scholarly journals Interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium leprae heat shock protein (hsp) 65 kD

1998 ◽  
Vol 114 (2) ◽  
pp. 196-203 ◽  
Author(s):  
Del C. Sasiain ◽  
DE LA Barrera ◽  
Fink ◽  
Finiasz ◽  
AlemÁN ◽  
...  
Keyword(s):  
T Cells ◽  
Tumour Necrosis ◽  
Cytotoxic T Cells ◽  
Mycobacterium Leprae ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Ifn Γ ◽  
Necrosis Factor

scholarly journals Apoptosis of blood lymphocytes in autoimmune thyropathies

2010 ◽  
Vol 56 (3) ◽  
pp. 16-20
Author(s):  
E B Kravets ◽  
O I Urazova ◽  
Iu V Nedosekova ◽  
A V Rogaleva
Keyword(s):  
Tumour Necrosis ◽  
Elevated Level ◽  
Positive Relationship ◽  
Tumour Necrosis Factor Alpha ◽  
Lymphocyte Apoptosis ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Ifn Γ ◽  
Necrosis Factor

This paper reports the results of a study of lymphocyte apoptosis in the blood of 81 patients presenting with autoimmune thyropathies, such as autoimmune thyroidism (AIT) and Grave's disease (GD). It was shown that AIT in patients with hypothyroidism and DTG is associated with an increased number of CD95+ lymphocytes «doomed» to apoptose. Moreover, AIT and DTG conditions are characterized by an elevated level of serum tumour necrosis factor-alpha (TNF-α). In euthyroid patients with AIT, this rise is accompanied by a decrease in the interferon-gamma (IFN-γ) level. Hypotyroid patients with AIT exhibit positive relationship between an increased number of CD95+ lymphocytes in blood and serum TNF-α levels.

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