scholarly journals Randomness of physiological signals in generation cryptographic key for secure communication between implantable medical devices inside the body and the outside world

Author(s):  
H. Chizari ◽  
E. Lupu ◽  
P. Thomas
2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hanjun Ryu ◽  
Hyun-moon Park ◽  
Moo-Kang Kim ◽  
Bosung Kim ◽  
Hyoun Seok Myoung ◽  
...  

AbstractSelf-powered implantable devices have the potential to extend device operation time inside the body and reduce the necessity for high-risk repeated surgery. Without the technological innovation of in vivo energy harvesters driven by biomechanical energy, energy harvesters are insufficient and inconvenient to power titanium-packaged implantable medical devices. Here, we report on a commercial coin battery-sized high-performance inertia-driven triboelectric nanogenerator (I-TENG) based on body motion and gravity. We demonstrate that the enclosed five-stacked I-TENG converts mechanical energy into electricity at 4.9 μW/cm3 (root-mean-square output). In a preclinical test, we show that the device successfully harvests energy using real-time output voltage data monitored via Bluetooth and demonstrate the ability to charge a lithium-ion battery. Furthermore, we successfully integrate a cardiac pacemaker with the I-TENG, and confirm the ventricle pacing and sensing operation mode of the self-rechargeable cardiac pacemaker system. This proof-of-concept device may lead to the development of new self-rechargeable implantable medical devices.


2012 ◽  
Vol 40 (4) ◽  
pp. 716-750 ◽  
Author(s):  
Leili Fatehi ◽  
Susan M. Wolf ◽  
Jeffrey McCullough ◽  
Ralph Hall ◽  
Frances Lawrenz ◽  
...  

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions (often defined as 1-100 nm, but sometimes defined to include dimensions up to 1000 nm, as discussed further below) where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products (biologics), implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. Nanotherapeutics and in vivo nanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes (including the bloodbrain barrier) and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents.


2010 ◽  
Vol 638-642 ◽  
pp. 754-759
Author(s):  
Lawrence E. Eiselstein ◽  
Robert D. Caligiuri

Implantable medical devices must be able to withstand the corrosive environment of the human body for 10 or more years without adverse consequences. Most reported research and development has been on developing materials and devices that are biocompatible and resistant to corrosion-fatigue, pitting, and crevice corrosion. However, little has been directly reported regarding implantable materials with respect to the rate at which they generate soluble ions in-vivo. Most of the biocompatibility studies have been done by examining animal implants and cell cultures rather than examining the rate at which these materials leach ions into the body. This paper will discuss what is currently known about the rate at which common implant materials (such as stainless steels, cobalt-chromium alloys, and nitinol) elute ions under in vitro conditions, what the limitations are of such data, and how this data can be used in medical device development.


2020 ◽  
Vol 10 (8) ◽  
pp. 2923 ◽  
Author(s):  
Jean-Pierre Alcaraz ◽  
Gauthier Menassol ◽  
Géraldine Penven ◽  
Jacques Thélu ◽  
Sarra El Ichi ◽  
...  

We discuss the perspectives of designing implantable medical devices that have the criterion of being symbiotic. Our starting point was whether the implanted device is intended to have any two-way (“duplex”) communication of energy or materials with the body. Such duplex communication extends the existing concepts of a biomaterial and biocompatibility to include the notion that it is important to consider the intended functional use of the implanted medical device. This demands a biomimetic approach to design functional symbiotic implantable medical devices that can be more efficient in mimicking what is happening at the molecular and cellular levels to create stable interfaces that allow for the unfettered exchanges of molecules between an implanted device and a body. Such a duplex level of communication is considered to be a necessary characteristic of symbiotic implanted medical devices that are designed to function for long periods of time inside the body to restore and assist the function of the body. We illustrate these perspectives with experience gained from implanting functional enzymatic biofuel cells.


2021 ◽  
Author(s):  
Federico Calì ◽  
Luca Fichera ◽  
Giuseppe Trusso Sfrazzetto ◽  
Giuseppe Nicotra ◽  
Gianfranco Sfuncia ◽  
...  

Sensors ◽  
2020 ◽  
Vol 20 (12) ◽  
pp. 3487 ◽  
Author(s):  
Sadeque Reza Khan ◽  
Sumanth Kumar Pavuluri ◽  
Gerard Cummins ◽  
Marc P. Y. Desmulliez

Wireless power transfer (WPT) systems have become increasingly suitable solutions for the electrical powering of advanced multifunctional micro-electronic devices such as those found in current biomedical implants. The design and implementation of high power transfer efficiency WPT systems are, however, challenging. The size of the WPT system, the separation distance between the outside environment and location of the implanted medical device inside the body, the operating frequency and tissue safety due to power dissipation are key parameters to consider in the design of WPT systems. This article provides a systematic review of the wide range of WPT systems that have been investigated over the last two decades to improve overall system performance. The various strategies implemented to transfer wireless power in implantable medical devices (IMDs) were reviewed, which includes capacitive coupling, inductive coupling, magnetic resonance coupling and, more recently, acoustic and optical powering methods. The strengths and limitations of all these techniques are benchmarked against each other and particular emphasis is placed on comparing the implanted receiver size, the WPT distance, power transfer efficiency and tissue safety presented by the resulting systems. Necessary improvements and trends of each WPT techniques are also indicated per specific IMD.


2018 ◽  
Vol 2018 ◽  
pp. 1-16
Author(s):  
Wonsuk Choi ◽  
Youngkyung Lee ◽  
Duhyeong Lee ◽  
Hyoseung Kim ◽  
Jin Hyung Park ◽  
...  

Implantable medical devices (IMDs) continuously monitor the condition of a patient and directly apply treatments if considered necessary. Because IMDs are highly effective for patients who frequently visit hospitals (e.g., because of chronic illnesses such as diabetes and heart disease), their use is increasing significantly. However, related security concerns have also come to the fore. It has been demonstrated that IMDs can be hacked—the IMD power can be turned off remotely, and abnormally large doses of drugs can be injected into the body. Thus, IMDs may ultimately threaten a patient’s life. In this paper, we propose an energy-aware key exchange protocol for securing IMDs. We utilize synchronous interpulse intervals (IPIs) as the source of a secret key. These IPIs enable IMDs to agree upon a secret key with an external programmer in an authenticated and transparent manner without any key material being exposed either before distribution or during initialization. We demonstrate that it is difficult for adversaries to guess the keys established using our method. In addition, we show that the reduced communication overhead of our method enhances battery life, making the proposed approach more energy-efficient than previous methods.


2019 ◽  
Author(s):  
Konlin Shen ◽  
Michel M. Maharbiz

AbstractObjectiveUltrasonic acoustic power transfer is an efficient mechanism for coupling energy to millimeter and sub-millimeter implants in the body. To date, published ultrasonically powered implants have been encapsulated with thin film polymers that are susceptible to well-documented failure modes in vivo, including water penetration and attack by the body. As with all medical implants, packaging with ceramic or metallic materials can reduce water vapor transmission and improve biostability to provide decadal device lifetime. In this paper, we evaluate methods of coupling acoustic energy to the interior of ceramic packages.MethodsThe classic wave approach and modal expansion are used to obtain analytical expressions for acoustic transmission through two different package designs and these approaches are validated experimentally. A candidate package design is demonstrated using alumina packages and titanium lids, designed to be acoustically transparent.ResultsBulk modes are shown to be more effective at coupling acoustic energy to a piezoelectric receiver than flexural modes. Using bulk modes, packaged motes have an overall link efficiency of roughly 10%, compared to 25% for unpackaged motes. Packaging does not have a significant effect on translational misalignment penalties, but does increase angular misalignment penalties. Passive amplitude-modulated backscatter communication is demonstrated.ConclusionThin lids enable the use of acoustically coupled devices even with package materials of very different acoustic impedance. Significance: This work provides an analysis and method for designing packages that enable acoustic coupling with implantable medical devices, which could facilitate clinical translation.


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