The effects of soil temperatures between 16° and 25 °C., and of soil moisture content between 19 and 40% of the moisture-holding capacity, on the virulence and type of attack of Rhizodonia Solani on young potato sprouts, were studied under controlled conditions and the results from 13 separate tests are discussed. The comparative growth rates of the pathogen on nutrient agar and in soil are outlined.At 25 °C. the disease diminished very abruptly. Between 23° and 16 °C., the pathogen appeared equally virulent throughout the range of soil moisture mentioned. The fluctuations which occurred in separate tests were not definite or consistent enough to warrant a conclusion that the virulence is greater at 16° than at 23°, or that a dry soil is more or less favorable to it than a wet one.In a fertile, steam sterilized loam, at medium moisture content, it required about ten days for the pathogen to grow as far as it did on the surface of a nutrient medium in four days. The growth rate at either 23° or 16 °C. was slightly higher in a wet soil than in one of medium moisture content, but in a dry soil the rate was somewhat less at 23° than at 16° in a medium or wet soil. Even in a fairly dry soil (19% moisture-holding capacity) at 16° the growth of the pathogen covered a distance of 5 cm. in ten days, which would appear adequate for infection of young sprouts from a set bearing viable sclerotia.The effort of the host to recover, by means of secondary and tertiary sprouts from the attacked primary sprout, was better in a wet soil than in a dry one at both 16° and 23 °C. The best effort was in a wet soil at 23°. A distinction is made between the effects of soil moisture and temperature in stimulating growth of the host, and their effect on parasitism itself.The remarkable tendency of the secondary sprouts to escape infection, regardless of soil temperature and soil moisture, is indicated. There was evidence that certain factors other than soil temperature and moisture may play an important role in the parasitism of R. Solani.