Approaches to the preparation of 3'-deoxynucleosides
Keyword(s):
The stability of 3'-O-sulphonyl derivatives of uridine towards nucleophilic displacement indicates that sulphonate replacement is unlikely to offer a general route to 3'-deoxynucleosides. The preparation of 3'-deoxyuridine by direct iodination of 2',5'-di-O-trityluridine with triphenylphosphite methiodide followed by catalytic hydrogenolysis is discussed as such a general route dependent on the availability of suitably protected nucleoside starting materials. Acyl migration takes place under the conditions of the iodination reaction, limiting the choice of protecting groups.
1986 ◽
Vol 51
(6)
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pp. 1340-1351
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Keyword(s):
2016 ◽
Vol 65
(12)
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pp. 2937-2942
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1970 ◽
Vol 18
(2)
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pp. 399-401
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Keyword(s):