scholarly journals The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 675
Author(s):  
Saartje Uyttebroek ◽  
Jolien Onsea ◽  
Willem-Jan Metsemakers ◽  
Lieven Dupont ◽  
David Devolder ◽  
...  

Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

2021 ◽  
Vol 44 (2) ◽  
pp. 111-114
Author(s):  
Tracy L. Cross

This column explores the concept of authenticity in the psychosocial development of students with gifts and talents. The author describes how authenticity is critical to students’ psychological well-being, particularly as it relates to their identity formation.


2021 ◽  
Vol 8 (3) ◽  
pp. 989-992
Author(s):  
Mula Ram Suthar ◽  
◽  
Manjry Anshumala Barla ◽  
Rakesh Roushan ◽  
◽  
...  

The Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is an infectious disease caused by coronavirus disease 2019 (COVID-19) and has affected people's lives globally, since first case was detected in Wuhan, China in December 2019. The coronavirus pandemic has turned the world’s attention to the immune system, the body’s defense mechanism against disease. Concept of Ojas is well explained in all ayurvedic classics, in modern perspective it is considered as immunity (Vyadhikshamatava). Ojas is necessary for well-being of the body, and mind. In Ayurveda textbook, the epidemics and along with their management are discussed under the term of Janapadodhvansa. The preventive and curative treatments for communicable diseases of the Janapadodhvansa (epidemics) are Panchkarma (five bio-purification therapies), Rasayana Chikitsa (rejuvenation treatment), Achara Rasayana (good conducts), and migrate to the place, free from communicable diseases. The intake of all types Rasayanas leads to increase of Ojas and reduce all psychological (mainly stress and emotional) disorder, thereby causes increase immunity responses and help to fight against covid-19. Key Words: Ayurveda, Covid-19, Immunity, Janapadodhvansa, Ojas, Rasayana Chikitsa.


2021 ◽  
Vol 26 (5) ◽  
pp. 497-501
Author(s):  
Ellen Rootring ◽  
Cheryl L. Sargel ◽  
Joseph D. Tobias

Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The potential role of chronic acetaminophen administration in the etiology of hepatoxicity is discussed and prevention strategies are presented.


2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Salvatore Masala ◽  
Eros Calabria ◽  
Marco Nezzo ◽  
Dominique De Vivo ◽  
Luca Neroni ◽  
...  

We will discuss a potential role of percutaneous vertebroplasty (PVP) in the management of a patient with immobilization syndrome due to paraplegia and vertebral osteoporotic fractures. While PVP is commonly used for the treatment of osteoporotic thoracolumbar vertebral compression fractures, its role in vertebral stabilization in patient with immobilization syndrome has not been reported in the literature. A 73-year-old woman affected by immobilization syndrome due to paraplegia and vertebral osteoporotic fractures was treated with PVP of vertebrae D12, L1, and L4. After PVP, the patient did not need any antalgic therapy, and there was a significant improvement regarding mobilization, performance of physiological functions, daily management of personal care, and treatment of decubitus ulcers, increasing life quality and psychological well-being.


2020 ◽  
Vol 12 (2) ◽  
pp. 24
Author(s):  
Marco Ciziceno ◽  
Pietro Pizzuto

The purpose of this paper is to examine the well-being dynamics across European countries during the Great Recession and to investigate the potential role of the quality of formal institutions in mitigating the negative effect of the economic downturn. This study uses the club convergence methodology by Phillips and Sul (2007; 2009) to group EU-28 countries that present similar features in terms of well-being during the period 2005-2017. The study also applies probit models to investigate the potential role of several social and institutional characteristics that are supposed to affect subjective well-being levels. The results show the existence of a “well-being gap” among European countries. The economic downturn started in 2008 has impacted the perceived well-being more in low-income and low-growth countries (less developed transition and Southern countries), than in high-income and more developed transition countries. The study also shows that countries that present well-functioning institutional systems and, more in general, good institutional performances show higher life satisfaction levels and tend to be more resilient to the negative effects generated by the economic shock.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S75-S76
Author(s):  
Toni C Antonucci

Abstract The United Nations has identified 17 Sustainable Development Goals (SDGs) designed to improve the health and well-being of the world’s most vulnerable populations. This presentation will review the potential role psychology, in particular, illustrative theories and research, in achieving the SDGs of reducing poverty and achieving gender equality and empowerment. We consider life span (individual) developmental and life course (environmental structure) theories as useful for explaining how poverty and inequality influence the individual and community at one point in time and over time. Further, we use research evidence to illustrate how naturally occurring resources can be garnered to better explain, understand, identify and create successful intervention programs. We emphasize the importance psychology to achieving SDGs and emphasize that the application psychology to changing the behavior and expectations of individuals and societies to achieve sustainable development that contributes to a world that celebrates optimal and sustainable development for all.


2015 ◽  
Vol 11 (2) ◽  
pp. 323-334 ◽  
Author(s):  
Andrea Caputo

This paper explores the potential role of gratitude on the reduction of loneliness feelings, even controlling for several variables related to social desirability, well-being (subjective happiness and life satisfaction) and socio-demographic characteristics. Through a web-based survey a convenience sample of 197 participants completed an online questionnaire including these measures. Correlation analyses and four-step hierarchical multiple regression analyses were conducted. The results show a negative correlation between gratitude and loneliness; specifically, gratitude succeeds in accounting for up to almost one-fifth of the total variability of loneliness even controlling for further variables. Being female, not having a stable and consolidated relationship and not participating in the labor force represent some risk factors affecting loneliness which should be taken into account in further research.


2014 ◽  
Vol 28 (4) ◽  
pp. 345-348 ◽  
Author(s):  
Manuele Casale ◽  
Lorenzo Sabatino ◽  
Valeria Frari ◽  
Francesco Mazzola ◽  
Rosa Dell'Aquila ◽  
...  

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