scholarly journals HAEMOcare: The First International Epidemiological Study Measuring Burden of Hemophilia in Developing Countries

TH Open ◽  
2019 ◽  
Vol 03 (02) ◽  
pp. e190-e199 ◽  
Author(s):  
Naresh Gupta ◽  
Abderrahmane Benbouzid ◽  
Meriem Belhani ◽  
Mohammed El Andaloussi ◽  
Khadija Maani ◽  
...  
Keyword(s):  
Developing Countries ◽  
Epidemiological Study ◽  
Treatment Center ◽  
Cross Sectional ◽  
Bleeding Rate ◽  
Joint Health ◽  
Clinical And Functional Status ◽  
Male Patients ◽  
Five Dimension

Introduction Optimizing hemophilia care remains challenging in developing countries. Burden-of-disease studies are important to develop strategies for improving hemophilia care. Aim The HAEMOcare study evaluated the factors contributing to hemophilia-related orthopedic disease burden in developing countries. Methods HAEMOcare was a noninterventional, cross-sectional, epidemiological study conducted in Algeria, India, Morocco, Oman, and South Africa. Male patients with severe hemophilia (N = 282) aged ≥6 years, without or with inhibitors, being treated on-demand for bleeding were included. Hemophilia-related orthopedic clinical and functional status was assessed using the Hemophilia Joint Health Score (HJHS), radiological status with the Pettersson Score, and quality of life with the EuroQol five-dimension questionnaire (EQ-5D-3L). Direct and indirect economic costs of hemophilia care were also calculated. Results Patients (mean [standard deviation, SD] age: 20.8 [10.6] years) experienced a mean annualized bleeding rate of 25.8. Overall mean (SD) HJHS and Pettersson score were 17.9 (12.8) and 15.0 (13.5), respectively; scores were similar between patients without or with inhibitors (p = 0.21 and 0.76, respectively). Approximately 70% of adults reported problems relating to pain/discomfort and mobility parameters in the EQ-5D-3L. Mean distance to a hemophilia treatment center (HTC) was 79.4 km. As expected, total costs of hemophilia were statistically significantly higher in patients with inhibitors versus without inhibitors (p = 0.002). Conclusion Inadequate access to HTCs and expert care, along with high bleeding rates, led to equivalent hemophilia-related orthopedic morbidity between hemophilia patients without and with inhibitors. HAEMOcare documented the economic and disease burdens associated with suboptimal hemophilia care in developing countries.

scholarly journals Distribution of the initial site of infection in diabetic foot and associated initiating etiologies

2021 ◽  
Vol 8 (11) ◽  
pp. 3320
Author(s):  
Joe Mathew ◽  
Rajeev S.
Keyword(s):  
Diabetic Foot ◽  
The Other ◽  
Common Condition ◽  
Cross Sectional ◽  
Site Specific ◽  
Loss Of Life ◽  
Factors Influencing ◽  
Male Patients ◽  
Nail Infection

Background: Diabetic foot is a very common condition responsible for a major bulk of surgical admissions and out-patient visits. Lack of awareness of many factors influencing the incidence of this disease complex has led to loss of life, limb and quality of life. The site-specific incidence of initial site and initiating factor has not been studied in diabetic foot.Methods: A study has been done over a period of one and a half years which looked into the distribution of initial site of infection in diabetic foot and associated initiating etiologies. The study was cross sectional. History, general inspection of foot, dermatological, neuropathic and vascular assessments were done, in addition to making careful notes about the site and cause of infection.Results:60.7% of patients were >60 years old, 55.3% were male patients. 63.3% of patients had diabetes for more than 10 years. In 29.3% the initial site of infection was the big toe, 22% in the ball of foot, 18% in the other 4 toes together, 14.7% in the interdigital spaces, 10.7% in the heel and 5.3% in the mid foot. In most of the cases the etiology is multifactorial, trauma in 56%, musculoskeletal deformities in 47.3%, callosities in 41.3%, cracks and fissures in 16.7%, fungal infection in 7.3%, nail infection in 6%, no initiating introduction of infection identified in 10.7%.Conclusions: Awareness of and thus particular stress being place on identification of specific site and cause of infection should help in care of the foot in diabetics.

scholarly journals Quality of life among older adults resident in long-stay care facilities

2012 ◽  
Vol 20 (6) ◽  
pp. 1186-1195 ◽  
Author(s):  
Luciano Magalhães Vitorino ◽  
Lisiane Manganelli Girardi Paskulin ◽  
Lucila Amaral Carneiro Vianna
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
Epidemiological Study ◽  
Social Relationships ◽  
Leisure Activity ◽  
Cross Sectional ◽  
The Social ◽  
Care Facilities

OBJECTIVES: to evaluate the older adults' perceptions of their quality of life (QoL) in two long-stay care facilities in Pouso Alegre and Santa Rita in Sapucaí, in the State of Minas Gerais, Brazil , and to identify the sociodemographic and health variables which interfere in this perception. METHOD: a cross-sectional epidemiological study of 77 older adults resident in institutions. The instruments used were: personal characterization; WHOQOL-bref and WHOQOL OLD. RESULT: the highest average obtained in the instruments was: the "Social Relationships" domain in the WHOQOL-bref (68%) and the "Sensory abilities" aspect in the WHOQOL-OLD (73.7%). The variables age, sex, physical activity and level of schooling have a significant correlation with the WHOQOL-bref and the variables sex and leisure have the same with the WHOQOL OLD. CONCLUSION: older adults who are younger, with higher levels of schooling and who undertake physical and leisure activity have, on average, better perceptions of their QoL. The older adults' QoL in this study had higher rates than that reported in the literature and was similar to that in the community. The results suggest the need to train those involved with older adults in institutions so that they may develop strategies which promote the adaptation, adjustment and maintenance of QoL.

Health related quality of life in male patients with osteoporosis: results of a cross sectional study

2012 ◽  
Vol 15 (4) ◽  
pp. 220-226 ◽  
Author(s):  
Karen Voigt ◽  
Stéphanie Taché ◽  
Matthias Hofer ◽  
Carsten Straßberger ◽  
Henna Riemenschneider ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cross Sectional Study ◽  
Health Related Quality ◽  
Sectional Study ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related ◽  
Male Patients

Gonadal function in male patients with metastatic renal cell cancer treated with sunitinib: Effects of testosterone replacement on quality of life.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 525-525
Author(s):  
Alberto Dalla Volta ◽  
Francesca Valcamonico ◽  
Carlo Cappelli ◽  
Andrea Delbarba ◽  
Vittorio D. Ferrari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Renal Cell ◽  
Cell Cancer ◽  
Cross Sectional Study ◽  
Testosterone Replacement ◽  
Sectional Study ◽  
Antiangiogenic Effect ◽  
Cross Sectional ◽  
Male Patients

525 Background: Sunitinib (S) is a standard first line treatment of metastatic renal cell carcinoma (mRCC). Asthenia and fatigue are the most prevalent toxicities but the relevant causes are not fully elucidated. Since endocrine glands are highly vascularized, the potent antiangiogenic effect of S can potentially impair their function. With the exception of hypothyroidism, the endocrine-related side-effects of S have not been extensively explored. Methods: We performed a cross-sectional study in which pituitary, thyroid, parathyroid, adrenal and gonadal functions were assessed in 25 mRCC patients who received 9 months of S therapy. Since a high prevalence of hypogonadism was observed, we subsequently enrolled 16 mRCC male patients in a prospective cohort study in which serum testosterone (T) serum free T, serum FSH and LH were evaluated at baseline and after 6 weeks (1 cycle) of S therapy. In patients eligible for testosterone replacement after andrologic evaluation, a FACT-G questionnaire for quality of life (QoL) assessment was prospectively administered at baseline and after 3 months. Results: In the cross sectional study 15/22 S treated male patients (68%) had serum T below the normal range and 13 of them (87%) presented with low/normal levels of LH. In the prospective study mean T levels (95% CI) were 5.04 ng/ml (3.4 - 6.7) at baseline and 4.1 ng/ml (3 - 5.3) after 6 weeks (p 0.05). The corresponding free T were 91.4 pg/ml (66 – 116.8) and 80.2 pg/ml (65 – 95.3) (p 0.24), respectively. Hypogonadism was observed in 5 (31%) patients at baseline and 10 (63%) patients after 6 weeks of S therapy. In the 5 patients becoming hypogonadic after S therapy, LH was 11.4 mU/ml (3.2 - 19.5) at baseline and 11.5 mUI/ml (0 – 23.5) after 6 weeks. Four patients were addressed to testosterone replacement. QoL significantly improved in 3 of them, with the strongest advantage in the physical comfort area. Conclusions: S therapy induces hypogonadism in a high proportion of male patients with mRCC. Low or inappropriately normal LH levels are consistent with a pituitary origin of the endocrine disorder. Testosterone replacement may improve the QoL and treatment tolerance.

scholarly journals The Psychosocial Impact of Rosacea in Men: First Quantitative Study

2021 ◽  
Vol 6 (4) ◽  
pp. 01-09
Author(s):  
Mohammed S Al Abadie ◽  
Farlin Asharaff ◽  
Dina Al Abadie
Keyword(s):  
Self Esteem ◽  
Coping Mechanisms ◽  
Psychosocial Impact ◽  
Emotional Impact ◽  
Function Score ◽  
Male Population ◽  
Cross Sectional ◽  
Male Patients ◽  
Mean Function

Psychosocial impact of Rosacea in men has generally been a topic that in understudied in literature. We conducted a cross-sectional paper-based survey was conducted with male patients who have experienced rosacea for at least five years at the dermatology outpatient department at New Cross Hospital in Wolverhampton, England to determine the psychosocial impact of Rosacea on Men Quality of life and self-esteem. 52 % of the male population were noted to be “often” mentally pre-occupied by rosacea and frustrated due to rosacea. 85 % of the male population “never” used cosmetic camouflage. Mean function score is noted to be 6.81. This indicates that men are less in favour of coping mechanisms. Results from this study highlight that despite the emotional impact rosacea has on the male population, they do not frequently use coping mechanisms. This emphasises the psychosocial impact of rosacea on male population and the need for dermatologists to address the emotional impact on men as part of management as well as to raise awareness around this topic.

scholarly journals Inequality in accessing learning during pandemic crises in developing countries: Reflections from COVID-19-induced online learning at a Kenyan pharmacy school

2021 ◽  
pp. 713-722
Author(s):  
Kihugi Veronica Njambi ◽  
Godfrey Wabwile Mayoka
Keyword(s):  
Developing Countries ◽  
Online Learning ◽  
Student Satisfaction ◽  
Online Survey ◽  
Cross Sectional Study ◽  
First Year ◽  
Cross Sectional ◽  
Perceptions Of Students ◽  
Learning Platforms

Background: Virtual learning platforms gained unprecedented prominence after the coronavirus disease 2019 (COVID-19) outbreak. Assuring the quality of education and student satisfaction are critical, especially in developing countries often plagued with infrastructural limitations, including information technology. Objectives: This study was conducted to assess the perceptions of students at a Kenyan Pharmacy School of online learning with regards to affordability and overall effectiveness. Methods: A cross-sectional study was conducted using an online survey containing pre-determined questions aligned to achieve the research objectives. Results: Students in senior classes (Fifth year) viewed online learning more favourably and had fewer challenges with accessibility than students in the lower classes (First year to third year). Conclusion: The study identified areas of strength, such as convenience, time-efficiency, and self-initiative, as well as weaknesses, including inequitable access, internet connectivity challenges, and unsatisfactory lecturer digital competency, with relation to online learning.

scholarly journals Prevalence of childhood Cancer among children attending referral hospitals of outpatient Department in Ethiopia

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Aklilu Endalamaw ◽  
Nega Tezera Assimamaw ◽  
Tadesse Awoke Ayele ◽  
Achenef Asmamaw Muche ◽  
Ejigu Gebeye Zeleke ◽  
...  
Keyword(s):  
Developing Countries ◽  
Childhood Cancer ◽  
Hodgkin Lymphoma ◽  
Low Income ◽  
Wilms Tumor ◽  
Sampling Technique ◽  
Lymphocytic Leukemia ◽  
Outpatient Department ◽  
Treatment Center ◽  
Cross Sectional

Abstract Introduction Childhood cancer is one of the leading causes of morbidity and mortality in the pediatrics age group. The problem affects both developed and developing countries. A high mortality rate has been observed in low-income counties. Despite its high fatality rate, less attention has been paid to the problem in developing countries, including Ethiopia. For this reason, childhood cancer is not well documented in the study setting. Therefore, we assessed the prevalence of childhood cancer in Ethiopia. Methods Institution based cross-sectional study design from January 1, 2019, to March 30, 2019, was conducted in the pediatrics treatment center. A systematic random sampling technique has used to select 1270 children in the pediatric outpatient department. The data were entered using Epi info version 7 and exported to SPSS version 20 for analysis. We checked model fitness for the advanced statistical methods, but it was difficult to proceed with logistic regression model to see the association between dependent and explanatory variables because of the unmet x2 assumption. We presented the results by using tables and figures. Results From the total 1270 study participants, 1257 were included in the final analysis provided that a 98.97% response rate. Out of these, 10(0.8%) children were diagnosed with cancer. Regarding its types, two each, Acute Lymphocytic Leukemia, Wilms tumor, Hodgkin lymphoma, and one each non-Hodgkin lymphoma, Parotid cancer, Retinoblastoma, and Breast cancer were reported. The prevalence of childhood cancer was 0.9 and 0.7% among male and female children, respectively. Conclusions Eight children diagnosed with cancer per 1000 children who visited the pediatric outpatient department. Even though childhood cancers have little attention from policymakers, the prevalence of childhood cancer remains prevalent. Therefore, researchers and policymakers shall give special emphasis to childhood cancer.

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