scholarly journals Dangerous zone during transportation of dangerous goods

2019 ◽  
Vol 138 ◽  
pp. 02019
Author(s):  
Vladimir Medvedev ◽  
Zakhar Oshchepkov ◽  
Ekaterina Bogomolova ◽  
Vladislav Bogomolov
Keyword(s):  
Development Process ◽  
Computer Modelling ◽  
Practical Importance ◽  
Railway Transport ◽  
Practical Result ◽  
New Approach ◽  
Dangerous Goods ◽  
Dangerous Zone ◽  
Guidance Documents ◽  
Technical Guidance

The purpose of research is to develop elements of an integrated security system for zone of dangerous goods by federal railway transport with the possibility to employ them on international scale and in other modes of transport. Improving the concept of dangerous zone during transportation of dangerous goods stands in as the first-priority work stage of the development process. Solving the main tasks of the research was based on such proven and fruitful theoretical and experimental methods as computer modelling, comparative typology and circular expert estimations, statistical analysis, probability theory, theory of similarity, and others. The most meaningful results of the development are both of theoretical and practical importance. The theoretical result consists in development of a new approach to the concept of dangerous zone during transportation of dangerous goods by rail. The practical result involves development of proposals for improvement of the Railway Transport System of Emergency Prevention and Response; introduction of amendments into the Safety Rules for Response to Emergencies related to Dangerous Goods during Their Transportation by Rail; emergency cards for dangerous goods and a number of other technical guidance documents. Processing of the experimental data has established that the expected effectiveness of the development is 7.5–10%

Hidden Politics? Assessing Lobbying Success During US Agency Guidance Development

2020 ◽  
Vol 30 (4) ◽  
pp. 548-562 ◽  
Author(s):  
Susan Webb Yackee
Keyword(s):  
Interest Groups ◽  
Development Process ◽  
Guidance Document ◽  
Public Attention ◽  
Policy Success ◽  
Government Documents ◽  
Us Government ◽  
Guidance Documents ◽  
The Relationship ◽  
Guidance Development

Abstract I test the proposition that interest groups achieve greater policy success when they lobby during the agency guidance document development process as opposed to the notice and comment process. Policymaking via guidance documents often receives lower levels of public attention, which provides greater flexibility to accommodate lobbying requests. I analyze the hypothesis during the creation of 41 rules by one US government agency—20 of which were promulgated using the notice and comment process and 21 via the guidance document process. I measure regulatory policy change using a content analysis of government documents and lobbying texts, and I also incorporate a telephone survey of interest groups who lobbied on these same rules. I find that interest groups perceive—and achieve—greater policy success when lobbying during the agency guidance process. The results yield new insights into the relationship between lobbying and regulatory policymaking.

The 18th FRAME Annual Lecture, October 2019: Human In Silico Trials in Pharmacology

2019 ◽  
Vol 47 (5-6) ◽  
pp. 221-227
Author(s):  
Blanca Rodriguez
Keyword(s):  
Drug Development ◽  
In Silico ◽  
Drug Testing ◽  
Development Process ◽  
Computer Modelling ◽  
Current Knowledge ◽  
Magnetic Resonance Images ◽  
Population Heterogeneity ◽  
Drug Development Process

Safety and efficacy testing is a crucial part of the drug development process, and several different methods are used to obtain the necessary data (e.g. in vitro testing, animal trials and clinical trials). Our group has been investigating the potential of modelling and simulation as an alternative approach to some of the methods used for testing drugs for cardiac effects. To achieve our goal of developing and promoting novel approaches in drug development, we formed multidisciplinary collaborations that included clinicians, computer scientists and biologists. Our in silico models are based on human data (e.g. magnetic resonance images, electrocardiogram) and on current knowledge of human electrophysiology, thus generating predictions that are directly applicable to humans. Such models are a particularly powerful tool because they encompass different sources of population heterogeneity, which is crucial for drug testing and for assessing how interindividual variability might affect clinical endpoints. Our group has shown that computer modelling can be used to predict the effects of a test drug in a virtual population or in combination with machine learning to predict different phenotypes when a drug is given to a diseased population. Furthermore, our user-friendly drug testing software is freely available and is being adopted by industry in their drug development process. We have been engaging with industry and regulators to show that our models can contribute to the replacement of animals in drug development. Our ambition is to generate models for simulation of different diseases and therapies for investigations from subcellular to whole organ.

Model-Based Development Process of Cybertronic Products and Production Systems

2014 ◽  
Vol 1018 ◽  
pp. 539-546 ◽  
Author(s):  
Hermann Meissner ◽  
Marcel Cadet ◽  
Nicole Stephan ◽  
Christian Bohr
Keyword(s):  
Development Process ◽  
Production Systems ◽  
Product Lifecycle Management ◽  
Mechatronic Systems ◽  
New Approach ◽  
Model Based ◽  
Open Networks ◽  
Development Processes ◽  
Faster Development ◽  
Lifecycle Management

The shift to satisfied customer markets forces manufacturers to offer customised products. Moreover, product lifecycles are shortened, which requires a faster development of products and corresponding production systems. Both challenges amplify complexity in production. This complexity is usually confronted with flexibility. A new approach offering decentralised structures, and thereby flexibility, comes from cybertronic systems (CTS), which are further developed mechatronic systems with the capability to communicate through open networks with other such mechatronic systems. Up to now no integrated development process to engineer cybertronic products (CTP) and production systems (CTPS) has been developed, although such a process is essential to use their beneficial properties for today’s market conditions. Therefore, research is conducted in the research project mecPro². First, the properties of cybertronic systems are investigated and dissociated from those of mechatronic systems. Based on these properties, the connections of CTP and CTPS are analysed and a systematics for description for both is identified. With this the model-based development processes of CTP and CTPS can be further defined as well as their intersections and afterwards implemented in a data model. Finally, the development process is summarised in a product lifecycle management software to support the development process.

scholarly journals Influence of operating firing field technologies on operational performance parameters

2018 ◽  
Vol 216 ◽  
pp. 02028
Author(s):  
Aleksandr Kazakov ◽  
Anton Suprunovskiy
Keyword(s):  
Control System ◽  
Computer Modeling ◽  
Operational Performance ◽  
Queuing Systems ◽  
Performance Parameters ◽  
Mathematical Apparatus ◽  
Railway Transport ◽  
New Approach ◽  
Software Product ◽  
Field Control

At present, introduction of operating firing field technologies is one of the urgent tasks of the Russian railway transport, as their use can significantly improve operational performance parameters. The factors and conditions of transition to operating firing field control system for operational performance are investigated in this paper. It provides the analysis of the problems that arise during the work of the operating firing field and proposes measures for their elimination. Methods of mathematical and computer modeling using the author’s software product were used. A new approach to multilevel simulation of the work of a transport operating firing field has been developed, which involves the use of the mathematical apparatus of multiphase queuing systems.

scholarly journals A New Application Methodology of the Fourier Transform for Rational Approximation of the Complex Error Function

2016 ◽  
Vol 8 (1) ◽  
pp. 14 ◽  
Author(s):  
S. M. Abrarov ◽  
B. M. Quine
Keyword(s):  
Fourier Transform ◽  
Rational Approximation ◽  
Error Function ◽  
Practical Importance ◽  
Exponential Functions ◽  
New Approach ◽  
Practical Applications ◽  
Input Parameters ◽  
The Fourier Transform

<p>This paper presents a new approach in application of the Fourier transform to the complex error function resulting in an efficient rational approximation. Specifically, the computational test shows that with only $17$ summation terms the obtained rational approximation of the complex error function provides accuracy ${10^{ - 15}}$ over the most domain of practical importance $0 \le x \le 40,000$ and ${10^{ - 4}} \le y \le {10^2}$ required for the HITRAN-based spectroscopic applications. Since the rational approximation does not contain trigonometric or exponential functions dependent upon the input parameters $x$ and $y$, it is rapid in computation. Such an example demonstrates that the considered methodology of the Fourier transform may be advantageous in practical applications.</p>

Safety management of high-speed railway transport

2017 ◽  
pp. 105-118
Author(s):  
Vladimir Shmatchenko ◽  
Pavel Plekhanov
Keyword(s):  
Life Cycle ◽  
Life Cycle Cost ◽  
High Speed ◽  
A Priori Estimates ◽  
Safety Management ◽  
Practical Importance ◽  
International Standards ◽  
Railway Transport ◽  
High Speed Railway ◽  
Safety Control

Objective: To determine the main approaches to safety management of high-speed railway transport on the basis of modern international and domestic practices in the specified sphere. Methods: Analysis methods of security risks on railway transport were considered in accordance with modern international standards of management of interconnected indices’ complex, which include reliability, availability, maintainability and safety and cost (Life Cycle Cost – LCC) at all stages of transportation systems’ life cycle: EN 50126 (IEC 62278), EN 50128 (IEC 62279), EN 50129 (IEC 62425) and IEC 60300-3-3. Results: The main approaches to safety measures of high-speed railway lines (VSM) were detected. The former involve using a lifecycle concept of engineering systems and facilities, management methodology of RAMS/LCC interconnected indices’ complex at all stages of a life cycle, wide application of the process approach and the tools of quality and safety management systems, development and implementation of technological maturity assessment methodology for security management activities, as well as object-oriented and coherent improvement of regulatory base, the systems of administrative and control and permission authorities, technical and technological development, management of external, inland and allocated risks under market relations. Practical importance: The examined approaches of VSM safety control make it possible to obtain a priori estimates of safety control processes and thus determine the achieved level of safety together with the levels of technological maturity of railway organizations’ processes.

A new approach to determine development model parameters by employing the isotropy of the development process

2017 ◽  
Vol 176 ◽  
pp. 79-83 ◽  
Author(s):  
C. Kaspar ◽  
J. Butschke ◽  
M. Irmscher ◽  
S. Martens ◽  
J.N. Burghartz
Keyword(s):  
Development Process ◽  
Development Model ◽  
Model Parameters ◽  
New Approach
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