Facile and Straightforward Synthesis of Racemic Version of Substituted 3-[3-(2-Hydroxyphenyl)-3-oxo-1-arylpropyl]-4-hydroxycoumarins: Easy Access to a Series of Biorelevant Warfarin Analogues
Keyword(s):
AbstractThe present communication deals with a straightforward, efficient, and green synthesis of a series of racemic version of 3-[3-(2-hydroxyphenyl)-3-oxo-1-arylpropyl]-4-hydroxycoumarins as biologically interesting warfarin analogues upon decarboxylative hydrolysis of bis-coumarin derivatives in aqueous potassium hydroxide solution. The salient features of this practical method are operational simplicity, avoidance of any organic solvents and tedious column chromatographic purification, clean reaction profiles, excellent yields, and gram-scale synthetic applicability.
1977 ◽
Vol 34
(6)
◽
pp. 653-654
1975 ◽
Vol 30
(9-10)
◽
pp. 732-739
◽
1964 ◽
Vol 42
(11)
◽
pp. 2488-2495
◽
2004 ◽
Vol 43
(2)
◽
pp. 369-388
◽
1986 ◽
Vol 51
(2)
◽
pp. 368-374
◽
2016 ◽
pp. 95-104
◽
1976 ◽
Vol 22
(8)
◽
pp. 1163-1168
◽