GFR, Body Mass Index, and Low High-Density Lipoprotein Concentration in Adults With and Without CKD

2007 ◽  
Vol 50 (4) ◽  
pp. 552-558 ◽  
Author(s):  
Joan C. Lo ◽  
Alan S. Go ◽  
Malini Chandra ◽  
Dongjie Fan ◽  
George A. Kaysen
e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Pradika H. Koampa ◽  
Karel Pandelaki ◽  
Marthen C.P. Wongkar

Abstract: Body Mass Index (BMI) is a measurement of nutritional status by calculating the ratio of height and weight. Type 2 Diabetes Mellitus (T2DM) is more common in a person with a BMI of more than normal. In patients with T2DM, there is lipid metabolism disorder, dyslipidaemia. Changes in lipid profiles consist of increased levels of total cholesterol, Low Density Lipoprotein (LDL), and triglycerides, and decreased levels of High Density Lipoprotein (HDL). This study aimed to obtain the correlation between body mass index and lipid profile in T2DM patients in Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study using patients’ medical record in Endocrine Clinic Prof. Dr. R. D. Kandou Hospital Manado from September to November 2015. The Pearson correlation test showed correlations between BMI and total cholesterol levels with r=0.037and p=0.763; between BMI and HDL levels with r=-0.249 and p=0.039; between BMI and LDL levels with r=0.091 and p=0,455; and between BMI and triglyceride levels with r=0.179 and p=0.142. Conclusion: Among T2DM patients, there were no significant correlations between body mass index and total cholesterol, LDL cholesterol, as wello as triglyceride levels. However, there was a significant correlation between body mass index and HDL levels. Keywords: body mass index, total cholesterol, HDL, LDL, triglycerides, T2DM Abstrak: Indeks Massa Tubuh (IMT) merupakan salah satu pengukuran status gizi dengan menghitung perbandingan tinggi badan dan berat badan. Diabetes Melitus Tipe 2 (DMT2) lebih sering terjadi pada individu dengan IMT lebih dari normal. Pada pasien DMT2 terjadi gangguan metabolisme lipid yaitu dislipidemia. Perubahan profil lipid yang terjadi yaitu peningkatan kadar Kolesterol Total, Low Density Lipoprotein (LDL), dan trigliserida, serta penurunan kadar High Density Lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dengan profil lipid pada pasien DMT2di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. Dr. R. D. Kandou Manado periode September – November 2015. Hasil uji korelasi Pearson memperlihatkan nilai hubungan antara IMT dan kadar kolesterol total r = 0,037 dan p = 0,763 ; nilai hubungan antara IMT dan kadar HDL r = -0,249 dan p = 0,039 ; nilai hubungan antara IMT dan kadar LDL r = 0,091 dan p = 0,455; serta nilai hubungan antara IMT dan kadar trigliserida r = 0,179 dan p = 0,142. Simpulan: Pada pasien DMT2 tidak dijumpai hubungan bermakna antara IMT dengan kadar kolesterol total, kadar LDL, dan kadar trigliserida, namun terdapat hubungan bermakna antara IMT dengan kadar HDL.Kata kunci: IMT, kolesterol total, HDL, LDL, trigliserida, DMT2


2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Rizky R. Syahrullah ◽  
Youla Assa ◽  
Murniati Tiho

Abstract: High density lipoprotein (HDL) is a lipoprotein containing apo A-1, associated with other apolipoproteins. One of the HDL functions is as the reversed transporter of cholesterol in order to reduce cholesterol level in peripheral tissues. Low HDL cholesterol level is often related to obesity. High cholesterol level, obesity, and low HDL level are known as risk factors of coronary heart diseases. Overweight subjects have higher probabality for suffering from heart diseases and stroke. This study aimed to elaborate high density lipoprotein (HDL) levels in males aged 40-59 years with body mass index higher than 23 kg/m2. This study used consecutive sampling method. Total subjects involved in this study were 20 males who lived in Malalayang. The results showed that there were 11 subjects with normal HDL levels and nine subjects (45%) with low HDL levels (<45 mg/dL). No subjects had high HDL level. Nineteen subjects (95%) were classified as obesity and only one subject (5%) as overweight. Conclusion: Most of the males 40-59 aged with body mass index ≥23 kg/m2 who lived in Malalayang Manado has normal HDL level. Keywords: males, high density lipoprotein, body mass index Abstrak: High density lipoprotein (HDL) ialah lipoprotein yang mengandung apoA-I, disamping apolipoprotein lainnya. Salah satu fungsi HDL ialah transpor balik kolesterol untuk menurunkan kadar kolesterol di jaringan perifer. Rendahnya kolesterol HDL sering dikaitkan dengan obesitas. Tingginya kolesterol, obesitas, dan rendahnya kadar HDL merupakan faktor risiko penyakit jantung koroner. Individu dengan berat badan berlebihan berpeluang lebih besar untuk terkena penyakit jantung dan stroke. Penelitian ini bertujuan untuk mengetahui gambaran kadar high density lipoprotein (HDL) pada laki-laki berusia 40-59 tahun dengan indeks massa tubuh ≥23 kg/m2. Metode penelitian yang digunakan ialah consecutive sampling. Subyek penelitian berjumlah 20 orang laki-laki yang berdomisili di Kecamatan Malalayang Manado. Hasil penelitian memperlihatkan 11 subyek (55%) dengan kadar HDL normal, sembilan subyek (45%) dengan kadar HDL rendah (<45 mg/dL); dan tidak ada (0%) yang memiliki kadar HDL tinggi (>60 mg/dL). Terdapat 19 subjek (95%) dengan obesitas dan hanya satu subjek (5%) yang mengalami overweight. Simpulan: Sebagian besar laki-laki berusia 40-59 tahun yang berdomisili di Kecamatan Malalayang Manado dengan indeks massa tubuh ≥23 kg/m2 mempunyai kadar HDL normal. Kata kunci: laki-laki, high density lipoprotein, indeks massa tubuh


Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Zefeng Zhang ◽  
Cathleen Gillespie ◽  
Frank Hu ◽  
Quanhe Yang

Background: Studies suggest that higher consumption of added sugar is associated with cardiovascular risk factors in adolescents. However, these studies were subject to measurement error due to the lack of adjustment for day-to-day variability. Hypothesis: We hypothesized that higher usual percent of calories from added sugar is associated with dyslipidemia. Methods: We analyzed data on 3322 adolescents aged 12-19 years who were not on low fat/low cholesterol diet or on sugar free/low sugar diet from the 2005-2010 National Health and Nutrition Examination Surveys. We estimated the usual percent of calories from added sugar from the diet accounting for measurement error. Multivariable linear regression was used to examine the associations between the percent of calories from added sugar with lipids profile. Results: The average usual percent of calories from added sugar was 17.5%. Ninety-one percent and 11% adolescents had usual percent ≥10% and ≥25%, respectively. After adjustment for potential confounders (age, sex, race/ethnicity, body mass index, parental educational attainment, smoking status, physical activity, 2010 Health Eating Index score except sugar component, and total calorie intake), usual percent of calories from added sugar was inversely associated with high-density lipoprotein and positively associated with triglycerides and the ratio of total cholesterol to high-density lipoprotein. Among the lowest and the highest quintiles of intake, high-density lipoprotein were 52.4 mg/dL (95% CI: 50.9 to 53.9) and 49.0 (95% CI: 47.9 to 50.2) (P trend = 0.003), triglycerides were 80.2 mg/dL (95% CI: 70.5 to 90.0) and 100.4 mg/dL (95% CI: 86.7 to 114.2) (P trend = 0.028), and the ratio of total cholesterol to high-density lipoprotein were 3.16 (95% CI: 2.8 to 3.6) and 3.49 (95% CI: 3.0 to 4.0) (P trend =0.006), respectively. The patterns of association were largely consistent across gender, race/ethnicity, and body mass index (normal vs. overweight/obese) subgroups, except in non-Hispanic black and Mexican American, in which the magnitude of the association tended to be smaller. Sensitivity analysis showed that, when intake data from the 1 st 24-hour dietary recall was used, the association remained significant but attenuated substantially. No association was found for total cholesterol and low-density lipoprotein. Conclusions: Overwhelming majority of US adolescents consumed more added sugar than recommended for heart health. Increased intake of added sugar is associated with several measures of dyslipidemia, and reduction of added sugar consumption among adolescents might reduce the risk of developing cardiovascular disease in adults.


2013 ◽  
Vol 1 (3) ◽  
Author(s):  
Yessica Octavia Sinaga ◽  
Murniati Tiho ◽  
Yanti M. Mewo

Abstract: Obesity or overweight has become a epidemic disease that threatening the world and is a secondary factor of coronary heart disease. Women with more than 30% of body fat and men with more than 25% of body fat are considered obese. Low levels of High Density Lipoprotein (HDL) are one of risk factors for atherosclerosis. The objective of this research is to obtain a picture of High Density Lipoprotein cholesterol in student of class 2011 of Faculty of Medicine, Sam Ratulangi University with Body Mass Index of > 23,0 kg/m2. This is a descriptive study with data collection using a purposive sampling technique, that is, taking samples from respondents know to have fulfilled the inclusive and exclusive criteria. The data were obtained from the examination of blood samples of every respondent and presented in the form of frequency distribution using Microsoft Excel 2007. The results of research conducted on 26 respondents show the picture of HDL cholesterol levels is that is 58% normal and 42% high.Keywords: Description of High Density Lipoprotein, Body Mass Index > 23,0 kg/m2.Abstrak: Obesitas atau kegemukan telah menjadi penyakit epidemik yang mengancam dunia dan merupakan faktor sekunder timbulnya penyakit jantung koroner (PJK). Wanita dengan lemak tubuh lebih dari 30% dan pria dengan lemak tubuh lebih dari 25% dianggap mengalami obesitas. Rendahnya kadar High Density Lipoprotein merupakan salah satu faktor resiko terjadinya aterosklerosis. Penelitian ini bertujuan untuk memperoleh gambaran kadar kolesterol High Density Lipoprotein darah pada mahasiswa angkatan 2011 Fakultas Kedokteran Universitas Sam Ratulangi dengan indeks massa tubuh > 23,0 kg/m2.Penelitian yang dilakukan bersifat deskriptif dengan teknik pengambilan data menggunakan teknik purposive, yaitu dengan mengambil sampel pada responden yang telah diketahui memenuhi kriteria inklusi dan eksklusi. Data diperoleh dari hasil pemeriksaan sampel darah setiap responden dan disajikan dalam bentuk distribusi frekuensi dengan menggunakan Microsoft Excel 2007. Hasil penelitian yang dilakukan pada 26 responden didapatkan gambaran High Density Lipoprotein adalah normal sebanyak 58% dan tinggi berjumlah 42%.Kata kunci: Gambaran Kadar Kolesterol High Density Lipoprotein, Indeks Massa Tubuh > 23,0 kg/m2.


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