Effect of Nigella sativa on Glucose Concentration, Lipid Peroxidation, Anti-Oxidant Defence System and Liver Damage in Experimentally-Induced Diabetic Rabbits

The loss of redox homeostasis induced by hyperglycemia is an early sign and key factor in the development of diabetic retinopathy. Due to the high level of long-chain polyunsaturated fatty acids, diabetic retina is highly susceptible to lipid peroxidation, source of pathophysiological alterations in diabetic retinopathy. Previous studies have shown that pterostilbene, a natural antioxidant polyphenol, is an effective therapy against diabetic retinopathy development, although its protective effects on lipid peroxidation are not well known. Plasma, urine and retinas from diabetic rabbits, control and diabetic rabbits treated daily with pterostilbene were analyzed. Lipid peroxidation was evaluated through the determination of derivatives from arachidonic, adrenic and docosahexaenoic acids by ultra-performance liquid chromatography coupled with tandem mass spectrometry. Diabetes increased lipid peroxidation in retina, plasma and urine samples and pterostilbene treatment restored control values, showing its ability to prevent early and main alterations in the development of diabetic retinopathy. Through our study, we are able to propose the use of a derivative of adrenic acid, 17(RS)-10-epi-SC-Δ15-11-dihomo-IsoF, for the first time, as a suitable biomarker of diabetic retinopathy in plasmas or urine.

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Protective effects of Erythronium japonicum and Corylopsis coreana Uyeki extracts against 1,3-dichloro-2-propanol-induced hepatotoxicity in rats

Applied Microscopy ◽

10.1186/s42649-020-00049-0 ◽

2020 ◽

Vol 50 (1) ◽

Author(s):

Seunghyun Kim ◽

Hee-Ock Boo ◽

Taeho Ahn ◽

Chun-Sik Bae

Keyword(s):

Liver Damage ◽

Enzyme Activities ◽

Oxygen Species ◽

Protective Effects ◽

Catalytic Activities ◽

Anti Oxidant ◽

Cyp2e1 Activity ◽

Pre Treatment ◽

Histopathological Studies ◽

Erythronium Japonicum

AbstractErythronium japonicum (E. japonicum) and Corylopsis coreana Uyeki (C. coreana Uyeki, Korean winter hazel) have been shown to significantly decrease 1,3-dichloro-2-propanol (1,3-DCP)-induced generation of reactive oxygen species and CYP2E1 activity in HuH7, human hepatocytes. In this study, we expanded upon the previous study and investigated the effects of E. japonicum and C. coreana Uyeki extracts on 1,3-DCP-induced liver damage in rats. The pre-treatment of rats with these extracts alleviated a decrease in body weight and reduced 1,3-DCP-induced increase in catalytic activities of hepatic enzymes, such as aspartate aminotransferase and alanine aminotransferase, in the serum. Moreover, treatment with the extracts restored the 1,3-DCP-induced decreases in anti-oxidant enzyme activities, such as the activities of superoxide dismutase and catalase, in the rat liver. Histopathological studies also strongly supported the results of enzyme activities. These results suggest a possibility that the extracts of E. japonicum and C. coreana Uyeki can be a remedy for alleviating 1,3-DCP-induced liver damage in animals.

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Nigella Sativa, as Preventive Strategy in COVID-19

Current Traditional Medicine ◽

10.2174/2215083807666210121152731 ◽

2021 ◽

Vol 07 ◽

Author(s):

Vaishali Mathur ◽

Mahak Sharma

Keyword(s):

Immune System ◽

Nigella Sativa ◽

Preventive Strategy ◽

Therapeutic Effects ◽

Human Contact ◽

The People ◽

Home Based ◽

Anti Oxidant ◽

Immune Booster ◽

Difficult Times

: During the recent difficult times when the whole world is fighting the pandemic named COVID-19, a herbal home based spice, which can help the people improve their immunity and fight against this infection. Nigella Sativa has been named as a prophetic Spice, as it has many therapeutic effects. It is found to control diabetes, reduce high cholesterol levels, and serve as an antioxidant, anti-cancer, anti – informatory and an immune booster. The compound Thymoquinone can be responsible for enhancing immune system as it acts as an anti-oxidant and has an anti-inflammatory property. As various research has showed that to protect from Coronavirus, it is important not only to avoid human contact, but also to strengthen the Immune system. This paper is a review of various studies which prove that Nigella Sativa, can be beneficial in enhancing the immune system and thus fight COVID – 19.

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