Eccentric Overload Muscle Damage is Attenuated By a Novel Angiotensin- (1-7) Treatment

2018 ◽  
Vol 39 (10) ◽  
pp. 743-748 ◽  
Author(s):  
Lenice Becker ◽  
Nádia Totou ◽  
Samara Moura ◽  
Lucas Kangussu ◽  
Ruben Millán ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Oral Formulation ◽  
Treated Group ◽  
Post Exercise ◽  
Tnf Α ◽  
Exercise Induced ◽  
Α Level ◽  
Eccentric Overload ◽  
Muscle Damage Markers ◽  
New Strategies

AbstractThe development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46±0.64 vs. placebo 3.80±0.77 cm) and 24 h after exercise (3.07±0.71 vs. 3.73±0.58 cm placebo) and higher MS at 24 h (24±12 N) and 48 h (30±15 N) vs. placebo (-8±9 N and -10±9 N). The CK for Ang-(1-7) (0.5±0.1 and 0.9±0.2 U/L) were lower at 48 and 72 h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38±2.5 pg/ml) vs. placebo (45±2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.

scholarly journals Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women

2009 ◽  
Vol 107 (3) ◽  
pp. 853-858 ◽  
Author(s):  
Christina M. Dieli-Conwright ◽  
Tanya M. Spektor ◽  
Judd C. Rice ◽  
E. Todd Schroeder
Keyword(s):  
Skeletal Muscle ◽  
Hormone Therapy ◽  
Mrna Expression ◽  
Postmenopausal Women ◽  
Muscle Damage ◽  
Exercise Bout ◽  
Control Group ◽  
Skeletal Muscle Damage ◽  
Tnf Α ◽  
Exercise Induced

Hormone therapy (HT) is a potential treatment to relieve symptoms of menopause and prevent the onset of disease such as osteoporosis in postmenopausal women. We evaluated changes in markers of exercise-induced skeletal muscle damage and inflammation [serum creatine kinase (CK), serum lactate dehydrogenase (LDH), and skeletal muscle mRNA expression of IL-6, IL-8, IL-15, and TNF-α] in postmenopausal women after a high-intensity resistance exercise bout. Fourteen postmenopausal women were divided into two groups: women not using HT (control; n = 6, 59 ± 4 yr, 63 ± 17 kg) and women using traditional HT (HT; n = 8, 59 ± 4 yr, 89 ± 24 kg). Both groups performed 10 sets of 10 maximal eccentric repetitions of single-leg extension on the Cybex dynamometer at 60°/s with 20-s rest periods between sets. Muscle biopsies of the vastus lateralis were obtained from the exercised leg at baseline and 4 h after the exercise bout. Gene expression was determined by RT-PCR for IL-6, IL-8, IL-15, and TNF-α. Blood draws were performed at baseline and 3 days after exercise to measure CK and LDH. Independent t-tests were performed to test group differences (control vs. HT). A probability level of P ≤ 0.05 was used to determine statistical significance. We observed significantly greater changes in mRNA expression of IL-6, IL-8, IL-15, and TNF-α ( P ≤ 0.01) in the control group compared with the HT group after the exercise bout. CK and LDH levels were significantly greater after exercise ( P ≤ 0.01) in the control group. Postmenopausal women not using HT experienced greater muscle damage after maximal eccentric exercise, indicating a possible protective effect of HT against exercise-induced skeletal muscle damage.

scholarly journals Sparassis crispa Intake Improves the Reduced Lipopolysaccharide-Induced TNF-α Production That Occurs upon Exhaustive Exercise in Mice

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2049 ◽  
Author(s):  
Masataka Uchida ◽  
Naoki Horii ◽  
Natsuki Hasegawa ◽  
Eri Oyanagi ◽  
Hiromi Yano ◽  
...  
Keyword(s):  
Small Intestine ◽  
Edible Mushroom ◽  
Treadmill Running ◽  
Exhaustive Exercise ◽  
Tnf Α ◽  
Normal Chow ◽  
Sparassis Crispa ◽  
Exercise Induced ◽  
Α Level ◽  
Myd88 Protein

Our previous study showed that lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production is inhibited by acute exhaustive exercise in mice, leading to transient immunodepression after exercise. Sparassis crispa (SC), an edible mushroom, has immunopotentiative properties. This study aimed to clarify the effects of SC intake on reduced LPS-induced TNF-α production upon exhaustive exercise in mice. Male C3H/HeN mice were randomly divided into three groups: normal chow intake + resting sedentary, normal chow intake + acute exhaustive treadmill running exercise, and SC intake (chow containing 5% SC powder for 8 weeks) + the exhaustive exercise groups. Each group was injected with LPS immediately after the exhaustive exercise or rest. Plasma and tissue TNF-α levels were significantly decreased by exhaustive exercise. However, this reduction of the TNF-α level was partially attenuated in the plasma and small intestine by SC intake. Although levels of TLR4 and MyD88 protein expression were significantly decreased in tissues by exhaustive exercise, the reduction of TLR4 and MyD88 levels in the small intestine was partially attenuated by SC intake. These results suggest that SC intake attenuates exhaustive exercise-induced reduction of TNF-α production via the retention of TLR4 and MyD88 expression in the small intestine.

Influence of different types of compression garments on exercise-induced muscle damage markers after a soccer match

2017 ◽  
Vol 26 (1) ◽  
pp. 27-42 ◽  
Author(s):  
Diego Marqués-Jiménez ◽  
Julio Calleja-González ◽  
Iñaki Arratibel-Imaz ◽  
Anne Delextrat ◽  
Fernando Uriarte ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Compression Garments ◽  
Soccer Match ◽  
Different Types ◽  
Exercise Induced ◽  
Muscle Damage Markers

Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage

1999 ◽  
Vol 87 (4) ◽  
pp. 1360-1367 ◽  
Author(s):  
Katsuhiko Suzuki ◽  
Manabu Totsuka ◽  
Shigeyuki Nakaji ◽  
Mutsuo Yamada ◽  
Satoru Kudoh ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Stress Hormones ◽  
Plasma Growth Hormone ◽  
Bioactive Substances ◽  
Daily Exercise ◽  
Repeated Exercise ◽  
Exercise Induced ◽  
Neutrophil Priming ◽  
Muscle Damage Markers ◽  
Experimental Challenge

We analyzed adaptation mechanisms regulating systemic inflammatory response of the stressed body by using an experimental challenge of repeated exercise bouts and accompanying muscle inflammation. Eight untrained men bicycled at 90 W for 90 min, 3 days in a row. Exercise induced peripheral neutrophilia with a leftward shift of neutrophil nucleus and neutrophil priming for oxidative activity determined by luminol-dependent chemiluminescence. Plasma growth hormone and interleukin-6 rose significantly after exercise and were closely correlated with the neutrophil responses. Serum creatine kinase and myoglobin levels as muscle damage markers rose after exercise in “delayed onset” and were closely correlated with the preceding neutrophil responses. These exercise-induced responses were strongest on day 1, but the magnitude gradually decreased with progressive daily exercise. In contrast, the magnitude of catecholamine responses to exercise sessions gradually rose, possibly suppressing neutrophil oxidative responses. These results indicate that stress-induced systemic release of bioactive substances may determine neutrophil mobilization and functional status, which then may affect local tissue damage of susceptible organs.

scholarly journals Effect of curcumin supplement or placebo in delayed onset muscle soreness: a systematic review and meta-analysis

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Natthanichar Rattanaseth ◽  
Patteera Panyarapeepat ◽  
Janisa Andrea Muljadi ◽  
Kornkit Chaijenkij ◽  
Jatupon Kongtharvonskul
Keyword(s):  
Muscle Soreness ◽  
Meta Analysis ◽  
Delayed Onset Muscle Soreness ◽  
Main Body ◽  
Level Of Evidence ◽  
Post Exercise ◽  
Multiple Strategies ◽  
Delayed Onset ◽  
Tnf Α ◽  
Exercise Induced

Abstract Background There are multiple strategies that have been suggested to attenuate delayed onset muscle soreness (DOMS). Curcumin has been shown to reduce exercise-induced oxidative stress (OS) and inflammation. However, currently, there is still controversy. Main body of the abstract We conduct this meta-analysis according to the PRISMA guidelines. Relevant studies were included from Medline and Scopus from the date of inception to May 04th, 2021 that reported VAS score, blood markers (creatinine kinese (CK), tumor necrotic factor (TNF)-α and interleukin (IL)-6) and range of motion of either group. There were total of 13 studies including 202 and 176 persons in curcumin and placebo group. The unstandardized mean difference (UMD) of VAS muscle soreness in post-exercise, 1, 2, 3 and 4 days was − 0.12 (95% CI − 0.46, 0.22), − 0.38 (− 0.83, 0.08), − 0.67 (− 1.19, − 0.16), − 0.86 (− 1.38, − 0.34), − 0.81 (− 1.27, − 036) and − 1.24 (− 1.50, − 0.99) scores lower in curcumin when compared to placebo. The UMD of CK was − 11.07 (95% CI − 24, 1.86), − 37.51 (− 68.04, − 6.97), − 45.40 (− 95.67, 4.86), − 53.33 (− 128.11, 21.45), − 90.98 (− 173.45, − 8.51) and 117.84 (− 338.69, 574.37) lower in curcumin when compared to placebo. No statistically significantly differences were noted for IL-6, TNF-α and ROM between two groups. Short conclusion This meta-analysis suggested that curcumin supplement reduced delayed onset muscle soreness and CK after exercise in 1, 2, 3, and 4 days when compared to placebo. However, TNF and IL were not affected by curcumin ingestion. Level of evidence I.

scholarly journals Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 372 ◽  
Author(s):  
María Martinez-Ferran ◽  
Fabian Sanchis-Gomar ◽  
Carl J. Lavie ◽  
Giuseppe Lippi ◽  
Helios Pareja-Galeano
Keyword(s):  
Systematic Review ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Web Of Science ◽  
Exercise Session ◽  
Post Exercise ◽  
High Doses ◽  
Exercise Induced ◽  
Cell Signaling Pathways

Free radicals produced during exercise play a role in modulating cell signaling pathways. High doses of antioxidants may hamper adaptations to exercise training. However, their benefits are unclear. This review aims to examine whether vitamin C (VitC) and/or vitamin E (VitE) supplementation (SUP) prevents exercise-induced muscle damage. The PubMed, Web of Science, Medline, CINAHL, and SPORTDiscus databases were searched, and 21 articles were included. Four studies examined the effects of acute VitC SUP given pre-exercise: in one study, lower CK levels post-exercise was observed; in three, no difference was recorded. In one study, acute VitE SUP reduced CK activity 1 h post-exercise in conditions of hypoxia. In three studies, chronic VitE SUP did not reduce CK activity after an exercise session. Chronic VitE SUP did not reduce creatine kinase (CK) concentrations after three strength training sessions, but it was effective after 6 days of endurance training in another study. Chronic SUP with VitC + E reduced CK activity post-exercise in two studies, but there was no such effect in four studies. Finally, three studies described the effects of chronic VitC + E SUP and long-term exercise, reporting dissimilar results. To conclude, although there is some evidence of a protective effect of VitC and/or VitE against exercise-induced muscle damage, the available data are not conclusive.

Effects of oral l-carnitine supplementation in racing Greyhounds

2007 ◽  
Vol 4 (3-4) ◽  
pp. 141-147 ◽  
Author(s):  
T S Epp ◽  
H H Erickson ◽  
J Woodworth ◽  
D C Poole
Keyword(s):  
Muscle Damage ◽  
Creatine Phosphokinase ◽  
The Novel ◽  
Carnitine Supplementation ◽  
Plasma Lactate ◽  
Post Exercise ◽  
Maximal Speed ◽  
Exercise Muscle ◽  
Exercise Induced ◽  
Very High

Abstractl-Carnitine supplementation can stimulate erythropoiesis, reduce exercise-induced plasma lactate concentrations and decrease post-exercise muscle damage. Next to horses, Greyhounds represent the premier animal racing species and perform short-duration, very high-intensity exercise that has the potential to incur substantial muscle damage. Under resting and standard racing conditions (5/16 mile), we tested the novel hypotheses that l-carnitine supplementation in Greyhounds would: (1) elevate haematocrit at rest and immediately post-exercise; (2) reduce peak post-exercise plasma lactate; and (3) reduce indices of muscle damage (plasma creatine phosphokinase, CPK and aspartate aminotransferase, AST). Six conditioned Greyhounds (30.1 ± 1.6 kg) underwent a randomized placebo-controlled crossover study to determine the effects of 6 weeks of l-carnitine supplementation (100 mg kg− 1 of body weight/day) at rest and following a maximal speed 5/16 mile race. In accordance with our hypotheses, l-carnitine elevated resting and immediately post-race haematocrit (control, 60.1 ± 1.7, l-carnitine, 63.6 ± 1.7; P < 0.05) and reduced peak post-race plasma CPK and AST concentrations (both P < 0.05). Those dogs with the highest peak post-exercise plasma CPK concentrations under placebo conditions evidenced the greatest reduction with l-carnitine supplementation (r = 0.99, P < 0.01). However, contrary to our hypotheses, l-carnitine did not change peak post-exercise plasma lactate concentrations (control, 27.0 ± 2.1, l-carnitine, 27.7 ± 1.3; P>0.05). We conclude that l-carnitine supplementation increases the potential for oxygen transport and reduces plasma indicators of muscle damage, CPK and AST in racing Greyhounds.

scholarly journals ProbioticBacillus coagulansGBI-30, 6086 reduces exercise-induced muscle damage and increases recovery

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2276 ◽  
Author(s):  
Ralf Jäger ◽  
Kevin A. Shields ◽  
Ryan P. Lowery ◽  
Eduardo O. De Souza ◽  
Jeremy M. Partl ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Athletic Performance ◽  
Vertical Jump ◽  
Bacillus Coagulans ◽  
Exercise Bout ◽  
Strenuous Exercise ◽  
Post Exercise ◽  
Nitrogen Levels ◽  
And Performance ◽  
Exercise Induced

Objective.Probiotics have been reported to support healthy digestive and immune function, aid in protein absorption, and decrease inflammation. Further, a trend to increase vertical jump power has been observed following co-administration of protein and probiotics in resistance-trained subjects. However, to date the potential beneficial effect of probiotics on recovery from high intensity resistance exercise have yet to be explored. Therefore, this study examined the effect of co-administration of protein and probiotics on muscle damage, recovery and performance following a damaging exercise bout.Design.Twenty nine (n= 29) recreationally-trained males (mean ± SD; 21.5 ± 2.8 years; 89.7 ± 28.2 kg; 177.4 ± 8.0 cm) were assigned to consume either 20 g of casein (PRO) or 20 g of casein plus probiotic (1 billion CFUBacillus coagulansGBI-30, 6086, PROBC) in a crossover, diet-controlled design. After two weeks of supplementation, perceptional measures, athletic performance, and muscle damage were analyzed following a damaging exercise bout.Results.The damaging exercise bout significantly increased muscle soreness, and reduced perceived recovery; however, PROBC significantly increased recovery at 24 and 72 h, and decreased soreness at 72 h post exercise in comparison to PRO. Perceptual measures were confirmed by increases in CK (PRO: +266.8%,p= 0.0002; PROBC: +137.7%,p= 0.01), with PROBC showing a trend towards reduced muscle damage (p= 0.08). The muscle-damaging exercise resulted in significantly increased muscle swelling and Blood Urea Nitrogen levels in both conditions with no difference between groups. The strenuous exercise significantly reduced athletic performance in PRO (Wingate Peak Power; PRO: (−39.8 watts, −5.3%,p= 0.03)), whereas PROBC maintained performance (+10.1 watts, +1.7%).Conclusions.The results provide evidence that probiotic supplementation in combination with protein tended to reduce indices of muscle damage, improves recovery, and maintains physical performance subsequent to damaging exercise.

Age-Related Variations of Serum CK and CK MB Response in Females

2000 ◽  
Vol 25 (6) ◽  
pp. 419-429 ◽  
Author(s):  
Mark G. Arnett ◽  
Richard Hyslop ◽  
Carolyn A. Dennehy ◽  
Carole M. Schneider
Keyword(s):  
Creatine Kinase ◽  
Key Words ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Inverse Relationship ◽  
Serum Creatine Kinase ◽  
Serum Estradiol ◽  
Post Exercise ◽  
Age Related ◽  
Exercise Induced

The objective was to determine whether serum creatine kinase (CK) and serum CK MB activity following exercise-induced muscle damage activity differs among females of varying menarchial status and to determine whether there is a relationship between serum estradiol (E2) concentration, CK, and CK MB activity. Fifteen menarchial (M), 15 premenarchial (P), and 10 postmenopausal (PM) females participated in the study. Exercise consisted of eccentric hamstring contractions. Estradiol concentrations were significantly higher in M women (p = .0001; M, 125.0 ± 20.8 pg/mL, P, 54.6 ± 38.6 pg/mL, PM, 46.2 ± 34.6 pg/mL). Menarchial women had lower resting CK and CK MB activity and responded with a higher efflux of CK and CK MB post exercise (p = .0001). An inverse relationship was found between E2 concentration and baseline CK (p = .02) and CK MB activity (p = .006). No relationship existed between post exercise efflux of CK and CK MB and E2 concentration. At rest, E2 influenced CK and CK MB activity across menarchial levels. However, E2 did not significantly reduce the level of CK and CK MB activity following this intense bout of eccentric exercise. Key words: exercise-induced muscle damage, estradiol, menarhial, premenarchial, postmenopausal

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