This chapter aimed to investigate the record of climatic and environmental change in the sedimentary filling of sebkha Mhabeul and their effect on hydric and eolian erosion within the wetland and its watershed. Along a 37 cm core, the sedimentary, geochemical, and geophysical signals at the Holocene-Anthropocene transition were followed. Sampling was carried out each 1 cm to obtain 37 samples. All studied parameters and clustering techniques indicate that the first 7 cm represent the Anthropocene strata. According to the age model, this upper part of the core records the last 300 yrs. The sedimentary record of the Anthropocene is marked by an increasing rate of sedimentation, grain size fining, heavy metals (Pb, Cu, Ni, Mn, and Fe) enrichment, which is related to increased erosion. Other intrinsic parameters such as CE, pH, Na, K, and CaCO3 enhance sediment erodibility. The measurement of the magnetic susceptibility along a 37 cm core collected from the sebkha Mhabeul shows an obvious upward increase related to a high content of heavy metals for the first 7 cm.