Migraine Headaches in Adolescents: A Student Population-Based Study in Monreale

We assessed the prevalence of migraine headaches in an epidemiological survey of an 11 to 14-year-old student population. Migraine headaches were classified on the basis of questionnaires and neurological examination using the operational diagnostic criteria of the International Headache Society. Prevalence of migraine without aura (IHS code 1.1) was 2.35%; that of migraine with aura (IHS code 1.2) was 0.62%. Migraine without aura was equally distributed among males and females, whereas migraine with aura was preponderant in the female cohort. The prevalence of migraine headaches in males was constant through the ages studied, whereas the prevalence of migraine headaches in females reached a peak at age 12 and plateaued over the following two years. Although the new IHS classification criteria of migraines are reliable and exhaustive, some subcriteria may not be valid in a juvenile population. For instance, the duration of the pain in young migraineurs is often briefer than in adults, and the intensity of pain was almost always described as moderate or severe. Therefore, in order to increase the reliability and comprehensiveness of the IHS classification, minor modifications should be made.

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Migrainous Disorder and its Relation to Migraine Without Aura and Migraine with Aura. A Genetic Epidemiological Study

Cephalalgia ◽

10.1046/j.1468-2982.1996.1606431.x ◽

1996 ◽

Vol 16 (6) ◽

pp. 431-435 ◽

Cited By ~ 31

Author(s):

MB Russell ◽

J Olesen

Keyword(s):

Migraine With Aura ◽

Migraine Without Aura ◽

International Headache Society ◽

Large Population ◽

Population Based ◽

Population Based Study ◽

Female Ratio ◽

First Degree Relatives ◽

Increased Risk ◽

Male Female Ratio

Migrainous disorder was analysed in a large population-based study of 4000 forty-year-old males and females. All interviews were conducted by one physician and the diagnostic criteria of the International Headache Society were used. Of the 48 people with migrainous disorder, 40 had migrainous disorder without aura and 9 had migrainous disorder with aura One person had co-occurrence of migrainous disorder with and without aura. The lifetime prevalence of migrainous disorder was 2.5% with a male: female ratio of 1:1.2. The first-degree relatives of probands with migrainous disorder were blindly interviewed. Compared with the general population, first-degree relatives of probands with migrainous disorder without aura had a slightly but less increased risk of migraine without aura than first-degree relatives of probands with migraine without aura. First-degree relatives of probands with migrainous disorder with aura had no increased risk of migraine with aura. We conclude that migrainous disorder without aura in some people is a type of migraine without aura and in other people not. Migrainous disorder with aura may be unrelated to migraine with aura. œ

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Clinical Characteristics of Migraine in A Population-Based Twin Sample: Similarities and Differences Between Migraine with and Without Aura

Cephalalgia ◽

10.1046/j.1468-2982.1999.1903151.x ◽

1999 ◽

Vol 19 (3) ◽

pp. 151-158 ◽

Cited By ~ 16

Author(s):

M Kallela ◽

M Wessman ◽

M Färkkilä ◽

A Palotie ◽

M Koskenvuo ◽

...

Keyword(s):

Migraine With Aura ◽

Migraine Without Aura ◽

Clinical Characteristics ◽

Telephone Interview ◽

International Headache Society ◽

Epidemiological Data ◽

Population Based ◽

Unilateral Headache ◽

Chi Squared ◽

Similarities And Differences

Objective: To look into clinical differences between migraine with and without aura in a population-based sample of migraineurs. Background: Migraine presents in two major forms, migraine with and migraine without aura. With the exception of the aura phase, the clinical characteristics of these entities are very similar. Despite this, however, the recent epidemiological data underline differences between migraine with and without aura. We tried to examine whether other features besides the aura differ between these two major forms of migraine. Methods: We studied 321 twins suffering from migraine with aura and 166 twins with migraine without aura from the population-based Finnish Twin Cohort. Migraine was diagnosed according to the criteria of the International Headache Society (MS). Analysis was based on the combination of a mailed questionnaire and a telephone interview by a neurologist. Special attention was paid to differences between migraine with and without aura. Results: Some qualities of headaches differed between IHS defined migraine with and without aura. Unilateral headache (Chi-squared p=0.039) and photophobia (Chi-squared p=0.010) were more typical for migraine with aura, while nausea was more typical for migraine without aura (Chi-squared p=0.002). Duration of headache in migraine without aura was also longer man in migraine with aura (Mann-Whitney U-test 0.007). Conclusions: There are clinical differences between IHS defined migraine with and without aura; even the headache phase between the two entities differs. It is worthwhile distinguishing between them when looking for the elusive genes for these more common forms of migraine.

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Migraine Prevalence in Adolescents Aged 13–15: A Student Population‐Based Study in Taiwan

Cephalalgia ◽

10.1046/j.1468-2982.2000.00076.x ◽

2000 ◽

Vol 20 (5) ◽

pp. 479-485 ◽

Cited By ~ 42

Author(s):

S‐R Lu ◽

J‐L Fuh ◽

K‐D Juang ◽

S‐J Wang

Keyword(s):

Response Rate ◽

International Headache Society ◽

Population Based ◽

Junior High Schools ◽

Questionnaire Response ◽

Population Based Study ◽

Migraine Headaches ◽

Migraine Prevalence ◽

Self Administered Questionnaire

To estimate the lifetime migraine prevalence in school adolescents aged 13–15 in Taiwan, we conducted a self‐administered questionnaire survey in four sampled public junior high schools. Migraine was diagnosed according to the diagnostic criteria of the International Headache Society. A total of 4064 students (1983 boys, 2081 girls) completed the questionnaire (response rate 91.6%). The lifetime prevalence of migraine was 6.8%. It was significantly higher in girls than boys (7.8% vs. 5.7%) and increased with age in both sexes. Students with migraine were more likely to be absent from school because of their headaches than those with non‐migraine headaches (30% vs. 14%, odds ratio (OR) 2.7). They were also more likely to use painkillers for their headaches than their non‐migraine headache peers (72% vs. 40%, OR 4.0). These results suggest that migraine is a common disorder of adolescents in Taiwan and its impact on the quality of life can not be ignored.

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Prevalence of menstrual migraine: A population-based study

Cephalalgia ◽

10.1177/0333102413507637 ◽

2013 ◽

Vol 34 (4) ◽

pp. 280-288 ◽

Cited By ~ 33

Author(s):

Kjersti G Vetvik ◽

E Anne MacGregor ◽

Christofer Lundqvist ◽

Michael B Russell

Keyword(s):

Epidemiological Study ◽

Migraine With Aura ◽

Migraine Without Aura ◽

Population Based ◽

International Classification ◽

Menstrual Migraine ◽

Headache Disorders ◽

Population Based Study ◽

Menstrual Cycles

Aim To present data from a population-based epidemiological study on menstrual migraine. Material and methods Altogether, 5000 women aged 30–34 years were screened for menstrual migraine. Women with self-reported menstrual migraine in at least half of their menstrual cycles were invited to an interview and examination. We expanded the International Classification of Headache Disorders III beta appendix criteria on menstrual migraine to include both migraine without aura and migraine with aura, as well as probable menstrual migraine with aura and migraine without aura. Results A total of 237 women were included in the study. The prevalence among all women was as follows: any type of menstrual migraine 7.6%; menstrual migraine without aura 6.1%; menstrual migraine with aura 0.6%; probable menstrual migraine without aura 0.6%; probable menstrual migraine with aura 0.3%. The corresponding figures among female migraineurs were: any type of menstrual migraine 22.0%, menstrual migraine without aura 17.6%, menstrual migraine with aura 1.7%, probable menstrual migraine without aura 1.6% and probable menstrual migraine with aura 1.0%. Conclusion More than one of every five female migraineurs aged 30–34 years have migraine in ≥50% of menstruations. The majority has menstrual migraine without aura and one of eight women had migraine with aura in relation to their menstruation. Our results indicate that the ICHD III beta appendix criteria of menstrual migraine are not exhaustive.

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Head-HUNT: Validity and Reliability of a Headache Questionnaire in a Large Population-Based Study in Norway

Cephalalgia ◽

10.1046/j.1468-2982.2000.00049.x ◽

2000 ◽

Vol 20 (4) ◽

pp. 244-251 ◽

Cited By ~ 92

Author(s):

K Hagen ◽

J-A Zwart ◽

L Vatten ◽

LJ Stovner ◽

G Bovim

Keyword(s):

Chronic Headache ◽

International Headache Society ◽

Large Population ◽

Population Based ◽

Validity And Reliability ◽

Population Based Study ◽

Patient Status ◽

Self Administered Questionnaire ◽

Migrainous Headache ◽

Made In

We have assessed the validity and reliability of a self-administered headache questionnaire used in the 'Nord-Trøndelag Health Survey 1995-97 (HUNT)' in Norway, by blindly comparing questionnaire-based headache diagnoses with those made in a clinical interview of a sample of the participants. Restrictive questionnaire-based diagnostic criteria for migraine, assessed according to modified criteria of the International Headache Society, performed excellently in selecting 'definite' migraine patients (100% positive predictive value). The best agreement concerning migraine diagnoses was achieved by using a liberal set of criteria (k 0.59). Similar agreement was found evaluating patient status as headache sufferers, and as sufferers from frequent headaches (>6 days per month) (k 0.57 and 0.50, respectively). The k values of nonmigrainous headache and chronic headache (>14 days per month) were 0.43 and 0.44, respectively. The results suggest that our self-administered questionnaire may be suitable in identifying a population with 'definite' migraine, and the questionnaire is an acceptable instrument in determining the prevalence in Nord-Trøndelag of headache sufferers, migraine, non-migrainous headache, and frequent or chronic headache sufferers.

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Side-Shifting Hemicrania Continua with Aura (Migraine with Aura with Autonomic Symptoms Responsive to Indomethacin?)

Cephalalgia ◽

10.1111/j.1468-2982.2006.01145.x ◽

2006 ◽

Vol 26 (8) ◽

pp. 917-919 ◽

Cited By ~ 15

Author(s):

MFP Peres ◽

MR Masruha ◽

WB Young

Keyword(s):

Chronic Migraine ◽

Migraine With Aura ◽

International Headache Society ◽

Hemicrania Continua ◽

Visual Aura ◽

Autonomic Symptom ◽

Autonomic Symptoms ◽

Atypical Features ◽

Ihs Classification ◽

Complex Cases

Atypical features of hemicrania continua (HC), including both visual aura and side shifting, have been reported previously. However, auras and variable unilaterality have never been reported together in HC. We report two patients with side-shifting HC with aura. These patients' symptoms are unilateral headaches, visual aura, autonomic features, throbbing pain, nausea and photo/phonophobia. One could speculate that the unilaterality and/or the autonomic symptom modules are indomethacin responsive. The patients can also be classified as chronic migraine with aura, with autonomic symptoms, responsive to indomethacin. Neither migraine subtype nor side-shifting HC with aura is included in the current International Headache Society (IHS) classification, so these patients are not classifiable. Side-shifting HC with aura implies the need to revisit the traditional IHS categorization of headaches into unique diagnostic groups. The modular headache theory may be a tool for the understanding of these rare and complex cases.

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Major depression subtypes are differentially associated with migraine subtype, prevalence and severity

Cephalalgia ◽

10.1177/0333102419884935 ◽

2019 ◽

Vol 40 (4) ◽

pp. 347-356 ◽

Cited By ~ 1

Author(s):

Claudia Pisanu ◽

Emma Lundin ◽

Martin Preisig ◽

Mehdi Gholam-Rezaee ◽

Enrique Castelao ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Migraine With Aura ◽

Migraine Without Aura ◽

Population Based ◽

Cross Sectional Study ◽

High Rate ◽

Major Depressive ◽

Cross Sectional ◽

Depression Subtypes

Objective Migraine and major depressive disorder show a high rate of comorbidity, but little is known about the associations between the subtypes of major depressive disorder and migraine. In this cross-sectional study we aimed at investigating a) the lifetime associations between the atypical, melancholic, combined and unspecified subtype of major depressive disorder and migraine with and without aura and b) the associations between major depressive disorder and its subtypes and the severity of migraine. Methods A total of 446 subjects with migraine (migraine without aura: n = 294; migraine with aura: n = 152) and 2511 controls from the population-based CoLaus/PsyCoLaus study, Switzerland, were included. Associations between major depressive disorder subtypes and migraine characteristics were tested using binary logistic or linear regression. Results Melancholic, combined and unspecified major depressive disorder were associated with increased frequency of migraine with aura, whereas only melancholic major depressive disorder was associated with increased frequency of migraine without aura. Lifetime and unspecified major depressive disorder were associated with severe migraine intensity among subjects with migraine with aura but not migraine without aura, while combined major depressive disorder was associated with higher migraine frequency independently from migraine subtype. Conclusion This study suggests that melancholic but not atypical major depressive disorder is associated with migraine and migraine subtypes. Future studies exploring pathophysiological mechanisms shared between melancholic depression and migraine are warranted.

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The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008

BMC Neurology ◽

10.1186/s12883-019-1462-8 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 3

Author(s):

Knut Hagen ◽

Lars Jacob Stovner ◽

Kristian Bernhard Nilsen ◽

Espen Saxhaug Kristoffersen ◽

Bendik Slagsvold Winsvold

Keyword(s):

Migraine With Aura ◽

Large Scale ◽

Population Based ◽

C Reactive Protein ◽

Cross Sectional ◽

Population Based Study ◽

Reactive Protein ◽

Scale Population ◽

Hs Crp ◽

The Impact

Abstract Background Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study. Methods A total of 50,807 (54%) out of 94,194 invited aged ≥20 years or older participated in the third wave of the Nord-Trøndelag Health Study study performed in 2006–2008. Among these, 38,807 (41%) had valid measures of hs-CRP and answered questions on headache and insomnia. Elevated hs-CRP was defined as > 3.0 mg/L. The cross-sectional association with headache was estimated by multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). Results In the fully adjusted model, elevated hs-CRP was associated with migraine (OR 1.14, 95% CI 1.04–1.25) and migraine with aura (OR 1.15, 95% CI 1.03–1.29). The association was strongest among individuals with headache ≥15 days/month for any headache (OR 1.26, 95% CI 1.08–1.48), migraine (OR 1.62, 95% CI 1.21–2.17), and migraine with aura (OR 1.84, 95% CI 1.27–2.67). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia. Conclusions Cross-sectional data from this large-scale population-based study showed that elevated hs-CRP was associated with headache ≥7 days/month, especially evident for migraine with aura.

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Migraine With Aura and Migraine Without Aura: An Epidemiological Study

Cephalalgia ◽

10.1046/j.1468-2982.1992.1204221.x ◽

1992 ◽

Vol 12 (4) ◽

pp. 221-228 ◽

Cited By ~ 348

Author(s):

Birthe Krogh Rasmussen ◽

Jes Olesen

Keyword(s):

Migraine With Aura ◽

Migraine Without Aura ◽

International Headache Society ◽

Age Distribution ◽

Cross Sectional Study ◽

Lifetime Prevalence ◽

Headache Disorders ◽

Cross Sectional ◽

Visual Disturbances ◽

Precipitating Factor

In a cross-sectional study of headache disorders in a representative general population of 1,000 persons the epidemiology of migraine with aura (MA) and migraine without aura (MO) was analysed in relation to sex and age distribution, symptomatology and precipitants. The headache disorders were classified on the basis of a clinical interview as well as a physical and a neurological examination using the operational diagnostic criteria of the International Headache Society (IHS). Lifetime prevalence of MA was 5%, male:female ratio 1:2. Lifetime prevalence of MO was 8%, M:F ratio 1:7. Women, but not men, were significantly more likely to have MO than MA. Neither MA nor MO showed correlation to age in the studied age interval (25–64 years). Premonitory symptoms occurred in 16% of subjects with MA and in 12% with MO. One or more precipitating factor was present in 61% with MA and in 90% with MO. In both MA and MO the most conspicuous precipitating factor was stress and mental tension. Visual disturbances were the most common aura phenomenon occurring in 90% of subjects with MA. Aura symptoms of sensory, motor or speech disturbances rarely occurred without coexisting visual disturbances. The pain phase of MA fulfilled the criteria for MO of the IHS. Headache was, however, less severe and shorter lasting in MA than in MO. Onset at menarche, menstrual precipitation, menstrual problems, influence of pregnancy and use of oral contraceptives all showed some relationship with the presence of MO and less with MA. The present findings suggest that MA and MO share the pain phase. Among subjects with MA and MO, 50% and 62%, respectively, had consulted their general practitioner because of migraine. Selection bias in previous clinical studies is demonstrated by comparisons with the present unselected sample.

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