scholarly journals COVID-19 Presented with Deep Vein Thrombosis in a Patient with Paroxysmal Nocturnal Haemoglobinuria

2021 ◽  
Author(s):  
Zlatko Pravdic ◽  
Mirjana Mitrovic ◽  
Andrija Bogdanovic ◽  
Marijana Virijevic ◽  
Nikica Sabljic ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Venous Thrombosis ◽  
Arterial Thrombosis ◽  
Distress Syndrome ◽  
Bone Marrow Failure ◽  
Rare Event ◽  
Paroxysmal Nocturnal Haemoglobinuria ◽  
Vein Thrombosis ◽  
High Incidence ◽  
Deep Vein

AbstractParoxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired clonal haematological disease characterized by complement-mediated haemolysis, bone marrow failure and venous thrombosis. Anticomplement therapy eculizumab improves survival and reduces complications. Severe acute respiratory distress syndrome corona virus 2 (SARS-CoV-2) disease 2019 (COVID-19) is associated with high incidence of both venous and arterial thrombosis in hospitalized patients with pneumonia. Deep venous thrombosis (DVT) as the presenting symptom of COVID-19 is a rare event. We describe a well-controlled PNH patient on eculizumab for more than 5 years who presented with DVT, while on warfarin, as the first sign of COVID-19. To our knowledge, this is the first described case of DVT in a PNH patient with COVID-19.

scholarly journals Spontaneous arterial thrombosis in a patient with advanced ovarian clear cell cancer: a case report and literature review

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092674
Author(s):  
Jing Chen ◽  
Huimin Sun ◽  
Minrong Wu ◽  
Xiaolin Zhong ◽  
Yuqin Zhang
Keyword(s):  
Ovarian Cancer ◽  
Venous Thrombosis ◽  
Arterial Thrombosis ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Cell Cancer ◽  
Underlying Disease ◽  
Low Molecular Weight ◽  
Vein Thrombosis ◽  
Deep Vein

Patients with ovarian cancer are often in a hypercoagulable state and have a high risk of venous thrombosis, including deep vein thrombosis and pulmonary embolism. However, arterial thrombosis is relatively rare in ovarian cancer. We report a case a 46-year-old woman with ovarian clear cell carcinoma who developed arterial and venous thrombosis in the lower extremities as the first manifestation. Her arterial thrombosis-related ischemic symptoms were not responsive to anticoagulant treatment of low-molecular-weight heparin, but improved after neoadjuvant chemotherapy and surgery. Therefore, we hypothesize that the optimal therapy for arterial thrombosis in ovarian cancer is treatment for the underlying disease (i.e., ovarian cancer). A thorough investigation is required to determine the relationships between arterial thrombosis and ovarian cancer and antithrombotic treatments for ovarian cancer related-arterial thrombosis.

Factor VII and Fibrinogen Levels as Risk Factors for Venous Thrombosis

1994 ◽  
Vol 71 (06) ◽  
pp. 719-722 ◽  
Author(s):  
T Koster ◽  
F R Rosendaal ◽  
P H Reitsma ◽  
P A van der Velden ◽  
E Briët ◽  
...  
Keyword(s):  
Risk Factors ◽  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Arterial Thrombosis ◽  
Plasma Fibrinogen ◽  
Factor Vii ◽  
Thrombotic Risk ◽  
Vein Thrombosis ◽  
Thrombosis Risk ◽  
Deep Vein

SummaryThe plasma levels of coagulation factor VII and fibrinogen are well known risk factors for arterial thrombosis. We tested the hypothesis that this association also exists for venous thrombosis. Additionally, MspI and Haelll polymorphisms in the factor VII and fibrinogen genes have recently been reported to be associated with the concentration of both proteins in the plasma. However, no conclusion could be drawn with respect to an increase or decrease in thrombosis risk. We undertook a population-based case-control study, in which 199 patients with a first, objectively confirmed episode of deep vein thrombosis, aged less than 70, and without a known malignant disorder were compared to 199 age-and sex-matched healthy controls, to evaluate the clinical importance of these reported findings.For fibrinogen we found a positive level-related association between the plasma fibrinogen level and thrombotic risk. Subjects with a plasma fibrinogen greater than 5 g/1 had an almost 4-fold increase of thrombosis risk. The frequencies of the different Haelll genotypes were out of balance only for the thrombosis patients, with a deficit of the H1H2 genotype. Possession of an H1H2 genotype was associated with a 40% reduction in thrombosis risk.For factor VII, neither the plasma level nor the MspI genotypes were related to deep vein thrombosis, although possession of a M2 allele was clearly associated with significantly lower factor VII levels. The frequencies of the Mspl-genotypes were the same for patients and control subjects and, exhibited Hardy-Weinberg equilibrium.Our results support that plasma fibrinogen, a determinant of arterial thrombosis is also a risk factor for venous thrombosis, while factor VII plasma concentration is unrelated to deep vein thrombosis, which is supported by the data from the DNA analysis of polymorphisms.

Incidence Of Venous Thrombosis, Increased Platelet Release Reaction And Thromboxane Synthesis Following Tourniquet Ischaemia

1981 ◽  
Author(s):  
J Zahavi ◽  
A J Price ◽  
J Westwick ◽  
V V Kakkar
Keyword(s):  
Venous Thrombosis ◽  
Young Patients ◽  
Surgical Trauma ◽  
Pneumatic Tourniquet ◽  
Vein Thrombosis ◽  
High Incidence ◽  
Total Knee ◽  
High Level ◽  
Deep Vein

Deep vein thrombosis (DVT) was established by ascending phlebography in 121 meniscectomy (M) (mean age 34 years) and 27 total knee replacement (TKR) (mean age 62.9 years) patients, both procedures performed under ischaemia (by inflating a pneumatic tourniquet to 500 mm Hg). In 27 of the M, 10 TKR and another 10 patients undergoing herniorrhaphy (H) and served as controls plasma β-thromboglobu- lin (βTG) was measured by radioimmunoassay and in 22 M and 10 TKR patients plasma thromboxane B2 (TxB2) was also determined. The incidence of DVT was 29% in the M patients. It increased significantly with age reaching a level of 50% at 60 years. In the TKR group 49% developed DVT. There was also a positive correlation between the severity of of DVT and patient age in both groups. The mean plasma βTG and TxB2, rose sharply (p<0.001) 5 min after the release of the tourniquet and were positively correlated to each other. The high level returned to the pre-operative level after 48 hours. In the H patients βTG did not alter significantly pos toperativelyThe high incidence of DVT in the relatively young patients who underwent M (minor surgical trauma similar to that of H) reaching the incidence of TKR patients (major surgical trauma) at 60 years, suggests that tourniquet ischaemia may be an important factor in the development of venous thrombosis in these patients. The increased in-vivo platelet activation and thromboxane synthesis, indicated by the increased plasma βTG and TxB2 levels, which was not detected in the H patients, suggests that platelets may play an important role in the initiation of the DVT in tourniquet ischaemia patients.

Outcome of Anticoagulation in Isolated Distal Deep Vein Thrombosis Compared to Proximal Deep Venous Thrombosis

2021 ◽  
Author(s):  
Danielle T Vlazny ◽  
Ahmed K Pasha ◽  
Wiktoria Kuczmik ◽  
Waldemar E Wysokinski ◽  
Matthew Bartlett ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Vein Thrombosis ◽  
Distal Deep Vein Thrombosis ◽  
Deep Vein

Low-dose subcutaneous heparin in prevention of deep-vein thrombosis

1972 ◽  
Vol 10 (23) ◽  
pp. 89-91
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Low Dose ◽  
Fatal Pulmonary Embolism ◽  
Vein Thrombosis ◽  
Subcutaneous Heparin ◽  
Prevention And Treatment ◽  
Deep Vein ◽  
Low Dosage

Earlier this year1 we discussed the prevention and treatment of venous thrombosis and concluded that heparin in low dosage seemed the most promising drug for preventing deep-vein thrombosis postoperatively, although the optimum regimen was not yet known. Sharnoff and his associates who began this work 10 years ago claim to have shown that this treatment largely prevents fatal pulmonary embolism.2

Comparative Study of Deep Vein Thrombosis Recanalization Using Doppler Ultrasound in Different Post-Treatment Intervals in Traumatic Patients

2022 ◽  
Author(s):  
Nazanin Farshchian ◽  
Negin Farshchian ◽  
Parisa Bahrami Kamangar
Keyword(s):  
Deep Vein Thrombosis ◽  
Doppler Ultrasound ◽  
Statistical Tests ◽  
Significance Level ◽  
Sonographic Diagnosis ◽  
Vein Thrombosis ◽  
Significant Difference ◽  
High Incidence ◽  
Deep Vein ◽  
Comparative Examination

Deep vein thrombosis (DVT) is a prevalent vascular disease characterized by pelvic and limb deep vein thrombophlebitis, and it has a high incidence in traumatic patients. Contrary to older studies, recent research has reported that recanalization in DVT is not a slow process. The present study aimed at the comparative examination of DVT recanalization with Doppler ultrasound in different intervals following treatment with heparin or enoxaparin. This prospective study was conducted on all traumatic patients hospitalized in Imam Reza Hospital of Kermanshah, Iran, with the clinical and sonographic diagnosis of DVT in limb veins. Doppler ultrasound was performed two weeks, one month, and three months following treatment in order to examine recanalization. Data were analyzed using statistical tests in SPSS16 at the significance level of <0.05. Based on Doppler ultrasound, a significant difference was found between the degree of recanalization in patients aged <45 years and those aged >45 years, between male and female patients, and between different DVT locations (P<0.05). After three months of treatment with heparin and enoxaparin, the degree of recanalization was increased in DVT. Moreover, it was found that Doppler ultrasound is a useful tool for the diagnosis of recanalization in patients with DVT.

scholarly journals Up-to-date thromboprophylaxis in elective spinal surgery. A systematic review

2014 ◽  
Vol 13 (2) ◽  
pp. 143-146 ◽  
Author(s):  
Leonardo Oliveira ◽  
Luis Marchi ◽  
Luiz Pimenta
Keyword(s):  
Systematic Review ◽  
Orthopedic Surgery ◽  
Spinal Surgery ◽  
Thrombotic Complication ◽  
Surgical Practice ◽  
Vein Thrombosis ◽  
Legal Problems ◽  
Prophylactic Measures ◽  
High Incidence ◽  
Deep Vein

Deep vein thrombosis (DVT) and pulmonary embolism (PE) present a high incidence after surgery, posing a high risk in surgical practice. Although a consensus does exist on thromboprophylaxis in orthopedic surgery, this topic remains controversial in regard to spinal surgery. In this current paper, we review and discuss the different forms of prophyilaxis presented in literature, in order to develop guidelines on prophylactic measures in spinal surgery, improving patient´s outcomes and reducing any medical/legal problems that could arise from a thrombotic complication.

Venous Thromboembolism

2020 ◽  
Author(s):  
Samuel Z. Goldhaber
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
Venous Thrombosis ◽  
Antithrombotic Agents ◽  
Vein Thrombosis ◽  
Recurrent Venous Thrombosis ◽  
Deep Vein ◽  
D Dimer ◽  
In Pregnancy

Venous thromboembolism, which involves venous thrombosis and pulmonary embolism, is a leading cause of morbidity and mortality in hospitalized patients and is being seen with increasing frequency in outpatients. This chapter discusses the risk factors, etiology, classification, pathophysiology, natural history, prognosis, diagnosis (including venous thrombosis, recurrent venous thrombosis, and pulmonary embolism), prophylaxis, and treatment of venous thromboembolism (including the pharmacology of antithrombotic agents), as well as venous thromboembolism in pregnancy and miscellaneous thromboembolic disorders (including thrombosis of unusual sites).  This review contains 8 figures, 16 tables, and 79 references. Keywords: Venous thromboembolism, pulmonary embolism, deep vein thrombosis, embolectomy, thrombolysis, hypercoagulability, duplex ultrasonography, D-dimer, anticoagulation

The Clinical Diagnosis Of Deep Venous Thrombosis

1981 ◽  
Author(s):  
E Briët ◽  
M J Boekhout-Mussert ◽  
L H van Hulsteijn ◽  
C W Koch ◽  
H W C Loose ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Doppler Ultrasound ◽  
Clinical Examination ◽  
False Positive ◽  
False Negative ◽  
Diagnostic Strategies ◽  
Vein Thrombosis ◽  
Deep Vein

Fifty-three patients were examined because of suspected deep venous thrombosis, by means of clinical examination, Doppler ultrasound and venography. Eighty-two legs were examined with all three methods. Venography was positive in 40 and normal in 42. The clinical examination was false positive in 4 legs and false negative in 6. The Doppler ultrasound studies gave false positive results in 3 legs and false negative results in 6. These results are better than those reported in the literature probably because the thrombosis extended to the popliteal vein or the more proximal veins in 38 of the 40 legs with deep vein thrombosis. This high percentage of upper leg vein thrombosis can be explained by the fact that 47 of the 53 patients were ambulant when they developed the signs and symptoms of thrombosis. It is concluded, that the clinical examination and Doppler ultrasonography can be used to diagnose deep vein thrombosis in ambulant patients in our clinic. We presume that the findings reported in the literature cannot be used indiscriminately as a basis for diagnostic strategies in other hospitals because of widely varying categories of patients, referral patterns and diagnostic criteria that are virtually impossible to standardize.

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