Objective Improvement in Cognitive Function following Aortic Coarctation Repair in an Adult

AbstractCoarctation of the aorta is a rare finding in adults and can present with vague symptoms. We report a case of a 64-year-old cognitively impaired female who presented with fatigue and tinnitus. After extensive workup, she was diagnosed with coarctation of the aorta and subsequently underwent repair. After operative intervention for her coarctation, her cognitive impairment was found to have an objective improvement evidenced by the Montreal Cognitive Assessment.

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The Relationship between Cardiorespiratory Fitness and Montreal Cognitive Assessment Scores in Older Adults

Gerontology ◽

10.1159/000489336 ◽

2018 ◽

Vol 64 (5) ◽

pp. 440-445 ◽

Cited By ~ 4

Author(s):

Stephen W. Farrell ◽

Aidin R. Abramowitz ◽

Benjamin L. Willis ◽

Carolyn E. Barlow ◽

Myron Weiner ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Cognitive Function ◽

Cardiorespiratory Fitness ◽

Cognitive Assessment ◽

Montreal Cognitive Assessment ◽

Categorical Variable ◽

Healthy Older Adults ◽

High Level ◽

The Relationship

Background: Relatively little is known regarding the association between objective measures of physical function such as cardiorespiratory fitness (CRF) and cognitive function tests in healthy older adults. Objective: To evaluate the relationship between CRF and cognitive function in adults aged 55 and older. Methods: Between 2008 and 2017, 4,931 men and women underwent a comprehensive preventive physical exam at the Cooper Clinic in Dallas, Texas. CRF was determined by duration of a maximal treadmill exercise test. Cognitive function was evaluated with the Montreal Cognitive Assessment (MoCA). In a multivariate model, adjusted odds ratios with 95% confidence intervals for MoCA scores < 26 (i.e., cognitive impairment) were determined by using CRF as both a continuous and a categorical variable. Results: The mean age of the sample was 61.0 ± 6.0 years; mean maximal MET values were 10.0 ± 2.2. Mean MoCA scores were 26.9 ± 2.2; 23.4% of the sample had MoCA scores indicative of cognitive impairment. The odds ratio for cognitive impairment was 0.93 (0.88–0.97) per 1-MET increment in CRF. When examined as a categorical variable, and using the lowest CRF quintile as the referent, there was a significantly reduced likelihood for cognitive impairment across the remaining ordered CRF categories (p trend = 0.004). Conclusion: The association between CRF and MoCA score in older adults suggests that meeting or exceeding public health guidelines for physical activity is likely to increase CRF in low fit individuals, maintain CRF in those with a moderate to high level of CRF, and thereby help to maintain cognitive function in healthy older adults.

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HUBUNGAN ANTARA JUMLAH LIMFOSIT TCD4+ DENGAN GANGGUAN FUNGSI KOGNITIF PADA PASIEN TERINFEKSI HIV

Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia ◽

10.52386/neurona.v36i3.72 ◽

2020 ◽

Vol 36 (3) ◽

Author(s):

Rilia Datan Sampepajung ◽

Audry Devisanty Wuysang ◽

Abdul Muis

Keyword(s):

Human Immunodeficiency Virus ◽

Cognitive Impairment ◽

Cognitive Function ◽

T Lymphocyte ◽

Cognitive Assessment ◽

Cross Sectional Study ◽

Montreal Cognitive Assessment ◽

Hiv Patients ◽

Cross Sectional ◽

Immunodeficiency Virus

CORRELATION BETWEEN QUANTITY OF CD4+ T LYMPHOCYTE AND COGNITIVE IMPAIRMENT IN PATIENTS WITH HIV INFECTIONABSTRACTIntroduction: CD4+T lymphocyte is a T-lymphocyte that has CD4 glycoprotein on its surface. The quantity of CD4+ T lymphocyte is associated with cognitive function impairment.Aim: To determine the correlation between the quantity of CD4+ T lymphocyte with the cognitive function impairment in patients infected by human immunodeficiency virus (HIV).Methods: This is a cross-sectional study on HIV patients at Wahidin Sudirohusodo Hospital, Makassar from October to December 2018. Cognitive function was assessed using Montreal Cognitive Assessment of Indonesian version (MoCA-Ina) and all infected HIV patients’ CD4+ T lymphocyte was counted through blood laboratory examination. The data processing used SPSS program.Results: There were 40 subjects with male majority (70%). Most subjects (75%) had low count of CD4+ T lymphocytes (<200cel/µL) and most of them (72.5%) had cognitive function impairment.Discussion: The CD4+T lymphocyte was associated significantly with executive and memory impairment in patients with HIV.Keywords: CD4+ T lymphocyte, cognitive impairment, HIVABSTRAKPendahuluan: Limfosit TCD4+ adalah limfosit T yang memiliki glikoprotein CD4 pada permukaan selnya. Jumlah limfosit TCD4+ telah diketahui berhubungan dengan gangguan fungsi kognitif.Tujuan: Mengetahui hubungan antara jumlah limfosit TCD4+ dengan gangguan fungsi kognitif pada pasien terinfeksi human immunodeficiency virus (HIV).Metode: Penelitian observasional dengan rancangan potong lintang terhadap pasien yang terinfeksi HIV di RSUP Dr. Wahidin Sudirohusodo, Makassar pada bulan Oktober-Desember 2018. Subjek dinilai fungsi kognitif menggunakan Montreal Cognitive Assessment versi Indonesia (MoCA-Ina) dan penghitungan jumlah limfosit TCD4+. Pengolahan data menggunakan program SPSS.Hasil: Terdapat 40 subjek yang mayoritas (70%) laki-laki. Terdapat 75% subjek memiliki kadar limfosit TCD4+ yang rendah (<200sel/µL) yang sebagian besarnya (72,5%) mengalami gangguan fungsi kognitif.Diskusi: Jumlah limfosit TCD4+ memiliki hubungan yang signifikan dengan komponen eksekutif dan memori dari fungsi kognitif pada pasien yang terinfeksi HIV.Kata kunci: Gangguan kognitif, HIV, limfosit TCD4+

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Effectiveness of Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in Improving Vascular Cognitive Impairment after Stroke

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/2795915 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Kun Marisa Farhana ◽

Rusdy Ghazali Malueka ◽

Samekto Wibowo ◽

Abdul Gofir

Keyword(s):

Cognitive Impairment ◽

Folic Acid ◽

Cognitive Function ◽

Experimental Design ◽

Cognitive Assessment ◽

Centella Asiatica ◽

Vascular Cognitive Impairment ◽

Montreal Cognitive Assessment ◽

Significant Difference ◽

Quasi Experimental

This study aimed to determine the effectiveness of gotu kola (Centella asiatica) in improving cognitive function in patients with vascular cognitive impairment (VCI). This study uses a quasi-experimental design. Subjects in this study were patients with poststroke cognitive impairment who were treated at two hospitals in Yogyakarta, Indonesia. The number of subjects was 48: 17 subjects were treated with 1000 mg/day of gotu kola extract, 17 subjects treated with 750 mg/day of gotu kola extract, and 14 subjects treated with 3 mg/day of folic acid for 6 weeks. A Montreal Cognitive Assessment-Indonesian version (MoCA-Ina) was conducted at the beginning of treatment and after 6 weeks of therapy. It was found that all trials effectively improved poststroke VCI based on MoCA-Ina scores over the course of the study. There is no significant difference in ΔMoCA-Ina (score at the 6th week of treatment − score at the beginning) mean score among the three groups, indicating that gotu kola is as effective as folic acid in improving poststroke VCI. Gotu kola was shown to be more effective than folic acid in improving memory domain. This study suggested that gotu kola extract is effective in improving cognitive function after stroke.

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Psychometric Properties of the Persian Montreal Cognitive Assessment in Mild Cognitive Impairment and Alzheimer Disease

Dementia and Geriatric Cognitive Disorders Extra ◽

10.1159/000514673 ◽

2021 ◽

pp. 51-57

Author(s):

Vahid Rashedi ◽

Mahshid Foroughan ◽

Negin Chehrehnegar

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Alzheimer Disease ◽

Psychometric Properties ◽

Cognitive Assessment ◽

Screening Test ◽

Cognitive Status ◽

Montreal Cognitive Assessment ◽

Cutoff Score ◽

Persian Version

Introduction: The Montreal Cognitive Assessment (MoCA) is a cognitive screening test widely used in clinical practice and suited for the detection of Mild Cognitive Impairment (MCI). The aims were to evaluate the psychometric properties of the Persian MoCA as a screening test for mild cognitive dysfunction in Iranian older adults and to assess its accuracy as a screening test for MCI and mild Alzheimer disease (AD). Method: One hundred twenty elderly with a mean age of 73.52 ± 7.46 years participated in this study. Twenty-one subjects had mild AD (MMSE score ≤21), 40 had MCI, and 59 were cognitively healthy controls. All the participants were administered the Mini-Mental State Examination (MMSE) to evaluate their general cognitive status. Also, a battery of comprehensive neuropsychological assessments was administered. Results: The mean score on the Persian version of the MoCA and the MMSE were 19.32 and 25.62 for MCI and 13.71 and 22.14 for AD patients, respectively. Using an optimal cutoff score of 22 the MoCA test detected 86% of MCI subjects, whereas the MMSE with a cutoff score of 26 detected 72% of MCI subjects. In AD patients with a cutoff score of 20, the MoCA had a sensitivity of 94% whereas the MMSE detected 61%. The specificity of the MoCA was 70% and 90% for MCI and AD, respectively. Discussion: The results of this study show that the Persian version of the MoCA is a reliable screening tool for detection of MCI and early stage AD. The MoCA is more sensitive than the MMSE in screening for cognitive impairment, proving it to be superior to MMSE in detecting MCI and mild AD.

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