scholarly journals Interventional Bronchus Occlusion Using Amplatzer Devices – A Promising Treatment Option for Children with Persistent Air Leak

2022 ◽  
Author(s):  
Katharina Schütz ◽  
Christoph M. Happel ◽  
Oliver Keil ◽  
Jens Dingemann ◽  
Julia Carlens ◽  
...  
Keyword(s):  
Treatment Option ◽  
Ventilatory Support ◽  
Lung Parenchyma ◽  
Efficacy And Safety ◽  
Air Leak ◽  
Chest Tubes ◽  
Surgical Interventions ◽  
Valuable Treatment ◽  
Promising Treatment ◽  
Persistent Air Leak

AbstractBackground: Persistent air leak (PAL) is a severe complication of secondary spontaneous pneumothorax (SSP). Surgical interventions are usually successful when medical treatment fails, but can be associated with significant complications and loss of potentially recoverable lung parenchyma. Methods: Retrospective analysis of efficacy and safety of interventional bronchus occlusions (IBO) using Amplatzer devices (ADs) in children with PAL secondary to SSP. Results: Six patients (four males, 4–15 years of age) underwent IBO using ADs as treatment for PAL. Necrotizing pneumonia (NP) was the most common cause (n=4) of PAL. Three patients were previously healthy and three suffered from chronic lung disease. All patients required at least two chest tubes prior to the intervention for a duration of 15–43 days and all required oxygen or higher level of ventilatory support. In three cases, previous surgical interventions had been performed without success. All children improved after endobronchial intervention and we observed no associated complications. All chest tubes were removed within 5–25 days post IBO. In patients with PAL related to NP (n=4), occluders were removed bronchoscopically without re-occurrence of pneumothorax after a mean of 70 days (IQR: 46.5–94). Conclusion: IBO using ADs is a safe and valuable treatment option in children with PAL independent of disease severity and underlying cause. A major advantage of this procedure is its less invasiveness compared to surgery and the parenchyma- preserving approach.

scholarly journals Application of autologous blood patch in patients with non-expanded lungs and persistent air leak

2020 ◽  
Vol 28 (3) ◽  
pp. 521-526
Author(s):  
Burhan Apilioğulları
Keyword(s):  
Autologous Blood ◽  
Lung Parenchyma ◽  
X Rays ◽  
Poor General Condition ◽  
Air Leak ◽  
Chemical Pleurodesis ◽  
Study Results ◽  
Blood Patch ◽  
Persistent Air Leak

Background: This study aims to evaluate the effectiveness of pleurodesis procedure by ensuring the expansion of the lung and occluding lung parenchyma leaks with an autologous blood patch. Methods: A total of 24 patients (17 males, 7 females; mean age 59.9±12.2 years; range, 30 to 86 years) who underwent autologous blood patch pleurodesis in our clinic between November 2015 and November 2019 were retrospectively analyzed. The patients were not eligible to undergo chemical pleurodesis due to a non-expandable lung or poor general condition. Demographic and clinical characteristics of the patients and postoperative data were evaluated. Results: The air leak stopped within 48 h after autologous blood patch pleurodesis in seven patients. The air leak significantly decreased in 13 patients, while it remained unchanged in four patients. A Heimlich valve was placed in the patients in whom the air leak stopped or significantly decreased. The follow-up chest X-rays showed that the respective lungs of these patients became completely expandable. Conclusion: Our study results suggest that the autologous blood patch procedure is a favorable option for the patients who are unable to benefit much from the conventional chemical pleurodesis methods due to contraindications to surgery or the presence of non-expandable lungs.

scholarly journals SGLT-2 Inhibitors: Are They a Promising Treatment Option in T2DM Patients with NAFLD?

2017 ◽  
Vol 60 (4) ◽  
pp. 167-170 ◽  
Author(s):  
Dimitrios Patoulias
Keyword(s):  
Treatment Option ◽  
Specific Treatment ◽  
Liver Function Tests ◽  
Diabetic Patients ◽  
Efficacy And Safety ◽  
Alcoholic Fatty Liver ◽  
Beneficial Effects ◽  
Co Morbidity ◽  
Promising Treatment

Sodium glucose co-transporter type 2 inhibitors (SGLT-2 inhibitors) are a class of antidiabetics, recently approved for the treatment of patients with T2DM. They feature cardioprotective and renoprotective action, while they exert beneficial effects on metabolic parameters. Non-alcoholic fatty liver disease (NAFLD) is a frequent co-morbidity in diabetic patients. Its prevalence reaches up to 70%. Since there is no specific treatment approved for NAFLD, both experimental and clinical studies have been recently conducted highlighting the efficacy and safety of SGLT-2 inhibitors mainly in animal models and secondarily in patients with T2DM and NAFLD. This class of antidiabetics seems very attractive, improving both glycemic control and liver function tests, while inhibiting NAFLD progression. However, further investigation is required to establish them as a first-line treatment option in T2DM patients with NAFLD, after thorough assessment of their efficacy and safety in clinical practice.

Role of the IBV Valve in Persistent Air Leak

2014 ◽  
Vol 9 (4) ◽  
pp. 254-256
Author(s):  
Salim Surani ◽  
Shweta Rao ◽  
Saherish Surani ◽  
Joseph Varon
Keyword(s):  
Air Leak ◽  
Persistent Air Leak

scholarly journals The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 675
Author(s):  
Saartje Uyttebroek ◽  
Jolien Onsea ◽  
Willem-Jan Metsemakers ◽  
Lieven Dupont ◽  
David Devolder ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Biofilm Formation ◽  
Potential Role ◽  
Phage Therapy ◽  
Well Being ◽  
Treatment Alternative ◽  
Surgical Interventions ◽  
Social And Emotional ◽  
Promising Treatment

Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

scholarly journals New pneumothorax complicating successful treatment of persistent air leak by endobronchial valves

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Yiu Cheong Yeung ◽  
Yu Hong Chan ◽  
Man Ying Ho ◽  
Ming Chiu Chan ◽  
Hau Chung Kwok ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Air Leak ◽  
Persistent Air Leak

scholarly journals Modifiable and Nonmodifiable Predictive Factors Associated with the Outcomes of Total Knee Arthroplasty

Joints ◽  
2019 ◽  
Vol 07 (01) ◽  
pp. 013-018
Author(s):  
Davide E. Bonasia ◽  
Anna Palazzolo ◽  
Umberto Cottino ◽  
Francesco Saccia ◽  
Claudio Mazzola ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Prognostic Factors ◽  
Treatment Option ◽  
Predictive Factors ◽  
Knee Arthroplasty ◽  
Factors Associated ◽  
Modifiable Factors ◽  
Valuable Treatment ◽  
Total Knee ◽  
The Right

AbstractTotal knee arthroplasty (TKA) is a valuable treatment option for advanced osteoarthritis in patients unresponsive to conservative treatments. Despite overall satisfactory results, the rate of unsatisfied patients after TKA remains high, ranging from 5 to 40%. Different modifiable and nonmodifiable prognostic factors associated with TKA outcomes have been described. The correction, whenever possible, of modifiable factors is fundamental in preoperative patients' optimization protocols. Nonmodifiable factors can help in predicting the outcomes and creating the right expectations in the patients undergoing TKA. The goal of this review is to summarize the modifiable and nonmodifiable prognostic factors associated with TKA outcomes.

scholarly journals Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report

2017 ◽  
Vol 17 (2) ◽  
pp. 558-561 ◽  
Author(s):  
Juyoung Ryu ◽  
Kangwook Lee ◽  
Changmug Joe ◽  
JongCheon Joo ◽  
Namhun Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Option ◽  
Carbohydrate Antigen ◽  
Klatskin Tumor ◽  
Preoperative Radiation ◽  
Noninvasive Treatment ◽  
Patients With Cancer ◽  
Radiofrequency Hyperthermia ◽  
Promising Treatment ◽  
Tomography Scan

Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy. However, because the treatment with radiation and chemotherapy was not successful, he decided to undergo hyperthermia combined with chemotherapy as a second treatment option. He was suffering from fatigue, dyspepsia, epigastralgia, and jaundice. Hyperthermia combined with chemotherapy was administered 32 times over a period of 4 months. The patient experienced no critical complications, and the patient’s condition improved, with the carbohydrate antigen 19-9 (CA 19-9) and the total bilirubin levels being relatively lowered. In addition, the computed tomography scan showed that the cholangiocarcinoma had not progressed. In conclusion, this case report suggests radiofrequency hyperthermia combined with chemotherapy may be a promising treatment option for patients with unresectable cholangiocarcinoma.

Late diagnosis of pulmonary agenesis

2021 ◽  
Vol 14 (10) ◽  
pp. e245233
Author(s):  
Diana Alexandra Pimenta ◽  
Filipa Lemos Aguiar ◽  
Beatriz Celeiros Fernandes ◽  
Rui Rolo
Keyword(s):  
Early Childhood ◽  
Clinical Presentation ◽  
Lung Parenchyma ◽  
Asthma Diagnosis ◽  
Cardiovascular Malformations ◽  
Surgical Interventions ◽  
Pulmonary Agenesis ◽  
History Of ◽  
Lung Infections ◽  
Respiratory Complaints

Pulmonary agenesis is defined as the complete absence of one or both lungs, including the bronchi, bronchioles, vasculature and lung parenchyma. Most of these malformations are detected in early childhood. A residual number remains asymptomatic and undiagnosed until adulthood. The clinical presentation is wide, ranging from asymptomatic to respiratory complaints like dyspnoea, respiratory distress and a history of recurrent lung infections. This case presents a 54-year-old woman with complaints of coughing, dyspnoea for medium exertion and wheezing for a couple of months. Based on the results of complementary diagnosis methods, right pulmonary agenesis was diagnosed without other malformations. Simultaneously, an asthma diagnosis was also performed. The treatment of pulmonary agenesis is symptomatic. Simultaneous cardiovascular malformations could require surgical interventions. This case demonstrates that pulmonary agenesis may remain undiagnosed, be identified incidentally, and have a good and long prognosis.

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