Development of a GUI for automating quality control of dose calibrators using Python

Quality control of dose calibrators is essential to evaluate the accuracy of the instrument response. In this work, a GUI (Graphical User Interface) has been developed to facilitate performing and recording quality control tests of dose calibrators. The interface is capable to automate several tests which include routine checks, accuracy test, linearity test, reproducibility test, repeatability test, concordance MBq/mCi test, and geometry test. In principle, the program computes correction factors that should be applied to minimize the uncertainty of measurements and the determining factors for success or failure of each test, then visualizes the results as tables and curves into a pdf file. Therefore, this interface can be considered as an efficient tool for performing quality control tests of dose calibrators thought it is still unable to offer the correction factors for the geometry test without experiment which will be achieved by integrating Monte Carlo simulation into the GUI.

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Experience with Certified Reference Material Proficiency Testing for Quality Control of Wheat

Journal of Near Infrared Spectroscopy ◽

10.1255/jnirs.166 ◽

1998 ◽

Vol 6 (A) ◽

pp. A53-A61

Author(s):

Judit Budai ◽

Judit Fükó

Keyword(s):

Quality Control ◽

Reference Material ◽

Proficiency Testing ◽

Reference Materials ◽

Certified Reference Material ◽

Certified Reference Materials ◽

Long Term Stability ◽

Determining Factors ◽

Chemical Section

The Chemical Section of OMH1,2 embarked on the preparation of a series of wheat samples as Certified Reference Materials (CRMs) in 1992. The certification processes were carried out according to the recommendations of ISO. Since then we have developed a series of flour samples as well. The investigations of the long-term stability and the application of wheat and flour CRMs are continuous. Wheat is one of the most widely grown crops in Hungary and it is one of the major determining factors of the economy. Its uniform and objective qualification is of great importance. There are well-equipped laboratories available with sufficient experience but, as the proficiency testing regularly showed, certified samples need to be used to achieve exact and uniform measuring results.

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SILVER: an efficient tool for stable isotope labeling LC-MS data quantitative analysis with quality control methods

Bioinformatics ◽

10.1093/bioinformatics/btt726 ◽

2013 ◽

Vol 30 (4) ◽

pp. 586-587 ◽

Cited By ~ 18

Author(s):

Cheng Chang ◽

Jiyang Zhang ◽

Mingfei Han ◽

Jie Ma ◽

Wei Zhang ◽

...

Keyword(s):

Quality Control ◽

Quantitative Analysis ◽

Stable Isotope ◽

Isotope Labeling ◽

Stable Isotope Labeling ◽

Control Methods ◽

Efficient Tool

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Design of quality-control specimens for use with a small multi-channel analyzer.

Clinical Chemistry ◽

10.1093/clinchem/23.11.2011 ◽

1977 ◽

Vol 23 (11) ◽

pp. 2011-2023 ◽

Cited By ~ 1

Author(s):

T E Caragher ◽

G F Grannis

Keyword(s):

Quality Control ◽

Performance Evaluation ◽

Linear Relationships ◽

Instrument Response ◽

Individual Specimen ◽

Channel Analyzer

Abstract Specimens having linear relationships between concentration and instrument response for seven analytes were prepared for use with a small multi-channel analyzer. The specimens had inter-specimen and inter-constituent relationships that facilitated the performance evaluation of all channels simultaneously with each individual specimen. Techniques are described for use of the specimens in various aspects of quality control.

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The factory diagnosis diagram: An efficient tool for quality control

Metal Finishing ◽

10.1016/s0026-0576(08)80260-7 ◽

2008 ◽

Vol 106 (7-8) ◽

pp. 56-62

Author(s):

Dieter Dengel ◽

Helmut Fischer ◽

Hans-Peter Vollmar

Keyword(s):

Quality Control ◽

Efficient Tool

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Constancy tests and quality assurance of the activimeters used in a Radiopharmaceutical Production Unit

Brazilian Journal of Radiation Sciences ◽

10.15392/bjrs.v7i2a.588 ◽

2019 ◽

Vol 7 (2A) ◽

Author(s):

Rodrigo Modesto Gadelha Gontijo ◽

Andréa Vidal Ferreira ◽

Leonardo Tafas Constantino Nascimento ◽

Flávia Mesquita Costa ◽

Juliana Batista Silva ◽

...

Keyword(s):

Quality Control ◽

Quality Assurance ◽

Entire Range ◽

Quality Assurance Program ◽

Dose Administration ◽

Accuracy And Precision ◽

Background Check ◽

Linearity Test ◽

Brazilian Standard ◽

Equipment Performance

Activimeters (or dose calibrators) are essential instruments to verify activity of radiopharmaceutical after production and also before the dose administration in humans or animals for molecular imaging. The efficiency and safety measurements depend on, beside other factors, constancy tests and quality assurance. Thereby, the aim of this work was to perform constancy tests and quality assurance in the activimeters of the UPPR/CDTN, based on the CNEN-NN 3.05 Brazilian standard and the manufacturer's manual. Physical inspection, auto zero, background check, camera voltage, data check and constancy test were done. In addition, accuracy and precision tests were performed using a set of standard certified radioactive sources (57Co, 133Ba and 137Cs), according to the CNEN NN 3.05 Brazilian standard. Linearity test was also performed to evaluate the response of the equipment in over the entire range of activities used in routine. The equipments are periodically submitted to the quality control tests and the results were compared. After performing the proposed tests it is possible to conclude that activimeters are in accordance with the requirements of the CNEN standard and manufacturer´s manual. A quality control checklist was prepared to guide users and to record the results of quality assurance testing to monitor the equipment performance. This initiative is part of the quality assurance program implemented at UPPR.

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RISKS IN QUALITY CONTROL OF SERIALLY PRODUCED PRODUCTS

Kontrol Diagnostika ◽

10.14489/td.2021.03.pp.060-064 ◽

2021 ◽

pp. 60-64 ◽

Cited By ~ 1

Author(s):

S. B. Danilevich ◽

V. V. Tretyak

Keyword(s):

Quality Control ◽

Measurement Accuracy ◽

Batch Size ◽

Control Methods ◽

Confidence Limits ◽

Number Of Factors ◽

The Monte Carlo Method ◽

Accuracy Of Measurements ◽

Uncertainty Of Measurements ◽

Risks Assessment

Product quality control methods must be effective, that is, ensure minimal risks of making erroneous decisions during control. Uncertainty of measurements during control and other factors lead to errors of the 1-st kind (a good product is rejected) or 2-nd kind (the wrong one is mistakenly accepted). The indicators of the quality control of mass-produced products are the risks of the customer and the manufacturer. The accuracy of these risks assessment depends on a number of factors, including the batch size. When developing and certifying control methods, it is proposed to use the upper confidence limits of the indicated risks. It was proposed to find these confidence limits and requirements for the measurement accuracy during control by the Monte Carlo method (simulation). The article discusses examples of determining the reliability of control depending on the accuracy of measurements, taking into account the volume of the batch of products.

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The linearity of x-ray devices radiation output and its relationship with patient thickness

International Journal of Physical Sciences and Engineering ◽

10.29332/ijpse.v3n3.351 ◽

2019 ◽

Vol 3 (3) ◽

pp. 1-6

Author(s):

I Gusti Agung Ayu Ratnawati ◽

Ni Komang Tri Suandayani ◽

Gusti Ngurah Sutapa

Keyword(s):

Quality Control ◽

The Body ◽

X Rays ◽

Radiation Technology ◽

X Ray ◽

Living Things ◽

Radiation Output ◽

Radiation Dose Exposure ◽

The Impact ◽

Linearity Test

Utilization of X-rays in the medical field is one way to improve public health. X-rays are one of the applications of radiation for radio diagnostics. X-ray examination using X-rays can provide information about the human body without the need for surgery. In the use of radiation technology it is realized that in addition to its use for radio diagnostics, X-rays harm the environment and living things around them, especially radiation workers. The impact that can result in cancer due to the accumulation of radiation dose exposure received by the body exceeds the specified threshold dose. Therefore safety standard guidelines that contain basic requirements for quality control (Quality Control -QC) must be obeyed. One of the test activities included in the QC program is the linearity test of X-ray radiation output.

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Pengujian Akurasi kVp dan Linearitas pada Pesawat Sinar-X di Laboratorium Prodi Diploma III Teknik Radiodiagnostik dan Radioterapi Purwokerto

Jurnal Imejing Diagnostik (JImeD) ◽

10.31983/jimed.v2i2.3179 ◽

2016 ◽

Vol 2 (2) ◽

pp. 172-174

Author(s):

Asri Indah Aryani ◽

Indra Kartika Nugroho ◽

Panji Wibowo Nurcahyo

Keyword(s):

Quality Control ◽

Test Performance ◽

Quantitative Research ◽

Quality Assurance Program ◽

Control Panel ◽

International Unit ◽

Allowable Limit ◽

X Ray ◽

Two Stages ◽

Linearity Test

Background: Quality control is part of the quality assurance program related to the techniques used in the monitoring the maintenance of the technical elements of the system that affect picture quality. KVp accuracy and linearity (test mAs) is one of the components which are tested on the routine test performance evaluations. The X-ray Biomedical International unit brands BRG 100 RF of Laboratory Diploma in Mechanical Radiodiagnostic and Radiotherapy Purwokerto have not been tested yet. The objectives of this study are to determine suitability output kVp accuracy and linearity that have been beeing setting at control panel X-ray unit.Methods: This research belongs to a quantitative research which was conducted in April 2016 at the Laboratory of Radiodiagnostic Diploma Engineering and Radiotherapy Purwokerto on X-ray Biomedical International unit brands BRG 100 RF. The tests carried out two stages of testing. They were the accuracy of kVp with MPD (Multi-purpose detector) tool at kVp 50, 60, 70, 80, 9 and testing linearity method using Stepwedge and Reciprocity mAs Densitometer at 55 kVp, 10 mAs with a variation of 200 mA and 100. The results was analysed based on the quality control examining contained in KMK RI No.1250, the value of deviation accuracy of kVp 6% and for linearity deviation value (mAs) ≤ ± 0.1.Result: The test results showed that there are some deviations occur repeatedly on the accuracy of kVp on the value of eksposi 50, 60, 70, 80, 90, are 0.78%, 1.31%, 1.32%, 1.63%, 2.5%, but the deviation is still within the allowable limits that does not exceed 10%. The linearity testing showes that there are differences in optical density values on the radiograph with variations mA and s which are still within the allowable limit that is ≤ ± 0.1.Conclusion: Based on the result of kVp accuracy and linearity test, the deviation value is still within the tolerance limit or still in accordance with the permissible tolerance according to KMK RI 1250 about quality control testing parameter

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