Copper(II) complexes of glycylglycine and imidazole

1968 ◽  
Vol 21 (3) ◽  
pp. 671 ◽  
Author(s):  
R Driver ◽  
WR Walker
Keyword(s):  
Formation Constant ◽  
Physicochemical Methods ◽  
First Time

As a result of an investigation of copper(11) complexes containing both glycylglyoine and imidazole, the following compounds are described for the first time: CuHA(Im)2ClO4,H2O, Cu2A2Im,8H2O, and CuAIm,H2O (H2A = glycylglycine = gg, HA = gg-, A = gg2-, and Im = imidazole). The complex CuA,3H2O has also been isolated and used to determine the formation constant of CuA+Im ↔ CuAIm. This has the value log K = 3.8 � 0.3. The structures of these compounds have been investigated by physicochemical methods and are discussed.

One-pot synthesis of the new Hydroxamic acid and its complexes with metals

2022 ◽  
Vol 19 ◽  
Author(s):  
Gulu Abbasova ◽  
Ajdar Medjidov
Keyword(s):  
Nmr Spectroscopy ◽  
Thermogravimetric Analysis ◽  
Hydroxamic Acid ◽  
Uv Spectroscopy ◽  
Molar Ratio ◽  
One Pot ◽  
Ethanol Medium ◽  
Physicochemical Methods ◽  
Colored Complexes ◽  
First Time

Abstract: A one-pot conversion of 2-hydroxy-1-naphthoic aldehyde to hydroxamic acid was described. An efficient photoorganocatalytic method of synthesis was developed. The obtained hydroxamic acid was identified by various physicochemical methods such as IR, UV- and NMR-spectroscopy. Solid colored complexes of copper (II) and iron (II), respectively, green and brown colours with the obtained hydroxamic acid were synthesized in ethanol medium for the first time. The molar ratio of ligand and metal in the complex was 2:1. Their structures were established using IR, UV- spectroscopy and thermogravimetric analysis.

Copper(II) complexes containing mixed β-diketone chelates

1970 ◽  
Vol 23 (6) ◽  
pp. 1135 ◽  
Author(s):  
LF Nicholas ◽  
WR Walker
Keyword(s):  
Physicochemical Methods ◽  
First Time

Copper(11) complexes of the type [CuAB]O, where A and B are the β-diketones acetylacetone (Hacac), trifluoroacetylaoetone (Htfa), hexafluorylacetylaoetone (Hhfa), thenoyltrifluoroacetone (Htta), or benzoylacetone (Hbza), have been prepared and investigated. The compounds Cu(acac)(tta), Cu(acac)(bza), Cu(tfa)(tta), Cu(tfa)(bza), Cu(hfa)(tta), Cu(hfa)(bza), and Cu(tta)(bza) are described for the first time. They have been investigated by physicochemical methods and are discussed in the light of recently reported findings on Cu(aoac)(tfa), Cu(acac)(hfa), and Cu(tfa)(hfa). However, it must be pointed out that these complexes may possibly be mixtures of mostly [CuAB]0 with slight yet equal amounts of CuA2 and CuB2.

scholarly journals Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture

2006 ◽  
Vol 2006 ◽  
pp. 1-7 ◽  
Author(s):  
Ilia Manolov ◽  
Sevda Raleva ◽  
Petya Genova ◽  
Alexey Savov ◽  
Liliana Froloshka ◽  
...  
Keyword(s):  
Viral Replication ◽  
Earth Metal ◽  
H Nmr ◽  
Immunodeficiency Virus ◽  
Physicochemical Methods ◽  
Anti Hiv Agents ◽  
First Time ◽  
Anti Hiv ◽  
Hiv 1

The cerium Ce(III), lanthanum La(III), and neodymium Nd(III) complexes with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one (warfarin) (W) and 3,3′-benzylidenebis[4-hydroxycoumarin] (1) were synthesized and studied for the first time for cytotoxicity (on MT-2 cells) and as anti-HIV agents under acute and chronic infection. The complexes were characterized by different physicochemical methods: mass spectrometry, ¹H NMR, ¹³C NMR, and IR spectroscopy. The spectra of the complexes were interpreted on the basis of comparison with the spectrum of the free ligands. Anti-HIV effect of the complexes/ligands was measured in MT-2 cells by microtiter infection assay. Detection of endogenous reverse transcriptase (RT) activity and RT processivity by PCR indicative for proviral DNA synthesis demonstrated that anti-HIV activity has not been linked to early stages of viral replication. No effect on late steps of viral replication has been found using cells chronically producing HIV-1LAIvirus. La(W) demonstrated anti-HIV activity (IC50=21.4μM) close to maximal nontoxic concentration. Nd(W), Ce(1), and Nd(1) demonstrated limited anti-HIV potency, so none of the complexes seems appropriate to be used in clinic. Further targeting of HIV-1 inhibition by La(W) is under progress.

Interaction entre les réactifs lanthanidiques et les bases de Lewis: Application à l'analyse conformationnelle d'alcools cyclohexaniques

1979 ◽  
Vol 57 (9) ◽  
pp. 1080-1088 ◽  
Author(s):  
James Bouquant ◽  
Alain Maujean ◽  
Josselin Chuche
Keyword(s):  
Conformational Equilibrium ◽  
Equilibrium Constants ◽  
Intrinsic Parameters ◽  
Tertiary Alcohols ◽  
Butyl Group ◽  
Tert Butyl Group ◽  
Physicochemical Methods ◽  
First Time ◽  
Good Agreement

A method for the determination of the intrinsic parameters K and Δ for lanthanide–substrate complexes has been extended to conformationally mobile molecules. These parameters, determined for a series of secondary cyclohexane alcohols (cyclohexanol and 2-methylcyclohexanol) and for tertiary alcohols (1-methylcyclohexanol and 1-ethylcyclohexanol) complexed with Eu(DPM)3 and Yb(DPM)3 lead to the determination of the conformational equilibrium constants between) the free species on one part and the complexed species on the other.The results obtained for the free species are in good agreement with those obtained by other physicochemical methods. For the complexed species an appreciable shift of conformational equilibrium is noted for low values of the association constants.For the first time, the tert-butyl group of Yb(DPM)3 has been used as a conformational probe. [Journal translation]

scholarly journals Expression and Functional Characterization of the First Bacteriophage-Encoded Chaperonin

2012 ◽  
Vol 86 (18) ◽  
pp. 10103-10111 ◽  
Author(s):  
Lidia P. Kurochkina ◽  
Pavel I. Semenyuk ◽  
Victor N. Orlov ◽  
Johan Robben ◽  
Nina N. Sykilinda ◽  
...  
Keyword(s):  
Thermal Inactivation ◽  
Functional Characterization ◽  
Content Type ◽  
Chaperonin Groel ◽  
Phage Propagation ◽  
Physicochemical Methods ◽  
First Time

Chaperonins promote protein foldingin vivoand are ubiquitously found in bacteria, archaea, and eukaryotes. The first viral chaperonin GroEL ortholog, gene product 146 (gp146), whose gene was earlier identified in the genome of bacteriophage EL, has been shown to be synthesized during phage propagation inPseudomonas aeruginosacells. The recombinant gp146 has been expressed inEscherichia coliand characterized by different physicochemical methods for the first time. Using serum against the recombinant protein, gp146's native substrate, the phage endolysin gp188, has been immunoprecipitated from the lysate of EL-infected bacteria and identified by mass spectrometry.In vitroexperiments have shown that gp146 has a protective effect against endolysin thermal inactivation and aggregation, providing evidence of its chaperonin function. The phage chaperonin has been found to have the architecture and some properties similar to those of GroEL but not to require cochaperonin for its functional activity.

scholarly journals Environmental Assessment of Soil Along Highways (Novosibirsk)

2015 ◽  
Vol 4 (6) ◽  
pp. 3-11 ◽  
Author(s):  
Благодатнова ◽  
Anastasiya Blagodatnova
Keyword(s):  
Environmental Assessment ◽  
Living Systems ◽  
Individual Species ◽  
Ecological State ◽  
Biological Testing ◽  
Vehicles Emissions ◽  
Physicochemical Methods ◽  
Chronic Pollution ◽  
Biological Methods ◽  
First Time

These studies were performed for the first time at the territory of Novosibirsk. Some of the methods have not been previously used in environmental assessment along the major highways. The approbation of these methods can make a certain contribution to the theory of bioindication and biological testing (including the data on the environmental identity of individual species of plants and soil photoautotrophs). Using biological methods has allowed to evaluate the effects of living systems’ exposure to chronic pollution by vehicles’ emissions, which is impossible to achieve with traditionally used physicochemical methods that determine the concentration of certain pollutants only at a given time in a given sample. in the soils of Novosibirsk were found: 63 species of soil algae and cyanobacteria belonging to 42 geniuses, 38 families, 19 orders of 7 classes, 4 groups. Changes of taxonomic and phytocenological organization algocyanobacterial groups can serve as indicators of the environmental conditions, in particular, they can diagnose the degree of stress. The article demonstrates the possibility of applying biological methods to estimate the ecological state of technospheric territories.

Syntheses and Properties of Cycloamidines Based on 4H-Imidazoles

2006 ◽  
Vol 61 (4) ◽  
pp. 437-447 ◽  
Author(s):  
Rainer Beckert ◽  
Catharina Hippius ◽  
Tillmann Gebauer ◽  
Frances Stöckner ◽  
Christina Lüdigk ◽  
...  
Keyword(s):  
Copper Complexes ◽  
Formation Constant ◽  
Formation Constants ◽  
Stable Complex ◽  
Single Electron Transfer ◽  
H Nmr ◽  
Reduction Potentials ◽  
Donor Acceptor ◽  
First Time ◽  
Derivatives Of

Employing three different syntheses a broad spectrum of 4H-imidazoles 3a - 3s has been synthesized. In the course of the two-fold aminolysis reaction leading to derivatives 3q - 3s, deeply colored byproducts could be isolated and structural characterized.These novel donor-acceptor derivatives of type 7 consist of an 1H- and 4H-imidazole which are connected by a nitrogen bridge and rearrange via rapid 1,3-/1,5-hydride shifts. Using 1H NMR experiments the aminolysis product 3p shows prototropic isomers which could be detected in equilibrium for the first time. Cyclovoltammetric measurements of a series of substituted 2-aryl derivatives 3d - 3i displayed two reversible single electron transfer steps with relatively small semiquinone formation constants between 102 and 4×103. The 4H-imidazole 3d was successfully converted into boratetraaza-pentalene 8a, which showed two well separated reduction potentials. The value of semiquinone formation constant of 8a (1.8×1015) is even higher than those reported for similar derivatives. 4H-imidazoles can also be employed for the efficient complexation of catalytically important metals as exemplified by copper complexes 11 and 12. Derivative 3m, which possesses an additional chelating pyridine substructure, formed a stable complex of structural composition Zn(3m)2 with diethyl zinc

Copper(II) complexes of the bidentate chelate di(2-pyridyl) sulphide

1968 ◽  
Vol 21 (2) ◽  
pp. 331 ◽  
Author(s):  
R Driver ◽  
WR Walker
Keyword(s):  
Bidentate Chelate ◽  
Physicochemical Methods ◽  
First Time

Copper(11) complexes containing the chelate di(2-pyridyl) sulphide (dps) are described for the first time. They include (i) mono complexes of the type Cu dpsX2 (X = Cl, Br, NO2, and 2X = SO4); (ii) five-coordinate bis complexes of the type [CuX dps2]ClO4 (X = Cl, ���Br, SCS, and NO,); and (iii) the bis complex Cu dps,-(ClO4)2,H2O. Attempts to prepare the compound with X = I yielded the yellow copper(1) complex Cu dpsI. These compounds have been investigated by physicochemical methods and are discussed in the light of known copper(11) complexes containing nitrogen chelates.

scholarly journals Obtaining Caustic Soda and Burkeite by Caustification of Mixture of Corbonate and Sodium Sulphate

2021 ◽  
pp. 13-24
Author(s):  
D. A. Tursunova ◽  
A. U. Erkaev ◽  
Z. K. Toirov ◽  
Bokhodir E. Sultonov
Keyword(s):  
Caustic Soda ◽  
Sodium Carbonate ◽  
Sodium Sulphate ◽  
Technological Parameters ◽  
Component System ◽  
Physicochemical Basis ◽  
Physicochemical Methods ◽  
The One ◽  
Sodium Sulfates ◽  
First Time

The optimal technological parameters for the production of caustic soda from sodium carbonate and sulfate and calcium hydroxide have been established. The influence of the concentration of lime milk on the rate of filtration by sediment and filtrate has been studied. Purpose of the Work: The purpose of this work is to determine the physicochemical basis for the production of sodium hydroxide and burkeite by causticization of sodium carbonate and sulfate. Scientific Novelty: In comparison with the known works, a theoretical profoanalytical analysis of the one-cation of four-component system and its constituents was carried out for the first time, and also determined the optimal technological parameters of causticization of solutions for local carbonates and sodium sulfates. Features of the Work: - the influence of the main technological parameters on the processes of causticization, filtration, evaporation; - research of intermediate and finished products by modern physicochemical methods; - study of the rheological properties of the solution depending on the temperature and concentration of the resulting solutions.

scholarly journals INVESTIGATION OF THE COMPOSITION OF LIQUID MIXTURES FOR SMOKING. DETERMINATION OF SYNTHETIC CANNABINOIDS AND α-PVP

2021 ◽  
Vol 36 (2) ◽  
pp. 93-103
Author(s):  
O. Tarasenko
Keyword(s):  
Synthetic Cannabinoids ◽  
Liquid Mixtures ◽  
World Market ◽  
Psychotropic Substances ◽  
General Scientific ◽  
Physicochemical Methods ◽  
Quantitative Identification ◽  
Instrumental Methods ◽  
First Time ◽  
Narcotic Drugs

The purpose of the article is to highlight the possibility of quantitative identification of narcotic drugs, psychotropic substances and their analogues in the context of studying the composition of liquid mixtures for smoking (vapes), to propose a method. Methodology. A set of general scientific and special methods was used to achieve this goal. In particular, using theoretical methods (analysis, generalization, comparison, modeling), systematized theoretical materials on the problems to be solved; the state of practical elaboration of the problem is empirically determined; organizational and experimental means (diagnostic, ascertaining, formative, corrective experiment) in combination with qualitative analysis and mathematical processing of the obtained results confirmed the effectiveness of the proposed method. The reliability of the results is ensured by the use of modern instrumental physicochemical, mathematical, statistical methods of analysis, as well as software processing of experimental data. Scientific novelty. The composition of liquid mixtures for smoking was determined using physicochemical methods of research, for the first time the possibility of quantitative identification of synthetic cannabinoids and α-PVP in the composition of vapes was proved. Conclusions. The composition of liquid mixtures for smoking (vapes) was determined and the possibility of quantitative identification of narcotic drugs, psychotropic substances and their analogues using various instrumental methods based on modern scientific research, in particular the content of synthetic cannabinoids and α-PVP in liquid mixtures for smoking by thin-layer, gas chromatography and using mass spectrometry. The effectiveness of current methods of researching synthetic cannabinoids was tested on specific examples and a contribution was made to the future development of methods for studying the composition of drug-containing liquid mixtures for smoking and those containing psychotropic substances, the demand for which is currently growing on the world market and in Ukraine. A method for isolating synthetic cannabinoids and α-PVP from a solution of smoking mixtures has been developed. The general approaches to the choice of the scheme of research of synthetic narcotic drugs and psychotropic substances depending on the questions, form (liquid), type and quantity of the objects submitted for research are offered.

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