be the most frequent followed by B, A and AB except among Hausa which revealed a pattern of O> A> B> AB. ABO, subgroups shows majority had A1 followed by A2 and A1B respectively.

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Factor VIII and Factor VIII Related Antigen in Normal Pregnancy

10.1055/s-0039-1682485 ◽

1977 ◽

Author(s):

G. O. S. de Melo

Keyword(s):

Factor Viii ◽

Pregnant Women ◽

Blood Group ◽

Normal Pregnancy ◽

Clear Tendency ◽

Factor Viii Related Antigen ◽

Blood Group A ◽

Significant Difference ◽

Group A ◽

In Pregnancy

Factor VIII and factor VIII related antigen were found to change proportionately during normal pregnancy. There was a clear tendency for levels of activity and antigen to increase as the duration of the pregnancy advanced. In the pregnant women studied a significant difference was observed in factor VIII levels between Blood Group A and Blood Group O. A similar difference was found in factor VIII related antigen levels. Age, weight and previous use of contraceptives seems to have no influence on factor VIII and factor VIII related antigen values in pregnancy.

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ABO-RH blood group and risk of covid-19 in a moroccan population

10.1101/2020.12.02.20242180 ◽

2020 ◽

Author(s):

Mourad Belaouni ◽

Elhoucine Malki ◽

Rabii El Bahraouy ◽

Bouchra El Maliki ◽

Mohammed Er-Rami ◽

...

Keyword(s):

Blood Group ◽

Comparison Group ◽

Blood Groups ◽

Military Hospital ◽

Control Group ◽

Rt Pcr ◽

Cross Sectional ◽

Moroccan Population ◽

Blood Group A ◽

Group A

AbstractIntroductionGiven the rapid spread, significant morbidity and mortality associated with COVID-19, there has been scientific interest in obtaining data detailing the factors influencing the risk of COVID-19 infection. The aim of this study was to reveal a possible association between the ABO-RH system and the risk of COVID-19 in the Moroccan population.Materials and methodsThis is an analytical cross-sectional study. It was carried out on 1094 patients for the diagnosis of Covid-19 by Rt-PCR at the Moulay Ismaïl military hospital in the province of Meknes. All Rt-PCR negative individuals were used as a comparison group.ResultsAmong the 1094 individuals who were diagnosed, RT-PCR for detection of SARS-CoV-2 was positive for 242 individuals. Comparison of the proportions of blood groups of the two groups showed that the proportion of blood group A in patients with COVID-19 was significantly higher than in people in the comparison group (P = 0.007), while the proportion of blood group O in patients with COVID-19 was significantly lower than in people in the control group (P = 0.017). Comparison of the Rh blood groups of the two groups did not find a significant association (P = 0.608).ConclusionAs demonstrated by several previous studies, we concluded that blood group A was associated with a higher risk of acquiring COVID-19. Equally, the O blood group was associated with a lower risk of infection.

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ABO blood group antigen therapy: a potential new strategy against solid tumors

Scientific Reports ◽

10.1038/s41598-021-95794-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Qiong Luo ◽

Mingxin Pan ◽

Hao Feng ◽

Lei Wang

Keyword(s):

Blood Group ◽

Killer Cell ◽

Membrane Attack Complex ◽

Blood Group Antigen ◽

Control Group ◽

Abo Blood Group ◽

Blood Group System ◽

Blood Group A ◽

Group A

AbstractThe economic burden of tumors is increasing, so there is an urgent need to develop new therapies for their treatment. Killing tumors by activating complement is an effective strategy for the treatment. We used the ABO blood group system and the corresponding antibodies to activate the killer cell capacity of the complement system. After the construction of a mouse model containing blood group A antibodies and inoculating colorectal cancer and breast cancer cells into the axillae of the mice, intratumoural injection using a lentivirus carrying a blood group antigen as a drug significantly reduced the tumor volume of the mice. Compared with the control group, the content of the C5b-9 complement membrane attack complex in the tumors of mice treated with the blood group A antigen was significantly increased, and the proportion of NK cells was also significantly increased. In vitro cell-based experiments proved that tumor cells expressing blood group A antigens showed significantly inhibited cell proliferation when added to serum containing blood group A antibodies. These results all prove that the ABO blood group antigen may become a powerful tool for the treatment of tumors in patients.

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Sex-based difference in influence of A blood group on increased risk of coronary artery disease among Chinese adults: a propensity score matching analysis

10.21203/rs.3.rs-16708/v1 ◽

2020 ◽

Author(s):

Yanbin Song ◽

Gaojun Cai ◽

Qichao Yang ◽

Feng Li ◽

Wei Lu

Keyword(s):

Coronary Artery Disease ◽

Risk Factor ◽

Coronary Artery ◽

Blood Group ◽

Abo Blood Group ◽

Propensity Score Matching Analysis ◽

Blood Group A ◽

Significant Difference ◽

Group A ◽

Artery Disease

Abstract Background ABO blood group is a risk factor for coronary artery disease (CAD), but whether it is more strongly associated with CAD in Chinese individuals is less clear. The aim of this current study was therefore to investigate the association among patients hospitalized for primary coronary angiography and to explore the potential mediator of plasma lipids. Methods A total of 1079 patients, including 698 with- and 381 without newly diagnosed CAD, were retrospectively enrolled from November 2012 to December 2018. Clinical characteristics, plasma lipid levels and ABO blood groups were recorded and analyzed. Characteristics of the patients with and without CAD were compared after propensity score matching analysis (346 vs. 346). Correlation analysis was performed to assess the relationship between ABO types and clinical variables. Logistic regression analysis was constructed to determine the association of ABO blood group with CAD. Results There was not significant difference in the distribution of ABO types between CAD and non-CAD group in overall population. However, propensity-matched analysis showed that CAD in the women subgroup presented more frequently with blood group A, but not non-CAD (60.2% versus 44.1%, P =0.014). The statistically significant difference was not observed among men (37.5% versus 30.3%, P =0.157). When compared with non-A blood group, the A blood group had not a greater difference in lipid profiles among women ( P all>0.05). Correlation analysis performed in women revealed that CAD was significantly correlated with A type (r= 0.171, P = 0.003). After adjustment for age, hypertension, cigarette smoking, drinking and lipid profiles, logistic regression analysis showed that blood group A was an significant predictor for CAD in women (OR=2.152, 95% CI 1.285~3.605, P =0.004) . Conclusion Cumulatively, the present study indicated that blood group A was a significantly risk factor for coronary artery disease in Chinese women.

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