scholarly journals HUBUNGAN ANTARA JUMLAH LIMFOSIT TCD4+ DENGAN GANGGUAN FUNGSI KOGNITIF PADA PASIEN TERINFEKSI HIV

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Rilia Datan Sampepajung ◽  
Audry Devisanty Wuysang ◽  
Abdul Muis
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
T Lymphocyte ◽  
Cognitive Assessment ◽  
Cross Sectional Study ◽  
Montreal Cognitive Assessment ◽  
Hiv Patients ◽  
Cross Sectional ◽  
Immunodeficiency Virus

  CORRELATION BETWEEN QUANTITY OF CD4+ T LYMPHOCYTE AND COGNITIVE IMPAIRMENT IN PATIENTS WITH HIV INFECTIONABSTRACTIntroduction: CD4+T lymphocyte is a T-lymphocyte that has CD4 glycoprotein on its surface. The quantity of CD4+ T lymphocyte is associated with cognitive function impairment.Aim: To determine the correlation between the quantity of CD4+ T lymphocyte with the cognitive function impairment in patients infected by human immunodeficiency virus (HIV).Methods: This is a cross-sectional  study on HIV patients at Wahidin Sudirohusodo Hospital, Makassar  from October to December 2018. Cognitive function was assessed using Montreal Cognitive Assessment of Indonesian version (MoCA-Ina) and all infected HIV patients’ CD4+ T lymphocyte was counted through blood laboratory examination. The data processing used SPSS program.Results: There were 40 subjects with male majority (70%). Most subjects (75%) had low count of CD4+ T lymphocytes (<200cel/µL) and most of them (72.5%) had cognitive function impairment.Discussion: The CD4+T lymphocyte was associated significantly with executive and memory impairment in patients with HIV.Keywords: CD4+ T lymphocyte, cognitive impairment, HIVABSTRAKPendahuluan: Limfosit TCD4+ adalah limfosit T yang memiliki glikoprotein CD4 pada permukaan selnya. Jumlah limfosit TCD4+ telah diketahui berhubungan dengan gangguan fungsi kognitif.Tujuan: Mengetahui hubungan antara jumlah limfosit TCD4+  dengan gangguan fungsi kognitif pada pasien terinfeksi human immunodeficiency virus (HIV).Metode: Penelitian observasional dengan rancangan potong lintang terhadap pasien yang terinfeksi HIV di RSUP Dr. Wahidin Sudirohusodo, Makassar pada bulan Oktober-Desember 2018. Subjek dinilai fungsi kognitif menggunakan Montreal Cognitive Assessment versi Indonesia (MoCA-Ina) dan penghitungan jumlah limfosit TCD4+. Pengolahan data menggunakan program SPSS.Hasil: Terdapat 40 subjek yang mayoritas (70%) laki-laki. Terdapat 75% subjek memiliki kadar limfosit TCD4+ yang rendah (<200sel/µL) yang sebagian besarnya (72,5%) mengalami gangguan fungsi kognitif.Diskusi: Jumlah limfosit TCD4+ memiliki hubungan yang signifikan dengan komponen eksekutif dan memori dari fungsi kognitif pada pasien yang terinfeksi HIV.Kata kunci: Gangguan kognitif, HIV, limfosit TCD4+  

scholarly journals A High Prevalence Rate of a Positive Screen for Cognitive Impairment in Patients With Human Immunodeficiency Virus Attending an Irish Clinic

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Patricia H. McNamara ◽  
Robert Coen ◽  
Janice Redmond ◽  
Colin P. Doherty ◽  
Colm Bergin
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cognitive Impairment ◽  
Large Scale ◽  
Screening Program ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Study Cohort ◽  
Cross Sectional ◽  
Positive Screen ◽  
Immunodeficiency Virus

Abstract Background Human immunodeficiency virus (HIV)-associated neurocognitive disorders occurs in 20%–50% of HIV-positive patients. We undertook this study to assess the prevalence of a positive screen for cognitive impairment in the clinic population at our institution and to demonstrate the feasibility of implementing a screening program in routine clinical encounters. Methods This was a cross-sectional study, and patients were recruited prospectively between December 2010 and February 2013. Inclusion criteria were as follows: patients were HIV positive, over the age of 18, capable of giving informed consent, and had sufficient ability to communicate in English. Patients were screened for cognitive impairment using the Brief Neurocognitive Screen. Results A total of 604 patients were recruited, and 51.5% had a positive screen for cognitive impairment. The majority of the study cohort were male (78.8%), mean age was 40.9 (standard deviation, 10.2) years, 70.9% were Irish, the most common mode of transmission was men who have sex with men (49.3%), 83% were on antiretroviral therapy, and 88.7% were virally suppressed. Logistic regression showed that the main factors predictive of a positive screen for cognitive impairment were the endorsement of cognitive symptoms (P = .024), being born in Africa (P &lt; .000001), the use of benzodiazepines (P = .00341), being unemployed (P = .008), and consumption of more than 40 units of alcohol weekly (P = .035). There was a positive screen for depression in 9.1% and a positive screen for anxiety in 24.5%. Conclusions The study highlights the necessity for a structured, prospective, large-scale screening program for cognitive impairment across countries with limited resources and demonstrates the feasibility of easily implementing this with minimal training.

scholarly journals Loneliness in Older Black Adults with Human Immunodeficiency Virus Is Associated with Poorer Cognition

Gerontology ◽  
2017 ◽  
Vol 63 (3) ◽  
pp. 253-262 ◽  
Author(s):  
S. Duke Han ◽  
Oluwatoyin Adeyemi ◽  
Robert S. Wilson ◽  
Sue Leurgans ◽  
Antonio Jimenez ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Standard Deviation ◽  
Cognitive Function ◽  
Cross Sectional Study ◽  
Self Report ◽  
Inverse Association ◽  
Black Adults ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
White Adults

Background: The human immunodeficiency virus (HIV) is associated with cognitive impairment, and loneliness is associated with cognitive decline in old age. Older Black adults with HIV may be at particular risk of loneliness due to stigma and lack of social resources. Objective: We tested the hypotheses that (1) older Black adults with HIV would show greater loneliness than older White adults with HIV, and (2) greater loneliness among older Black adults with HIV would be associated with poorer cognitive function. Methods: A total of 370 participants (177 with HIV, 193 without HIV; mean age 58.8 years, standard deviation 6.2 years; mean education 13.4 years, standard deviation 2.9 years; 73.9% male, 68.9% Black) in a community-based cross-sectional study of the Rush Center of Excellence on Disparities in HIV and Aging (CEDHA) completed a 5-item self-report scale used to measure emotional loneliness and a battery of cognitive measures. Results: Contrary to our expectations, older Black adults indicated less overall loneliness than White adults (β = -0.3893, SE = 0.1466, p = 0.0087) in models controlling for the effects of age, education, sex, global cognition, and income. However, in models with cognitive function as the outcome, an interaction between race and loneliness was observed, such that older Black adults who indicated greater loneliness showed poorer cognitive function relative to White adults (β = -0.2736, SE = 0.1138, p = 0.0174). Conclusion: Older Black adults with HIV reported less loneliness than older White adults; however, the inverse association between loneliness and cognitive function was stronger in Black than White older adults. Additional work is needed to elucidate the mechanisms underlying this interaction.

scholarly journals CORRELATIONS BETWEEN CLUSTER DIFFERENTIATION 4 COUNTS, HUMAN IMMUNODEFICIENCY VIRUS CLINICAL STAGES, AND HEMOGLOBIN LEVEL AMONG HUMAN IMMUNODEFICIENCY VIRUS PATIENTS WITH ANEMIA IN MERPATI CLINIC, WANGAYA HOSPITAL, DENPASAR, BALI, INDONESIA: A CROSS-SECTI

2019 ◽  
pp. 426-429
Author(s):  
KETUT SURYANA ◽  
HAMONG SUHARSONO ◽  
GEDE BUDIASA ◽  
JARWA ANTARA ◽  
PUJI ASTUTI ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
Hiv Patients ◽  
Cross Sectional ◽  
Cd4 Counts ◽  
Immunodeficiency Virus ◽  
Clinical Stages ◽  
The Mean ◽  
Study Participants

Objective: The objective of this study was to determine the correlation between cluster of differentiation 4 (CD4) counts, human immunodeficiency virus (HIV) clinical stages, and hemoglobin (Hb) level among HIV-infected patients with anemia. Methods: A cross-sectional study was conducted in November 2017 at Merpati Clinic of Wangaya Hospital, Denpasar, Bali, Indonesia. We selected 79 HIV patients with anemia to participate in our study. We grouped CD4 counts into two categories: <200 cells/μL and ≥200 cells/μL, and we classified the HIV clinical stages into HIV and acquired immunodeficiency syndrome (AIDS). Results: About 55.7% (44) of men and 44.3% (35) of women were participated in this study. As many as, 91.1% (72) of participants were AIDS patients. The mean Hb was 8.77 g/dl with SD 1.79 g/dl. 81% (64) of study participants were suffered from anemia on chronic disease or inflammatory anemia, and 19% (15) of study participants were suffered from iron deficiency anemia. The median for CD4 counts was 94 cells/μL (3–309 cells/μL) with as many as 78.5% (62) of participants were found to have low CD4 counts (<200 cells/μL). Spearman analysis revealed a positive correlation between CD4 counts and Hb level (r=0.427, p<0.001). Independent sample t-test analysis found a correlation between the HIV clinical stages and Hb level. There was a difference between the mean of Hb level in each stage with the average difference of 0.8 g/dl (95% confidence interval 0.04–1.6; p<0.04). Conclusions: There is a correlation between CD4 counts, HIV clinical stages, and Hb level among HIV patients with anemia.

scholarly journals SKRINING COGNITIVE IMPAIRMENT PADA PASIEN HIPERTENSI DI BANDUNG

2019 ◽  
Vol 5 (2) ◽  
pp. 114-120
Author(s):  
Irma Darmawati ◽  
Heni Purnama ◽  
Linlin Lindayani
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Cognitive Assessment ◽  
Cross Sectional Study ◽  
Montreal Cognitive Assessment ◽  
Sectional Study ◽  
Cross Sectional

Hipertensi merupakan salah satu faktor resiko tertinggi untuk gangguan fungsi kognitif. Studi sebelumnya melaporkan bahwa terjadi peningkatan white matter lession pada pasien hipertensi. Akan tetapi, penelitian tentang deteksi dini gangguan fungsi kognitif pada pasien hipertensi di Indonesia masih terbatas. Tujuan dari penelitian ini adalah mengidentifikasi gangguan fungsi kognitif pada pasien dengan hipertensi. Jenis penelitian yanga akan digunakan adalah cross-sectional study. Peserta dalam penelitian adalah seseorang berusia lebih dari 18 tahun yang didiagnosa hipertensi, tidak ada riwayat penyakit yang berhubungan dengan fungsi kognitif seperti stroke, epilepsy atau riwayat bedah otak. Fungsi Kognitif diukur dengan menggunakan The Montreal Cognitive Assessment (MoCA). Sebanyak 120 pasien dengan hipertensi berhasil direkrut dalam penelitian ini. Sebanyak 68.9% mengalami gangguan fungsi kognitif dengan nilai rata-rata paling rendah adalah dalam kemampuan mengingat angka, huruf, pengurangan, dan orientasi. Deteksi dini gangguan kognitif pada pasien hipertensi harus dilakukan secara rutin di klinik ataupun pusat pelayanan kesehatan primer lainnnya.

scholarly journals Patients with mild cognitive impairment diagnosed at dementia clinic display decreased maximum occlusal force: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroyuki Suzuki ◽  
Junichi Furuya ◽  
Rena Hidaka ◽  
Saki Miyajima ◽  
Chiaki Matsubara ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Oral Health ◽  
Cognitive Function ◽  
Cognitive Assessment ◽  
Odds Ratio ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Occlusal Force

Abstract Background Previous research indicates that patients with mild cognitive impairment (MCI) are more likely to have poor oral health and impairments in oral functions, which may be due to few remaining teeth and impaired tongue and lip motor function. However, the oral health of those patients following comprehensive cognitive assessment by a dementia specialist has not been sufficiently investigated. Therefore, this study aimed to clarify the oral function of patients with MCI and the association between oral health and lower cognitive function. Methods This cross-sectional study included 96 participants (men: 35; women: 61; mean age: 73.3 ± 8.5 years) who visited a dementia clinic between December 2017 and January 2020. Participants’ cognitive function was assessed by a dementia specialist using neuropsychological and hematological tests and neuroimaging immediately after enrollment. The participants were divided into the healthy and MCI groups according to comprehensive cognitive assessment. Participants’ age, sex, body mass index, primary disease, education level, drinking habits, smoking habits, living environment, employment status, and exercise habits were evaluated. Moreover, oral outcomes, including the number of existing teeth, number of functional teeth (natural and prosthetic teeth which were occluded with antagonists), denture use, oral dryness, tongue and lip motor function, tongue pressure, occlusal force, masticatory ability, and swallowing ability were recorded. The Mann–Whitney U test, χ2, and Fisher’s exact tests were used for between-group comparisons. Furthermore, logistic regression analysis using MCI diagnosis as the target variable was performed. Results A comprehensive evaluation of the cognitive function of the study participants by the dementia specialist revealed that 48 participants (mean age: 69.8 ± 8.8 years) were healthy and 48 (mean age: 76.9 ± 6.7 years) had MCI. MCI participants were significantly older (p < 0.001) and had significantly fewer existing teeth (p = 0.031) and lower maximum occlusal force (p = 0.019) than healthy participants. Age (odds ratio: 1.126, p = 0.002) and maximum occlusal force (odds ratio: 0.978, p = 0.048) were significantly associated with lower cognitive function. Conclusions Patients with MCI had poorer oral health than healthy individuals. Decreased maximum occlusal force was independently associated with lower cognitive function, even when adjusted for age and sex.

scholarly journals Correlation between Lymphocyte CD4 Count, Treatment Duration, Opportunistic Infection and Cognitive Function in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients

2018 ◽  
Vol 6 (4) ◽  
pp. 643-647 ◽  
Author(s):  
Fasihah Irfani Fitri ◽  
Aldy Safruddin Rambe ◽  
Aida Fitri
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cognitive Function ◽  
Opportunistic Infections ◽  
Cross Sectional Study ◽  
Cd4 Count ◽  
Aids Patients ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Cd4 Lymphocyte ◽  
Hiv Aids

BACKGROUND: Human immunodeficiency virus (HIV) infection is an epidemic worldwide, despite the marked benefits of antiretroviral therapy (ARV) in reducing severe HIV-associated dementia. A milder form of neurocognitive disorders are still prevalent and remain a challenge.AIM: This study aimed to determine the correlation between plasma cluster of differentiation 4 (CD4) lymphocyte, duration of ARV treatment, opportunistic infections, and cognitive function in HIV-AIDS patients.METHODS: A cross-sectional study involving 85 HIV-AIDS patients was conducted at Adam Malik General Hospital Medan, Indonesia. All subjects were subjected to physical, neurologic examination and Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) to assess cognitive function and measurement of lymphocyte CD4 counts.RESULTS: Out of the 85 subjects evaluated, the proportion concerning sexes include 52 males (61.2 %) and 33 females (38.8%). The mean age was 38.53 ± 9.77 years old. There was a significant correlation between CD4 lymphocyte counts and MoCA-INA score (r = 0.271, p = 0.012), but there was no significant correlation between duration of ARV treatment and MoCA-INA score. There was also no difference in MoCA-INA score based on the presence of opportunistic infection.CONCLUSION: Lymphocyte CD4 count was independently correlated with cognitive function in HIV-AIDS patients.

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