The Role of the Blobs in Determining the Perception of Drifting Plaids and Their Motion Aftereffects

Perception ◽  
1994 ◽  
Vol 23 (10) ◽  
pp. 1163-1169 ◽  
Author(s):  
Peter Wenderoth ◽  
David Alais ◽  
Darren Burke ◽  
Rick van der Zwan

Motion aftereffects (MAEs) can be induced by adaptation to a pair of differently oriented drifting gratings whether the gratings are presented simultaneously, as a coherent plaid, or in alternation. The fact that the former MAEs were generally larger than the latter led to the suggestion that simultaneous adaptation involved higher-level extrastriate processes not involved in the alternating effects. In the past few years evidence has accumulated that the difference is in fact due to a low-level monocular process which can be termed the ‘blob-tracking mechanism’. A review is presented of the evidence on MAEs induced by simultaneous and alternating adaptation, the evidence for the monocularity of the blob-tracking mechanism, the data which implicate the blob mechanism in the determination of MAE magnitude, perceived plaid drift direction, and in perceived plaid coherence.

Author(s):  
Maxwell Deutscher

Memory is central to every way in which we deal with things. One might subsume memory under the category of intellect, since it is our capacity to retain what we sense, enjoy and suffer, and thus to become knowing in our perception and other activities. As intelligent retention, memory cannot be distinguished from our acquisition of skills, habits and customs – our capabilities both for prudence and for deliberate risk. As retention, memory is a vital condition of the formation of language. Amnesia illustrates dramatically the difference between memory as retention of language and skills, and memory as the power to recollect and to recognize specific events and situations. In amnesia we lose, not our general power of retention, but rather our recall of facts – the prior events of our life, and our power to recognize people and places. Amnesiacs recognize kinds of things. They may know it is a wristwatch they are wearing, while unable to recognize it as their own. This recall of events and facts that enables us to recognize things as our own, is more than just the ability to give correctly an account of them. One might accurately describe some part of one’s past inadvertently, or after hypnosis, or by relying on incidental information. Thus, present research on memory both as retention and as recall of specific episodes, attempts to describe the connection which persists between experience and recall. Neurological or computer models of such a connection owe something to traditional notions of a memory trace, but emphasize also the re-tracing of original memories by later experience and episodes of recall. Historically, recollection has often been thought of as a mode of perceiving the past. Such an idea lends an exaggerated status to the role of imagery, which is but one member of a family of recollective activities that includes reliving, remembering, reminiscing and mulling over what has happened. It may be not in having imagery but in miming someone’s behaviour that one relives an event. Also, like imagery, what we feel about the past may seem integral to recollection. A sense of being brought close to the past arises particularly when events that involve our feelings are concerned. Yet we may also recollect an event, vividly and accurately, while feeling clinically detached from it, devoid of imagery. How a past event or situation remains connected with subsequent recollection has become a principal theoretical question about memory. It is argued that it is because of what we did or experienced that we recollect it. Otherwise, we are only imagining it or relying upon ancillary information. Neurological or computer models of such a connection owe something to traditional notions of a memory trace, but emphasize also the re-tracing of original memories by later experience and episodes of recall. Some argue that our very idea of memory is that of the retention of a structural analogue of what we do recall of them. Such an idea is not of some perfect harmony between what we remember and our recollection of it. Rather, it is suggested, only to the extent that we retain a structural analogue of some aspect of an event or situation do we remember, rather than imagine or infer it.


1990 ◽  
Vol 140 ◽  
pp. 447-448
Author(s):  
P. Pismis ◽  
E. Moreno ◽  
A. Garcia-Barreto

The existence of non–steady phenomena, namely activity in the form of radial motions (outflow) of matter from the nuclei of galaxies is well established at present. Active Galactic Nuclei (AGN) constitute a topic of great interest and are intensively studied by all existing observational techniques. Conventionally objects classified as AGN span a range from quasars, radio galaxies to Seyferts 1 and 2. It appears, however, that there exist galaxies which exhibit somewhat milder activity which does not qualify their inclusion in the AGN group. The designation of MAGN (M for mildly) was suggested in the past (Pismis, 1986) to cover the less energetic nuclei. It may be reasonable to consider that active nuclei form a sequence, the difference along it being due to the energetics of the nuclei, from the most active quasars and radio galaxies down to the mildest ones like M31 or our Galaxy. The phenomenon underlying the activity may thus be universal, subject to the intrinsic energetics of the nuclei (Pismis, 1987).


2011 ◽  
Vol 44 (5) ◽  
pp. 935-944 ◽  
Author(s):  
Pavel Strunz ◽  
Gerhard Schumacher ◽  
Hellmuth Klingelhöffer ◽  
Albrecht Wiedenmann ◽  
Jan Šaroun ◽  
...  

Exposure of a superalloy to an external load results in anisotropic coarsening of the γ′ precipitates, so-called rafting. It was reported in the past that γ′ rafting can also occur as a result of purely thermal treatment, without the simultaneous presence of an external load, if the specimen has been pre-deformed at relatively low temperature. The evolution of γ′ morphology in pre-deformed specimens of SCA425 Ni-base superalloy was examined in the present study. Unlike in the previous experiments, the compressive stress was used for pre-straining.In situsmall-angle neutron scattering (SANS) was employed, which enabled the determination of the morphology directly at high temperature. Both for strong and for weak pre-straining, rounding of the originally cuboidal precipitates towards an ellipsoidal shape on heating was observed. Weak pre-straining (0.1, 0.5%) does not cause rafting on subsequent heating. On the other hand, the detailed evaluation of SANS data provides some indication of rafting during the subsequent heating after severe compressive pre-straining (2%). The experiment indicates the role of dislocation rearrangement at the matrix/precipitate interface during pre-straining.


2006 ◽  
Vol 34 (5) ◽  
pp. 601-629 ◽  
Author(s):  
Robin K. Henson

Effect sizes are critical to result interpretation and synthesis across studies. Although statistical significance testing has historically dominated the determination of result importance, modern views emphasize the role of effect sizes and confidence intervals. This article accessibly discusses how to calculate and interpret the effect sizes that counseling psychologists use most frequently. To provide context, the author presents a brief history of statistical significance tests. Second, the author discusses the difference between statistical, practical, and clinical significance. Third, the author reviews and graphically demonstrates two common types of effect sizes, commenting on multivariate and corrected effect sizes. Fourth, the author emphasizes meta-analytic thinking and the potential role of confidence intervals around effect sizes. Finally, the author gives a hypothetical example of how to report and potentially interpret some effect sizes.


2017 ◽  
Vol 12 (6) ◽  
pp. 636-640 ◽  
Author(s):  
Adam Piechna ◽  
Leszek Lombarski ◽  
Bogdan Ciszek ◽  
Krzysztof Cieslicki

Background Intracranial arterial dissections might be attributed to the particular biomechanical properties of their specific layers. Also, knowledge of adventitia properties would be crucial in the context of intracranial balloon angioplasty. Aims The purpose of this work was to determine the rupture pressure of separated adventitia and compare it to intact cerebral arterial segments. Methods Brain specimens were harvested from 14 autopsy subjects (age range from 23 to 86 years). Pressure-inflation tests were conducted on proximal segments of middle cerebral arteries and separated adventitia layers from contralateral arteries to assess the rupture pressure values. Results The averaged rupture pressure of adventitia layers was 1.41 SD 0.25 atm (1072 SD 190 mmHg), whereas for intact arterial segments it was 2.32 SD 0.70 atm (1763 SD 532 mmHg) and diminished with age according to nonlinear regression trends. The difference beetween the aformentioned rupture pressures was positively correlated with rupture pressure of intact arterial segments ( R2 = 0.88; p < 0.001). Conclusions The obtained experimental results indicate a leading role of adventitia in building arterial strength under supraphysiological pressure conditions. The greater the rupture pressure of complete cerebral arteries, the smaller the contribution of adventitia in overall wall resistance.


2016 ◽  
Author(s):  
Imadol V Jeff-Eke

We present a rationale and proposed approach to the modification and development of bind sites using their respective cognate ligands as template. This is in support of a plausible “instructive” role for the ligand and therefore its involvement in determination of the structure and properties of bind sites. We emphasize the relationship between substrate and active site as an example of the relationship between ligand and bind sites, respectively. This is based on the assumption that there are shared features between all ligand:bind site complexes. Therefore, principles that apply to a specific complex can be applied, in general, to other protein-based complexes. We define ligand-associated probability bias as the difference between the probability of finding activity-determining conformations (ADCs) in the presence- and absence of ligands. For cognate ligands, the given bias is in favor of these ADCs. Thus, bind sites are more likely to assume ADCs when their cognate ligands are present. We relate such probability bias to structural reorganization, disorganization, and preorganization events. We then propose a means of deriving an [apparent] preorganized bind site structure by way of reorganization events that occur with cognate ligand. Finally, we propose a means of deriving an [actual] preorganized bind site structure by way of reorganization events that occur with cognate ligand, albeit during the folding process. The assumption is that the role of the ligand in derivation of such [actual] preorganized bind site structures is an instructive role, and is in support of the Haurowitz-Pauling hypothesis.


2016 ◽  
Author(s):  
Imadol V Jeff-Eke

We present a rationale and proposed approach to the modification and development of bind sites using their respective cognate ligands as template. This is in support of a plausible “instructive” role for the ligand and therefore its involvement in determination of the structure and properties of bind sites. We emphasize the relationship between substrate and active site as an example of the relationship between ligand and bind sites, respectively. This is based on the assumption that there are shared features between all ligand:bind site complexes. Therefore, principles that apply to a specific complex can be applied, in general, to other protein-based complexes. We define ligand-associated probability bias as the difference between the probability of finding activity-determining conformations (ADCs) in the presence- and absence of ligands. For cognate ligands, the given bias is in favor of these ADCs. Thus, bind sites are more likely to assume ADCs when their cognate ligands are present. We relate such probability bias to structural reorganization, disorganization, and preorganization events. We then propose a means of deriving an [apparent] preorganized bind site structure by way of reorganization events that occur with cognate ligand. Finally, we propose a means of deriving an [actual] preorganized bind site structure by way of reorganization events that occur with cognate ligand, albeit during the folding process. The assumption is that the role of the ligand in derivation of such [actual] preorganized bind site structures is an instructive role, and is in support of the Haurowitz-Pauling hypothesis.


Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 642 ◽  
Author(s):  
Donald A. Tomalia ◽  
Linda S. Nixon ◽  
David M. Hedstrand

This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.


Author(s):  
Sarah M R Wille ◽  
Simon Elliott

Abstract (Forensic) toxicology has faced many challenges, both analytically and interpretatively, especially in relation to an increase in potential drugs of interest. Analytical toxicology and its application to medicine and forensic science have progressed rapidly within the past centuries. Technological innovations have enabled detection of more substances with increasing sensitivity in a variety of matrices. Our understanding of the effects (both intended and unintended) have also increased along with determination and degree of toxicity. However, it is clear there is even more to understand and consider. The analytical focus has been on typical matrices such as blood and urine but other matrices could further increase our understanding, especially in postmortem (PM) situations. Within this context, the role of PM changes and potential redistribution of drugs requires further research and identification of markers of its occurrence and extent. Whilst instrumentation has improved, in the future, nanotechnology may play a role in selective and sensitive analysis as well as bioassays. Toxicologists often only have an advisory impact on pre-analytical and pre-interpretative considerations. The collection of appropriate samples at the right time in an appropriate way as well as obtaining sufficient circumstance background is paramount in ensuring an effective analytical strategy to provide useful results that can be interpreted within context. Nevertheless, key interpretative considerations such as pharmacogenomics and drug–drug interactions as well as determination of tolerance remain and in the future, analytical confirmation of an individual’s metabolic profile may support a personalized medicine and judicial approach. This should be supported by the compilation and appropriate application of drug data pursuant to the situation. Specifically, in PM circumstances, data pertaining to where a drug was not/may have been/was contributory will be beneficial with associated pathological considerations. This article describes the challenges faced within toxicology and discusses progress to a future where they are being addressed.


2020 ◽  
Vol 2 (3) ◽  
pp. 118-123
Author(s):  
OLGA YUTSCHENKO ◽  
◽  
YULIA GAMALEEVA

The purpose of research. The article deals with the general tendencies of the formation process of a historical figure as a national hero in media space. Winston Churchill’s cinematography imagery is analyzed and the features of interpretation of his role in history are defined. The purpose of research is determination of specificities in the formation process of imagery’s historical figure as national hero in cinematography. Results. Nowadays the way of representing historical space through the media sphere is one of the most popular for auditory and at the same time, it represents the new vision of the historical past. The tendency of connecting historical past and historical figure together drifts the angle from the whole epoch to «historical faces». That's the reason why historical epochs are translated through imagery of figures from the past. In this case historical space is gradually tapered to the person’s story and becomes more individual.


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