F.VIII R:Ag in Hepatitis

1979 ◽  
Author(s):  
R. Kotitschke ◽  
J. Scharrer
Keyword(s):  
Chronic Hepatitis ◽  
Blood Donors ◽  
Blood Donation ◽  
Normal Population ◽  
Rabbit Antiserum ◽  
Two Dimensional ◽  
Plastic Plate ◽  
Significant Difference ◽  
Acute Hepatitis B ◽  
The One

F.VIII R:Ag was determined by quantitative immunelectrophoresis (I.E.) with a prefabricated system. The prefabricated system consists of a monospecific f.VIII rabbit antiserum in agarose on a plastic plate for the one and two dimensional immunelectrophoresis. The lognormal distribution of the f.VIII R:Ag concentration in the normal population was confirmed (for n=70 the f.VIII R:Ag in % of normal is = 95.4 ± 31.9). Among the normal population there was no significant difference between blood donors (one blood donation in 8 weeks; for n=43 the f.VIII R:Ag in % of normal is = 95.9 ± 34.0) and non blood donors (n=27;f.VIII R:Ag = 94.6 ± 28.4 %). The f.VIII R:Ag concentration in acute hepatitis B ranged from normal to raised values (for n=10, a factor of 1.8 times of normal was found) and was normal again after health recovery (n=10, the factor was 1.0). in chronic hepatitis the f.VIII R:Ag concentration was raised in the majority of the cases (for n=10, the factor was 3.8). Out of 22 carrier sera 20 showed reduced, 2 elevated levels of the f.VIII R:Ag concentration. in 5 sera no f.VIII R:Ag could be demonstrated. The f.VIII R:Ag concentration was normal for n=10, reduced for n=20 and elevated for n=6 in non A-non B hepatitis (n=36). Contrary to results found in the literature no difference in the electrophoretic mobility of the f.VIII R:Ag was found between hepatitis patients sera and normal sera.

F.VIII R.Ag in Hepatitis

1979 ◽  
Author(s):  
R. Kotitschke ◽  
J. Scharrer
Keyword(s):  
Chronic Hepatitis ◽  
Blood Donors ◽  
Blood Donation ◽  
Normal Population ◽  
Rabbit Antiserum ◽  
Two Dimensional ◽  
Plastic Plate ◽  
Significant Difference ◽  
Acute Hepatitis B ◽  
The One

F.VIII R:Ag was determined by quantitative immunelectrophoresis (I.E.) with a pre-fabricated system. The prefabricated system consists of a monospecific f.VIII rabbit antiserum in agarose on a plastic plate for the one-and two-dimensional immunelectrophoresis. The lognormal distribution of the f.VIII R:Ag concentration in the normal population was confirmed (for n=70 the f.VIII R:Ag in ± of normal is = 95.4 ± 31.9). Among the normal population there was no significant difference between blood donors (one blood donation in 8 weeks; for n=43 the f.VIII R:Ag in % of normal is = 95.9 ± 34.0) and non blood donors (n=27;f.VIII R:Ag = 94.6 ± 28.4 %). The f.VIII R:Ag concentration in acute hepatitis B ranged from normal to raised values (for n=10, a factor of 1.8 times of normal was found) and was normal again after health recovery (n=10, the factor was 1.0). In chronic hepatitis the f.VIII R:Ag concentration was raised in the majority of the’ cases (for n=10, the factor was 3.8). Out of 22 carrier sera 20 showed reduced, 2 elevated levels of the f.VIII R:Ag concentration. In 5 sera no f.VIII R:Ag could be demonstrated. The f.VIII R:Ag concentration was normal for n=10, reduced for n=20 and elevated for n=6 in non A-non B hepatitis (n=36). Contrary to results found in the literature no difference in the electrophoretic mobility of the f.VIII R:Ag was found between hepatitis-patients sera and normal sera.

scholarly journals Volume Measurements in Aortic Root Assessment Using Two-Dimensional Echocardiography

2016 ◽  
Vol 10 ◽  
pp. CMC.S39383
Author(s):  
Adebayo T. Oyedeji ◽  
Bolaji E. Egbewale ◽  
Adeseye A. Akintunde ◽  
Ebenezer A. Ajayi ◽  
Olukolade O. Owojori ◽  
...  
Keyword(s):  
Aortic Root ◽  
Normal Population ◽  
Age Groups ◽  
Aortic Dilatation ◽  
Two Dimensional ◽  
Linear Measurements ◽  
2D Echocardiography ◽  
Significant Difference ◽  
Volume Measurements ◽  
Dimensional Echocardiography

Background Aortic dilatation is associated with the presence of aortic diseases. Current guidelines for assessing the aortic root (AoR) depend on linear measurements acquired by two-dimensional (2D) echocardiography. We considered that real-time three-dimensional echocardiography, which correlates better with AoR volume obtained by computed tomography, is widely unavailable, and therefore, there is a need to determine the AoR volume using 2D echocardiography. Methods Fifty-one consecutive apparently healthy volunteers were recruited and subsequently divided into three age groups. Specified planes of acquisition and previously defined landmarks were identified, and phases of the cardiac cycle that allowed for measurement standardization were used. Volume was determined by the modified Simpson's method. Results Although the average diastolic and systolic volume measurements of the AoR dimensions were not significantly different across the three age groups in the study population, a highly significant difference was observed in the volume measurements between male and female normotensive persons, P < 0.01 in each case. AoR volume measurements were five times in the diseased compared with the normotensive individuals; however, linear measurements were only 1.5 times in size of the normal individuals. Both point and interval estimates of the volume measurements of AoR in adult normotensives in three age groups were presented as baseline information. Conclusions We hereby present a novel way to determine the AoR volume using 2D echocardiography and the normal reference range with respect to age and gender. We also established the relevance of our measurement by comparing the normal population with two isolated diseased aortas.

scholarly journals The Biomechanics of Erections: Modeling the Penis as a One-Comparment Pressurized Vessel vs. Modeling it as a Two-Compartments Pressurized Vessel

2009 ◽  
Vol 3 (2) ◽  
Author(s):  
A. Mohamed ◽  
A. Erdman ◽  
G. Timm
Keyword(s):  
Structural Integrity ◽  
Tunica Albuginea ◽  
Three Dimensional ◽  
The Body ◽  
Physical Models ◽  
Von Mises Stress ◽  
Two Dimensional ◽  
Biomechanical Models ◽  
Significant Difference ◽  
The One

Previous biomechanical models of the penis that have attempted to simulate penile erections have either been limited to two-dimensional geometry, simplified three-dimensional geometry or made inaccurate assumptions altogether. Most models designed the shaft of the penis as a one-compartment pressurized vessel fixed at one end, when in reality it is a two-compartments pressurized vessel, in which the compartments diverge as they enter the body and are fixed at two separate points. This study began by designing simplified two-dimensional and three-dimensional models of the erect penis using Finite Element Analysis (FEA) methods with varying anatomical considerations for analyzing structural stresses, axial buckling and lateral deformation. The study then validated the results by building physical models replicating the computer models. Finally a more complex and anatomically accurate model of the penis was designed and analyzed. There was a significant difference in the peak von-Mises stress distribution between the one-compartment pressurized vessel and the more anatomically correct two-compartments pressurized vessel. Furthermore, the two-compartments diverging pressurized vessel was found to have more structural integrity when subject to external lateral forces than the one-compartment pressurized vessel. This study suggests that Mother Nature has favored an anatomy of two corporal cavernosal bodies separated by a perforated septum as opposed to one corporal body, due to better structural integrity of the tunica albuginea when subject to external forces.

Comparison of Gravity Collection Versus Suction Collection for Transfusion Purposes in Dogs

2013 ◽  
Vol 49 (5) ◽  
pp. 301-307 ◽  
Author(s):  
Bérénice Conversy ◽  
Marie-Claude Blais ◽  
Lisa Carioto ◽  
Julie Beaudoin
Keyword(s):  
Blood Donors ◽  
Blood Product ◽  
Blood Donation ◽  
Cost Effective ◽  
Clinical Parameters ◽  
Cost Effective Method ◽  
Significant Difference ◽  
Before And After ◽  
Collection Methods ◽  
Time Point

Blood donation is an essential step in transfusion medicine that must take into account the donor’s welfare, collection effectiveness, and blood product quality. This prospective study enrolled 13 canine blood donors, each subjected to both gravity and suction collection methods, in a randomized order. Clinical parameters, including heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), and rectal temperature (RT), were evaluated at four time points, including when the donor was on the floor and on the collection table, and before and after blood donation. The number of times the donor and needle required repositioning, the duration of the donation, the noise created by the apparatus, and the presence of a hematoma were evaluated. The weight, index of hemolysis, and hematocrit of each unit of blood were recorded. There was no significant difference between collection methods for either the clinical parameters at each time point or the prevalence of hematoma formation, the frequency of needle repositioning, the hemolysis index, or hematocrit. Collection by suction was noisier (P &lt; 0.0001), faster (P = 0.004), and associated with significantly less donor repositioning (P = 0.007). Suction appears to be a safe and cost-effective method that should be considered to optimize blood donation.

scholarly journals Hepatitis G virus in Saudi blood donors and chronic hepatitis B and C patients

2014 ◽  
Vol 8 (01) ◽  
pp. 110-115 ◽  
Author(s):  
Abdulkarim Alhetheel ◽  
Malak Mohsen El-Hazmi
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Blood Donors ◽  
Study Groups ◽  
Exposure Rate ◽  
Hepatitis G Virus ◽  
Healthy Donors ◽  
Significant Difference ◽  
Chronic Hbv ◽  
Hepatitis G

Introduction: Screening blood donors for blood-borne pathogens is very critical for the recipient’s safety. Similar to hepatitis B and C infections, hepatitis G infection is transmitted through contaminated blood and causes acute and chronic hepatitis. Previous reports have shown that the prevalence of hepatitis G virus (HGV) RNA among healthy Saudi donors was 1%-2%. However, the exposure rate of this virus has never been studied. We hypothesized that the prevalence of HGV infection may have changed overtime due to socio-economic and environmental factors. Since hepatitis B and C infections are endemic in Saudi Arabia, we investigated the exposure rate of HGV infection in healthy donors and chronically infected hepatitis B and C patients. Methodology: A prospective study was done on healthy donors and patients with chronic HBV and HCV infections. Hepatitis B and C viral loads were measured by real-time polymerase chain reaction. HGV exposure rate was evaluated by detection of HGV antibodies. Results: Analysis of samples from healthy donors (n = 210), chronic HBV+ patients (n = 169), and chronic HCV+ patients (n = 105) showed that nine samples (4.3%), seven samples (4.1%), and four samples (3.8%) were positive for HGV antibodies, respectively. The non-significant difference in the exposure rates of HGV between the study groups may indicate that HGV infection occurs independent of HBV or HCV infections. Conclusions: We showed for the first time that the exposure rate of HGV infection among the Saudi population is 4.3%, and we recommend HGV screening for all blood donors.

scholarly journals Prevalence of transfusion transmissible infection in blood donors at tertiary care centre of Eastern Uttar Pradesh

2020 ◽  
Vol 11 (4) ◽  
pp. 5243-5247
Author(s):  
Sandip Kumar ◽  
Neeraj Dhameja ◽  
Satendra Kumar ◽  
Sunil Rao ◽  
Lalit Prashant Meena ◽  
...  
Keyword(s):  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Care ◽  
Transmitted Disease ◽  
Public Information ◽  
Uttar Pradesh ◽  
Blood Bank ◽  
Tertiary Care Centre ◽  
Screening Criteria ◽  
The One

Microbiological safety is very important aspect of blood transfusion services (BTS). Viral infectious agents possess a great risk of transfusion transmitted disease. On the one hand, blood or component transfusion is a lifesaving modality but on the other hand it can cause great mortality or morbidity in recipient if not used judiciously. The main aim of the study is to evaluate the prevalence of HIV, HBV, HCV, Syphilis and Malaria amongst all types of donors donated at blood bank of Sir Sunderlal Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi during the year 2017. This was a retrospective study. The blood donors included in this study include all donors coming directly to blood bank and blood donation camps organized by blood bank. Total donation during that period was 22255 units. A detailed questionnaire was given to the donors for registration. A total of 226 units (1.01%) were seropositive. The sero-prevalence of HIV, HBV, HCV, and Syphilis were 0.9% (21), 0.79% (177), 0.09% (22), 0.02% (6) respectively. No cases of malaria were detected. TTI can be reduced by motivating maximum voluntary blood donation, reducing replacement donation, public information and donor education awareness programme, stringent donor screening criteria and vigilance of error.

scholarly journals Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Mustafa Kerem Calgin ◽  
Yeliz Cetinkol
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Normal Population ◽  
Antiviral Treatment ◽  
Inverse Correlation ◽  
Systemic Circulation ◽  
Hbv Dna ◽  
Significant Difference

Background & Objective: Liver and intestines are anatomically and physiologically linked. Zonulin is a protein modulating intercellular tight junctions and regulating intestinal permeability. Copeptin was studied as a marker of systemic circulation disorders in research about vasopressin and was associated with liver disease prognosis. Serum zonulin and copeptin levels were measured in patients with diagnosis of chronic hepatitis B (CHB) with the aim of easing antiviral treatment management in clinical applications and to investigate the association with normal population and viral load. Methods: Analysis included the serum of 30 CHB patients and 17 controls. HBV-DNA real-time PCR tests were completed. CHB patients were divided into three subgroups according to viral load in serum. Zonulin and copeptin levels were measured using ELISA kits. Results: Serum zonulin and copeptin levels were significantly low in CHB patients compared to controls (p<0.001). When CHB subgroups are investigated in terms of serum zonulin and copeptin levels, there was an inverse correlation observed with significant difference (p<0.01, p<0.05). Conclusion: The negative correlation between serum zonulin and copeptin with HBV-DNA load revealed in our study shows they may be used to monitor treatment. Zonulin and copeptin assays provide the possibility of developing new approaches to CHB diagnosis and monitoring. doi: https://doi.org/10.12669/pjms.35.3.144 How to cite this:Calgin MK, Cetinkol Y. Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.144 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Unsteady flow of gas at high pressure into a closed volume filled with liquid

2020 ◽  
Vol 6 (4) ◽  
pp. 127-140
Author(s):  
Maksim V. Alekseev ◽  
Ivan S. Vozhakov ◽  
Sergey I. Lezhnin
Keyword(s):  
Numerical Study ◽  
Three Dimensional ◽  
Water System ◽  
Liquid Lead ◽  
Asymptotic Model ◽  
Closed Volume ◽  
Two Dimensional ◽  
Open Platform ◽  
Significant Difference ◽  
The One

Within the framework of 2D (two-dimensional, axisymmetric) and 3D (three-dimensional) formulations of the problem, this article presents a numerical simulation of the process of gas outflow under pressure into a closed container partially filled with liquid. The authors have performed the numerical modeling using the open platform OpenFOAM with the help of a solver based on the method of liquid volumes (VOF method) with a standard k-e turbulence model. A comparison is made with the one-dimensional (1D) asymptotic model, in which the oscillations of the fluid as a whole are determined by the enthalpy balance. A numerical study of the evolution of pressure during gas outflow is carried out. The results show that the physical properties of the fluid used affect the amplitude and frequency of the pulsations. The modeling has shown that gas flows into water in the form of a jet, and a projectile forms in liquid lead near the hole through which it flows out. The significant influence of three-dimensional effects on the evolution of gas outflow into liquid is demonstrated. Satisfactory agreement was obtained for both two-dimensional and three-dimensional calculations and the results obtained using the asymptotic model. For the “gas — water” system, the results of calculations by the asymptotic model give a significant difference from the results of numerical calculations.

scholarly journals Potential risk of induced malaria by blood transfusion in South-eastern Nigeria

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Chigozie Jesse Uneke ◽  
Ogbonnaya Ogbu ◽  
Vincent Nwojiji
Keyword(s):  
Blood Transfusion ◽  
Thick Film ◽  
Blood Donors ◽  
Blood Donation ◽  
Health Hazard ◽  
Sub Saharan Africa ◽  
Wet Season ◽  
Potential Health ◽  
South Eastern ◽  
Significant Difference

Induced malaria by blood transfusion is a potential health hazard but is often neglected in many malaria endemic areas. Standard parasitological technique was used to determine the prevalence of malaria among blood donors in the South-eastern Nigeria. Of the total 325 blood donors (310 males and 15 females) screened, 133 (40.9%, CI 95%: 35.6-46.2%) were infected with malaria parasite, 78 (58.6%) had 1-10 parasites per 100 thick film fields ('+' or 4-40 parasites per mm3) while 55 (41.4%) had 11-100 parasites per 100 thick film fields ('++' or 41-400 parasites per mm3). P. falciparum was identified in all the infected cases, however 3 (2.3%) persons had mixed infection with P. malariae. Males were more infected (41.3%, CI 95%: 35.8-46.8%) than females (33.3%, CI 95%: 9.4-57.2%). The infection decreased with age with highest prevalence of 48.5% among those aged 20-25 years. The infection significantly varied with age but not with sex (P<0.05). Individuals with blood group B were slightly more infected (42.1%, 95%CI., 19.6-64.6%) than those of groups O (41.0%,CI 95%: 35.3-46.7%) and A (40.0%, CI 95%: 20.8-59.2%) but there was no significant difference (P < 0.05). Highest prevalence of infection was recorded in the month of April corresponding to the onset of the wet season. An overhaul of existing blood donation policies in many health facilities in the sub-Saharan Africa to incorporate malaria screening is advocated. Curative antimalarial drugs followed by prophylactic drugs should be given to all recipients of Parasitized blood.

scholarly journals Seroprevalence of HBsAg among blood donar’s in Sher-E-Bangla Medical College, Barisal

1970 ◽  
Vol 1 (1) ◽  
pp. 38-40
Author(s):  
G Mahmood ◽  
CR Debnath ◽  
B Biswas
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Blood Donation ◽  
Medical Officer ◽  
College Hospital ◽  
Screening Programs ◽  
Medical College ◽  
Healthy Donors ◽  
Significant Difference ◽  
Age Range

Hepatitis B virus infection is a global health problem. About 350 to 400 million people are chronically infected with hepatitis B in the world. This is a retrospective study carried out in the department of transfusion medicine, Sher- E-Bangla Medical College Hospital, Barisal, during the period 1st January to 31st December 2007, among the blood donors who attended for blood donation. During this period 12,914 patients attended the department for transfusion. Among them 12,014 were male and 900 were female, age range was 18 to 60 years. Among them professional donors were 955, voluntary donors were 4494 and replacement donors were 7556 and HBsAg was positive in 0.42%, 0.87% and 1.11% respectively. Overall prevalence was 0.98%. The aim of this study was to determine the prevalence of HBsAg among blood donors at Sher-E-Bangla Medical College, Barisal. Blood samples were collected from 12914 healthy donors. All donors were pre-screened by a questionnaire provided by the institution and passed the physical examination conducted by the medical officer in charge. Blood donors data and results of HBsAg were analyzed using the blood bank's records. There was an overall prevalence of 0.98% of HBsAg(+) among all the tested blood donors. There was statistically significant difference between sexes. These results stress the importance of screening programs that must be implemented.   doi: 10.3329/blj.v1i1.2624 Bangladesh Liver Journal Vol.1(1) 2009 p.38-40 

Sign in / Sign up

Export Citation Format

Share Document