Separation of Autonomous Function from Cell Density in Non-Immunogenic Hyperthyroidism

SummaryRegional autonomous cell mass (Q: cell density ratio) and function (T: toxicity index) were compared by double isotope parametric thyroid scintigraphy (Als et al., Nucl. Med. 1995; 34) in 53 patients with non-immunogenic hyperthyroidism before and after radioiodine therapy (aRIT) and showed a break-down (medians) of Q: 4.3→1.0 (toxic adenomas: TA), 2→1.1 (multifocal functional autonomies: MFA) (p <0.0001) as of T: 96→1.7 (TA), 15→1.1 (MFA) (p <0.001). Five functional aRIT patterns resulted: euthyroidism (n = 37, 70%), at half with scarred/non-scarred autonomous areas (low/higher T, respectively), primary hypothyroidism (n = 4), residual hyperthyroidism (n = 7), secondary hyperthyroidism (n = 5). The last two groups with persistent subnormal TSH values were clearly separated by divergent T, thyroxine and triiodothyronine levels. A resulting T >1 may represent a clinically sub-critical mass of residual autonomous tissue. This new technique facilitates individual prethera-peutic evaluations and aRIT quality control.

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Non-Immunogenic Hyperthyroidism before and after Radioiodine Therapy: Cell Mass and Autonomous Function

Radioactive Isotopes in Clinical Medicine and Research ◽

10.1007/978-3-0348-7772-5_60 ◽

1997 ◽

pp. 387-390

Author(s):

C. Als ◽

H. Rösler ◽

M. Listewnik ◽

D. Lüscher ◽

E. P. Ritter

Keyword(s):

Radioiodine Therapy ◽

Cell Mass ◽

Autonomous Function ◽

Before And After ◽

Immunogenic Hyperthyroidism

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Separation of Autonomous Function from Cell Density in Non-Immunogenic Hyperthyroidism

Nuklearmedizin ◽

10.1055/s-0038-1629717 ◽

1995 ◽

Vol 34 (06) ◽

pp. 215-222 ◽

Cited By ~ 1

Author(s):

Maria Listevnik ◽

H. Rösier ◽

E.-P. Ritter ◽

Claudine Als

Keyword(s):

Cell Density ◽

Visual Analysis ◽

Thyroid Tissue ◽

Density Ratio ◽

Regional Function ◽

Natural Evolution ◽

Tissue Mass ◽

Autonomous Function ◽

Functional Autonomy ◽

Immunogenic Hyperthyroidism

SummaryA new quantitative subtraction method of thyroid scans is proposed which shows that regional function (F) by far exceeds regional cellularity or cell density (C) in potentially toxic thyroidal areas of non-immunogenic hyperthyroidism (NIH). Methods: A multistep processing of radioiodine and MIBI thyroid scans of patients with non-immunogenic hyperthyroidism led to normalized images of regional function excess and of perinodular enhancement. Two numeric factors were derived from regions of interest: Q (cell density ratio) comparing MIBI uptake in autonomous and suppressed areas and T (toxicity index): the maximal F/C contrast. Results: Q never exceeded 61; T, however, expanded toxicity levels over a range of 6-8735 with toxic adenomas (median = 165) and with hot areas of multifocal functional autonomy (median = 15). T was weakly correlated to serum TT3 (r = 0.41), but not to autonomous tissue mass, ultrasonographic or cytologic criteria. Conclusions: T is governed by inherent features of autonomous tissue and the response of the imbedded thyroid tissue to TSH stimulation. This standardized technique consolidates experiences from visual analysis; the huge T range mirrors the natural evolution from compensated autonomy towards hyperthyroid, decompensated stages.

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Effect of thyroid function on serum somatomedin activity

Acta Endocrinologica ◽

10.1530/acta.0.0960491 ◽

1981 ◽

Vol 96 (4) ◽

pp. 491-497 ◽

Cited By ~ 23

Author(s):

Josef Marek ◽

Marie Schüllerová ◽

Olga Schreiberová ◽

Zdeňka Límanová

Keyword(s):

Thyroid Hormones ◽

Replacement Therapy ◽

Primary Hypothyroidism ◽

Embryonic Chick ◽

Mean Values ◽

Before And After ◽

And Function ◽

Hypothyroid Patients ◽

Hyperthyroid Patients

Abstract. To obtain more information about a possible role of somatomedins in mediating the effects of thyroid hormones on the development and function of epiphyseal cartilage, somatomedin activity, measured on the basis of 35S incorporation in embryonic chick cartilage, was studied in thyrotoxic patients before and after treatment with carbimazole or surgery and in a group of patients with primary hypothyroidism. In 29 hyperthyroid patients mean values of somatomedin were 1.29 ± 0.03 sem and differed significantly (P < 0.01) from normals (1.04 ± 0.03). In 15 carbimazole treated patients and in 5 operated patients with thyrotoxicosis somatomedin levels fell from 1.29 ± 0.04 to 1.03 ± 0.04 (P < 0.01) when the patients became euthyroid. Correspondingly, somatomedin levels in 12 untreated hypothyroid patients (0.82 ± 0.04) were significantly less than in normals (P < 0.01) and increased from 0.77 ± 0.09 to 1.14 ± 0.13 (P < 0.05) in 4 patients on replacement therapy. In conclusion: somatomedin levels rise when thyroid hormones are present in excess, and fall when these are deficient. This suggests that thyroid hormones are important regulators of somatomedin levels.

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EFEITOS DO DEEP RUNNING SOBRE A AMPLITUDE DE MOVIMENTO E A CAPACIDADE FUNCIONAL DOS MEMBROS SUPERIORES DE MULHERES MASTECTOMIZADAS: RELATO DE CASOS

Revista Científica JOPEF ◽

10.34059/ciejop.2019v27i1-11 ◽

2019 ◽

pp. 121-131

Keyword(s):

Range Of Motion ◽

Upper Limb ◽

Functional Capacity ◽

External Rotation ◽

Treatment Protocol ◽

Range Of Movement ◽

Flexion Extension ◽

Before And After ◽

In The Beginning ◽

And Function

Introduction: Breast cancer is the most common type of cancer among women in Brazil and in the worl. The surgical treatment procedure may cause severe morbidity in the upper limb homolateral to surgery, including the reduction of the range of motion, with consequent impairment of function. A physiotherapeutic approach has an important role in the recover range of motion and the functionality of these women, guaranteeing the occupational, domestestic, familiar and conjugated activities, and, in this way, also improving the quality of life. Objectives: To analyse chances in the shoulder's range of motion and the functional capacity of the upper limbs, promoted by the deep running procedure in women with late postoperative mastectomy. Methods: All the patients were submitted to an evaluation in the beginning and end of the treatment, including: goniometry of flexion, extension, abduction, adduction, internal and external rotation of the shoulder joint; and function capacity analysis in activities that involve the upper members by DASH questionnaire. The treatment protocol includes twelve sessions of deep running, realized twice a week, in deep pool, for 20-minute during six weeks. Results: Were submitted to treatment a total of 4 patients. Despite the improvement in the numerical values, statistically significant differences were not found on the range of movements and in the functional capacity of upper members before and after the deep running sessions in post-mastectomy women. Conclusion: Deep running had effects on the numerical values of range of movement and upper limb functionality in women in the late postoperative period of the mastectomy procedure, but without statistically significant differences.

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The repeatability of measurements of male pelvic floor anatomy and function made from transperineal ultrasound images of healthy men and those before and after prostatectomy

Neurourology and Urodynamics ◽

10.1002/nau.24701 ◽

2021 ◽

Author(s):

David Cowley ◽

Ryan E. Stafford ◽

Paul W. Hodges

Keyword(s):

Pelvic Floor ◽

Transperineal Ultrasound ◽

Ultrasound Images ◽

Healthy Men ◽

Before And After ◽

And Function

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Are Three Weeks of Oral Anticoagulation Sufficient for Safe Cardioversion in Atrial Fibrillation?

Medicina ◽

10.3390/medicina57060554 ◽

2021 ◽

Vol 57 (6) ◽

pp. 554

Author(s):

Stefan Naydenov ◽

Nikolay Runev ◽

Emil Manov

Keyword(s):

Atrial Fibrillation ◽

Sinus Rhythm ◽

Oral Anticoagulation ◽

Left Atrial ◽

Left Atrial Volume ◽

Open Label ◽

Before And After ◽

Individualized Approach ◽

Baseline Factors ◽

And Function

Background and Objectives: Patients with atrial fibrillation (AF), lasting >48 h, considered for cardioversion, are recommended ≥3 weeks of oral anticoagulation before sinus rhythm restoration because of high risk of development of left atrial thrombosis (LAT) and stroke. However, the optimal duration of anticoagulation in the presence of overt LAT is unknown. Materials and Methods: An open-label study aimed to investigate the prevalence of spontaneous echo contrast (SEC) and LAT before and after 3 weeks of direct oral anticoagulant (DOAC) treatment. We included 51 consecutive patients (50.9% males), mean age 69.3 ± 7.4 years with paroxysmal/unknown duration of AF, considered for cardioversion, who agreed to have transesophageal echocardiography at enrollment and 3 weeks later. Results: At baseline SEC was present in 26 (50.9%) and LAT in 10 (19.6%) of 51 patients. After 3 weeks on DOAC, SEC persisted in 12 (25.0%) and LAT in 7 (14.5%) of 48 patients, p < 0.05 vs. baseline. Factors, associated most strongly with persistence of SEC/LAT, were left atrial appendage (LAA) emptying velocity <20 cm/s (OR = 2.82), LAA lobes >2 (OR = 1.84), and indexed left atrial volume ≥34 mL/m2 (OR = 1.37). Conclusions: In our study the incidence of SEC/LAT, particularly in AF with unknown duration, was not as low as we expected. The prevalence of SEC/LAT seemed to be dependent on factors not routinely evaluated in AF patients planned for cardioversion (indexed LA volume, LAA morphology and number of lobules, LAA emptying velocity, etc.). Our data suggested an individualized approach for DOAC duration in AF patients before an attempt for restoration of sinus rhythm is made, taking into consideration the LAA morphology and function.

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Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic -Cell Mass and Function in a Rodent Model of Type 2 Diabetes

Diabetes ◽

10.2337/db05-1602 ◽

2006 ◽

Vol 55 (6) ◽

pp. 1695-1704 ◽

Cited By ~ 333

Author(s):

J. Mu ◽

J. Woods ◽

Y.-P. Zhou ◽

R. S. Roy ◽

Z. Li ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cell Mass ◽

Dipeptidyl Peptidase ◽

Rodent Model ◽

Pancreatic Cell ◽

Dipeptidyl Peptidase 4 ◽

And Function

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Lack of effects of circulating thyroid hormone levels on serum leptin concentrations

Acta Endocrinologica ◽

10.1530/eje.0.1370659 ◽

1997 ◽

pp. 659-663 ◽

Cited By ~ 53

Author(s):

S Corbetta ◽

P Englaro ◽

S Giambona ◽

L Persani ◽

WF Blum ◽

...

Keyword(s):

Thyroid Hormones ◽

Standard Deviation Score ◽

Protein Product ◽

Primary Hypothyroidism ◽

Central Hypothyroidism ◽

Serum Leptin ◽

Thyroxine Therapy ◽

Significant Difference ◽

Before And After ◽

Thyroxine Replacement Therapy

Leptin is the protein product of the ob gene, secreted by adipocytes. It has been suggested that it may play an important role in regulating appetite and energy expenditure. The aim of this study was to evaluate a possible interaction of thyroid hormones with the leptin system. We studied 114 adult patients (65 females and 49 males): 36 were affected with primary hypothyroidism (PH), 38 with central hypothyroidism (CH) and 40 with thyrotoxicosis (TT). Patients with CH were studied both before and after 6 months of L-thyroxine replacement therapy. Body mass index (BMI; kg/m2), thyroid function and fasting serum leptin were assessed in all patients. Since BMI has been proved to be the major influencing variable of circulating leptin levels, data were expressed as standard deviation score (SDS) calculated from 393 male and 561 female controls matched for age and BMI. No difference in SDS was recorded between males and females whatever the levels of circulating thyroid hormones. In males, no significant difference was recorded among the SDSs of PH (-0.36 +/- 1.2), TT (-0.35 +/- 1.2) and CH (0.01 +/- 1.4) patients. Females with PH had an SDSs significantly lower than TT females (-0.77 +/- 1.0 vs -0.06 +/- 1.2; P < 0.02), while no significant differences between CH (-0.34 +/- 0.7) and TT females or between CH and PH females were observed. SDS in CH patients after 6 months of L-thyroxine therapy significantly varied only in females (0.25 +/- 1.4). In conclusion, circulating thyroid hormones do not appear to play any relevant role in leptin synthesis and secretion. However, as females with either overt hypo- or hyper-thyroidism or central hypothyroidism after L-thyroxine therapy show differences in their SDSs, a subtle interaction between sex steroids and thyroid status in modulating leptin secretion, at least in women, may occur.

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