Pregnancy Outcomes after Endometrial Ablation in a Multi-institutional Cohort

2018 ◽  
Vol 35 (10) ◽  
pp. 931-935 ◽  
Author(s):  
David Hackney ◽  
Sherif El-Nashar ◽  
David Sheyn ◽  
Alison Bauer
Keyword(s):  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Endometrial Ablation ◽  
Control Group ◽  
Clinical Database ◽  
Morbidly Adherent Placenta ◽  
Adherent Placenta ◽  
Retrospective Cohort Analysis ◽  
Reproductive Aged Women

Objective The objective of this study was to determine the incidence of morbidly adherent placenta in pregnancies after endometrial ablation. Study Design We performed a retrospective cohort analysis using a large, multiinstitutional deidentified clinical database, IBM EPM: Explore (IBM Corporation, Somers, NY). We identified women who underwent endometrial ablation and had a subsequent delivery between 1999 and 2016. Patients with a delivery and no prior ablation were used as controls. The association between morbidly adherent placenta, ablation, and other known risk factors for morbidly adherent placenta was analyzed using multivariable logistic regression. Results Of 162,100 reproductive-aged women who underwent endometrial ablation, 2,770 women (1.71%) subsequently had a delivery. The rate of morbidly adherent placenta was 1 in 13.9 pregnancies after ablation compared with 1 in 838.7 pregnancies in the control group (adjusted odds ratio [aOR], 20.22, p < 0.0001). Conclusion Pregnancies that occurred after endometrial ablation were associated with increased rates of morbidly adherent placenta.

scholarly journals OncoVee™-MiniPDX-Guided Anticancer Treatment for Gastric Cancer Patients With Synchronous Liver Metastases: A Retrospective Cohort Analysis

2022 ◽  
Vol 11 ◽  
Author(s):  
Yutong Ge ◽  
Xin Zhang ◽  
Wei Liang ◽  
Cuiju Tang ◽  
Dongying Gu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Retrospective Cohort ◽  
Response Rate ◽  
Cohort Analysis ◽  
Control Group ◽  
Observation Group ◽  
Retrospective Cohort Analysis ◽  
Gastric Cancer Patients ◽  
And Control

BackgroundIt is estimated that 35% of gastric cancer patients appear with synchronous distant metastases—the vast majority of patients presenting with metastatic hepatic disease. How to choose the most appropriate drugs or regimens is crucial to improve the prognosis of patients. We conducted this retrospective cohort analysis to evaluate the efficacy of OncoVee™-MiniPDX-guided treatment for these patients.MethodsGastric cancer patients with liver metastases (GCLM) were enrolled. Patients were divided into MiniPDX and control group according to their wishes. In the observation group, the OncoVee™-MiniPDX model was conducted to screen the most sensitive drug or regimens to determine the clinical administration. Meanwhile, patients were treated with regular medications in the control group according to the guidelines without the MiniPDX model. The primary endpoint was overall survival (OS), and the secondary outcomes included objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS).ResultsA total of 68 patients with GCLM were included, with the observation and control groups of 21 and 47 patients, respectively. The baseline characteristics of patients were balanced between these two groups. MiniPDX drug sensitivity tests were associated with the increased use of targeted drugs when compared with the control group (33.3 vs. 0%, p=0.032). Median OS was estimated to be 9.4 (95% CI, 7.9–11.2) months and 7.9 (95% CI, 7.2–8.7) months in the observation and control group, respectively. Both univariate (control group vs. MiniPDX group: HR=2.586, 95% CI= 1.362–4.908, p=0.004) and multivariate regression analyses (Control group vs. MiniPDX group: adjusted HR (aHR)=4.288, 95% CI= 1.452–12.671, p=0.008) showed the superiority of the observation group on OS. Similarly, MiniPDX-based regiments significantly improve the PFS of these cases (median PFS 6.7 months vs. 4.2 months, aHR=2.773, 95% CI=1.532–3.983, p=0.029). ORR and DCR were also improved in MiniPDX group comparing with control group (ORR, 57.14 vs. 25.53%, p=0.029; DCR: 85.71 vs. 68.08%, p=0.035).ConclusionOncoVee™-MiniPDX model, which was used to select drugs to guide antitumor treatment, was promising to prolong survival and improve the response rate of patients with GCLM. Further well-designed studies are needed to confirm the clinical benefits of MiniPDX.

Ethnicity and incidence of congenital hypothyroidism in the capital of Macedonia

2017 ◽  
Vol 30 (4) ◽  
Author(s):  
Violeta Anastasovska ◽  
Mirjana Kocova
Keyword(s):  
Congenital Hypothyroidism ◽  
Ethnic Differences ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Thyroid Stimulating Hormone ◽  
Male Ratio ◽  
Retrospective Cohort Analysis ◽  
Race Ethnicity ◽  
Genetic And Environmental Factors

AbstractBackground:Congenital hypothyroidism (CH) is a common and preventable cause of intellectual disability for which early diagnosis is difficult without newborn screening. Genetic and environmental factors, race, ethnicity, sex, and pregnancy outcomes were noted as risk factors. In the study we aimed to determine the incidence of CH among different ethnic groups in the capital of Macedoina – a multiethnic city.Methods:A 14-year retrospective cohort analysis was performed on 121,507 newborns in the capital of Macedonia, Skopje, screened for whole-blood thyroid-stimulating hormone (TSH), in dry blood spots collected 48–72 h after birth, during the period 2002–2015. A TSH value of 15 mIU/L was used as cutoff point until 2010 and 10 mIU/L thereafter.Results:Primary CH was detected in 46 newborns (female to male ratio 1.3) with overall incidence of 3.8/10,000 (1/2641). The incidence of primary CH was significantly increased after lowering the TSH cutoff value (p=0.038), primarily due to detected neonates with transient CH for this period. Ethnic differences in the incidence of primary CH were detected. CH incidence among Roma neonates (6.7/10,000) was significantly higher (p<0.05) than the incidence detected in Macedonians (3.9/10,000) or Albanians (3.7/10,000).Conclusions:Increased incidence of CH in Roma newborns was detected as compared to other ethnicities in the capital of Macedonia. Further analysis of factors in direct interrelationship with the increased CH incidence in Roma newborns, as well as elucidation of impact of the CH incidence in this ethnicity on the overall incidence in Skopje, is warranted.

scholarly journals Association of epilepsy and asthma: a population-based retrospective cohort study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4792 ◽  
Author(s):  
Kuo-Liang Chiang ◽  
Fang-Chuan Kuo ◽  
Jen-Yu Lee ◽  
Chin-Yin Huang
Keyword(s):  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Population Based ◽  
Control Group ◽  
Research Database ◽  
Asthma Incidence ◽  
Kaplan Meier ◽  
Retrospective Cohort Analysis ◽  
Increased Risk ◽  
Epilepsy Diagnosis

Background Epidemiologic data supporting the epilepsy–asthma association are insufficient. Therefore, we examined this association in this study. Methods By using claims data from the National Health Insurance Research Database (Taiwan), we executed a retrospective cohort analysis. Analysis 1 entailed comparing 150,827 patients diagnosed as having incident asthma during 1996–2013 with disease-free controls who were selected randomly during the same period, frequency matched in terms of age and sex. Similarly, analysis 2 entailed comparing 25,274 patients newly diagnosed as having epilepsy with sex- and age-matched controls who were selected randomly. At the end of 2013, we evaluated in analysis 1 the epilepsy incidence and risk and evaluated in analysis 2 the asthma incidence and risk. We applied Kaplan–Meier analysis to derive plots of the proportion of asthma-free seizures. Results In analysis 1, the asthma group exhibited a higher epilepsy incidence than did the control group (3.05 versus 2.26 per 1,000 person-years; adjusted hazard ratio: 1.39, 95% CI [1.33–1.45]). We also noted a greater risk of subsequent epilepsy in women and girls. In analysis 2, we determined that the asthma incidence between the control and epilepsy groups did not differ significantly; however, some age subgroups including children and individuals in their 30s had an increased risk. A negative association was found in adolescents. The Kaplan–Meier analysis revealed epilepsy to be positively associated with subsequent onset of asthma within seven years of epilepsy diagnosis. Discussion Asthma may be associated with high epilepsy risk, and epilepsy may be associated with high asthma risk among children and individuals in their 30s. Nevertheless, people with epilepsy in other age subgroups should be aware of the possibility of developing asthma within seven years of epilepsy diagnosis.

scholarly journals Maternal HBsAg carriers and pregnancy outcomes: a retrospective cohort analysis of 85,190 pregnancies

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yulong Zhang ◽  
Jiacheng Chen ◽  
Tingting Liao ◽  
Siwen Chen ◽  
Jianying Yan ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Postpartum Hemorrhage ◽  
Premature Birth ◽  
Retrospective Cohort ◽  
Placental Abruption ◽  
Cohort Analysis ◽  
Carrier Status ◽  
Retrospective Cohort Analysis ◽  
Adverse Pregnancy

Abstract Background Nowadays, a positive HBV carrier status is common among pregnant women, especially in endemic areas (such as China), little is known about the impact of maternal HBV infection on the risk of adverse pregnancy outcomes. Pregnant women with HBV infection often develop obstetric complications, such as pregnancy-induced hypertension (PIH) syndrome, postpartum hemorrhage, and gestational diabetes mellitus (GDM), and their infants often exhibit neonatal complications. Methods This study undertook a retrospective cohort analysis to explore the association of HBV carrier status with adverse pregnancy outcomes. A cohort of 85,190 women including 9699 HBsAg-positive and 73,076 HBsAg-negative pregnancies was retrospectively analyzed. Results It’s found that HBsAg-positive pregnancies may result in higher risk of various maternal outcomes such as ICP (OR 3.4,95%CI 2.80 to 4.13), postpartum hemorrhage (OR 1.16,95%CI 1.00 to 1.34). Interestingly, there was a decreased risk of Preeclampsia (OR 0.91,95%CI 0.87 to 0.96), premature rupture of membrane (OR 0.91,95%CI 0.87 to 0.96) and gestational hypertension (OR 0.828,95%CI 0.701 to 0.978). And in vaginal delivery subgroup analysis, It’s found that the HBsAg-positive group had a higher risk of placental abruption (OR, 1.44; 95% CI, 1.16–1.79). Conclusions The present results suggest that compared with HBV positive pregnancies were more likely to be ICP and postpartum hemorrhage. HBV-positive pregnant women underwent vaginal delivery were more likely to have placental abruption and premature birth compared with HBV-negative women. Obstetricians should be aware of ICP, postpartum hemorrhage, placental abruption and premature birth in HBV-positive pregnant women.

scholarly journals Correction to: Maternal HBsAg carriers and pregnancy outcomes: a retrospective cohort analysis of 85,190 pregnancies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yulong Zhang ◽  
Jiacheng Chen ◽  
Tingting Liao ◽  
Siwen Chen ◽  
Jianying Yan ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Hbsag Carriers ◽  
Retrospective Cohort Analysis

An amendment to this paper has been published and can be accessed via the original article.

Are perceptual disorder signs in diplegic cerebral palsied children stable over time? A retrospective cohort analysis

2020 ◽  
Vol 72 (2) ◽  
Author(s):  
Silvia Alboresi ◽  
Alice Sghedoni ◽  
Giulia Borelli ◽  
Stefania Costi ◽  
Laura Beccani ◽  
...  
Keyword(s):  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Retrospective Cohort Analysis ◽  
Over Time
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