scholarly journals Genetic and environment factors of mental disorders: Twin studies about Alzheimer’s disease, Phobia and Autism Spectrum Disorder

2021 ◽  
Vol 292 ◽  
pp. 03062
Author(s):  
Siyang Wei ◽  
Zilan Xin ◽  
Yuankai Zhang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autism Spectrum Disorder ◽  
Mental Disorders ◽  
Twin Studies ◽  
Autism Spectrum ◽  
The Body ◽  
Spectrum Disorder ◽  
Environmental Contribution ◽  
Nerve System

With the natural and social environment changing, people’s mental health is facing severe challenges. Many people are suffering from mental disorders in the present day. A large part of mental disorders can be linked with the nerve system. And nerve system disorders tend to be associated with the development of nerve systems. The gene and the environment can play an important role in the development of the body, and abnormal genes and detrimental environmental factors can contribute a lot to nerve system disorders. Previous research has studied the occurrence and gene-and-environmental impact of many nerve system disorders. Among them, this essay chooses three kinds of disorders: Alzheimer’s disease (AD), Phobia, and Autism Spectrum Disorder, which can cause a lot of trouble in people’s daily life. In this essay, we are to study the occurrence of some nerve systems’ disorders and hope to study the genetic and environmental contribution of these disorders. These three disorders gain a lot of attention as they are very common, and they can partly reflect the contribution of genes and the environment.

scholarly journals Disease prediction using graph convolutional networks: Application to Autism Spectrum Disorder and Alzheimer’s disease

2018 ◽  
Vol 48 ◽  
pp. 117-130 ◽  
Author(s):  
Sarah Parisot ◽  
Sofia Ira Ktena ◽  
Enzo Ferrante ◽  
Matthew Lee ◽  
Ricardo Guerrero ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Disease Prediction ◽  
Convolutional Networks

Age at death and comorbidity of dementia-related disorders among individuals with autism spectrum disorder

2019 ◽  
Vol 5 (4) ◽  
pp. 293-302 ◽  
Author(s):  
Lucy Barnard-Brak ◽  
David Richman ◽  
Zhanxia Yang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autism Spectrum Disorder ◽  
General Population ◽  
Vital Statistics ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Age At Death ◽  
Geriatric Population ◽  
Content Type

Purpose Autism spectrum disorder (ASD) is a lifelong disorder that requires intervention and support services for a growing geriatric population. The purpose of this paper is to examine the mean age at death of individuals with ASD and subsequent comorbidity with Alzheimer’s disease, and any form of dementia, as a whole and according to sex. Design/methodology/approach Data consisted of 1,754 individuals who had an ASD listed as one of the causes of deaths from the National Vital Statistics System with data from 1999 to 2015. In the current study, the authors present contradictory results with a mean age at death for individuals with ASD was 68 years by adjusting for changing prevalence rates. Findings Females with ASD had a higher mean age at death than males with ASD; consistent with the trend in the sex differences in the general population. The results of the current study also indicate that individuals with ASD were, in fact, less likely than the general population to have Alzheimer’s disease or a form of dementia. However, males with ASD were significantly more likely to have acquired Alzheimer’s disease or a form of dementia as compared to females with ASD. Originality/value Guan and Li (2017) reported a mean age at death of 36 years old for individuals with ASD, which was subsequently reported in the mass media, most notably CNN. The authors contend that this study provides a more accurate estimate mean age at death.

scholarly journals Genetic and environmental factors of schizophrenia and autism spectrum disorder: insights from twin studies

2020 ◽  
Vol 127 (11) ◽  
pp. 1501-1515 ◽  
Author(s):  
Akira Imamura ◽  
Yoshiro Morimoto ◽  
Shinji Ono ◽  
Naohiro Kurotaki ◽  
Shinji Kanegae ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Environmental Factors ◽  
Psychiatric Disorders ◽  
Twin Studies ◽  
Autism Spectrum ◽  
The Body ◽  
Spectrum Disorder ◽  
Tissue Type ◽  
Epigenetic Changes ◽  
Genetic And Environmental Factors

Abstract Twin studies of psychiatric disorders such as schizophrenia and autism spectrum disorder have employed epidemiological approaches that determine heritability by comparing the concordance rate between monozygotic twins (MZs) and dizygotic twins. The basis for these studies is that MZs share 100% of their genetic information. Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel their possible causes. Although recent advances in next-generation sequencing have increased the accuracy of this line of research, there has been greater emphasis placed on epigenetic changes versus DNA sequence changes as the probable cause of discordant psychiatric disorders in MZs. Since the epigenetic status differs in each tissue type, in addition to the DNA from the peripheral blood, studies using DNA from nerve cells induced from postmortem brains or induced pluripotent stem cells are being carried out. Although it was originally thought that epigenetic changes occurred as a result of environmental factors, and thus were not transmittable, it is now known that such changes might possibly be transmitted between generations. Therefore, the potential possible effects of intestinal flora inside the body are currently being investigated as a cause of discordance in MZs. As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions.

Proteins Commonly Linked to Autism Spectrum Disorder and Alzheimer's Disease

2018 ◽  
Vol 19 (9) ◽  
pp. 876-880 ◽  
Author(s):  
Athanasios Alexiou ◽  
Georgia Soursou ◽  
Nagendra Sastry Yarla ◽  
Ghulam Md Ashraf
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder
Sign in / Sign up

Export Citation Format

Share Document