scholarly journals What Role Does Synovitis Play in Craniomandibular Dysfunction (CMD)? A 3T-MRI Study

2019 ◽  
Vol 191 (10) ◽  
pp. 924-931
Author(s):  
Herbert Stimmer ◽  
Lucas Ritschl ◽  
Carolin Goetz ◽  
Andreas Kolk ◽  
Benedikt Hofauer ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Signs And Symptoms ◽  
Joint Inflammation ◽  
Joint Effusion ◽  
Mri Findings ◽  
Disc Disease ◽  
Craniomandibular Dysfunction ◽  
Clinical Signs And Symptoms ◽  
Mri Study ◽  
Arthrosis Deformans

Purpose The purpose of the present study was to investigate the degree and clinical relevance of synovitis in craniomandibular dysfunction. Materials and Methods In total, 140 temporomandibular joints were examined using a 3 T MRI scanner. Quantitative analysis of synovial enhancement was performed and interrelated with arthrosis deformans, degenerative disc disease, joint effusion, bone marrow edema and restriction of motion. Results We found a statistically high and significant correlation between the degenerative changes as mentioned above and the intensity of synovial enhancement. Conclusion The study shows that typical MRI findings in CMD patients are often combined with signs of synovitis. Presumably joint inflammation has an effect on the clinical signs and symptoms and also the prognosis of CMD. These results should be taken into consideration when selecting treatment. Key Points:  Citation Format

scholarly journals Temporomandibular Joint Monoarthritis in Rheumatoid Arthritis - A Rare Case Report

2021 ◽  
Vol 48 (3) ◽  
pp. 43-45
Author(s):  
Md Abu Shahin ◽  
Sudhir Karmacharya ◽  
Md Ariful Islam ◽  
Mamun Khan ◽  
Abdulla Al Morshed ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Temporomandibular Joint ◽  
High Titer ◽  
Clinical Signs ◽  
Joint Stiffness ◽  
Signs And Symptoms ◽  
Joint Inflammation ◽  
Joint Involvement ◽  
Inflammatory Disorder ◽  
Clinical Signs And Symptoms

Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disorder that is characterized by joint inflammation, erosive properties and symmetric multiple joint involvement. Temporomandibular joint (TMJ) is very rare to be affected in the early phase of the disease, thus posing diagnostic challenges for the rheumatologist. TMJ complaints are present in about more than 50% of patients of RA. TMJ is usually among the last joint to be involved and is associated with many clinical signs and symptoms of which pain is a major problem leading to inflammation, limited movements, swelling, joint stiffness, and muscle spasm. Here reported case is 64 years old male, ex-smoker, diagnosed case of diabetes mellitus for 7 years, hypertension for 2 years, came to hospital with the complains of pain in left jaw for 1 year. He had no history of other joint pain, morning stiffness or any deformities. The patient was diagnosed as a case of rheumatoid arthritis on the basis of inflammatory monoarthritis with high titer positive RA factor and anti CCP. The patient gradually improved after treatment with methotrexate. Inflammatory markers like ESR dropped down with the clinical improvement. TMJ is seldom joint to be affected first in the disease course. Bangladesh Med J. 2019 Sep; 48 (3): 43-45

scholarly journals Magnetic resonance imaging of temporomandibular joint in juvenile idiopathic arthritis

2020 ◽  
Vol 8 (5) ◽  
pp. 1848
Author(s):  
Namrita Sachdev ◽  
Yashvant Singh ◽  
Parikha Rampal ◽  
Sana .
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Joint Effusion ◽  
Facial Dysmorphism ◽  
Cross Sectional ◽  
Wide Range ◽  
Clinical Signs And Symptoms ◽  
Mri Changes ◽  
Sensitivity Specificity

Background: Juvenile Idiopathic Arthritis (JIA) is the most common autoimmune inflammatory synovial arthritis causing wide range of disability in children. The involvement of temporo-mandibular joint (TMJ) in JIA varies ranging from 17% to 87%. Unlike other synovial joints, the TM joint is particularly vulnerable to inflammatory damage as the mandibular growth plate is superficial. JIA is a clinical diagnosis and is characterized by synovial hyperplasia and inflammation leading to joint effusion. TMJ involvement is clinically difficult to assess and often goes untreated. Children with TMJ arthritis have mastication dysfunction and pain. Delayed detection and treatment leads to abnormalities like micrognathia, jaw deformity, facial dysmorphism and chewing problems. MRI is the most sensitive modality to diagnose synovitis and involvement of TMJ in children of JIA.Methods: A cross-sectional observational study was undertaken in 30 children diagnosed as JIA as per ILAE criteria. They were evaluated clinically followed by contrast enhanced MRI for evidence of TMJ arthritis.Results: Of the 60 joints evaluated, clinical involvement was found in 18 joints (10 patients). 12(66.7%) out of them had MRI changes. 3(7.1%) joints out of 42 asymptomatic joints had MRI changes. 13 joints had synovial hypertrophy, 8 joints showed bone erosions. Bone marrow edema was seen in 2 joints, with no evidence of cartilage involvement in any joint. The sensitivity, specificity, PPV and NPV of clinical examination to diagnose TMJ arthritis as compared to MRI was 80.0%, 86.7%, 66.7% and 92.7% respectively.Conclusions: With paucity of clinical signs and symptoms, early involvement of TMJ arthritis in children of JIA can be detected by MRI to prevent long term disability in patients.

Role of diffusion weighted imaging (DWI) in detection and characterization of cerebral stroke

2021 ◽  
Vol 12 (2) ◽  
pp. 88-91
Author(s):  
M T Makada ◽  
Keyword(s):  
Clinical Signs ◽  
High Sensitivity ◽  
Signs And Symptoms ◽  
Lesion Detection ◽  
Cerebral Stroke ◽  
Time Interval ◽  
Initial Symptom ◽  
Self Diffusion ◽  
Clinical Signs And Symptoms ◽  
Mri Study

Background: DW MRI is a relatively recent imaging technique in which water self-diffusion is a source of contrast on MR images. 1Because cytotoxic edema occurs in just a few minutes of a critical decrease in cerebral blood flow, DWI may show most acute infarctions. This is particularly useful when thrombolytic therapy, which can only be used within a short window of opportunity, is considered. Also, DWI identifies acute lesions in patients with multiple chronic ischemic lesions. It also identifies the new extension of the previous ischemic lesions. Methodology: 50 patients with clinical signs and symptoms of stroke who underwent conventional MR imaging of brain were randomly considered for this study. These patients were prospectively subjected for DWI along with conventional MRI study. DW images were evaluated for the calculation of ADC values and ADC maps. Result: The age range of patients in this group varied from 5 years to 82 years; majority of patients being in 51 to 70 years age group. 28 patients were male and 22 were female. Of the 50 patients in this group, the MR study was performed in time interval ranging from within 6 hours after the initial symptom onset upto 4 to 7 days time interval between onset of symptoms and study. DWI imaging shows very high sensitivity compared to T2 weighted imaging particularly imaging within first 12 hours of symptoms onset. After 12 hours DWI and T2 weighted imaging show almost equal sensitivity for lesion detection.

scholarly journals Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 5
Author(s):  
Donatella Rita Petretto ◽  
Gian Pietro Carrogu ◽  
Luca Gaviano ◽  
Lorenzo Pili ◽  
Roberto Pili
Keyword(s):  
Young Woman ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Neurocognitive Disorders ◽  
Lessons Learned ◽  
Alzheimer Dementia ◽  
Clinical Notes ◽  
Alois Alzheimer ◽  
Clinical Signs And Symptoms

Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called “Alzheimer Dementia” in a young woman whose name was Augustine Deter [...]

scholarly journals Correction to: Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome

Pituitary ◽  
2020 ◽  
Author(s):  
Eliza B. Geer ◽  
Roberto Salvatori ◽  
Atanaska Elenkova ◽  
Maria Fleseriu ◽  
Rosario Pivonello ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Patient Reported Outcomes ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Cushing's Syndrome ◽  
Original Version ◽  
Patient Reported ◽  
Author Group ◽  
Clinical Signs And Symptoms

The original version of the article unfortunately contained an error in the first name and the surname of one of the authors in the author group. The last author name was incorrectly published as ‘F. Pecori Giraldi’ and the corrected name is ‘Francesca Pecori Giraldi’ (First name: Francesca; Surname: Pecori Giraldi).

scholarly journals A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

2016 ◽  
Vol 15 (2) ◽  
pp. 220-223 ◽  
Author(s):  
Shadi Saghafi ◽  
Reza Zare-Mahmoodabadi ◽  
Narges Ghazi ◽  
Mohammad Zargari
Keyword(s):  
Giant Cell ◽  
Medical Science ◽  
Age Distribution ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Posterior Maxilla ◽  
Frequent Site ◽  
Male Patients ◽  
Clinical Signs And Symptoms ◽  
Anterior Mandible

Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (PGCGs) in Iranian population.Methods: The data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to our department between 1972 and 2010. This 38-year retrospective study was based on existing data. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented. Results: A total of 1019 patients were affected GCGLs including 435 CGCGs and 584 PGCGs during the study. The mean age was 28.91 ± 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases (57.70%), whereas PGCGs were more frequent in males (50.85%). Five hundred and ninety-eight cases of all giant cell lesions (58.7 %) occurred in the mandible. Posterior mandible was the most frequent site for both CGCG and PGCG cases. The second most common site for PGCG was posterior maxilla (21%), whereas anterior mandible was involved in CGCG (19.45%). The majority of patients were asymptomatic. Conclusions: In contrast to most of previous studies PGCGs occur more common in the first decade and also more frequently in male patients. Although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations which may help in the diagnosis and management of these lesions.Bangladesh Journal of Medical Science Vol.15(2) 2016 p.220-223

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