Abnormal Blood Yield Stress as an Aetiological Factor in Postoperative Deep Venous Thrombosis

1975 ◽  
Author(s):  
W. V. Humphreys ◽  
A. Walker ◽  
D. Charlesworth
Keyword(s):  
Deep Vein Thrombosis ◽  
Yield Stress ◽  
Malignant Disease ◽  
Aetiological Factor ◽  
Venous Stasis ◽  
Vein Thrombosis ◽  
High Incidence ◽  
Deep Vein ◽  
Postoperative Deep Venous Thrombosis ◽  
Low Shear

An elevated blood viscosity could lead to increased venous stasis and a higher incidence of post-operative deep vein thrombosis. Immediately preoperatively we have measured, using a Contraves low shear 2 viscometer, blood yield stress and viscosity at high and low shear rate in 28 general surgical patients. These patients were then screened by the standard I125 fibrinogen technique to detect the development of deep vein thrombosis post-operatively.13 patients developed a deep vein thrombosis. These patients had a significantly higher blood yield stress, corrected to a standard haemoerit of 45%, than the others (P < 0.01 students t). All other viscosity parameters were normal in these patients. Patients with malignant disease had a very high incidence of thrombosis (90%: 30%) and significantly higher yield stress values (mean 0.26 dynes/cm2: mean 0.194 dynes/cm2, P < 0.0005 students t) compared to patients with benign disease.We conclude that a high blood yield stress could be an important aetiological factor in thrombosis and the high values obtained in patients with malignant disease could partly explain the high incidence in these patients.

Comparative Study of Deep Vein Thrombosis Recanalization Using Doppler Ultrasound in Different Post-Treatment Intervals in Traumatic Patients

2022 ◽  
Author(s):  
Nazanin Farshchian ◽  
Negin Farshchian ◽  
Parisa Bahrami Kamangar
Keyword(s):  
Deep Vein Thrombosis ◽  
Doppler Ultrasound ◽  
Statistical Tests ◽  
Significance Level ◽  
Sonographic Diagnosis ◽  
Vein Thrombosis ◽  
Significant Difference ◽  
High Incidence ◽  
Deep Vein ◽  
Comparative Examination

Deep vein thrombosis (DVT) is a prevalent vascular disease characterized by pelvic and limb deep vein thrombophlebitis, and it has a high incidence in traumatic patients. Contrary to older studies, recent research has reported that recanalization in DVT is not a slow process. The present study aimed at the comparative examination of DVT recanalization with Doppler ultrasound in different intervals following treatment with heparin or enoxaparin. This prospective study was conducted on all traumatic patients hospitalized in Imam Reza Hospital of Kermanshah, Iran, with the clinical and sonographic diagnosis of DVT in limb veins. Doppler ultrasound was performed two weeks, one month, and three months following treatment in order to examine recanalization. Data were analyzed using statistical tests in SPSS16 at the significance level of <0.05. Based on Doppler ultrasound, a significant difference was found between the degree of recanalization in patients aged <45 years and those aged >45 years, between male and female patients, and between different DVT locations (P<0.05). After three months of treatment with heparin and enoxaparin, the degree of recanalization was increased in DVT. Moreover, it was found that Doppler ultrasound is a useful tool for the diagnosis of recanalization in patients with DVT.

High Incidence of Deep Vein Thrombosis in the Perioperative Period of Neurosurgical Patients

2018 ◽  
Vol 112 ◽  
pp. e103-e112 ◽  
Author(s):  
Manabu Natsumeda ◽  
Takeo Uzuka ◽  
Jun Watanabe ◽  
Masafumi Fukuda ◽  
Yasuhisa Akaiwa ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Perioperative Period ◽  
Vein Thrombosis ◽  
Neurosurgical Patients ◽  
High Incidence ◽  
Deep Vein

scholarly journals Prevalence of deep vein thrombosis in patients with paraplegia caused by traumas

2013 ◽  
Vol 12 (4) ◽  
pp. 271-277
Author(s):  
Nelson Mesquita Junior ◽  
Flavia Natalia Marques Kingerski ◽  
Giovana Liz Marioto ◽  
Fabio Alex Fonseca Viegas ◽  
Suzelaine Fidelis da Silva Mesquita ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Doppler Ultrasonography ◽  
Color Doppler ◽  
Color Doppler Ultrasonography ◽  
University Hospital ◽  
Venous Stasis ◽  
Common Disease ◽  
Cross Sectional ◽  
Vein Thrombosis ◽  
Deep Vein

BACKGROUND: Deep vein thrombosis is a common disease among people who are immobilized. Immobility is inherent to paraplegia and leads to venous stasis, which is one of the factors covered by Virchow's triad describing its development. Trauma is the primary cause of paraplegia and is currently increasing at a rate of 4% per year. OBJECTIVE: To determine the prevalence of deep vein thrombosis in paraplegic patients whose paraplegia was caused by traumas, using color Doppler ultrasonography for diagnosis. METHODS: This was a cross-sectional observational study of 30 trauma-induced paraplegia patients, selected after analysis of medical records at the neurosurgery department of a University Hospital in Curitiba, Brazil, and by a proactive survey of associations that care for the physically disabled. The prevalence of deep vein thrombosis was analyzed using 95% confidence intervals. RESULTS: Spinal cord trauma was the cause of paraplegia in 29 patients. The most common cause of trauma was gunshot wounding, reported by 17 patients. Deep vein thrombosis was diagnosed by color Doppler ultrasonography in 14 patients in the sample. The most often affected vein was the posterior tibial, in 11 patients. The left lower limb was involved three times more often than the right. Edema was observed in 25 individuals, cyanosis in 14, ulcers in 8 and localized increase in temperature in 13. CONCLUSIONS: Deep vein thrombosis was prevalent, occurring in 46.7% of the patients.

Hardware Design and Research of Intermittent Pressure Thrombotic Treatment Controller Based on Cortex M3

2012 ◽  
Vol 170-173 ◽  
pp. 3329-3333
Author(s):  
Yu Ping Wang ◽  
Hui Hong Zhu ◽  
Yi Zhang ◽  
Pan Wei Xue ◽  
Jian Wang ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Thromboembolism ◽  
Hardware Design ◽  
Venous Stasis ◽  
Physical Methods ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Air Discharge

Based on the master chip microcontroller ARM CortexM3, intermittent pressure thrombosis treatment instrument controller controls air pulse through the pump, thecushion is so quickly inflated.After each effective inflatable pressure, the controller makes automatically inflatable cushion air discharge, so the use of physical methods is to prevent and treat human venous thromboembolism, reduce venous stasis, and effectively prevent deep vein thrombosis formation.

scholarly journals Pathophysiological Processes Underlying the High Prevalence of Deep Vein Thrombosis in Critically Ill COVID-19 Patients

2021 ◽  
Vol 11 ◽  
Author(s):  
Sebastian Voicu ◽  
Chahinez Ketfi ◽  
Alain Stépanian ◽  
Benjamin G. Chousterman ◽  
Nassim Mohamedi ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Critically Ill ◽  
Venous Blood ◽  
Lower Limbs ◽  
Venous Stasis ◽  
Venous Blood Flow ◽  
Mechanically Ventilated ◽  
Vein Thrombosis ◽  
High Prevalence ◽  
Deep Vein

Coronavirus disease 2019 (COVID-19) predisposes to deep vein thrombosis (DVT) and pulmonary embolism (PE) particularly in mechanically ventilated adults with severe pneumonia. The extremely high prevalence of DVT in the COVID-19 patients hospitalized in the intensive care unit (ICU) has been established between 25 and 84% based on studies including systematic duplex ultrasound of the lower limbs when prophylactic anticoagulation was systematically administrated. DVT prevalence has been shown to be markedly higher than in mechanically ventilated influenza patients (6–8%). Unusually high inflammatory and prothrombotic phenotype represents a striking feature of COVID-19 patients, as reflected by markedly elevated reactive protein C, fibrinogen, interleukin 6, von Willebrand factor, and factor VIII. Moreover, in critically ill patients, venous stasis has been associated with the prothrombotic phenotype attributed to COVID-19, which increases the risk of thrombosis. Venous stasis results among others from immobilization under muscular paralysis, mechanical ventilation with high positive end-expiratory pressure, and pulmonary microvascular network injuries or occlusions. Venous return to the heart is subsequently decreased with increase in central and peripheral venous pressures, marked proximal and distal veins dilation, and drops in venous blood flow velocities, leading to a spontaneous contrast “sludge pattern” in veins considered as prothrombotic. Together with endothelial lesions and hypercoagulability status, venous stasis completes the Virchow triad and considerably increases the prevalence of DVT and PE in critically ill COVID-19 patients, therefore raising questions regarding the optimal doses for thromboprophylaxis during ICU stay.

scholarly journals The Prevalence of May Thurner Syndrome in Children with Ileo-Femoral Deep Vein Thrombosis- Does It Take 2 to Tango?

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4263-4263
Author(s):  
Divya Subburaj ◽  
Pamala Cox ◽  
Victoria E. Price ◽  
Ketan Kulkarni
Keyword(s):  
Risk Factor ◽  
Deep Vein Thrombosis ◽  
Pediatric Patients ◽  
Conflicts Of Interest ◽  
Anticoagulation Therapy ◽  
Venous Stasis ◽  
Thrombotic Risk ◽  
Vein Thrombosis ◽  
Catheter Directed Thrombolysis ◽  
Deep Vein

Abstract Introduction: May-Thurner syndrome (MTS) is characterised by compression of the left external iliac vein by overriding right common iliac artery resulting in venous stasis. It carries a higher risk of left iliofemoral deep vein thrombosis (DVT), however the prevalence and management guidelines are unclear in pediatrics. We reviewed the prevalence of MTS in children diagnosed with left iliofemoral DVT at our center, associated prothrombotic risk factors and their clinical outcomes. Methods: This is a retrospective audit of pediatric patients (&lt;18 years) with left iliofemoral DVT treated at the IWK Health Center from January 1 2008 to December 31 2020. Results: Twelve pediatric patients with left iliofemoral DVT were identified at our center and all patients except one had MRV/CTV during their course of anticoagulation to evaluate for MTS. MTS was diagnosed on imaging in 8 of the eleven evaluable patients with DVT and one patient had an incidental diagnosis of MTS with no DVT. The median age at diagnosis of MTS was 15 years (13-16), male:female ratio of 1:8. The overall prevalence rate was of MTS was 72.72% (8/11) in patients with left iliofemoral DVT. All patients with iliofemoral DVT and MTS had at least one other prothrombotic risk factor- initiation of estrogen containing contraceptive pills in the preceding 3 months of the DVT (n=5), inherited thrombophilia (n=2) and obesity (n=2). All patients with MTS were referred to vascular surgery. Only one patient required catheter directed thrombolysis and stenting at presentation of DVT, the remaining 7 patients were managed with anticoagulation alone. Complete (n=1) or partial (n=7) resolution of the thrombus was seen in all 8 patients. Median duration of follow up was 3 years. Recurrent DVT was seen in 1 patient and two patients came off anticoagulation at 6 months post therapy. Post thrombotic syndrome was seen in 4 patients, mild in 3 and moderate in 1; as per modified Villalta score. Conclusion: We observed a high prevalence of MTS in patients with left iliofemoral DVT which may be due our screening approachwith upfront radiographic evaluation for MTS in all patients with left iliofemoral DVT. A second pro-thrombotic risk factor was identified in all patients, which raises the possibility of a "two hit theory" for the occurrence of DVT in MTS. Compared to published adult studies, majority of our pediatric patients were managed conservatively with anticoagulation therapy alone. Disclosures No relevant conflicts of interest to declare.

DVT Prophylaxis in the Perioperative Setting

2002 ◽  
Vol 12 (9) ◽  
pp. 326-331 ◽  
Author(s):  
Agnes Arnold
Keyword(s):  
Deep Vein Thrombosis ◽  
Endothelial Damage ◽  
Venous Stasis ◽  
Vein Thrombosis ◽  
Dvt Prophylaxis ◽  
Deep Vein ◽  
The Impact

In last month's BJPN, Agnes Arnold discussed the pathophysiology of deep vein thrombosis and suggested ways that the risk could be reduced, particularly with respect to DVTs resulting from endothelial damage in surgery. In this, the second of a two-part series, Agnes continues by looking at hypercoagulability of blood and venous stasis and the impact of these conditions on the risk of DVT.

Sign in / Sign up

Export Citation Format

Share Document