The Irradiated Larynx and Voice

1983 ◽  
Vol 26 (4) ◽  
pp. 482-485 ◽  
Author(s):  
Margaret L. Stoicheff ◽  
Antonio Ciampi ◽  
Jean E. Passi ◽  
John M. Fredrickson
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Laryngeal Cancer ◽  
Normal Subjects ◽  
Control Group ◽  
Perceptual Evaluation ◽  
Quantitative Rating ◽  
Male Patients ◽  
The Voice

The voices of patients with laryngeal cancer following a specific radiotherapy regimen were subjected to perceptual evaluation. Interval scaling of the severity of perceived dysphonia was completed for the voices of male patients sampled before and 1 year following radiation therapy and for a set of male controls. Eight listeners did this quantitative rating and also specified the predominant quality in each voice. The results indicated that the degree of dysphonia in the pretreatment group was highest. Radiotherapy decreased this dysphonia but not to the point that posttreatment voices were indistinguishable from those of normal subjects. Also, the voice qualities of laryngeal cancer patients shifted toward those of the control group following radiotherapy with over one half of the irradiated patients judged to have rough or normal qualities.

scholarly journals Neuroticism and responses to social comparison among cancer patients

2009 ◽  
Vol 23 (6) ◽  
pp. 475-487 ◽  
Author(s):  
Abraham P. Buunk ◽  
Thecla M. Brakel ◽  
Femke T.C. Bennenbroek ◽  
Heidi E. Stiegelis ◽  
Robbert Sanderman ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Social Comparison ◽  
Cancer Patients ◽  
Validation Study ◽  
Negative Mood ◽  
Emotional Reactions ◽  
Control Group ◽  
Main Study ◽  
Different Types ◽  
Comparison Information

The present study examined how the effects of three audiotapes containing different types of social comparison information on the mood of cancer patients depended on the level of neuroticism. On the procedural tape, a man and woman discussed the process of radiation therapy, on the emotion tape, they focussed on emotional reactions to their illness and treatment, while on the coping tape they focussed on the way they had been coping. A validation study among 115 students showed that the tapes were perceived as they were intended. The main study was conducted among 226 patients who were about to undergo radiation therapy. Compared to patients in the control group, as patients were higher in neuroticism, they reported less negative mood after listening to the procedural and the coping tape. Furthermore, as patients were higher in neuroticism, they reported less negative mood after listening to the coping tape than to the emotion tape. Copyright © 2009 John Wiley & Sons, Ltd.

Plasma Endogenous Digoxin-Like Substance Levels are Dependent on Blood O2 in Man

1994 ◽  
Vol 87 (4) ◽  
pp. 447-451 ◽  
Author(s):  
Claudio Ferri ◽  
Cesare Bellini ◽  
Simonetta Coassin ◽  
Claudio De Angelis ◽  
Alessandro Perrone ◽  
...  
Keyword(s):  
Partial Pressure ◽  
Normal Subjects ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Plasma Digoxin ◽  
O2 Partial Pressure ◽  
Male Patients ◽  
Normal Men ◽  
Hypoxic Group

1. Recently, we have demonstrated that hypoxic breathing is followed by an increase in plasma digoxin-like substance in normal men. 2. This study was undertaken in order to evaluate whether or not a low arterial O2 partial pressure is combined with an increase in plasma digoxin-like substance in chronic pathological conditions also. 3. Sixteen male patients (mean age 53.1 ± 3.7 years) affected by chronic obstructive pulmonary disease of a mild stage were studied. They were further subdivided according to their arterial O2 partial pressure into ‘mild hypoxic’ (n = 8, mean age 52.5 ± 2.7 years), with an arterial O2 partial pressure between 66 and 75 mmHg, and ‘severe hypoxic’ (n = 8, mean age 54.3 ± 5.1 years), with an arterial O2 partial pressure 65 mmHg, groups. Seven healthy men (mean age 48.5 ± 4.8 years) voluntarily participated as the control group. 4. Plasma digoxin-like substance levels were significantly higher in ‘severe hypoxic’ patients (203.5 ± 9.9 pg/ml) than in both ‘mild hypoxic’ patients (169.5 ± 31.4 pg/ml, P < 0.02) and normal subjects (158.9 ± 12.4 pg/ml, P < 0.0001) and were directly correlated with urinary Na+ excretion (severe hypoxic group, r = 0.756, P < 0.007; mild hypoxic group, r = 0.789, P < 0.02). Considering the two hypoxic groups together, plasma digoxin-like substance levels were negatively correlated with arterial O2 partial pressure (r = −0.740, P < 0.001). However, when patients were subdivided according to the degree of hypoxia, the negative correlation between arterial O2 partial pressure and plasma digoxin-like substance persisted only in severe hypoxic patients (r = −0.761, P < 0.03). 5. These results indicate a clear linkage between blood O2 and endogenous digoxin-like substance regulation. In particular, hypoxia may be regarded as an important stimulus for the release of the endogenous digoxin-like substance in man.

scholarly journals Genome of Helicobacter pylori and Serotype of HPV Detected in Oropharyngeal and Laryngeal Cancer and Chronic Inflammation Patients

2021 ◽  
Vol 18 (18) ◽  
pp. 9545
Author(s):  
Jaromír Astl ◽  
Richard Holy ◽  
Eva Maute ◽  
Jan Rotnágl ◽  
David Kalfeřt ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
High Risk ◽  
Cancer Patients ◽  
Chronic Inflammation ◽  
Laryngeal Cancer ◽  
Hpv Infection ◽  
Unknown Primary ◽  
Control Group ◽  
Palatine Tonsils ◽  
Cancer Group

Objective: Oropharyngeal/laryngeal carcinoma are common cancers of the upper aerodigestive system. Human papillomavirus (HPV) is described as the most frequent in the cancer of unknown primary. The presence of Helicobacter pylori (HP) in the oral cavity is discussed in some papers. The aim of study: To analyze the incidence of HPV and HP in oropharyngeal/laryngeal cancer persons versus persons with chronic tonsillar inflammation and healthy persons. Methods: The samples were taken in three groups: (1) tissue of oropharynx/larynx cancer (103 specimens); (2) tissue of palatine tonsils (85 specimens); and (3) healthy control group (50 specimens). We analyzed the presence of HP (PCR) and HPV genomic DNA (Sacace HPV High-Risk Screen Real-TM Quant) in the samples. Results: HP was detected in 86 samples (83.5%) and high-risk HPV in 62 samples (60.2%). We found a very high incidence of HP. In the cancer group, HP was detected in 82.5% cases and HPV positivity in 57.8%. In total, 7.2% of the cancer patients were negative for HP and HPV together. In turn, 53.6% of the cancer patients were positive for HP and HPV together. Four cases (4.2%) were positive for HPV only. VacA positivity was detected in 82 (79.6%) of the cancer cases and VacA negativity in 21 (20.4%) if the cancer cases. The incidence of HP in chronic inflammation (n = 85) was 65 cases (76.5%) and the incidence of HPV was 38 cases (44.7%). VacA positivity was detected in 59 (69.4%) of the chronic inflammation cases and VacA negativity was found in 26 (30.6%) of the chronic inflammation cases. Regarding the control group, we found HP positivity in 5 cases (11.1%) and HPV positivity in 19 cases (42.2%). There was VacA positivity in 6 cases (50.0%) of the control group. Statistically significantly lower prevalence of HP (p < 0.001) and HPV (p = 0.006) was found in the control group. Conclusions: We suggest that the palatine tonsils are colonized by HP. In our study, HP was present in oropharyngeal cancer in more cases in comparison with HPV infection. The presence of VacA from HP can have an influence on the human epithelial and immune cells’ regulation ways. Our results do not support idea that the CagA-positive HP is a primary carcinogen in oropharyngeal area.

A clinicopathological study on laryngeal cancer (Preprint)

2020 ◽  
Author(s):  
Suman Arasikere Panchappa
Keyword(s):  
Cell Carcinoma ◽  
Cancer Patients ◽  
Laryngeal Cancer ◽  
Histopathological Examination ◽  
Disease Stage ◽  
Treatment Modalities ◽  
Low Socioeconomic ◽  
Common Clinical Presentation ◽  
Male Patients ◽  
The Common

BACKGROUND The study was conducted at Governemnt Rajaji Hospital OBJECTIVE Laryngeal cancer is primarily a disease of middle aged men. It has peak incidence in the seventh decade. Worldwide it is the common head and neck cancer. Squamous cell carcinoma is the most common type of tumor, comprising 90 percent or more of all laryngeal malignancies. Laryngeal cancer is more common in areas with higher levels of social poverty. The study is done to find out the common clinical presentation of patients with laryngeal carcinoma with reference to the age profile, the symptomatology, disease stage, etiological factors, occupational history, histological profile and to determine the treatment modalities offered to the laryngeal cancer patients attending ENT OPD at GRH., Madurai. METHODS This is a hospital based prospective study. The study was conducted at Government Rajaji Hospital.,Madurai.,India.All the newly diagnosed laryngeal cancer patients were included in the study between July 2013 to June 2014.Totaly we had 113 patients in this study. RESULTS In our study most of them were male patients. The most common age group Was 65 years.We had only 4 female patients in our study and all had supraglottic growth. All the patients belonged to low socioeconomic strata.The most common part of larynx involved is supraglottis. None of our patients had distant metastasis. The most common presentation was difficulty in breathing and stridor, later followed by change of voice and dysphagia.The common histopathological finding was squmous cell carcinoma. In that moderatelty differentiated was the most common type.The most common stage was stage III. The most common treatment offered at our hospital was concurrent chemoradiotherapy. CONCLUSIONS Diagnosis of laryngeal cancer is based on good history, clinical examination, direct examination of the larynx, CT scan and supported by histopathological examination. This study has been done to increase awareness on early diagnosis and treatment which leads to the better life style of the laryngeal cancer patients.

A comparison of seminal vesicle size on CT between autosomal dominant polycystic kidney disease (ADPKD) patients and normal subjects

2010 ◽  
Vol 51 (5) ◽  
pp. 569-572 ◽  
Author(s):  
Ijin Joo ◽  
Seung Hyup Kim ◽  
Jeong Yeon Cho
Keyword(s):  
Autosomal Dominant ◽  
Normal Subjects ◽  
Seminal Vesicles ◽  
Control Group ◽  
3D Ct ◽  
Polycystic Kidney ◽  
Mean Width ◽  
Male Patients ◽  
The Mean ◽  
Autosomal Dominant Polycystic Kidney

Background: Extrarenal manifestations are common in autosomal dominant polycystic kidney disease (ADPKD). Although seminal vesicles can also be involved in patients with ADPKD, little is known about the size differences of the seminal vesicles between ADPKD patients and normal subjects. Purpose: To determine whether the size of seminal vesicles in ADPKD patients is larger than that in normal subjects with the use of three-dimensional (3D) CT. Material and Methods: Using a retrospective case-control study design, we reviewed the findings of 696 male patients with an age range of 20–69 years who underwent contrast enhanced multi-detector computed tomography (MDCT) imaging of the kidney in our institution from August 2007 to July 2008. A total of 68 male patients with ADPKD comprised the study group. Another 68 age-matched non-ADPKD male patients comprised the control group. The size of bilateral seminal vesicles was assessed by measurement of the short dimension on axial, coronal, and sagittal images by the use of a picture archiving and communication system (PACS). Results: The mean width of seminal vesicles in ADPKD patients was 1.70±0.40 cm (axial images), 1.86±0.45 cm (coronal), and 1.59±0.39 cm (sagittal). For control group subjects, the mean width was 1.53±0.29 cm (axial), 1.68±0.43 cm (coronal), and 1.48±0.31 cm (sagittal). The mean size differences between the ADPKD and control groups for the measured widths on axial and coronal images were statistically significant ( P=0.01 and P=0.02, respectively). The width as measured on axial images showed a decrease with age in the control group subjects (linear trend, P=0.005), but no significant decrease was noted in ADPKD patients. Conclusion: The seminal vesicles were demonstrated to be larger in ADPKD patients as compared with normal subjects as determined with the use of 3D CT.

Distribution Patterns of Uric Acid in Coronary Artery Disease

1967 ◽  
Vol 13 (2) ◽  
pp. 132-141 ◽  
Author(s):  
Morris London ◽  
Mary Hums
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Heart Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Distribution Patterns ◽  
Normal Subjects ◽  
Acute Stage ◽  
Control Group ◽  
Male Patients ◽  
Artery Disease

Abstract The uric acid levels in each of 335 cardiac patients were studied over a period of more than 3 months from the onset of the acute stage of coronary heart disease. Comparison was made with uric acid values obtained from a group of 316 normal subjects. Male patients with arteriosclerotic coronary artery disease with infarction generally exhibited rising concentrations of serum uric acid during the first weeks after an attack and a gradual return toward normal levels after 3 months. Female patients of the two groups studied and male patients with arteriosclerotic coronary artery disease, but without infarction, had uric acid levels averaging much higher than those of the control group.

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