Natural Product Chemistry Research in Iraq

Today's west an east scientists developed synthetic drugs but because of problems of the side effects and high cost in addition to resistant developed which not happened in using natural drugs this push the scientist in all over the world to look for new drugs from natural compounds. In Iraq. Since 1980 up today we started a plan led by scientist in Chemistry ,Pharmacology, Physician ,Biology in all universities & medical research centers and we started to develop anew methods for extraction ,isolation,identication of active constituent and trying the active constituent biologicaly and Pharmacologicaly in invitro and invivo on experimental animals . We started screening of more than thousand plants which indigenous in Iraq and take the knowledge from folkloric physician and old information about these from ancient books and references we found around two hundred promising plants we developed methods of extraction , isolation using chromatography and trying to evaluate their efficacy .We managed to prepare drugs to treat warts from ficus caria vitexin from cratagus azorolus, prosoptatin anew antihyperlipidemic drug from prosopis farcta etc. A new method of isolation and identification by new phytochemical methods and new experimental tool for each active constituent are as example how to separate alkaloids, cardiac glycosides inotropic agents , polyphenoles etc. In addition to bacteriological ,toxi-pathological methods then pass to prepare anew natural drugs prepared with highly sophisticated methods and with highly efficiency which may be better than synthetic drugs and more safe .

Unraveling the Low Frequency Triggered Electromagnetic Signatures in Potentized Homeopathic Medicine

In the present work, a novel experimental tool was developed to precisely measure the potency levels in various homeopathic medicines, under various excitation frequencies. Electromagnetic responses (output voltages) are detected from the homeopathic medicines in different potencies. These unique electromagnetic responses were captured using an electromagnetic coil at 300 Hz and 4.8 kHz for each potency level developed in-house. Different potencies of Homeopathic medicine Ferrum Metallicum (FM-1X to FM-6X), prepared with α‑lactose monohydrate as its base, exhibited significant and distinct electromagnetic signals. At high excitation frequency, the output signal voltage from high homeopathic potencies had a better resolution compared to the signal obtained at lower frequency. The electromagnetic signal of various homeopathic medicines was also measured, and a distinct output voltage corresponding to each potency level was detected. Our experimental results confirmed that each homeopathic medicine has characteristic electromagnetic signals under excitation/resonance frequency. The results not only provide scientific evidence to easily classify the homeopathic medicine potency but, also helps to understand the science behind the curative action in terms of photon emission of homeopathic medicines.

Just a Hunch: Reading, Writing, ... and Architecture

<p>Victor Hugo’s character, Claude Frollo, expressed Hugo’s linguistic analogy for architecture in his novel of 1831, Notre-Dame de Paris. Frollo directs the eyes of his companions from the book resting on his desk to the shadow of the nearby Notre-Dame cathedral, stating: ‘This will kill that’. Hugo expressed the belief that prior to the printing press, the communication of mankind occurred through architecture. His concern was for the fate of architecture following the invention of a new form of communication; the printed text. This thesis questions the concern that print will ‘kill’ architecture through an exploration of architectural research and design led by text. A validity of print as an experimental tool for architectural design is established through a range of output; visual and physical expression, creative writing, and formal writing. These design modes reveal unique architecture from within Hugo’s Notre-Dame de Paris. The outcomes of this research draw attention to the imaginative possibilities that text provides for architecture. It finds that architecture exists within text and allows for interpretation and conversion, into both real and imagined space. It provides a framework through which this can occur within other text, not just Notre-Dame de Paris. The conclusion is reached that text is a design tool which offers significant opportunities to the experimentation and design of architecture.</p>

Just a Hunch: Reading, Writing, ... and Architecture

<p>Victor Hugo’s character, Claude Frollo, expressed Hugo’s linguistic analogy for architecture in his novel of 1831, Notre-Dame de Paris. Frollo directs the eyes of his companions from the book resting on his desk to the shadow of the nearby Notre-Dame cathedral, stating: ‘This will kill that’. Hugo expressed the belief that prior to the printing press, the communication of mankind occurred through architecture. His concern was for the fate of architecture following the invention of a new form of communication; the printed text. This thesis questions the concern that print will ‘kill’ architecture through an exploration of architectural research and design led by text. A validity of print as an experimental tool for architectural design is established through a range of output; visual and physical expression, creative writing, and formal writing. These design modes reveal unique architecture from within Hugo’s Notre-Dame de Paris. The outcomes of this research draw attention to the imaginative possibilities that text provides for architecture. It finds that architecture exists within text and allows for interpretation and conversion, into both real and imagined space. It provides a framework through which this can occur within other text, not just Notre-Dame de Paris. The conclusion is reached that text is a design tool which offers significant opportunities to the experimentation and design of architecture.</p>

Enhancing conceptual understanding via Diffraction Grating Innovative Media (DIAGRAM)

Diffraction grating innovative media (DIAGRAM) is a physics experimental tool that can be implemented in the learning of diffraction grating material. This research endeavored to analyse students’ conceptual understanding on diffraction grating material after using the diffraction grating innovative media (DIAGRAM). Pre-experimental design was used as the method in this research with one-group pretest-posttest as the design and 10 female students and 1 male students from three schools in Indonesia which are in Banjaran, Pamarayan and Makassar participated. Starting from interpretation test using multiple choices test consisting of 8 questions and using google form, the stage then carried out learning activity utilizing the DIAGRAM and given a posttest in the end of the class. At the last data had been analysed by N-Gain. The come about of this consider were gotten by students’ increment in high category which is 0,73. To sum up, diffraction grating innovative media (DIAGRAM) can make enhancement of senior high school students’ conceptual understanding in diffraction grating material.

Intrinsic motivation for singing in songbirds is enhanced by temporary singing suppression and regulated by dopamine

Behaviors driven by intrinsic motivation are critical for development and optimization of physical and brain functions, but their underlying mechanisms are not well studied due to the complexity and autonomy of the behavior. Songbirds, such as zebra finches, offer a unique opportunity to study neural substrates of intrinsic motivation because they spontaneously produce many renditions of songs with highly-quantifiable structure for vocal practice, even in the absence of apparent recipients (“undirected singing”). Neural substrates underlying intrinsic motivation for undirected singing are still poorly understood partly because singing motivation cannot be easily manipulated due to its autonomy. Also, undirected singing itself acts as an internal reward, which could increase singing motivation, leading to difficulty in measuring singing motivation independent of singing-associated reward. Here, we report a simple procedure to easily manipulate and quantify intrinsic motivation for undirected singing independent of singing-associated reward. We demonstrate that intrinsic motivation for undirected singing is dramatically enhanced by temporary suppression of singing behavior and the degree of enhancement depends on the duration of suppression. Moreover, by examining latencies to the first song following singing suppression as a measure of singing motivation independent of singing-associated reward, we demonstrate that intrinsic singing motivation is critically regulated by dopamine through D2 receptors. These results provide a simple experimental tool to manipulate and measure the intrinsic motivation for undirected singing and illustrate the importance of zebra finches as a model system to study the neural basis of intrinsically-motivated behaviors.

Development of Arduino-Based Electrical Practicum e-Module

The development of IoT-based innovative learning media to improve student competence is needed in the era of industrial revolution 4.0. This study aims to develop an electrical practicum e-module using the Arduino Uno experimental tool to get valid, practical, and effective criteria. The research method uses R&D with four D models. The development stage consists of the stages of defining, designing, developing, and limited dissemination. Data analysis used descriptive analysis with Aiken V. The results showed that the e-module get the criteria of high validity with index V = 0.87. 60% of the total number of students responded positively to the media, and 40% were very active when using the media, so the modules developed were considered practical. The effectiveness level of the module shows that 100% of the students get a higher learning outcome value than the learning completeness score, so it can be concluded that the e-module has met the effective criteria.

History of the Concept of Similarity in Natural Sciences

The concept of similarity has been discussed by many scientists and philosophers since ancient times. Thales of Miletus, Euclid, Aristotle, Galileo, Newton, Edgar Buckingham, and the modern philosopher of science Susan G. Sterrett are examples of intellectuals who perceived and examined the concept of similarity, while many scientists incorporated it in their scientific methodology. The wide range and variety of definitions of similarity could result in confusion regarding the meaning of the concept, the role the similarity mechanism plays in scientific methodology, and the identification of scientific fields to which similarity could be applied. The main aim of this paper was to enhance the understanding of the notion of similarity. To this end, we examined the historical evolution of the concept of similarity and the utilization of the mechanism of similarity in various eras of human intellectual activity, ranging from antiquity to the present day. In this context, the research hypothesis we investigated was the existence of specific and distinct stages of evolution within the long history of the concept of similarity in parallel with the evolution of scientific thought. A core question that motivated our work was when and under which conditions did the transition from the “technocratic” utilization of similarity (i.e., the use of similarity as a solution for practical problems) to its theoretical documentation and its conscious and systematic use as a significant experimental tool occurred. Another important question examined was whether there was a certain era that favored the development of the concept of similarity more than other historical periods. In order to address this hypothesis and respond to these questions, we sought to trace the evolution of conceptualizing and using similarity in different spatial and temporal contexts, formed by the corresponding historical, institutional, religious, and social conditions as well as the characteristics of the scientific methodology established during the period the similarity concept evolved.

Built Environment Characteristics, Daily Travel, and Biometric Readings: Creation of an Experimental Tool Based on a Smartwatch Platform

Travel surveys can uncover information regarding travel behaviour, needs, and more. Collected information is utilised to make choices when reorganising or planning built environments. Over the years, methods for conducting travel surveys have changed from interviews and forms to automated travel diaries in order to monitor trips made by travellers. With the fast progression of technological advancements, new possibilities for operationalising such travel diaries can be implemented, changing from utilising mobile to wearable devices. Wearable devices are often equipped with sensors which collect continuous biometric data from sources that are not reachable from standard mobile devices. Data collected through wearable devices range from heart rate and blood pressure to temperature and perspiration. This advancement opens new possible layers of information in the collection of travel data. Such biometric data can be used to derive psychophysiological conditions related to cognitive load, which can uncover in-depth knowledge regarding stress and emotions. This paper aims to explore the possibilities of data analysis on the data collected through a software combining travel survey data, such as position and time, with heartrate, to gain knowledge of the implications of such data. The knowledge about the implications of spatial configurations can be used to create more accessible environments.

The goldfish Carassius auratus: an emerging animal model for comparative cardiac research

The use of unconventional model organisms is significantly increasing in different fields of research, widely contributing to advance life sciences understanding. Among fishes, the cyprinid Carassius auratus (goldfish) is largely used for studies on comparative and evolutionary endocrinology, neurobiology, adaptive and conservation physiology, as well as for translational research aimed to explore mechanisms that may be useful in an applicative biomedical context. More recently, the research possibilities offered by the goldfish are further expanded to cardiac studies. A growing literature is available to illustrate the complex networks involved in the modulation of the goldfish cardiac performance, also in relation to the influence of environmental signals. However, an overview on the existing current knowledge is not yet available. By discussing the mechanisms that in C. auratus finely regulate the cardiac function under basal conditions and under environmental challenges, this review highlights the remarkable flexibility of the goldfish heart in relation not only to the basic morpho-functional design and complex neuro-humoral traits, but also to its extraordinary biochemical-metabolic plasticity and its adaptive potential. The purpose of this review is also to emphasize the power of the heart of C. auratus as an experimental tool useful to investigate mechanisms that could be difficult to explore using more conventional animal models and complex cardiac designs.