Diagnostic value Of Ethanol Gelation Test (EGT) And Fibrin- (OGEN) Degradation Products (FDP) In Suspected Deep Vein Thrombosis (DVT), Correlated To The 125-1-Fibrinogen Uptake Test (FUT)

1981 ◽  
Author(s):  
T Hamborg ◽  
A Skjennald ◽  
H C Godal
Keyword(s):  
Degradation Products ◽  
Diagnostic Value ◽  
Control Groups ◽  
P Values ◽  
Vein Thrombosis ◽  
Chi Squared ◽  
Uptake Test ◽  
Blood Specimens ◽  
Deep Vein ◽  
Gelation Test

The study was performed in order to investigate the correlation between EGT, respectively FDP, and a positive FUT (FUT+), confirmed by venography. Control groups: patients 1) with a negative FUT (FOT−) in spite of DVT, 2) without DVT, because a negative venography also implies FUT−. Accordingly, FUT was not accomplished in this group.The material consisted of 41 patients with clinically suspected DVT; 20 with and 21 without DVT. Of the patients with DVT, 9 were definitely FUT+ and 11 definitely FUT−.EGT was applied for detection of soluble fibrin, Thrombo- Wellcotest for FDP and the Chi-squared test for statistical analysis. Blood specimens were analysed 0-1 days before isotope injection in patients with DVT, or 0-2 days before a negative venography.Conclusions: In this material, 1) Concurrently abnormal EGT and FDP was specific for the FUT+ patients. 2) On the other hand, a positive FUT could be excluded when both parameters were normal. 3) In patients with DVT, a positive EGT was found only in the FUT+ patients. (P values in the table refers to comparison with the FUT+ group).

Diagnostic Value Of Ethanol Gelation Test (EGT) For Detection Of Early Deep Vein Thrombosis (DVT) In Patients With Stroke

1981 ◽  
Author(s):  
T Hamborg ◽  
H C Godal
Keyword(s):  
Average Frequency ◽  
Diagnostic Value ◽  
Sex Distribution ◽  
Marked Rise ◽  
Duration Of Symptoms ◽  
Vein Thrombosis ◽  
Motor Paralysis ◽  
Completed Stroke ◽  
Uptake Test ◽  
Deep Vein

In the present study, EGT was applied for detection of fibrinaemia in patients with early DVT, as diagnosed by the 125-I-fibrinogen uptake test (FUT). The study included 25 patients with completed stroke and upper motor paralysis of at least one extremity. Patients who were critically ill, or with duration of symptoms for more than one week, were not included.The isotope was injected at admission and FUT became definitely positive (FUT+) 2-12 (mean 5) days later in 17 patients (68%). In the remaining 8, FUT was negative (FUT−) for 11-14 days. FUT recordings were taken for up to 2 weeks, and EGT was analyzed thrice a week, or at least until DVT was diagnosed. The two groups were comparable in respect with age and sex distribution, mortality and frequency of serious impairment of consciousness.Results: During the study period, EGT was positive at least once in 13 of the 17 FUT+ patients, against only 1 of the 8 FUT− patients (P< 0.02). EGT was positive in 34 (37%) of totally 97 specimens from the FUT+ group, but in only 1 (2%) of 50 specimens from the FUT− group (P<0.001). In the FUT+ group, the frequency of positive EGT increased from about 10 to 70%, with a marked rise three days (day −3) before the first positive FUT (day 0).During the period from day −11 to −4, the average frequency was 13% (3/24), while it was 46% (33/72) in the last period from day −3 to +9). This increase in correlation to the time of first positive FUT, was statistically significant (P<0.01).Conclusion: A positive EGT in moderately ill stroke patients, necessitates further examinations in respect with DVT, as some of these may need anticoagulants to prevent serious embolic complications.

D-Dimers, Thrombin Antithrombin III Complexes and Prothrombin Fragments 1 + 2: Diagnostic value in Clinically Suspected Deep Vein Thrombosis

1991 ◽  
Vol 65 (01) ◽  
pp. 028-032 ◽  
Author(s):  
B Boneu ◽  
G Bes ◽  
H Pelzer ◽  
P Sié ◽  
H Boccalon
Keyword(s):  
Deep Vein Thrombosis ◽  
Antithrombin Iii ◽  
High Sensitivity ◽  
Diagnostic Value ◽  
Predictive Values ◽  
Vein Thrombosis ◽  
High Negative Predictive Value ◽  
Deep Vein ◽  
D Dimer ◽  
Mercury Strain Gauge

SummaryThis study was performed to determine the accuracy of D-Dimer fibrin derivatives, thrombin-antithrombin III (TAT) complexes and prothrombin fragments 1 + 2 (F 1 + 2) determinations for the diagnosis of deep vein thrombosis (DVT). One hundred and sixteen consecutive patients referred to the angiology unit of our hospital for a clinically suspected DVT were investigated. They were submitted to mercury strain gauge plethysmography and to ultrasonic duplex scanning examination; in cases of inconclusive results or of proximal DVT (n = 35), an ascending phlebography was performed. After these investigations were completed, the diagnosis of DVT was confirmed in 34 and excluded in 82. One half of the patients were already under anticoagulant therapy at the time of investigation. The 3 biological markers were assayed using commercially available ELISA techniques and the D-Dimer was also assayed with a fast latex method. The normal distribution of these markers was established in 40 healthy blood donors. The most accurate assay for the diagnosis of DVT was the D-Dimer ELISA which had both a high sensitivity (94%) and a high negative predictive value (95%). The D-Dirner latex, TAT complexes and F 1 + 2 were far less sensitive and provided negative predictive values which ranged between 78 and 85%. In spite of positive and significant correlations between the levels of ihe 3 markers, their association did not improve their overall accuracy for detecting D\/L Therefore, with the exception of the D-Dimer ELISA, these markers were of little value for the diagnosis of DVT in this specific population.

Outcome of Treatment of Deep-Vein Thrombosis with Urokinase: Relationship to Dosage, Duration of Therapy, Age of the Thrombus and Laboratory Changes

1984 ◽  
Vol 51 (02) ◽  
pp. 236-239 ◽  
Author(s):  
A D’Angelo ◽  
P M Mannucci
Keyword(s):  
Degradation Products ◽  
High Rate ◽  
Bleeding Complications ◽  
Vein Thrombosis ◽  
Treatment Regimens ◽  
Duration Of Therapy ◽  
Laboratory Changes ◽  
Deep Vein ◽  
Dose Dependent ◽  
Higher Doses

SummaryForty-one patients with phlebographically proven DVT of the popliteal, femoral or iliac veins were treated with different regimens of urokinase (UK) given by continuous intravenous infusion. The four groups were comparable with respect to localization, extension and estimated age of the thrombi. Another phlebographic picture was taken within 48 hr after the end of UK infusion. Substantial lysis had occurred in 2 of 10 patients treated with 1500 U/kg/h for 2 days, in 4 of 11 treated with 2500/U/kg/h for 3 days, in 2 of 10 treated with 2500 U/kg/h for 7 days and in 4 of 10 treated with 4000 U/kg/h for 4 days. Only thrombi younger than 8 days could be lysed, with 61% (8/13) rate of lysis for thrombi less than 5 days old. Bleeding complications were observed more frequently with the higher doses and longer durations of therapy. The four treatment regimens all induced dose-dependent changes in fibrinogen, fibrin(ogen) degradation products, plasminogen and antiplasmin. Neither pre- nor postinfusion values of these parameters could differentiate patients with lysis from those without lysis. It is concluded that UK can provoke a high rate of thrombolysis of DVT treated early after the appearance of symptoms but that there is no relationship between UK-induced modifications of fibrinolysis and the outcome of therapy.

Performance of five D-dimer assays for the exclusion of symptomatic distal leg vein thrombosis

2012 ◽  
Vol 107 (02) ◽  
pp. 369-378 ◽  
Author(s):  
Jan Schwonberg ◽  
Carola Hecking ◽  
Marc Schindewolf ◽  
Dimitrios Zgouras ◽  
Susanne Lehmeyer ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Diagnostic Value ◽  
Vein Thrombosis ◽  
Clinical Probability ◽  
Wells Score ◽  
Deep Vein ◽  
Test Result ◽  
D Dimer ◽  
Rule Out ◽  
Compression Ultrasonography

SummaryThe diagnostic value of D-dimer (DD) in the exclusion of proximal deep-vein thrombosis (DVT) is well-established but is less well-known in the exclusion of distal (infrapopliteal) DVT. Therefore, we evaluated the diagnostic abilities of five DD assays (Vidas-DD, Liatest-DD, HemosIL-DD, HemosIL-DDHS, Innovance-DD) for excluding symptomatic proximal and distal leg DVT. A total of 243 outpatients whose symptoms were suggestive of DVT received complete compression ultrasonography (cCUS) of the symptomatic leg(s). The clinical probability of DVT (PTP) was assessed by Wells score. Thirty-eight proximal and 31 distal DVTs (17 tibial/fibular DVTs, 14 muscle DVTs) were diagnosed by cCUS. Although all assays showed high sensitivity for proximal DVT (range 97–100%), the sensitivity was poor for distal DVT (range 78–93%). None of the assays were individually able to rule out all DVTs as a stand-alone test (negative predictive value [NPV] 91–96%). However, a negative DD test result combined with a low PTP exhibited a NPV of 100% for all DVTs (including proximal, tibial/fibular, and muscle DVTs) with the HemosIL-DDHS and Innovance-DD. All proximal and tibial/fibular DVTs, but not all muscle DVTs, could be ruled out with this strategy using the Liatest-DD and Vidas-DD. The HemosIL-DD could not exclude distal leg DVT, even in combination with a low PTP. The combination of a negative DD with a low PTP showed a specificity of 32–35% for all DVTs. In conclusion, our study shows that when used in conjunction with a low PTP some DD assays are useful tools for the exclusion of distal leg DVT.

Evaluating anticoagulation sensitivity among elderly patients managed with an institution’s heparin protocol using initial anti-factor Xa levels

2020 ◽  
Vol 77 (Supplement_1) ◽  
pp. S13-S18
Author(s):  
Adley Lemke ◽  
Jean Kohs ◽  
Lynn Weber
Keyword(s):  
Elderly Patients ◽  
Retrospective Cohort ◽  
Elderly Population ◽  
Factor Xa ◽  
The Elderly ◽  
Target Level ◽  
P Values ◽  
Vein Thrombosis ◽  
Coronary Syndrome ◽  
Deep Vein

Abstract Purpose The purpose of this study was to assess an institution’s heparin protocols in elderly and nonelderly adult populations to see if a response difference was observed. Methods This was a retrospective cohort study of hospitalized adults who were prescribed unfractionated heparin due to surgery, acute coronary syndrome (ACS), or deep vein thrombosis/pulmonary embolism (DVT/PE) from February 11, 2016, through August 1, 2017. Patients were divided into nonelderly adults 18 to 69 years of age and elderly patients 70 years of age or older. The anti-factor Xa (anti-Xa) level after protocol initiation was compared to the institution’s goal range of 0.3 to 0.7 IU/mL. Outcomes of each protocol in the elderly population were compared to outcomes in their nonelderly counterparts to determine if there was a difference in heparin response. Results A total of 325 patients were included in the analysis, comprising 150 elderly and 175 nonelderly adults. Elderly patients had a higher initial anti-Xa levels than did their nonelderly adult counterparts in the ACS, DVT/PE, and surgery protocols, with P values of 0.02, &lt;0.001, and 0.01, respectively. Only the ACS protocol demonstrated increased frequency of above-target-level anti-Xa levels in the elderly (P = 0.03). Conclusion Elderly patients had significantly higher initial anti-Xa levels than did nonelderly adult patients across all protocols. This study identifies the need to further study elderly patients’ increased heparin sensitivity to determine if a separate dosing protocol is needed.

Diagnostic Value of Plasma Thrombin-Antithrombin III Complex and D-Dimer Concentration in Patients with Varicose Veins for Exclusion of Deep-Vein Thrombosis

1998 ◽  
Vol 91 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Tomio Kawasaki ◽  
Nobutoshi Shinoki ◽  
Shin-ichi Iwamoto ◽  
Hironobu Fujimura ◽  
Norihide Yoshikawa ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Antithrombin Iii ◽  
Varicose Veins ◽  
Diagnostic Value ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Thrombin Antithrombin Iii Complex ◽  
D Dimer

Antiphospholipid antibody profile: implications for the evaluation and management of patients

Lupus ◽  
2010 ◽  
Vol 19 (4) ◽  
pp. 432-435 ◽  
Author(s):  
A. Tincani ◽  
L. Andreoli ◽  
C. Casu ◽  
R. Cattaneo ◽  
P. Meroni
Keyword(s):  
Pregnancy Loss ◽  
Severe Disease ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Antiphospholipid Antibody ◽  
Vein Thrombosis ◽  
Glycoprotein I ◽  
Antibody Assays ◽  
Independent Risk Factors ◽  
Deep Vein

According to the classification criteria of antiphospholipid syndrome, lupus anticoagulant, anticardiolipin and anti-β2 glycoprotein I antibody assays are independent risk factors for the occurrence of vascular thrombosis and pregnancy loss. However, it is generally accepted that patients carrying multiple positivity have more a severe disease and higher recurrence rate despite treatment. On the other hand, the diagnostic value of a positive result in one only assay is more controversial, particularly in the presence of clinical manifestations such as deep vein thrombosis or early miscarriages, which are rather common in the general population. In this review we speculate on current and future strategies to interpret different antiphospholipid antibody profiles in the clinical practice. Lupus (2010) 19, 432—435.

FIBRIN/FIBRINOGEN DEGRADATION PRODUCTS AND DEEP-VEIN THROMBOSIS

The Lancet ◽  
1972 ◽  
Vol 299 (7751) ◽  
pp. 640-641
Author(s):  
J.D. Cash ◽  
P.C. Das ◽  
C.V. Ruckley ◽  
A.A. Donaldson ◽  
W.A. Copland ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Degradation Products ◽  
Fibrinogen Degradation Products ◽  
Vein Thrombosis ◽  
Deep Vein
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