Bioactive isoindolinone alkaloid from Hericium erinaceum

The purpose of this study was to enhance the immune-enhancing activity of mushroom strains through fermentation to promote food use of leaf extracts of S. quelpaertensis containing β-glucan. We evaluated the immunomodulatory effect of extracts from fermented S. quelpaertensis leaves (SQGL, SQHE, SQPL). S. quelpaertensis leaves fermentation products were prepared by using mushroom mycelia (Ganoderma lucidum, Hericium erinaceum, Phellinus linteus). The content of β-glucan, a major substance in S. quelpaertensis leaves fermentation products, was 3.73 ± 0.50 mg/mL in the extract (SQ) of S. quelpaertensis leaves. The fermented mushrooms, SQGL, were the highest at 5.57 ± 0.86 mg/100 mL, followed by SQHE and SQPL, and the β-glucan content of all of the glucan was >75.3%. To test the immune activity, S. quelpaertensis leaf fermentation products were administered to mice at different doses (60, 160, and 360 mg/kg) for two weeks. Th cell and macrophage populations were found to increase significantly at all three doses compared to the negative control after two weeks. SQGL and SQHE were highest at 160 mg/kg, and SQPL showed the highest Th cell proliferation at 60 mg/kg. In addition, the production of IFN-γ, IL-4, IL-10, and nitric oxide was significantly higher than that of the negative control after two weeks. In particular, an increase was seen at a low concentration of 60 mg/kg. Therefore, the S. quelpaertensis leaf fermentation product can be very useful as a functional ingredient for enhancing immunity.

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Erinacene D, a new aromatic compound from Hericium erinaceum

The Journal of Antibiotics ◽

10.1038/ja.2014.57 ◽

2014 ◽

Vol 67 (10) ◽

pp. 727-729 ◽

Cited By ~ 8

Author(s):

Wei Li ◽

Ya Nan Sun ◽

Wei Zhou ◽

Sang Hee Shim ◽

Young Ho Kim

Keyword(s):

Aromatic Compound ◽

Hericium Erinaceum

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The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats

The Korean Journal of Internal Medicine ◽

10.3904/kjim.2019.050 ◽

2020 ◽

Author(s):

Ali Durmus ◽

Ilgim Durmus ◽

Omer Bender ◽

Oguzhan Karatepe

Keyword(s):

Experimental Colitis ◽

Chemically Induced ◽

Hericium Erinaceum

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Terpenoids and Sterols from Some Japanese Mushrooms

Natural Product Communications ◽

10.1177/1934578x1400900332 ◽

2014 ◽

Vol 9 (3) ◽

pp. 1934578X1400900 ◽

Cited By ~ 8

Author(s):

Yasunori Yaoita ◽

Masao Kikuchi ◽

Koichi Machida

Keyword(s):

Lentinula Edodes ◽

Chemical Constituents ◽

Structural Features ◽

Tricholoma Matsutake ◽

Pholiota Nameko ◽

The Past ◽

Polyporus Umbellatus ◽

Hericium Erinaceum ◽

New Compounds ◽

Hypsizigus Marmoreus

Over the past twenty years, our research group has been studying the chemical constituents of mushrooms. From nineteen species, namely, Amanita virgineoides Bas (Amanitaceae), Daedaleopsis tricolor (Bull.: Fr.) Bond. et Sing. (Polyporaceae), Grifola frondosa (Fr.) S. F. Gray (Polyporaceae), Hericium erinaceum (Bull.: Fr.) Pers. (Hericiaceae), Hypsizigus marmoreus (Peck) Bigelow (Tricholomataceae), Lactarius piperatus (Scop.: Fr.) S. F. Gray (Russulaceae), Lentinula edodes (Berk.) Sing. (Pleurotaceae), Lyophyllyum connatum (Schum.: Fr.) Sing. (Tricholomataceae), Naematoloma sublateritium (Fr.) Karst. (Strophariaceae), Ompharia lapidescens Schroeter (Polyporaceae), Panellus serotinus (Pers.: Fr.) Kuhn. (Tricholomataceae), Pholiota nameko (T. Ito) S. Ito et Imai in Imai (Strophariaceae), Pleurotus eringii (DC.: Fr.) Quel. (Pleurotaceae), Polyporus umbellatus Fries (Polyporaceae), Russula delica Fr. (Russulaceae), Russula sanguinea (Bull.) Fr. (Russulaceae), Sarcodon aspratus (Berk.) S. Ito (Thelephoraceae), Tricholoma matsutake (S. Ito et Imai) Sing. (Tricholomataceae), and Tricholoma portentosum (Fr.) Quel. (Tricholomataceae), we isolated eight new sesquiterpenoids, six new meroterpenoids, three new triterpenoids, and twenty eight new sterols. In this review, structural features of these new compounds are discussed.

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