Unchanged Plasma Concentrations of Endothelin-1 in Healthy Men During Short-Term Infusions of AMP, dDAVP and of Norepinephrine

1991 ◽  
Vol 23 (04) ◽  
pp. 191-192 ◽  
Author(s):  
O. Wagner ◽  
P. Nowotny ◽  
H. Vierhapper
Keyword(s):  
Plasma Concentrations ◽  
Short Term ◽  
Healthy Men ◽  
Endothelin 1

scholarly journals Unchanged Testosterone Production Rates in Growth Hormone-Treated Healthy Men1

1998 ◽  
Vol 83 (10) ◽  
pp. 3735-3736
Author(s):  
H. Vierhapper ◽  
P. Nowotny ◽  
W. Waldhäusl
Keyword(s):  
Plasma Concentrations ◽  
Term Treatment ◽  
Dilution Technique ◽  
Production Rates ◽  
Short Term ◽  
Short Term Treatment ◽  
Healthy Men ◽  
Stable Isotope Dilution ◽  
Testosterone Production ◽  
Daily Dose

The effect of biosynthetic human GH on the production rates of testosterone was determined in healthy men (n = 7) using the stable isotope dilution technique and mass spectrometry. 1α,2α-d-Testosterone (20 μg/h) was infused for 10 h (0800–1800 h). Blood samples obtained at 20-min intervals from 1400–1800 h were pooled during two 2-h periods. Subsequently, each volunteer received a daily dose of biosynthetic human GH (4 IU/day sc) for 7 days. This resulted in a rise in plasma concentrations of somatomedin-C from, basal, 0.67 ± 0.13 U/mL to 1.20± 0.2 U/mL on day 7 (P < 0.0001). Testosterone production rates (basal: 209.9 ± 31.0 μg/h) were unchanged by treatment with GH (day 7: 192.2 ± 30.1 μg/h). In healthy men, short-term treatment with sc GH does not influence endogenous testosterone production rates.

scholarly journals 38 Effects of combining nose flap weaning with short-term creep feeding of beef calves on cow and calf performance

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 39-40
Author(s):  
Kendi Tjardes ◽  
Katy Lippolis
Keyword(s):  
Plasma Concentrations ◽  
Short Term ◽  
Beef Calves ◽  
Diarrhea Virus ◽  
Creep Feed ◽  
Calf Performance ◽  
Cow Performance ◽  
Term Creep ◽  
Viral Diarrhea Virus ◽  
Short Term Creep

Abstract One hundred four Angus calves were ranked by gender, BW, age, and dam parity, and assigned to 1 of 4 pre-weaning treatments: 1) nose flaps for 7-d prior to weaning (NF), 2) traditional weaning (TRAD), 3) traditional weaning and creep feed for 3-wk prior to weaning (TRADC), or 4) nose flaps for 7-d prior to weaning and creep feed for 3-wk prior to weaning (NFC). Cow-calf pairs were housed in dry lot pens on d -28. From d -21 to 0, calves in creep treatments were provided free choice access to creep feed. Nose flaps were placed on d -7, and calves were weaned on d 0. Calves were vaccinated and dewormed on d -21 and 0. There was no difference (P ≥ 0.97) in calf BW on d -28 or -21. During the 7-d period that nose flaps were placed, NFC calves had greater (P ≤ 0.0001) ADG than NF and TRAD calves, and tended to have greater (P ≤ 0.10) ADG than TRADC calves. At weaning on d 0, TRADC and NFC calves tended to have greater BW (P = 0.07) and had greater overall change in BW (P < 0.0001) during the pre-weaning period than TRAD and NF calves. Additionally, there was a greater (P ≤ 0.001) increase in BW of NFC and TRADC cows during the pre-weaning period compared to NF and TRAD cows. From d -21 to 0 there was no differences (P > 0.41) in plasma concentrations for Bovine Viral Diarrhea Virus (BVD). By d 14, the TRADC calves had the greatest plasma concentrations for BVD (P < 0.04). Therefore, providing short-term creep feed prior to placing nose flaps can improve pre-weaning calf and cow performance compared to traditional and nose flap weaning without creep feed supplementation, however, did not improve response to vaccination.

Lack of Effect of Exercise Time of Day on Acute Energy Intake in Healthy Men

2010 ◽  
Vol 20 (4) ◽  
pp. 350-356 ◽  
Author(s):  
Katriona J.M O’Donoghue ◽  
Paul A. Fournier ◽  
Kym J. Guelfi
Keyword(s):  
Energy Intake ◽  
Time Of Day ◽  
Treadmill Running ◽  
Short Term ◽  
Exercise Time ◽  
Acute Bout ◽  
Healthy Men ◽  
Significant Difference ◽  
Term Energy ◽  
Successful Weight Loss

Although the manipulation of exercise and dietary intake to achieve successful weight loss has been extensively studied, it is unclear how the time of day that exercise is performed may affect subsequent energy intake. The purpose of the current study was to investigate the effect of an acute bout of exercise performed in the morning compared with an equivalent bout of exercise performed in the afternoon on short-term energy intake. Nine healthy male participants completed 3 trials: morning exercise (AM), afternoon exercise (PM), or control (no exercise; CON) in a randomized counterbalanced design. Exercise consisted of 45 min of treadmill running at 75% VO2peak. Energy intake was assessed over a 26-hr period with the participants eating ad libitum from a standard assortment of food items of known quantity and composition. There was no significant difference in overall energy intake (M ± SD; CON 23,505 ± 6,938 kJ, AM 24,957 ± 5,607 kJ, PM 24,560 ± 5,988 kJ; p = .590) or macronutrient preferences during the 26-hr period examined between trials. Likewise, no differences in energy intake or macronutrient preferences were observed at any of the specific individual meal periods examined (i.e., breakfast, lunch, dinner) between trials. These results suggest that the time of day that exercise is performed does not significantly affect short-term energy intake in healthy men.

scholarly journals Short-Term Treadmill Running as a Model for Studying Cell-Free DNA Kinetics In Vivo

2011 ◽  
Vol 57 (4) ◽  
pp. 633-636 ◽  
Author(s):  
Thomas Beiter ◽  
Annunziata Fragasso ◽  
Jens Hudemann ◽  
Andreas M Nieß ◽  
Perikles Simon
Keyword(s):  
Time Course ◽  
Treadmill Exercise ◽  
Plasma Concentrations ◽  
High Mobility ◽  
Treadmill Running ◽  
Short Term ◽  
Cell Free Dna ◽  
Free Dna ◽  
Cross Country

BACKGROUND Increased plasma concentrations of cell-free DNA (cf-DNA) are considered a hallmark of various clinical conditions. Despite intensive research in this field, limited data are available concerning the time course of release and clearance of cf-DNA in vivo. METHODS We extracted cf-DNA from plasma samples taken before and immediately after a 10-km cross-country run, and from samples taken before, immediately after, and 30 min after exhaustive short-term treadmill exercise. The contribution of nuclear (nDNA) and mitochondrial DNA (mtDNA) was measured by quantitative real-time PCR. The incremental treadmill exercise setup was exploited to delineate the precise sequencing and timing of cf-nDNA, lactate, and high-mobility group box 1 protein (HMGB1) release during the exercise and recovery phases. RESULTS Postexercise plasma cf-nDNA concentrations in cross-country and treadmill runners were significantly increased, by 7.6-fold and 9.9-fold, respectively (P < 0.001). cf-nDNA concentrations were not correlated with age, sex, or body mass index. Plasma concentrations of cf-nDNA and HMGB1 in postexercise samples of treadmill runners were significantly correlated (r = 0.84; P = 0.004). cf-mtDNA concentrations were not affected by treadmill exercise. Time-course analyses demonstrated that cf-nDNA is released within minutes after the onset of exercise and is rapidly cleared from the circulation after the cessation of exercise. Nearly congruent kinetics for cf-nDNA, lactate, and HMGB1 were observed during the exercise phase. CONCLUSIONS A single bout of exhaustive short-term treadmill exercise constitutes a versatile model system suitable for addressing basic questions about cf-DNA biology.

Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers 

1997 ◽  
Vol 87 (6) ◽  
pp. 1348-1358 ◽  
Author(s):  
Jorn Lotsch ◽  
Gerd Kobal ◽  
Anne Stockmann ◽  
Kay Brune ◽  
Gerd Geisslinger ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Analgesic Activity ◽  
Intravenous Administration ◽  
Opioid Analgesic ◽  
Plasma Concentrations ◽  
Experimental Pain ◽  
Controlled Study ◽  
Short Term ◽  
Analgesic Effects ◽  
Relative Contribution

Background The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine. Methods In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experimental pain model based on pain-related cortical potentials and pain ratings after specific stimulation of the nasal nociceptor with short pulses of gaseous carbon dioxide. Results Morphine significantly reduced subjective and objective pain correlates compared with placebo. In contrast, M-6-G produced no statistically significant effects. The addition of M-6-G to morphine did not increase the effects of morphine. Morphine produced significantly more side effects than M-6-G. Conclusion After short-term intravenous administration at doses that produce plasma concentrations of M-6-G similar to those seen after administration of morphine, M-6-G had no analgesic effects in the present placebo-controlled study in healthy volunteers.

INCREASED PLASMA CONCENTRATIONS OF ENDOTHELIN-1 AND BIG ENDOTHELIN-1 IN ACUTE MYOCARDIAL INFARCTION

The Lancet ◽  
1989 ◽  
Vol 334 (8653) ◽  
pp. 53-54 ◽  
Author(s):  
Takashi Miyauchi ◽  
Masashi Yanagisawa ◽  
Takuji Tomizawa ◽  
Yasuro Sugishita ◽  
Nobuhiro Suzuki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Plasma Concentrations ◽  
Endothelin 1

Recovery ability of common carp (Cyprinus carpio) after a short-term exposure to terbuthylazine

2013 ◽  
Vol 16 (1) ◽  
pp. 17-23 ◽  
Author(s):  
I. Mikulikova ◽  
H. Modra ◽  
J. Blahova ◽  
K. Kruzikova´ ◽  
P. Marsalek ◽  
...  
Keyword(s):  
Cyprinus Carpio ◽  
Histopathological Examination ◽  
Recovery Period ◽  
Plasma Concentrations ◽  
Hepatosomatic Index ◽  
Short Term ◽  
Plasma Albumin ◽  
Short Term Exposure ◽  
High Regeneration ◽  
Biomarkers Of Oxidative Stress

Abstract Effects of a high terbuthylazine concentration (3.3 mg/l) on Cyprinus carpio were studied using a commercial herbicide formulation Click 500 SC (terbuthylazine 500 g/l). The fish were exposed to the pesticide for 24 h and allowed to recover for 6 days. Biometric parameters, plasma biochemical parameters and biomarkers of oxidative stress as well as histopathological changes in selected tissues were assessed on day 1 and 7. After a 24-h exposure, there were significant alterations found in the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as in the plasma concentrations of glucose, natrium, chlorides, calcium and phosphorus. Hepatosomatic index, plasma albumin and lactate reflected the treatment with a delay. Ion levels and ALT were found to be restored after a 6-day recovery period, which was too short for AST activity and glucose to diminish to the control levels. The histopathological examination revealed disorders in the gills of the exposed fish, however, the changes were not detected after a 6-day recovery period. The study shows high regeneration potential of the fish.

scholarly journals Effects of AIDS and Gender on Steady-State Plasma and Intrapulmonary Ethionamide Concentrations

2000 ◽  
Vol 44 (5) ◽  
pp. 1337-1341 ◽  
Author(s):  
John E. Conte ◽  
Jeffrey A. Golden ◽  
Mari McQuitty ◽  
Juliana Kipps ◽  
Emil T. Lin ◽  
...  
Keyword(s):  
Plasma Concentrations ◽  
Antimycobacterial Activity ◽  
Spectrometric Method ◽  
Mass Spectrometric Method ◽  
Epithelial Lining ◽  
Alveolar Cells ◽  
Epithelial Lining Fluid ◽  
Healthy Men ◽  
And Gender ◽  
Adult Volunteers

ABSTRACT Ethionamide, 250 mg every 12 h for a total of nine doses, was administered to 40 adult volunteers (10 men with AIDS, 10 healthy men, 10 women with AIDS, and 10 healthy women). Blood was obtained for drug assay prior to administration of the first dose, 2 h after the last dose, and at the completion of standardized bronchoscopy and bronchoalveolar lavage, which were performed 4 h after the last dose. Ethionamide was measured in epithelial lining fluid (ELF) and alveolar cells (AC) using a new mass spectrometric method. The presence of AIDS or gender was without significant effect on the concentrations of ethionamide in plasma, AC, or ELF. Plasma concentrations (mean ± standard deviation [SD]) were 0.97 ± 0.65 and 0.65 ± 0.35 μg/ml at 2 and 4 h after the last dose, respectively, and both values were significantly greater than the concentration of ethionamide in AC (0.38 ± 0.47 μg/ml) (P < 0.05). The concentration of ethionamide was significantly greater in ELF (5.63 ± 3.8 μg/ml) than in AC or plasma at 2 and 4 h and was approximately 10 to 20 times the reported MIC for ethionamide-susceptible strains of Mycobacterium tuberculosis. For all 40 subjects, the ELF/plasma concentration ratios (mean ± SD) at 2 and 4 h were 8.7 ± 11.7 and 9.7 ± 5.6, respectively. We conclude that the absorption of orally administered ethionamide, as measured in this study, was not affected by gender or the presence of AIDS. Ethionamide concentrations were significantly greater in ELF than in plasma or AC, suggesting that substantial antimycobacterial activity resides in this compartment.

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