Gas hydrates in the Shenhu area are mainly hosted in clayey silt sediments, which have the relatively high irreducible fluid saturation and gas entry pressure. And then, they will have an impact on gas production from hydrate-bearing clayey silt sediments, which was evaluated by the numerical simulations of SH2 site in Shenhu area in this paper. The results showed that, with the increase in irreducible water saturation and irreducible gas saturation, the amount of water production and gas production was obviously reduced. When the irreducible water saturation increased from 0.10 to 0.50, the cumulative CH4 production volume decreased from 1668799 m3 to 1536262 m3, and the cumulative water production volume dropped from 620304 m3 to 564797 m3, respectively. When the irreducible gas saturation increased from 0.01 to 0.05, the cumulative CH4 production volume dropped from 1812522 m3 to 1622121 m3, and the cumulative water production volume dropped from 672088 m3 to 600617 m3, respectively. In addition, the capillary pressure increased obviously with the increase in gas entry pressure, but the effect on gas production was small and the effect on water production could be negligible. In conclusion, irreducible water and gas saturation had an important effect on the gas production from gas hydrate, whereas the effects of gas entry pressure could be ignored.